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Items: 50


LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.

Cebrià-Costa JP, Pascual-Reguant L, Gonzalez-Perez A, Serra-Bardenys G, Querol J, Cosín M, Verde G, Cigliano RA, Sanseverino W, Segura-Bayona S, Iturbide A, Andreu D, Nuciforo P, Bernado-Morales C, Rodilla V, Arribas J, Yelamos J, de Herreros AG, Stracker TH, Peiró S.

Oncogene. 2020 Jan;39(1):79-121. doi: 10.1038/s41388-019-0969-1. Epub 2019 Aug 28.


The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease.

Segura-Bayona S, Stracker TH.

Cell Mol Life Sci. 2019 Oct;76(19):3827-3841. doi: 10.1007/s00018-019-03208-z. Epub 2019 Jul 13. Review.


Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit.

Picchioni D, Antolin-Fontes A, Camacho N, Schmitz C, Pons-Pons A, Rodríguez-Escribà M, Machallekidou A, Güler MN, Siatra P, Carretero-Junquera M, Serrano A, Hovde SL, Knobel PA, Novoa EM, Solà-Vilarrubias M, Kaguni LS, Stracker TH, Ribas de Pouplana L.

Cell Rep. 2019 Apr 2;27(1):40-47.e5. doi: 10.1016/j.celrep.2019.03.022.


Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice.

Terré B, Lewis M, Gil-Gómez G, Han Z, Lu H, Aguilera M, Prats N, Roy S, Zhao H, Stracker TH.

Development. 2019 Apr 23;146(8). pii: dev162628. doi: 10.1242/dev.162628.


E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning?

Stracker TH.

Dev Biol. 2019 Feb 1;446(1):20-21. doi: 10.1016/j.ydbio.2018.12.007. Epub 2018 Dec 8. No abstract available.


EXD2: A new regulator of mitochondrial translation and potential target for cancer therapy.

Stracker TH.

Mol Cell Oncol. 2018 Mar 27;5(3):e1445943. doi: 10.1080/23723556.2018.1445943. eCollection 2018.


Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors.

Lee SB, Segura-Bayona S, Villamor-Payà M, Saredi G, Todd MAM, Attolini CS, Chang TY, Stracker TH, Groth A.

Sci Adv. 2018 Aug 8;4(8):eaat4985. doi: 10.1126/sciadv.aat4985. eCollection 2018 Aug.


Molecular basis of Tousled-Like Kinase 2 activation.

Mortuza GB, Hermida D, Pedersen AK, Segura-Bayona S, López-Méndez B, Redondo P, Rüther P, Pozdnyakova I, Garrote AM, Muñoz IG, Villamor-Payà M, Jauset C, Olsen JV, Stracker TH, Montoya G.

Nat Commun. 2018 Jun 28;9(1):2535. doi: 10.1038/s41467-018-04941-y.


Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.

Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR.

Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24.


CCNO mutations in NPH?

Núnez-Ollé M, Stracker TH, Gil-Gómez G.

Aging (Albany NY). 2018 Feb 3;10(2):158-159. doi: 10.18632/aging.101379. No abstract available.


EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH.

Nat Cell Biol. 2018 Feb;20(2):162-174. doi: 10.1038/s41556-017-0016-9. Epub 2018 Jan 15.


Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.

Núnez-Ollé M, Jung C, Terré B, Balsiger NA, Plata C, Roset R, Pardo-Pastor C, Garrido M, Rojas S, Alameda F, Lloreta J, Martín-Caballero J, Flores JM, Stracker TH, Valverde MA, Muñoz FJ, Gil-Gómez G.

Oncotarget. 2017 Oct 12;8(59):99261-99273. doi: 10.18632/oncotarget.21818. eCollection 2017 Nov 21.


Null diffusion-based enrichment for metabolomics data.

Picart-Armada S, Fernández-Albert F, Vinaixa M, Rodríguez MA, Aivio S, Stracker TH, Yanes O, Perera-Lluna A.

PLoS One. 2017 Dec 6;12(12):e0189012. doi: 10.1371/journal.pone.0189012. eCollection 2017.


Chaperoning the DNA damage response.

Stracker TH.

FEBS J. 2017 Aug;284(15):2375-2377. doi: 10.1111/febs.14156.


Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.

Segura-Bayona S, Knobel PA, González-Burón H, Youssef SA, Peña-Blanco A, Coyaud É, López-Rovira T, Rein K, Palenzuela L, Colombelli J, Forrow S, Raught B, Groth A, de Bruin A, Stracker TH.

Cell Death Differ. 2017 Nov;24(11):1872-1885. doi: 10.1038/cdd.2017.108. Epub 2017 Jul 14.


Positional Enrichment by Proton Analysis (PEPA): A One-Dimensional 1 H-NMR Approach for 13 C Stable Isotope Tracer Studies in Metabolomics.

Vinaixa M, Rodríguez MA, Aivio S, Capellades J, Gómez J, Canyellas N, Stracker TH, Yanes O.

Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3531-3535. doi: 10.1002/anie.201611347. Epub 2017 Feb 21.


PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas.

Navarro J, Gozalbo-López B, Méndez AC, Dantzer F, Schreiber V, Martínez C, Arana DM, Farrés J, Revilla-Nuin B, Bueno MF, Ampurdanés C, Galindo-Campos MA, Knobel PA, Segura-Bayona S, Martin-Caballero J, Stracker TH, Aparicio P, Del Val M, Yélamos J.

Sci Rep. 2017 Feb 9;7:41962. doi: 10.1038/srep41962.


GEMC1 is a critical regulator of multiciliated cell differentiation.

Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH.

EMBO J. 2016 May 2;35(9):942-60. doi: 10.15252/embj.201592821. Epub 2016 Mar 1.


NBS1 is required for macrophage homeostasis and functional activity in mice.

Pereira-Lopes S, Tur J, Calatayud-Subias JA, Lloberas J, Stracker TH, Celada A.

Blood. 2015 Nov 26;126(22):2502-10. doi: 10.1182/blood-2015-04-637371. Epub 2015 Aug 31.


EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.

Rein K, Yanez DA, Terré B, Palenzuela L, Aivio S, Wei K, Edelmann W, Stark JM, Stracker TH.

Nucleic Acids Res. 2015 Sep 3;43(15):7371-87. doi: 10.1093/nar/gkv691. Epub 2015 Jul 8.


CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.

Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker TH.

Nat Commun. 2015 Jul 9;6:7676. doi: 10.1038/ncomms8676.


ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion.

Chen WT, Ebelt ND, Stracker TH, Xhemalce B, Van Den Berg CL, Miller KM.

Elife. 2015 Jun 1;4. doi: 10.7554/eLife.07270.


Systematic identification of molecular links between core and candidate genes in breast cancer.

Arroyo R, Suñé G, Zanzoni A, Duran-Frigola M, Alcalde V, Stracker TH, Soler-López M, Aloy P.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1436-1450. doi: 10.1016/j.jmb.2015.01.014. Epub 2015 Jan 29.


The MRE11 complex: an important source of stress relief.

Rein K, Stracker TH.

Exp Cell Res. 2014 Nov 15;329(1):162-9. doi: 10.1016/j.yexcr.2014.10.010. Epub 2014 Oct 18. Review. No abstract available.


Regulation of USP28 deubiquitinating activity by SUMO conjugation.

Zhen Y, Knobel PA, Stracker TH, Reverter D.

J Biol Chem. 2014 Dec 12;289(50):34838-50. doi: 10.1074/jbc.M114.601849. Epub 2014 Oct 30.


A-to-I editing on tRNAs: biochemical, biological and evolutionary implications.

Torres AG, Piñeyro D, Filonava L, Stracker TH, Batlle E, Ribas de Pouplana L.

FEBS Lett. 2014 Nov 28;588(23):4279-86. doi: 10.1016/j.febslet.2014.09.025. Epub 2014 Sep 27. Review.


USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.

Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP, Stracker TH.

Mol Cell Biol. 2014 Jun;34(11):2062-74. doi: 10.1128/MCB.00197-14. Epub 2014 Mar 31.


PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.

Bianchi J, Rudd SG, Jozwiakowski SK, Bailey LJ, Soura V, Taylor E, Stevanovic I, Green AJ, Stracker TH, Lindsay HD, Doherty AJ.

Mol Cell. 2013 Nov 21;52(4):566-73. doi: 10.1016/j.molcel.2013.10.035.


Cep63 and cep152 cooperate to ensure centriole duplication.

Brown NJ, Marjanović M, Lüders J, Stracker TH, Costanzo V.

PLoS One. 2013 Jul 30;8(7):e69986. doi: 10.1371/journal.pone.0069986. Print 2013.


The ATM signaling network in development and disease.

Stracker TH, Roig I, Knobel PA, Marjanović M.

Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037. eCollection 2013.


Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.

Foster SS, De S, Johnson LK, Petrini JH, Stracker TH.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9953-8. doi: 10.1073/pnas.1120476109. Epub 2012 Jun 5.


The MRE11 complex: starting from the ends.

Stracker TH, Petrini JH.

Nat Rev Mol Cell Biol. 2011 Feb;12(2):90-103. doi: 10.1038/nrm3047. Review.


Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.

Stracker TH, Usui T, Petrini JH.

DNA Repair (Amst). 2009 Sep 2;8(9):1047-54. doi: 10.1016/j.dnarep.2009.04.012. Epub 2009 May 26. Review.


Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Deriano L, Stracker TH, Baker A, Petrini JH, Roth DB.

Mol Cell. 2009 Apr 10;34(1):13-25. doi: 10.1016/j.molcel.2009.03.009.


Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.

Genes Dev. 2009 Jan 15;23(2):171-80. doi: 10.1101/gad.1746609.


Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.


Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH.

Mol Cell. 2008 Jul 11;31(1):21-32. doi: 10.1016/j.molcel.2008.04.028. Erratum in: Mol Cell. 2008 Dec 26;32(6):889.


The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.

Nature. 2007 May 10;447(7141):218-21. Epub 2007 Apr 11.


Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes.

Araujo FD, Stracker TH, Carson CT, Lee DV, Weitzman MD.

J Virol. 2005 Sep;79(17):11382-91.


Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins.

Stracker TH, Lee DV, Carson CT, Araujo FD, Ornelles DA, Weitzman MD.

J Virol. 2005 Jun;79(11):6664-73.


The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.

Stracker TH, Theunissen JW, Morales M, Petrini JH.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):845-54. Review.


Structural and functional analysis of Mre11-3.

Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP.

Nucleic Acids Res. 2004 Mar 26;32(6):1886-93. Print 2004.


The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication.

Stracker TH, Cassell GD, Ward P, Loo YM, van Breukelen B, Carrington-Lawrence SD, Hamatake RK, van der Vliet PC, Weller SK, Melendy T, Weitzman MD.

J Virol. 2004 Jan;78(1):441-53.


The Mre11 complex is required for ATM activation and the G2/M checkpoint.

Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD.

EMBO J. 2003 Dec 15;22(24):6610-20.


The cellular response to DNA double-strand breaks: defining the sensors and mediators.

Petrini JH, Stracker TH.

Trends Cell Biol. 2003 Sep;13(9):458-62.


Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.

Stracker TH, Carson CT, Weitzman MD.

Nature. 2002 Jul 18;418(6895):348-52.


Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti (Diptera: Culicidae).

Stracker TH, Thompson S, Grossman GL, Riehle MA, Brown MR.

J Med Entomol. 2002 Mar;39(2):331-42.


A genetic screen identifies a cellular regulator of adeno-associated virus.

Cathomen T, Stracker TH, Gilbert LB, Weitzman MD.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14991-6. Epub 2001 Dec 4.


Identification of a steroidogenic neurohormone in female mosquitoes.

Brown MR, Graf R, Swiderek KM, Fendley D, Stracker TH, Champagne DE, Lea AO.

J Biol Chem. 1998 Feb 13;273(7):3967-71.

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