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Items: 25


VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL.

Cell. 2019 Aug 8;178(4):1030. doi: 10.1016/j.cell.2019.07.036. No abstract available.


VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL.

Cell. 2019 Jul 25;178(3):748-761.e17. doi: 10.1016/j.cell.2019.05.051. Epub 2019 Jul 4. Erratum in: Cell. 2019 Aug 8;178(4):1030.


PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

Kenakin T, Strachan RT.

Trends Pharmacol Sci. 2018 Aug;39(8):748-765. doi: 10.1016/ Epub 2018 Jun 7. Review.


Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.

Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4.


Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK.

JCI Insight. 2017 Sep 7;2(17). pii: 95998. doi: 10.1172/jci.insight.95998. eCollection 2017 Sep 7.


Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27.


GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.


Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ.

Nature. 2016 Jul 21;535(7612):448-52. Epub 2016 Jul 13.


Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ.

Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11.


Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA.

Circulation. 2015 Jun 16;131(24):2120-30. doi: 10.1161/CIRCULATIONAHA.115.015687. Epub 2015 May 20.


Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.

Hegde A, Strachan RT, Walker JK.

PLoS One. 2015 Feb 6;10(2):e0116458. doi: 10.1371/journal.pone.0116458. eCollection 2015.


Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Tang W, Strachan RT, Lefkowitz RJ, Rockman HA.

J Biol Chem. 2014 Oct 10;289(41):28271-83. doi: 10.1074/jbc.M114.585067. Epub 2014 Aug 28.


Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ.

J Biol Chem. 2014 May 16;289(20):14211-24. doi: 10.1074/jbc.M114.548131. Epub 2014 Mar 25.


Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ.

Mol Pharmacol. 2014 Mar;85(3):472-81. doi: 10.1124/mol.113.089516. Epub 2013 Dec 6.


Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice.

Lin R, Degan S, Theriot BS, Fischer BM, Strachan RT, Liang J, Pierce RA, Sunday ME, Noble PW, Kraft M, Brody AR, Walker JK.

Br J Pharmacol. 2012 Apr;165(7):2365-77. doi: 10.1111/j.1476-5381.2011.01725.x.


Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ.

Sci Signal. 2011 Aug 9;4(185):ra51. doi: 10.1126/scisignal.2001707.


A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.


p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.

Strachan RT, Allen JA, Sheffler DJ, Roth BL.

Biochemistry. 2010 Mar 30;49(12):2657-71. doi: 10.1021/bi901921k.


Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity.

Strachan RT, Sciaky N, Cronan MR, Kroeze WK, Roth BL.

Mol Pharmacol. 2010 Mar;77(3):327-38. doi: 10.1124/mol.109.061440. Epub 2009 Nov 20.


Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.

Jones KA, Srivastava DP, Allen JA, Strachan RT, Roth BL, Penzes P.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19575-80. doi: 10.1073/pnas.0905884106. Epub 2009 Nov 4.


Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.

Strachan RT, Sheffler DJ, Willard B, Kinter M, Kiselar JG, Roth BL.

J Biol Chem. 2009 Feb 27;284(9):5557-73. doi: 10.1074/jbc.M805705200. Epub 2008 Dec 22.


Screening the receptorome: an efficient approach for drug discovery and target validation.

Strachan RT, Ferrara G, Roth BL.

Drug Discov Today. 2006 Aug;11(15-16):708-16. Review.


Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.

Davies MA, Setola V, Strachan RT, Sheffler DJ, Salay E, Hufeisen SJ, Roth BL.

Pharmacogenomics J. 2006 Jan-Feb;6(1):42-51.


A survey of dystocia in beef cattle in Southern Queensland.

Wythes JR, Strachan RT, Durand MR.

Aust Vet J. 1976 Dec;52(12):570-4.


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