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Best matches for Strømgaard K[au]:

SLC6 neurotransmitter transporters: structure, function, and regulation. Kristensen AS et al. Pharmacol Rev. (2011)

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. Maric HM et al. Nat Chem Biol. (2017)

Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations. Sereikaitė V et al. Chembiochem. (2018)

Search results

Items: 1 to 50 of 116

1.

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers.

Najarzadeh Z, Mohammad-Beigi H, Nedergaard Pedersen J, Christiansen G, Sønderby TV, Shojaosadati SA, Morshedi D, Strømgaard K, Meisl G, Sutherland D, Skov Pedersen J, Otzen DE.

Biomolecules. 2019 Oct 26;9(11). pii: E659. doi: 10.3390/biom9110659.

2.

Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction.

Sereikaite V, Fritzius T, Kasaragod VB, Bader N, Maric HM, Schindelin H, Bettler B, Strømgaard K.

J Med Chem. 2019 Oct 10;62(19):8819-8830. doi: 10.1021/acs.jmedchem.9b01087. Epub 2019 Sep 25.

PMID:
31509708
3.

Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities.

Petersen J, Strømgaard K, Frølund B, Clemmensen C.

Drugs. 2019 Jul;79(11):1187-1197. doi: 10.1007/s40265-019-01153-6. Review.

PMID:
31243696
4.

Recent achievements in developing selective Gq inhibitors.

Zhang H, Nielsen AL, Strømgaard K.

Med Res Rev. 2019 Jun 19. doi: 10.1002/med.21598. [Epub ahead of print] Review.

PMID:
31218731
5.

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor.

Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG, Hansen PBL, Hasseldam H, Heitz M, Özcelik D, Tuck EJ, Kopanitsa MV, Grant SGN, Lykke-Hartmann K, Johansen FF, Lambertsen KL, Strømgaard K.

Neuropharmacology. 2019 May 15;150:100-111. doi: 10.1016/j.neuropharm.2019.02.035. Epub 2019 Mar 2.

PMID:
30836092
6.

Structure-Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM-254890.

Xiong XF, Zhang H, Boesgaard MW, Underwood CR, Bräuner-Osborne H, Strømgaard K.

ChemMedChem. 2019 Apr 17;14(8):865-870. doi: 10.1002/cmdc.201900018. Epub 2019 Mar 21.

PMID:
30790465
7.

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity.

Malfacini D, Patt J, Annala S, Harpsøe K, Eryilmaz F, Reher R, Crüsemann M, Hanke W, Zhang H, Tietze D, Gloriam DE, Bräuner-Osborne H, Strømgaard K, König GM, Inoue A, Gomeza J, Kostenis E.

J Biol Chem. 2019 Apr 12;294(15):5747-5758. doi: 10.1074/jbc.RA118.007250. Epub 2019 Feb 11.

8.

Controlling Ca2+ Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers.

Nørager NG, Poulsen MH, Strømgaard K.

J Med Chem. 2018 Sep 13;61(17):8048-8053. doi: 10.1021/acs.jmedchem.8b00756. Epub 2018 Aug 31.

PMID:
30125106
9.

Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations.

Sereikaitė V, Jensen TMT, Bartling CRO, Jemth P, Pless SA, Strømgaard K.

Chembiochem. 2018 Oct 18;19(20):2136-2145. doi: 10.1002/cbic.201800350. Epub 2018 Oct 1. Review.

PMID:
30073762
10.

Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359.

Zhang H, Nielsen AL, Boesgaard MW, Harpsøe K, Daly NL, Xiong XF, Underwood CR, Haugaard-Kedström LM, Bräuner-Osborne H, Gloriam DE, Strømgaard K.

Eur J Med Chem. 2018 Aug 5;156:847-860. doi: 10.1016/j.ejmech.2018.07.023. Epub 2018 Jul 12.

PMID:
30055466
11.

Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms.

Bleem A, Christiansen G, Madsen DJ, Maric H, Strømgaard K, Bryers JD, Daggett V, Meyer RL, Otzen DE.

J Mol Biol. 2018 Oct 12;430(20):3751-3763. doi: 10.1016/j.jmb.2018.06.043. Epub 2018 Jun 30.

12.

Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease.

Jensen TMT, Albertsen L, Bartling CRO, Haugaard-Kedström LM, Strømgaard K.

Chembiochem. 2018 Mar 26. doi: 10.1002/cbic.201800004. [Epub ahead of print]

PMID:
29578633
13.

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats.

Sommer JB, Bach A, Malá H, Strømgaard K, Mogensen J, Pickering DS.

Pharmacol Biochem Behav. 2017 Oct;161:62-67. doi: 10.1016/j.pbb.2017.09.008. Epub 2017 Sep 21.

PMID:
28943199
14.

Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers.

Rannversson H, Andersen J, Bang-Andersen B, Strømgaard K.

ACS Chem Biol. 2017 Oct 20;12(10):2558-2562. doi: 10.1021/acschembio.7b00338. Epub 2017 Sep 26.

PMID:
28910072
15.

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.

Sommer JB, Bach A, Malá H, Gynther M, Bjerre AS, Gram MG, Marschner L, Strømgaard K, Mogensen J, Pickering DS.

Neurochem Res. 2017 Dec;42(12):3401-3413. doi: 10.1007/s11064-017-2381-y. Epub 2017 Aug 21.

PMID:
28828633
16.

Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions.

Pedersen SW, Albertsen L, Moran GE, Levesque B, Pedersen SB, Bartels L, Wapenaar H, Ye F, Zhang M, Bowen ME, Strømgaard K.

ACS Chem Biol. 2017 Sep 15;12(9):2313-2323. doi: 10.1021/acschembio.7b00361. Epub 2017 Aug 1.

17.

Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein.

Zhang H, Xiong XF, Boesgaard MW, Underwood CR, Bräuner-Osborne H, Strømgaard K.

ChemMedChem. 2017 Jun 7;12(11):830-834. doi: 10.1002/cmdc.201700155. Epub 2017 May 16.

PMID:
28509439
18.

Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.

Roszko KL, Bi R, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M.

JCI Insight. 2017 Feb 9;2(3):e91079. doi: 10.1172/jci.insight.91079.

19.

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.

Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K.

Nat Chem Biol. 2017 Feb;13(2):153-160. doi: 10.1038/nchembio.2246. Epub 2016 Nov 28.

PMID:
27893705
20.

In vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury.

Sommer JB, Bach A, Malá H, Strømgaard K, Mogensen J, Pickering DS.

Eur J Neurosci. 2017 Jan;45(2):238-248. doi: 10.1111/ejn.13483. Epub 2016 Dec 4.

PMID:
27859797
21.

Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors.

Xiong XF, Zhang H, Underwood CR, Harpsøe K, Gardella TJ, Wöldike MF, Mannstadt M, Gloriam DE, Bräuner-Osborne H, Strømgaard K.

Nat Chem. 2016 Nov;8(11):1035-1041. doi: 10.1038/nchem.2577. Epub 2016 Jul 25.

22.

Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis.

Pedersen SW, Moran GE, Sereikaitė V, Haugaard-Kedström LM, Strømgaard K.

Chembiochem. 2016 Oct 17;17(20):1936-1944. doi: 10.1002/cbic.201600322. Epub 2016 Sep 7.

PMID:
27472651
23.

Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands.

Andersen J, Ladefoged LK, Kristensen TN, Munro L, Grouleff J, Stuhr-Hansen N, Kristensen AS, Schiøtt B, Strømgaard K.

ACS Chem Neurosci. 2016 Oct 19;7(10):1406-1417. Epub 2016 Aug 10.

PMID:
27425420
24.

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.

Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J.

Neuron. 2016 Oct 5;92(1):126-142. doi: 10.1016/j.neuron.2016.08.035. Epub 2016 Sep 15.

25.

PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarization in cortical spreading depression.

Kucharz K, Søndergaard Rasmussen I, Bach A, Strømgaard K, Lauritzen M.

J Cereb Blood Flow Metab. 2017 May;37(5):1820-1828. doi: 10.1177/0271678X16645595. Epub 2016 Jan 1.

26.

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.

Rannversson H, Andersen J, Sørensen L, Bang-Andersen B, Park M, Huber T, Sakmar TP, Strømgaard K.

Nat Commun. 2016 Apr 19;7:11261. doi: 10.1038/ncomms11261.

27.

Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function.

Andreasen JT, Nasser A, Caballero-Puntiverio M, Sahlholt M, Bach A, Gynther M, Strømgaard K, Pickering DS.

Eur J Pharmacol. 2016 Jun 5;780:166-73. doi: 10.1016/j.ejphar.2016.03.045. Epub 2016 Mar 28.

PMID:
27032314
28.

Ligand binding to the PDZ domains of postsynaptic density protein 95.

Toto A, Pedersen SW, Karlsson OA, Moran GE, Andersson E, Chi CN, Strømgaard K, Gianni S, Jemth P.

Protein Eng Des Sel. 2016 May;29(5):169-75. doi: 10.1093/protein/gzw004. Epub 2016 Mar 2.

PMID:
26941280
29.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.

30.

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter.

Andersen J, Ringsted KB, Bang-Andersen B, Strømgaard K, Kristensen AS.

Sci Rep. 2015 Oct 27;5:15650. doi: 10.1038/srep15650.

31.

Binding of the multimodal antidepressant drug vortioxetine to the human serotonin transporter.

Andersen J, Ladefoged LK, Wang D, Kristensen TN, Bang-Andersen B, Kristensen AS, Schiøtt B, Strømgaard K.

ACS Chem Neurosci. 2015 Nov 18;6(11):1892-900. doi: 10.1021/acschemneuro.5b00225. Epub 2015 Oct 11.

PMID:
26389667
32.

Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.

Rannversson H, Wilson P, Kristensen KB, Sinning S, Kristensen AS, Strømgaard K, Andersen J.

J Biol Chem. 2015 Jun 5;290(23):14582-94. doi: 10.1074/jbc.M114.629071. Epub 2015 Apr 22.

33.

Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family.

Nissen KB, Haugaard-Kedström LM, Wilbek TS, Nielsen LS, Åberg E, Kristensen AS, Bach A, Jemth P, Strømgaard K.

PLoS One. 2015 Feb 6;10(2):e0117668. doi: 10.1371/journal.pone.0117668. eCollection 2015.

34.

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor.

Nissen KB, Andersen JJ, Haugaard-Kedström LM, Bach A, Strømgaard K.

J Med Chem. 2015 Feb 12;58(3):1575-80. doi: 10.1021/jm501755d. Epub 2015 Jan 30.

PMID:
25590984
35.

Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin.

Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H.

Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767.

PMID:
25531214
36.

Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors.

Maric HM, Kasaragod VB, Haugaard-Kedström L, Hausrat TJ, Kneussel M, Schindelin H, Strømgaard K.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):490-4. doi: 10.1002/anie.201409043. Epub 2014 Nov 20.

PMID:
25413248
37.

Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.

Eildal JN, Bach A, Dogan J, Ye F, Zhang M, Jemth P, Strømgaard K.

Chembiochem. 2015 Jan 2;16(1):64-9. doi: 10.1002/cbic.201402547. Epub 2014 Nov 18.

PMID:
25407949
38.

Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.

Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Strømgaard K.

Chembiochem. 2015 Jan 2;16(1):59-63. doi: 10.1002/cbic.201402512. Epub 2014 Nov 7. No abstract available.

39.

Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors.

Xiong XF, Poulsen MH, Hussein RA, Nørager NG, Strømgaard K.

ChemMedChem. 2014 Dec;9(12):2661-70. doi: 10.1002/cmdc.201402278. Epub 2014 Sep 29.

PMID:
25267300
40.

Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines.

Stuhr-Hansen N, Bork N, Strømgaard K.

Org Biomol Chem. 2014 Aug 14;12(30):5745-51. doi: 10.1039/c4ob00073k. Epub 2014 Jun 26.

PMID:
24967660
41.

Design and Synthesis of Peptide YY Analogues with C-terminal Backbone Amide-to-Ester Modifications.

Albertsen L, Andersen JJ, Paulsson JF, Thomsen JK, Norrild JC, Strømgaard K.

ACS Med Chem Lett. 2013 Oct 21;4(12):1228-32. doi: 10.1021/ml400335g. eCollection 2013 Dec 12.

42.

Binding of ArgTX-636 in the NMDA receptor ion channel.

Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS.

J Mol Biol. 2015 Jan 16;427(1):176-89. doi: 10.1016/j.jmb.2014.05.017. Epub 2014 May 24.

43.

Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors.

Nørager NG, Poulsen MH, Jensen AG, Jeppesen NS, Kristensen AS, Strømgaard K.

J Med Chem. 2014 Jun 12;57(11):4940-9. doi: 10.1021/jm5004705. Epub 2014 May 29.

PMID:
24824658
44.

The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain.

Pedersen SW, Hultqvist G, Strømgaard K, Jemth P.

PLoS One. 2014 Apr 18;9(4):e95619. doi: 10.1371/journal.pone.0095619. eCollection 2014.

45.

Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin.

Poulsen MH, Lucas S, Strømgaard K, Kristensen AS.

Neurochem Res. 2014 Oct;39(10):1906-13. doi: 10.1007/s11064-014-1258-6. Epub 2014 Feb 22.

PMID:
24557991
46.

Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac).

Andersen J, Stuhr-Hansen N, Zachariassen LG, Koldsø H, Schiøtt B, Strømgaard K, Kristensen AS.

Mol Pharmacol. 2014 May;85(5):703-14. doi: 10.1124/mol.113.091249. Epub 2014 Feb 10.

PMID:
24516100
47.

Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.

Pedersen SW, Pedersen SB, Anker L, Hultqvist G, Kristensen AS, Jemth P, Strømgaard K.

Nat Commun. 2014;5:3215. doi: 10.1038/ncomms4215.

PMID:
24477114
48.

Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites.

Sørensen L, Strømgaard K, Kristensen AS.

ACS Chem Biol. 2014 Apr 18;9(4):935-44. doi: 10.1021/cb4007198. Epub 2014 Feb 3.

PMID:
24450286
49.

Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

Poulsen MH, Lucas S, Strømgaard K, Kristensen AS.

Mol Pharmacol. 2014 Feb;85(2):261-8. doi: 10.1124/mol.113.089961. Epub 2013 Nov 12.

PMID:
24220009
50.

Recombinant production of peptide C-terminal α-amides using an engineered intein.

Albertsen L, Shaw AC, Norrild JC, Strømgaard K.

Bioconjug Chem. 2013 Nov 20;24(11):1883-94. doi: 10.1021/bc4002689. Epub 2013 Nov 6.

PMID:
24138202

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