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Items: 38

1.

Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.

Blomster LV, Strøbaek D, Hougaard C, Klein J, Pinborg LH, Mikkelsen JD, Christophersen P.

Glia. 2016 Dec;64(12):2065-2078. doi: 10.1002/glia.23040. Epub 2016 Jul 29.

PMID:
27470924
2.

A pharmacological assessment of agonists and modulators at α4β2γ2 and α4β2δ GABAA receptors: The challenge in comparing apples with oranges.

Ahring PK, Bang LH, Jensen ML, Strøbæk D, Hartiadi LY, Chebib M, Absalom N.

Pharmacol Res. 2016 Sep;111:563-576. doi: 10.1016/j.phrs.2016.05.014. Epub 2016 May 10.

PMID:
27178730
3.

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC.

J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20.

4.

Kv7 channels as targets for anti-epileptic and psychiatric drug-development.

Grunnet M, Strøbæk D, Hougaard C, Christophersen P.

Eur J Pharmacol. 2014 Mar 5;726:133-7. doi: 10.1016/j.ejphar.2014.01.017. Epub 2014 Jan 20. Review.

PMID:
24457124
5.

Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells.

Rasmussen AH, Strøbæk D, Dyhring T, Jensen ML, Peters D, Grunnet M, Timmermann DB, Ahring PK.

Brain Res. 2014 Jan 13;1542:1-11. doi: 10.1016/j.brainres.2013.10.024. Epub 2013 Oct 21.

PMID:
24157862
6.

Characterization of a novel high-potency positive modulator of K(v)7 channels.

Dalby-Brown W, Jessen C, Hougaard C, Jensen ML, Jacobsen TA, Nielsen KS, Erichsen HK, Grunnet M, Ahring PK, Christophersen P, Strøbæk D, Jørgensen S.

Eur J Pharmacol. 2013 Jun 5;709(1-3):52-63. doi: 10.1016/j.ejphar.2013.03.039. Epub 2013 Apr 3.

PMID:
23562623
7.

A high-throughput screening campaign for detection of ca(2+)-activated k(+) channel activators and inhibitors using a fluorometric imaging plate reader-based tl(+)-influx assay.

Jørgensen S, Dyhring T, Brown DT, Strøbæk D, Christophersen P, Demnitz J.

Assay Drug Dev Technol. 2013 Apr;11(3):163-72. doi: 10.1089/adt.2012.479. Epub 2012 Nov 30.

PMID:
23198866
8.

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.

Kasumu AW, Hougaard C, Rode F, Jacobsen TA, Sabatier JM, Eriksen BL, Strøbæk D, Liang X, Egorova P, Vorontsova D, Christophersen P, Rønn LC, Bezprozvanny I.

Chem Biol. 2012 Oct 26;19(10):1340-53. doi: 10.1016/j.chembiol.2012.07.013.

9.

NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.

Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P.

Br J Pharmacol. 2013 Jan;168(2):432-44. doi: 10.1111/j.1476-5381.2012.02143.x.

10.

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.

Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EØ, Strøbæk D, Shepard PD, Christophersen P.

Front Pharmacol. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011. eCollection 2012.

11.

Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype.

Hougaard C, Hammami S, Eriksen BL, Sørensen US, Jensen ML, Strøbæk D, Christophersen P.

Mol Pharmacol. 2012 Feb;81(2):210-9. doi: 10.1124/mol.111.074252. Epub 2011 Nov 1.

PMID:
22046005
12.

Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.

Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H.

Mol Pharmacol. 2011 Jun;79(6):899-909. doi: 10.1124/mol.110.069807. Epub 2011 Mar 1.

13.

Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment.

Hougaard C, Jensen ML, Dale TJ, Miller DD, Davies DJ, Eriksen BL, Strøbaek D, Trezise DJ, Christophersen P.

Mol Pharmacol. 2009 Sep;76(3):569-78. doi: 10.1124/mol.109.056663. Epub 2009 Jun 10.

PMID:
19515965
14.

Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels.

Ji H, Hougaard C, Herrik KF, Strøbaek D, Christophersen P, Shepard PD.

Eur J Neurosci. 2009 May;29(9):1883-95. doi: 10.1111/j.1460-9568.2009.06735.x. Epub 2009 Apr 20.

15.

Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells.

Kjaer K, Strøbaek D, Christophersen P, Rønn LC.

Brain Res. 2009 Jul 24;1281:15-24. doi: 10.1016/j.brainres.2009.05.015. Epub 2009 May 13. Erratum in: Brain Res. 2009 Sep 29;1291:153.

PMID:
19446535
16.
17.

Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.

Sørensen US, Strøbaek D, Christophersen P, Hougaard C, Jensen ML, Nielsen EØ, Peters D, Teuber L.

J Med Chem. 2008 Dec 11;51(23):7625-34. doi: 10.1021/jm800809f.

PMID:
18998663
18.

A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.

Hougaard C, Fraser MO, Chien C, Bookout A, Katofiasc M, Jensen BS, Rode F, Bitsch-Nørhave J, Teuber L, Thor KB, Strøbaek D, Burgard EC, Rønn LC.

J Pharmacol Exp Ther. 2009 Jan;328(1):28-39. doi: 10.1124/jpet.108.143123. Epub 2008 Sep 26.

PMID:
18820135
19.

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

Hougaard C, Eriksen BL, Jørgensen S, Johansen TH, Dyhring T, Madsen LS, Strøbaek D, Christophersen P.

Br J Pharmacol. 2007 Jul;151(5):655-65. Epub 2007 May 8.

20.

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.

Strøbaek D, Hougaard C, Johansen TH, Sørensen US, Nielsen EØ, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P.

Mol Pharmacol. 2006 Nov;70(5):1771-82. Epub 2006 Aug 22.

PMID:
16926279
21.

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M.

J Biol Chem. 2005 Dec 16;280(50):41404-11. Epub 2005 Oct 20.

22.

Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.

Korsgaard MP, Hartz BP, Brown WD, Ahring PK, Strøbaek D, Mirza NR.

J Pharmacol Exp Ther. 2005 Jul;314(1):282-92. Epub 2005 Apr 6.

PMID:
15814569
23.

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Strøbaek D, Teuber L, Jørgensen TD, Ahring PK, Kjaer K, Hansen RS, Olesen SP, Christophersen P, Skaaning-Jensen B.

Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5.

24.

Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas.

Hélix N, Strøbaek D, Dahl BH, Christophersen P.

J Membr Biol. 2003 Nov 15;196(2):83-94.

PMID:
14724745
25.

Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352.

Schrøder RL, Strøbaek D, Olesen SP, Christophersen P.

Pflugers Arch. 2003 Aug;446(5):607-16. Epub 2003 Jul 8.

PMID:
12851819
26.

The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments?

Jensen BS, Strøbaek D, Olesen SP, Christophersen P.

Curr Drug Targets. 2001 Dec;2(4):401-22. Review.

PMID:
11732639
27.

KCNQ4 channel activation by BMS-204352 and retigabine.

Schrøder RL, Jespersen T, Christophersen P, Strøbaek D, Jensen BS, Olesen SP.

Neuropharmacology. 2001 Jun;40(7):888-98. Erratum in: Neuropharmacology. 2003 Mar;44(4):553.

PMID:
11378159
28.

An ERG channel inhibitor from the scorpion Buthus eupeus.

Korolkova YV, Kozlov SA, Lipkin AV, Pluzhnikov KA, Hadley JK, Filippov AK, Brown DA, Angelo K, Strøbaek D, Jespersen T, Olesen SP, Jensen BS, Grishin EV.

J Biol Chem. 2001 Mar 30;276(13):9868-76. Epub 2001 Jan 2.

29.

Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.

Schrøder RL, Jensen BS, Strøbaek D, Olesen SP, Christophersen P.

Pflugers Arch. 2000 Oct;440(6):809-18.

PMID:
11041545
30.

Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.

Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP.

Br J Pharmacol. 2000 Mar;129(5):991-9.

31.

Activation of the human intermediate-conductance Ca(2+)-activated K(+) channel by 1-ethyl-2-benzimidazolinone is strongly Ca(2+)-dependent.

Pedersen KA, Schrøder RL, Skaaning-Jensen B, Strøbaek D, Olesen SP, Christophersen P.

Biochim Biophys Acta. 1999 Aug 20;1420(1-2):231-40.

32.

Functional characterization of a cloned human intermediate-conductance Ca(2+)-activated K+ channel.

Jørgensen TD, Jensen BS, Strøbaek D, Christophersen P, Olesen SP, Ahring PK.

Ann N Y Acad Sci. 1999 Apr 30;868:423-6. No abstract available.

PMID:
10414313
33.

Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.

Jensen BS, Strobaek D, Christophersen P, Jorgensen TD, Hansen C, Silahtaroglu A, Olesen SP, Ahring PK.

Am J Physiol. 1998 Sep;275(3):C848-56. doi: 10.1152/ajpcell.1998.275.3.C848.

PMID:
9730970
34.

Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells.

Ahring PK, Strøbaek D, Christophersen P, Olesen SP, Johansen TE.

FEBS Lett. 1997 Sep 22;415(1):67-70.

35.

ATP activates K and Cl channels via purinoceptor-mediated release of Ca2+ in human coronary artery smooth muscle.

Strøbaek D, Christophersen P, Dissing S, Olesen SP.

Am J Physiol. 1996 Nov;271(5 Pt 1):C1463-71.

PMID:
8944628
36.

Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain.

Tseng-Crank J, Godinot N, Johansen TE, Ahring PK, Strøbaek D, Mertz R, Foster CD, Olesen SP, Reinhart PH.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9200-5.

37.
38.

Modulation of the Ca(2+)-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2+.

Strøbaek D, Christophersen P, Holm NR, Moldt P, Ahring PK, Johansen TE, Olesen SP.

Neuropharmacology. 1996;35(7):903-14.

PMID:
8938721

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