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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.

Das Gupta K, Shakespear MR, Curson JEB, Murthy AMV, Iyer A, Hodson MP, Ramnath D, Tillu VA, von Pein JB, Reid RC, Tunny K, Hohenhaus DM, Moradi SV, Kelly GM, Kobayashi T, Gunter JH, Stevenson AJ, Xu W, Luo L, Jones A, Johnston WA, Blumenthal A, Alexandrov K, Collins BM, Stow JL, Fairlie DP, Sweet MJ.

Cell Rep. 2020 Feb 25;30(8):2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007.


A life in pictures-Marilyn Gist Farquhar.

Stow JL, Saraste J, Brown WJ.

J Cell Biol. 2020 Feb 3;219(2). pii: e202001010. doi: 10.1083/jcb.202001010. No abstract available.


Signalling, sorting and scaffolding adaptors for Toll-like receptors.

Luo L, Lucas RM, Liu L, Stow JL.

J Cell Sci. 2019 Dec 30;133(5). pii: jcs239194. doi: 10.1242/jcs.239194. Review.


SCIMP is a universal Toll-like receptor adaptor in macrophages.

Luo L, Curson JEB, Liu L, Wall AA, Tuladhar N, Lucas RM, Sweet MJ, Stow JL.

J Leukoc Biol. 2020 Feb;107(2):251-262. doi: 10.1002/JLB.2MA0819-138RR. Epub 2019 Aug 29.


Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation.

Loh Z, Fitzsimmons RL, Reid RC, Ramnath D, Clouston A, Gupta PK, Irvine KM, Powell EE, Schroder K, Stow JL, Sweet MJ, Fairlie DP, Iyer A.

Br J Pharmacol. 2019 Oct;176(19):3775-3790. doi: 10.1111/bph.14768. Epub 2019 Aug 17.


Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes.

Wall AA, Condon ND, Luo L, Stow JL.

Philos Trans R Soc Lond B Biol Sci. 2019 Feb 4;374(1765):20180151. doi: 10.1098/rstb.2018.0151.


Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.

Tong SJ, Wall AA, Hung Y, Luo L, Stow JL.

Small GTPases. 2019 Mar 7:1-17. doi: 10.1080/21541248.2019.1587278. [Epub ahead of print] Erratum in: Small GTPases. 2020 Jan 11;:1.


RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

Guo D, Lui GYL, Lai SL, Wilmott JS, Tikoo S, Jackett LA, Quek C, Brown DL, Sharp DM, Kwan RYQ, Chacon D, Wong JH, Beck D, van Geldermalsen M, Holst J, Thompson JF, Mann GJ, Scolyer RA, Stow JL, Weninger W, Haass NK, Beaumont KA.

Int J Cancer. 2019 Jun 15;144(12):3070-3085. doi: 10.1002/ijc.32064. Epub 2019 Jan 3.


Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes.

Kamato D, Burch M, Zhou Y, Mohamed R, Stow JL, Osman N, Zheng W, Little PJ.

Cell Signal. 2019 Jan;53:365-373. doi: 10.1016/j.cellsig.2018.11.005. Epub 2018 Nov 10.


TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses.

Luo L, Wall AA, Tong SJ, Hung Y, Xiao Z, Tarique AA, Sly PD, Fantino E, Marzolo MP, Stow JL.

Cell Rep. 2018 Sep 11;24(11):3033-3044. doi: 10.1016/j.celrep.2018.08.028.


Differential expression of genes and receptors in monocytes from patients with cystic fibrosis.

Tarique AA, Sly PD, Cardenas DG, Luo L, Stow JL, Bell SC, Wainwright CE, Fantino E.

J Cyst Fibros. 2019 May;18(3):342-348. doi: 10.1016/j.jcf.2018.07.012. Epub 2018 Sep 1.


Macropinosome formation by tent pole ruffling in macrophages.

Condon ND, Heddleston JM, Chew TL, Luo L, McPherson PS, Ioannou MS, Hodgson L, Stow JL, Wall AA.

J Cell Biol. 2018 Nov 5;217(11):3873-3885. doi: 10.1083/jcb.201804137. Epub 2018 Aug 27.


Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.

Kojic M, Gaik M, Kiska B, Salerno-Kochan A, Hunt S, Tedoldi A, Mureev S, Jones A, Whittle B, Genovesi LA, Adolphe C, Brown DL, Stow JL, Alexandrov K, Sah P, Glatt S, Wainwright BJ.

Nat Commun. 2018 Aug 10;9(1):3195. doi: 10.1038/s41467-018-05765-6.


Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion.

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K.

Cell Rep. 2018 Aug 7;24(6):1425-1433. doi: 10.1016/j.celrep.2018.07.027.


Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes.

Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ.

JCI Insight. 2018 Jul 26;3(14). pii: 120274. doi: 10.1172/jci.insight.120274. eCollection 2018 Jul 26.


Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL.

Schuelein R, Spencer H, Dagley LF, Li PF, Luo L, Stow JL, Abraham G, Naderer T, Gomez-Valero L, Buchrieser C, Sugimoto C, Yamagishi J, Webb AI, Pasricha S, Hartland EL.

Cell Microbiol. 2018 Sep;20(9):e12852. doi: 10.1111/cmi.12852. Epub 2018 May 18.


pTRAPs: Transmembrane adaptors in innate immune signaling.

Curson JEB, Luo L, Sweet MJ, Stow JL.

J Leukoc Biol. 2018 Mar 30. doi: 10.1002/JLB.2RI1117-474R. [Epub ahead of print]


Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP.

Luo L, Tong SJ, Wall AA, Khromykh T, Sweet MJ, Stow JL.

Immunol Cell Biol. 2017 Jul;95(6):564-570. doi: 10.1038/icb.2017.10. Epub 2017 Mar 14.


Salmonella effector SopD2 interferes with Rab34 function.

Teo WX, Yang Z, Kerr MC, Luo L, Guo Z, Alexandrov K, Stow JL, Teasdale RD.

Cell Biol Int. 2017 Apr;41(4):433-446. doi: 10.1002/cbin.10739. Epub 2017 Feb 27.


Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.

Wall AA, Luo L, Hung Y, Tong SJ, Condon ND, Blumenthal A, Sweet MJ, Stow JL.

J Biol Chem. 2017 Mar 17;292(11):4411-4422. doi: 10.1074/jbc.M116.766337. Epub 2017 Jan 27.


SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.

Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, Ross IL, Hibbs ML, Stow JL, Sweet MJ.

Nat Commun. 2017 Jan 18;8:14133. doi: 10.1038/ncomms14133.


Image-Based Analysis of Phagocytosis: Measuring Engulfment and Internalization.

Condon ND, Wall AA, Yeo JC, Hamilton NA, Stow JL.

Methods Mol Biol. 2017;1519:201-214.


Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages.

Yeo JC, Wall AA, Luo L, Condon ND, Stow JL.

Traffic. 2016 Sep;17(9):1014-26. doi: 10.1111/tra.12415. Epub 2016 Jun 23.


Sequential recruitment of Rab GTPases during early stages of phagocytosis.

Yeo JC, Wall AA, Luo L, Stow JL.

Cell Logist. 2016 Jan 29;6(1):e1140615. eCollection 2016 Jan-Mar.


The cell surface environment for pathogen recognition and entry.

Stow JL, Condon ND.

Clin Transl Immunology. 2016 Apr 15;5(4):e71. doi: 10.1038/cti.2016.15. eCollection 2016 Apr. Review.


The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists.

Chen KW, Bezbradica JS, Groß CJ, Wall AA, Sweet MJ, Stow JL, Schroder K.

Eur J Immunol. 2016 Apr;46(4):1004-10. doi: 10.1002/eji.201545943. Epub 2016 Feb 1.


The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements.

Luo L, Xue J, Kwan A, Gamsjaeger R, Wielens J, von Kleist L, Cubeddu L, Guo Z, Stow JL, Parker MW, Mackay JP, Robinson PJ.

J Biol Chem. 2016 Apr 29;291(18):9411-24. doi: 10.1074/jbc.M115.703108. Epub 2016 Feb 18.


RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

Tuong ZK, Lau P, Du X, Condon ND, Goode JM, Oh TG, Yeo JC, Muscat GE, Stow JL.

PLoS One. 2016 Jan 26;11(1):e0147179. doi: 10.1371/journal.pone.0147179. eCollection 2016.


The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.

Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ.

J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14.


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD.

Sci Rep. 2015 Oct 6;5:14763. doi: 10.1038/srep14763.


RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.

Yu CH, Micaroni M, Puyskens A, Schultz TE, Yeo JC, Stanley AC, Lucas M, Kurihara J, Dobos KM, Stow JL, Blumenthal A.

J Immunol. 2015 Oct 15;195(8):3890-900. doi: 10.4049/jimmunol.1500017. Epub 2015 Sep 14.


Dynamic imaging of the recycling endosomal network in macrophages.

Wall AA, Condon ND, Yeo JC, Hamilton NA, Stow JL.

Methods Cell Biol. 2015;130:1-18. doi: 10.1016/bs.mcb.2015.04.007. Epub 2015 Jun 11.


Mechanisms of unconventional secretion of IL-1 family cytokines.

Monteleone M, Stow JL, Schroder K.

Cytokine. 2015 Aug;74(2):213-8. doi: 10.1016/j.cyto.2015.03.022. Epub 2015 Apr 25.


Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.

Yeo JC, Wall AA, Luo L, Stow JL.

Mol Biol Cell. 2015 Mar 1;26(5):952-65. doi: 10.1091/mbc.E14-10-1457. Epub 2015 Jan 7.


Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.

King NP, Newton P, Schuelein R, Brown DL, Petru M, Zarsky V, Dolezal P, Luo L, Bugarcic A, Stanley AC, Murray RZ, Collins BM, Teasdale RD, Hartland EL, Stow JL.

Cell Microbiol. 2015 Jun;17(6):767-84. doi: 10.1111/cmi.12405. Epub 2015 Jan 24.


Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.

Lau P, Tuong ZK, Wang SC, Fitzsimmons RL, Goode JM, Thomas GP, Cowin GJ, Pearen MA, Mardon K, Stow JL, Muscat GE.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E159-71. doi: 10.1152/ajpendo.00056.2014. Epub 2014 Nov 25.


Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking.

Murray RZ, Stow JL.

Front Immunol. 2014 Oct 27;5:538. doi: 10.3389/fimmu.2014.00538. eCollection 2014. Review.


Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.

Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL.

Nat Commun. 2014 Jul 15;5:4407. doi: 10.1038/ncomms5407.


Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation.

Inder KL, Ruelcke JE, Petelin L, Moon H, Choi E, Rae J, Blumenthal A, Hutmacher D, Saunders NA, Stow JL, Parton RG, Hill MM.

J Extracell Vesicles. 2014 Jun 25;3. doi: 10.3402/jev.v3.23784. eCollection 2014.


On linear models and parameter identifiability in experimental biological systems.

Lamberton TO, Condon ND, Stow JL, Hamilton NA.

J Theor Biol. 2014 Oct 7;358:102-21. doi: 10.1016/j.jtbi.2014.05.028. Epub 2014 May 29.


Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits.

Jagirdar K, Smit DJ, Ainger SA, Lee KJ, Brown DL, Chapman B, Zhen Zhao Z, Montgomery GW, Martin NG, Stow JL, Duffy DL, Sturm RA.

Pigment Cell Melanoma Res. 2014 Jul;27(4):552-64. doi: 10.1111/pcmr.12253. Epub 2014 May 12.


PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model.

Low PC, Manzanero S, Mohannak N, Narayana VK, Nguyen TH, Kvaskoff D, Brennan FH, Ruitenberg MJ, Gelderblom M, Magnus T, Kim HA, Broughton BR, Sobey CG, Vanhaesebroeck B, Stow JL, Arumugam TV, Meunier FA.

Nat Commun. 2014 Mar 14;5:3450. doi: 10.1038/ncomms4450.


The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages.

Stanley AC, Wong CX, Micaroni M, Venturato J, Khromykh T, Stow JL, Lacy P.

Immunol Cell Biol. 2014 Mar;92(3):275-86. doi: 10.1038/icb.2013.90. Epub 2013 Dec 17.


Meeting report - Arf and Rab family G proteins.

Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E.

J Cell Sci. 2013 Dec 1;126(Pt 23):5313-6. doi: 10.1242/jcs.143610.


Nobel Prize discovery paves the way for immunological traffic.

Stow JL.

Nat Rev Immunol. 2013 Dec;13(12):839-41. doi: 10.1038/nri3564. No abstract available.


Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry.

Luo L, King NP, Yeo JC, Jones A, Stow JL.

Proteomics. 2014 Jan;14(1):19-23. doi: 10.1002/pmic.201300315.


High-throughput quantification of early stages of phagocytosis.

Yeo JC, Wall AA, Stow JL, Hamilton NA.

Biotechniques. 2013 Sep;55(3):115-24. doi: 10.2144/000114075.


Intracellular trafficking and secretion of inflammatory cytokines.

Stow JL, Murray RZ.

Cytokine Growth Factor Rev. 2013 Jun;24(3):227-39. doi: 10.1016/j.cytogfr.2013.04.001. Epub 2013 May 4. Review.


Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages.

Micaroni M, Stanley AC, Khromykh T, Venturato J, Wong CX, Lim JP, Marsh BJ, Storrie B, Gleeson PA, Stow JL.

PLoS One. 2013;8(2):e57034. doi: 10.1371/journal.pone.0057034. Epub 2013 Feb 21.

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