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Early detection and imaging strategies to reveal and target developing pancreatic cancer.

Crawford HC, Wallace MB, Storz P.

Expert Rev Anticancer Ther. 2020 Jan 27:1-3. doi: 10.1080/14737140.2020.1720654. [Epub ahead of print] No abstract available.


The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells.

Lieb WS, Lungu C, Tamas R, Berreth H, Rathert P, Storz P, Olayioye MA, Hausser A.

Int J Cancer. 2019 Nov 19. doi: 10.1002/ijc.32798. [Epub ahead of print]


Sangivamycin and its derivatives inhibit Haspin-Histone H3-survivin signaling and induce pancreatic cancer cell death.

Bastea LI, Hollant LMA, Döppler HR, Reid EM, Storz P.

Sci Rep. 2019 Nov 12;9(1):16588. doi: 10.1038/s41598-019-53223-0.


Pomalidomide-induced changes in the pancreatic tumor microenvironment and potential for therapy.

Storz P.

Oncoscience. 2019 Aug 23;6(7-8):351-353. doi: 10.18632/oncoscience.486. eCollection 2019 Jul. No abstract available.


Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.

Wang Y, Hoeppner LH, Angom RS, Wang E, Dutta S, Doeppler HR, Wang F, Shen T, Scarisbrick IA, Guha S, Storz P, Bhattacharya R, Mukhopadhyay D.

J Biol Chem. 2019 Oct 25;294(43):15759-15767. doi: 10.1074/jbc.RA119.010152. Epub 2019 Sep 6.


Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.

Liu X, Clemens DL, Grunkemeyer JA, Price JD, O'Connell K, Chapman NM, Storz P, Wen H, Cox JL, Reid WL, Hollingsworth MA, Thayer S.

Sci Rep. 2019 Jul 23;9(1):10656. doi: 10.1038/s41598-019-46933-y.


Targeting the tumor microenvironment in pancreatic ductal adenocarcinoma.

Pandey V, Storz P.

Expert Rev Anticancer Ther. 2019 Jun;19(6):473-482. doi: 10.1080/14737140.2019.1622417. Epub 2019 May 31.


Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture.

Fleming Martinez AK, Storz P.

J Vis Exp. 2019 Feb 11;(144). doi: 10.3791/59096.


Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions.

Bastea LI, Liou GY, Pandey V, Fleming AK, von Roemeling CA, Doeppler H, Li Z, Qiu Y, Edenfield B, Copland JA, Tun HW, Storz P.

Cancer Res. 2019 Apr 1;79(7):1535-1548. doi: 10.1158/0008-5472.CAN-18-1153. Epub 2019 Jan 29.


The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast.

Durand N, Borges S, Hall T, Bastea L, Döppler H, Edenfield BH, Thompson EA, Geiger X, Storz P.

Oncotarget. 2018 Nov 20;9(91):36358-36370. doi: 10.18632/oncotarget.26357. eCollection 2018 Nov 20.


How Much Stereoscopic Effect Does Laparoscopy Need? Controlled, Prospective Randomized Trial on Surgical Task Efficiency in Standardized Phantom Tasks.

Kunert W, Auer T, Storz P, Braun M, Kirschniak A, Falch C.

Surg Innov. 2018 Oct;25(5):515-524. doi: 10.1177/1553350618784801. Epub 2018 Jul 20.


Evaluation of self-educational training methods to learn laparoscopic skills - a randomized controlled trial.

Axt S, Storz P, Ehrenberg C, Falch C, Immenroth M, Kirschniak A, Muller S.

BMC Med Educ. 2018 May 2;18(1):85. doi: 10.1186/s12909-018-1193-3.


Protein kinase D1: gatekeeper of the epithelial phenotype and key regulator of cancer metastasis?

Storz P.

Br J Cancer. 2018 Feb 20;118(4):459-461. doi: 10.1038/bjc.2018.1. Epub 2018 Feb 20. No abstract available.


Paracrine Secretion of Transforming Growth Factor β by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues.

Akanuma N, Liu J, Liou GY, Yin X, Bejar KR, Liu C, Sun LZ, Storz P, Wang P.

Pancreas. 2017 Oct;46(9):1202-1207. doi: 10.1097/MPA.0000000000000913.


Src-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion.

Durand N, Bastea LI, Döppler H, Eiseler T, Storz P.

Sci Rep. 2017 Aug 25;7(1):9524. doi: 10.1038/s41598-017-10210-7.


Protein kinase C isoforms in the normal pancreas and in pancreatic disease.

Fleming AK, Storz P.

Cell Signal. 2017 Dec;40:1-9. doi: 10.1016/j.cellsig.2017.08.005. Epub 2017 Aug 18. Review.


Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD.

J Pathol. 2017 Sep;243(1):65-77. doi: 10.1002/path.4928. Epub 2017 Jul 27.


A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.

Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM Jr, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA.

Gastroenterology. 2017 Jul;153(1):e6-e13. doi: 10.1053/j.gastro.2017.05.050. Epub 2017 Jun 3. No abstract available.


The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis.

Liou GY, Bastea L, Fleming A, Döppler H, Edenfield BH, Dawson DW, Zhang L, Bardeesy N, Storz P.

Cell Rep. 2017 May 16;19(7):1322-1333. doi: 10.1016/j.celrep.2017.04.052.


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer.

Döppler H, Storz P.

Front Oncol. 2017 Mar 15;7:41. doi: 10.3389/fonc.2017.00041. eCollection 2017. Review.


Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.

Storz P.

Nat Rev Gastroenterol Hepatol. 2017 May;14(5):296-304. doi: 10.1038/nrgastro.2017.12. Epub 2017 Mar 8. Review.


Targeting reactive oxygen species in development and progression of pancreatic cancer.

Durand N, Storz P.

Expert Rev Anticancer Ther. 2017 Jan;17(1):19-31. Epub 2016 Nov 23. Review.


Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l γ.

Durand N, Bastea LI, Long J, Döppler H, Ling K, Storz P.

Sci Rep. 2016 Oct 24;6:35963. doi: 10.1038/srep35963.


Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages.

Colonne PM, Winchell CG, Graham JG, Onyilagha FI, MacDonald LJ, Doeppler HR, Storz P, Kurten RC, Beare PA, Heinzen RA, Voth DE.

PLoS Pathog. 2016 Oct 6;12(10):e1005915. doi: 10.1371/journal.ppat.1005915. eCollection 2016 Oct.


The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer.

Döppler H, Panayiotou R, Reid EM, Maimo W, Bastea L, Storz P.

Sci Rep. 2016 Sep 21;6:33758. doi: 10.1038/srep33758.


Legumain is activated in macrophages during pancreatitis.

Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11.


[Surgical Training in Germany: Desire and Reality].

Axt S, Johannink J, Storz P, Mees ST, Röth AA, Kirschniak A.

Zentralbl Chir. 2016 Jun;141(3):290-6. doi: 10.1055/s-0042-102966. Epub 2016 Jun 22. German.


A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.

Liou GY, Storz P, Leitges M.

Mol Cell Oncol. 2015 Dec 10;3(1):e1035477. doi: 10.1080/23723556.2015.1035477. eCollection 2016 Jan.


KRas, ROS and the initiation of pancreatic cancer.

Storz P.

Small GTPases. 2017 Jan 2;8(1):38-42. doi: 10.1080/21541248.2016.1192714. Epub 2016 May 24.


Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma.

Yushi Q, Li Z, Von Roemeling CA, Doeppler H, Marlow LA, Kim BY, Radisky DC, Storz P, Copland JA, Tun HW.

Oncotarget. 2016 May 31;7(22):32156-71. doi: 10.18632/oncotarget.8537.


LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming.

Ren B, Best B, Ramakrishnan DP, Walcott BP, Storz P, Silverstein RL.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1197-208. doi: 10.1161/ATVBAHA.116.307421. Epub 2016 Mar 24.


Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P.

Cell Rep. 2016 Mar 15;14(10):2325-36. doi: 10.1016/j.celrep.2016.02.029. Epub 2016 Mar 3.


Pure Natural Orifice Transluminal Endoscopic Surgery (NOTES) with a new elongated, curved Transanal Endoscopic Operation (TEO) device for rectosigmoid resection: a survival study in a porcine model.

Wilhelm P, Axt S, Storz P, Wenz S, Müller S, Kirschniak A.

Tech Coloproctol. 2016 May;20(5):273-278. doi: 10.1007/s10151-016-1446-2. Epub 2016 Mar 3.


Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion.

Durand N, Borges S, Storz P.

J Clin Med. 2016 Feb 3;5(2). pii: E20. doi: 10.3390/jcm5020020. Review.


NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.

Hessmann E, Zhang JS, Chen NM, Hasselluhn M, Liou GY, Storz P, Ellenrieder V, Billadeau DD, Koenig A.

Stem Cells Int. 2016;2016:5272498. doi: 10.1155/2016/5272498. Epub 2015 Nov 30.


Differences in Metabolic Programming Define the Site of Breast Cancer Cell Metastasis.

Döppler H, Storz P.

Cell Metab. 2015 Oct 6;22(4):536-7. doi: 10.1016/j.cmet.2015.09.022.


The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.

Döppler H, Bastea L, Borges S, Geiger X, Storz P.

Oncotarget. 2015 Oct 6;6(30):29740-52. doi: 10.18632/oncotarget.4965.


Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.

Kourtidis A, Ngok SP, Pulimeno P, Feathers RW, Carpio LR, Baker TR, Carr JM, Yan IK, Borges S, Perez EA, Storz P, Copland JA, Patel T, Thompson EA, Citi S, Anastasiadis PZ.

Nat Cell Biol. 2015 Sep;17(9):1145-57. doi: 10.1038/ncb3227. Epub 2015 Aug 24.


Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.

Durand N, Borges S, Storz P.

Cell Mol Life Sci. 2015 Nov;72(22):4369-82. doi: 10.1007/s00018-015-2011-2. Epub 2015 Aug 8. Review.


Protein kinase D enzymes: novel kinase targets in pancreatic cancer.

Liou GY, Storz P.

Expert Rev Gastroenterol Hepatol. 2015;9(9):1143-6. doi: 10.1586/17474124.2015.1069706. Epub 2015 Jul 17. Review.


Pancreatic oncogenic signaling cascades converge at Protein Kinase D1.

Liou GY, Leitges M, Storz P.

Cell Cycle. 2015;14(10):1489-90. doi: 10.1080/15384101.2015.1032646. No abstract available.


Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer.

Liou GY, Storz P.

Oncoscience. 2015 Mar 28;2(3):247-51. eCollection 2015.


Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.

Borges S, Perez EA, Thompson EA, Radisky DC, Geiger XJ, Storz P.

Mol Cancer Ther. 2015 Jun;14(6):1306-16. doi: 10.1158/1535-7163.MCT-14-0945. Epub 2015 Apr 7.


Detecting reactive oxygen species by immunohistochemistry.

Liou GY, Storz P.

Methods Mol Biol. 2015;1292:97-104. doi: 10.1007/978-1-4939-2522-3_7.


Ultrastable fiber amplifier delivering 145-fs pulses with 6-μJ energy at 10-MHz repetition rate.

Wunram M, Storz P, Brida D, Leitenstorfer A.

Opt Lett. 2015 Mar 1;40(5):823-6. doi: 10.1364/OL.40.000823.


Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.


NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.


Targeting protein kinase C subtypes in pancreatic cancer.

Storz P.

Expert Rev Anticancer Ther. 2015 Apr;15(4):433-8. doi: 10.1586/14737140.2015.1003810. Epub 2015 Jan 20. Review.

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