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Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy.

Karanam NK, Ding L, Aroumougame A, Story MD.

Transl Res. 2020 Mar;217:33-46. doi: 10.1016/j.trsl.2019.10.003. Epub 2019 Oct 21.


miR-125a-5p Functions as Tumor Suppressor microRNA And Is a Marker of Locoregional Recurrence And Poor prognosis in Head And Neck Cancer.

Vo DT, Karanam NK, Ding L, Saha D, Yordy JS, Giri U, Heymach JV, Story MD.

Neoplasia. 2019 Sep;21(9):849-862. doi: 10.1016/j.neo.2019.06.004. Epub 2019 Jul 18.


Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas.

Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S.

Cancer Res. 2019 Jul 15;79(14):3749-3761. doi: 10.1158/0008-5472.CAN-19-0680. Epub 2019 May 14.


Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro.

Abramowicz A, Wojakowska A, Marczak L, Lysek-Gladysinska M, Smolarz M, Story MD, Polanska J, Widlak P, Pietrowska M.

J Radiat Res. 2019 May 1;60(3):289-297. doi: 10.1093/jrr/rrz001.



Story MD, Durante M.

Med Phys. 2018 Nov;45(11):e1111-e1122. doi: 10.1002/mp.13064. Review.


The Reciprocity between Radiotherapy and Cancer Immunotherapy.

Wang Y, Liu ZG, Yuan H, Deng W, Li J, Huang Y, Kim BYS, Story MD, Jiang W.

Clin Cancer Res. 2019 Mar 15;25(6):1709-1717. doi: 10.1158/1078-0432.CCR-18-2581. Epub 2018 Nov 9. Review.


Developing Predictive or Prognostic Biomarkers for Charged Particle Radiotherapy.

Story MD, Wang J.

Int J Part Ther. 2018 Summer;5(1):94-102. doi: 10.14338/IJPT-18-00027.1.


Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells.

Li Z, Jella KK, Jaafar L, Li S, Park S, Story MD, Wang H, Wang Y, Dynan WS.

Sci Rep. 2018 Jul 23;8(1):11038. doi: 10.1038/s41598-018-29350-5.


Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology.

Mohan R, Held KD, Story MD, Grosshans D, Capala J.

Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):816-831. doi: 10.1016/j.ijrobp.2017.12.260. Epub 2017 Dec 21. Review. Erratum in: Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):1004.


EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair.

Saki M, Makino H, Javvadi P, Tomimatsu N, Ding LH, Clark JE, Gavin E, Takeda K, Andrews J, Saha D, Story MD, Burma S, Nirodi CS.

Mol Cancer Res. 2017 Nov;15(11):1503-1516. doi: 10.1158/1541-7786.MCR-17-0136. Epub 2017 Aug 11.


Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair.

Mohamad O, Sishc BJ, Saha J, Pompos A, Rahimi A, Story MD, Davis AJ, Kim DWN.

Cancers (Basel). 2017 Jun 9;9(6). pii: E66. doi: 10.3390/cancers9060066. Review.


Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer.

Skinner HD, Giri U, Yang LP, Kumar M, Liu Y, Story MD, Pickering CR, Byers LA, Williams MD, Wang J, Shen L, Yoo SY, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV.

Clin Cancer Res. 2017 Jun 1;23(11):2713-2722. doi: 10.1158/1078-0432.CCR-16-2586. Epub 2017 May 5.


Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy.

Zhang Z, Wodzak M, Belzile O, Zhou H, Sishc B, Yan H, Stojadinovic S, Mason RP, Brekken RA, Chopra R, Story MD, Timmerman R, Saha D.

Radiat Res. 2016 Jun;185(6):616-22. doi: 10.1667/RR14382.1. Epub 2016 May 25.


Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy.

Held KD, Blakely EA, Story MD, Lowenstein DI.

Radiat Res. 2016 Jun;185(6):563-7. doi: 10.1667/RR14412.1. Epub 2016 May 19.


Proteomic Profiling Identifies PTK2/FAK as a Driver of Radioresistance in HPV-negative Head and Neck Cancer.

Skinner HD, Giri U, Yang L, Woo SH, Story MD, Pickering CR, Byers LA, Williams MD, El-Naggar A, Wang J, Diao L, Shen L, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV.

Clin Cancer Res. 2016 Sep 15;22(18):4643-50. doi: 10.1158/1078-0432.CCR-15-2785. Epub 2016 Apr 1.


Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease.

Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS.

Exp Biol Med (Maywood). 2016 Apr;241(7):706-18. doi: 10.1177/1535370216642047. Epub 2016 Mar 27.


ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S.

Ann ICRP. 2016 Jun;45(1 Suppl):239-52. doi: 10.1177/0146645315621849. Epub 2016 Mar 8.


Galactic cosmic ray simulation at the NASA Space Radiation Laboratory.

Norbury JW, Schimmerling W, Slaba TC, Azzam EI, Badavi FF, Baiocco G, Benton E, Bindi V, Blakely EA, Blattnig SR, Boothman DA, Borak TB, Britten RA, Curtis S, Dingfelder M, Durante M, Dynan WS, Eisch AJ, Robin Elgart S, Goodhead DT, Guida PM, Heilbronn LH, Hellweg CE, Huff JL, Kronenberg A, La Tessa C, Lowenstein DI, Miller J, Morita T, Narici L, Nelson GA, Norman RB, Ottolenghi A, Patel ZS, Reitz G, Rusek A, Schreurs AS, Scott-Carnell LA, Semones E, Shay JW, Shurshakov VA, Sihver L, Simonsen LC, Story MD, Turker MS, Uchihori Y, Williams J, Zeitlin CJ.

Life Sci Space Res (Amst). 2016 Feb;8:38-51. doi: 10.1016/j.lssr.2016.02.001. Epub 2016 Feb 17.


The Role of Hypofractionated Radiation Therapy with Photons, Protons, and Heavy Ions for Treating Extracranial Lesions.

Laine AM, Pompos A, Timmerman R, Jiang S, Story MD, Pistenmaa D, Choy H.

Front Oncol. 2016 Jan 11;5:302. doi: 10.3389/fonc.2015.00302. eCollection 2015. Review.


ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.

Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S; ICRP.

Ann ICRP. 2015 Dec;44(3-4):7-357. doi: 10.1177/0146645315595585. Review.


Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.

Zhang S, Matsunaga S, Lin YF, Sishc B, Shang Z, Sui J, Shih HY, Zhao Y, Foreman O, Story MD, Chen DJ, Chen BP.

Oncogene. 2016 Jul 28;35(30):3909-18. doi: 10.1038/onc.2015.459. Epub 2015 Nov 30.


Time, Dose, and Volume Responses in a Mouse Pulmonary Injury Model Following Ablative Irradiation.

Hong ZY, Lee CG, Shim HS, Lee EJ, Song KH, Choi BW, Cho J, Story MD.

Lung. 2016 Feb;194(1):81-90. doi: 10.1007/s00408-015-9825-4. Epub 2015 Nov 12.


Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET.

Ding LH, Park S, Xie Y, Girard L, Minna JD, Story MD.

Mutagenesis. 2015 Sep;30(5):685-94. doi: 10.1093/mutage/gev028. Epub 2015 May 22.


An experimental model-based exploration of cytokines in ablative radiation-induced lung injury in vivo and in vitro.

Hong ZY, Song KH, Yoon JH, Cho J, Story MD.

Lung. 2015 Jun;193(3):409-19. doi: 10.1007/s00408-015-9705-y. Epub 2015 Mar 7.


Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.

Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O.

Cancer Res. 2015 Apr 1;75(7):1527-36. doi: 10.1158/0008-5472.CAN-14-2735. Epub 2015 Jan 29.


Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes.

Keck MK, Zuo Z, Khattri A, Stricker TP, Brown CD, Imanguli M, Rieke D, Endhardt K, Fang P, Brägelmann J, DeBoer R, El-Dinali M, Aktolga S, Lei Z, Tan P, Rozen SG, Salgia R, Weichselbaum RR, Lingen MW, Story MD, Ang KK, Cohen EE, White KP, Vokes EE, Seiwert TY.

Clin Cancer Res. 2015 Feb 15;21(4):870-81. doi: 10.1158/1078-0432.CCR-14-2481. Epub 2014 Dec 9.


Characterization of transcription factor networks involved in umbilical cord blood CD34+ stem cells-derived erythropoiesis.

Li B, Ding L, Yang C, Kang B, Liu L, Story MD, Pace BS.

PLoS One. 2014 Sep 11;9(9):e107133. doi: 10.1371/journal.pone.0107133. eCollection 2014.


Strain background determines lymphoma incidence in Atm knockout mice.

Genik PC, Bielefeldt-Ohmann H, Liu X, Story MD, Ding L, Bush JM, Fallgren CM, Weil MM.

Neoplasia. 2014 Feb;16(2):129-36. doi: 10.1593/neo.131980.


DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.

Camacho CV, Todorova PK, Hardebeck MC, Tomimatsu N, Gil del Alcazar CR, Ilcheva M, Mukherjee B, McEllin B, Vemireddy V, Hatanpaa K, Story MD, Habib AA, Murty VV, Bachoo R, Burma S.

Oncogene. 2015 Feb 19;34(8):1064-72. doi: 10.1038/onc.2014.29. Epub 2014 Mar 17.


Development of a small animal model to simulate clinical stereotactic body radiotherapy-induced central and peripheral lung injuries.

Hong ZY, Eun SH, Park K, Choi WH, Lee JI, Lee EJ, Lee JM, Story MD, Cho J.

J Radiat Res. 2014 Jul;55(4):648-57. doi: 10.1093/jrr/rrt234. Epub 2014 Feb 20.


Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW.

Clin Cancer Res. 2014 Mar 15;20(6):1610-22. doi: 10.1158/1078-0432.CCR-13-2589. Epub 2014 Jan 31.


Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.

Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, Gazdar AF, Auchus RJ, Shay JW.

PLoS One. 2013 Jun 13;8(6):e65624. doi: 10.1371/journal.pone.0065624. Print 2013.


Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energy.

Ding LH, Park S, Peyton M, Girard L, Xie Y, Minna JD, Story MD.

BMC Genomics. 2013 Jun 1;14:372. doi: 10.1186/1471-2164-14-372.


Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK.

Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. Erratum in: Mol Cell Biol. 2013 Aug;33(16):3390.


Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation.

Steffen LS, Bacher JW, Peng Y, Le PN, Ding LH, Genik PC, Ray FA, Bedford JS, Fallgren CM, Bailey SM, Ullrich RL, Weil MM, Story MD.

Mutagenesis. 2013 Jan;28(1):71-9. doi: 10.1093/mutage/ges055. Epub 2012 Sep 17.


An athymic rat model of cutaneous radiation injury designed to study human tissue-based wound therapy.

Rifkin LH, Stojadinovic S, Stewart CH, Song KH, Maxted MC, Bell MH, Kashefi NS, Speiser MP, Saint-Cyr M, Story MD, Rohrich RJ, Brown SA, Solberg TD.

Radiat Oncol. 2012 May 8;7:68. doi: 10.1186/1748-717X-7-68.


Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation.

Li B, Ding L, Li W, Story MD, Pace BS.

BMC Genomics. 2012 Apr 26;13:153. doi: 10.1186/1471-2164-13-153.


Molecular profiling to optimize treatment in non-small cell lung cancer: a review of potential molecular targets for radiation therapy by the translational research program of the radiation therapy oncology group.

Ausborn NL, Le QT, Bradley JD, Choy H, Dicker AP, Saha D, Simko J, Story MD, Torossian A, Lu B.

Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):e453-64. doi: 10.1016/j.ijrobp.2012.01.056. Epub 2012 Apr 18. Review.


Cyclophilin B expression is associated with in vitro radioresistance and clinical outcome after radiotherapy.

Williams PD, Owens CR, Dziegielewski J, Moskaluk CA, Read PW, Larner JM, Story MD, Brock WA, Amundson SA, Lee JK, Theodorescu D.

Neoplasia. 2011 Dec;13(12):1122-31.


Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture.

Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ.

Nucleic Acids Res. 2011 Jul;39(13):5474-88. doi: 10.1093/nar/gkr149. Epub 2011 Mar 18.


DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy.

Moeller BJ, Yordy JS, Williams MD, Giri U, Raju U, Molkentine DP, Byers LA, Heymach JV, Story MD, Lee JJ, Sturgis EM, Weber RS, Garden AS, Ang KK, Schwartz DL.

Clin Cancer Res. 2011 Apr 1;17(7):2035-43. doi: 10.1158/1078-0432.CCR-10-2641. Epub 2011 Feb 24.


Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.

Kwak YT, Radaideh SM, Ding L, Li R, Frenkel E, Story MD, Girard L, Minna J, Verma UN.

Mol Cancer Res. 2011 Mar;9(3):341-9. doi: 10.1158/1541-7786.MCR-10-0248. Epub 2011 Feb 11.


Human lymphoma cells develop resistance to radiation in the presence of astrocytes in vitro.

Koto M, Cho H, Riesterer O, Giri U, Story MD, Ha CS, Raju U.

Anticancer Res. 2011 Jan;31(1):33-8.


Blasted cell line names.

Wang J, Byers LA, Yordy JS, Liu W, Shen L, Baggerly KA, Giri U, Myers JN, Ang KK, Story MD, Girard L, Minna JD, Heymach JV, Coombes KR.

Cancer Inform. 2010 Oct 14;9:251-5. doi: 10.4137/CIN.S5613.


Radiogenomics predicting tumor responses to radiotherapy in lung cancer.

Das AK, Bell MH, Nirodi CS, Story MD, Minna JD.

Semin Radiat Oncol. 2010 Jul;20(3):149-55. doi: 10.1016/j.semradonc.2010.01.002. Review.


An orthotopic lung tumor model for image-guided microirradiation in rats.

Saha D, Watkins L, Yin Y, Thorpe P, Story MD, Song K, Raghavan P, Timmerman R, Chen B, Minna JD, Solberg TD.

Radiat Res. 2010 Jul;174(1):62-71. doi: 10.1667/RR2157.1.


Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks.

Camacho CV, Mukherjee B, McEllin B, Ding LH, Hu B, Habib AA, Xie XJ, Nirodi CS, Saha D, Story MD, Balajee AS, Bachoo RM, Boothman DA, Burma S.

Carcinogenesis. 2010 Oct;31(10):1889-96. doi: 10.1093/carcin/bgq153. Epub 2010 Jul 26.


High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model.

Cho J, Kodym R, Seliounine S, Richardson JA, Solberg TD, Story MD.

Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):895-902. doi: 10.1016/j.ijrobp.2009.12.074.


DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle.

Roig AI, Hight SK, Minna JD, Shay JW, Rusek A, Story MD.

Int J Radiat Biol. 2010 Mar;86(3):194-204. doi: 10.3109/09553000903418603.

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