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Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Tumor.

Zou Y, Wei Y, Sun Y, Bao J, Yao F, Li Z, Meng F, Hu C, Storm G, Zhong Z.

Theranostics. 2019 Oct 17;9(26):8061-8072. doi: 10.7150/thno.37184. eCollection 2019.


Characterisation of the inflammatory cytokine and growth factor profile in a rabbit model of proliferative vitreoretinopathy.

Wong CW, Cheung N, Ho C, Barathi V, Storm G, Wong TT.

Sci Rep. 2019 Oct 28;9(1):15419. doi: 10.1038/s41598-019-51633-8.


Site-specific pharmaco-laser therapy: A novel treatment modality for refractory port wine stains.

van Raath MI, van Amesfoort JE, Hermann M, Ince Y, Zwart MJ, Echague AV, Chen Y, Ding B, Huang X, Storm G, Heger M.

J Clin Transl Res. 2019 May 1;5(1):1-24. eCollection 2019 Sep 8. Review.


Development and characterization of liposomal formulation of bortezomib.

Deshantri AK, Metselaar JM, Zagkou S, Storm G, Mandhane SN, Fens MHAM, Schiffelers RM.

Int J Pharm X. 2019 Mar 23;1:100011. doi: 10.1016/j.ijpx.2019.100011. eCollection 2019 Dec.


ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.

Kuninty PR, Bansal R, De Geus SWL, Mardhian DF, Schnittert J, van Baarlen J, Storm G, Bijlsma MF, van Laarhoven HW, Metselaar JM, Kuppen PJK, Vahrmeijer AL, Östman A, Sier CFM, Prakash J.

Sci Adv. 2019 Sep 4;5(9):eaax2770. doi: 10.1126/sciadv.aax2770. eCollection 2019 Sep.


Shelf-Life Evaluation and Lyophilization of PBCA-Based Polymeric Microbubbles.

Ojha T, Pathak V, Drude N, Weiler M, Rommel D, Rütten S, Geinitz B, van Steenbergen MJ, Storm G, Kiessling F, Lammers T.

Pharmaceutics. 2019 Aug 26;11(9). pii: E433. doi: 10.3390/pharmaceutics11090433.


Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs.

Fülöp T, Kozma GT, Vashegyi I, Mészáros T, Rosivall L, Urbanics R, Storm G, Metselaar JM, Szebeni J.

J Control Release. 2019 Sep 10;309:333-338. doi: 10.1016/j.jconrel.2019.07.005. Epub 2019 Jul 8.


Setting standards to promote progress in bio-nano science.

Lammers T, Storm G.

Nat Nanotechnol. 2019 Jul;14(7):626. doi: 10.1038/s41565-019-0497-8. No abstract available.


Anti-Inflammatory Properties of Plant Derived Natural Products - A Systematic Review.

Allijn IE, Brinkhuis RP, Storm G, Schiffelers RM.

Curr Med Chem. 2019;26(24):4506-4536. doi: 10.2174/0929867325666190523123357.


Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo.

Wei Y, Gu X, Cheng L, Meng F, Storm G, Zhong Z.

Acta Biomater. 2019 Jul 1;92:196-204. doi: 10.1016/j.actbio.2019.05.034. Epub 2019 May 15.


TG101348, a selective JAK2 antagonist, ameliorates hepatic fibrogenesis in vivo.

Akcora BÖ, Dathathri E, Ortiz-Perez A, Gabriël AV, Storm G, Prakash J, Bansal R.

FASEB J. 2019 Aug;33(8):9466-9475. doi: 10.1096/fj.201900215RR. Epub 2019 May 17.


Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall.

Lobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C.

Bioconjug Chem. 2019 Jun 7. doi: 10.1021/acs.bioconjchem.9b00256. [Epub ahead of print]


The efficiency and safety of steroid addition to multimodal cocktail periarticular injection in knee joint arthroplasty: a meta-analysis of randomized controlled trials.

Deng Z, Li Y, Storm GR, Kotian RN, Sun X, Lei G, Gao S, Lu W.

Sci Rep. 2019 May 7;9(1):7031. doi: 10.1038/s41598-019-43540-9.


Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo.

Ergen C, Niemietz PM, Heymann F, Baues M, Gremse F, Pola R, van Bloois L, Storm G, Kiessling F, Trautwein C, Luedde T, Lammers T, Tacke F.

Biomaterials. 2019 Jun;206:49-60. doi: 10.1016/j.biomaterials.2019.03.025. Epub 2019 Mar 22.


Port wine stain treatment outcomes have not improved over the past three decades.

van Raath MI, Chohan S, Wolkerstorfer A, van der Horst CMAM, Storm G, Heger M.

J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1369-1377. doi: 10.1111/jdv.15599. Epub 2019 Apr 23.


Hyperthermia-triggered release of hypoxic cell radiosensitizers from temperature-sensitive liposomes improves radiotherapy efficacy in vitro.

Sadeghi N, Kok RJ, Bos C, Zandvliet M, Geerts WJC, Storm G, Moonen CTW, Lammers T, Deckers R.

Nanotechnology. 2019 Jun 28;30(26):264001. doi: 10.1088/1361-6528/ab0ce6. Epub 2019 Mar 5.


Liposomes with asymmetric bilayers produced from inverse emulsions for nucleic acid delivery.

de Matos MBC, Miranda BS, Rizky Nuari Y, Storm G, Leneweit G, Schiffelers RM, Kok RJ.

J Drug Target. 2019 Jun - Jul;27(5-6):681-689. doi: 10.1080/1061186X.2019.1579819. Epub 2019 Feb 27.


A technical protocol for an experimental ex vivo model using arterially perfused porcine eyes.

Rousou C, Hoogenboom P, van Overdam KA, Storm G, Dorrestijn J, Mastrobattista E.

Exp Eye Res. 2019 Apr;181:171-177. doi: 10.1016/j.exer.2019.02.003. Epub 2019 Feb 5.


Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma.

Deshantri AK, Fens MH, Ruiter RWJ, Metselaar JM, Storm G, van Bloois L, Varela-Moreira A, Mandhane SN, Mutis T, Martens ACM, Groen RWJ, Schiffelers RM.

J Control Release. 2019 Feb 28;296:232-240. doi: 10.1016/j.jconrel.2019.01.028. Epub 2019 Jan 22.


Engineered Relaxin as theranostic nanomedicine to diagnose and ameliorate liver cirrhosis.

Nagórniewicz B, Mardhian DF, Booijink R, Storm G, Prakash J, Bansal R.

Nanomedicine. 2019 Apr;17:106-118. doi: 10.1016/j.nano.2018.12.008. Epub 2019 Jan 22.


Antibiotic-nanomedicines: facing the challenge of effective treatment of antibiotic-resistant respiratory tract infections.

Ritsema JA, der Weide HV, Te Welscher YM, Goessens WH, van Nostrum CF, Storm G, Bakker-Woudenberg IA, Hays JP.

Future Microbiol. 2018 Nov;13:1683-1692. doi: 10.2217/fmb-2018-0194. Epub 2018 Nov 30.


Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation.

Snipstad S, Sulheim E, de Lange Davies C, Moonen C, Storm G, Kiessling F, Schmid R, Lammers T.

Expert Opin Drug Deliv. 2018 Dec;15(12):1249-1261. doi: 10.1080/17425247.2018.1547279. Epub 2018 Nov 19. Review.


A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes.

Shimizu T, Abu Lila AS, Kawaguchi Y, Shimazaki Y, Watanabe Y, Mima Y, Hashimoto Y, Okuhira K, Storm G, Ishima Y, Ishida T.

J Immunol. 2018 Nov 15;201(10):2969-2976. doi: 10.4049/jimmunol.1701351. Epub 2018 Oct 17.


Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo.

Yang W, Wei Y, Yang L, Zhang J, Zhong Z, Storm G, Meng F.

J Control Release. 2018 Nov 28;290:141-149. doi: 10.1016/j.jconrel.2018.10.013. Epub 2018 Oct 10.


Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo.

Mardhian DF, Storm G, Bansal R, Prakash J.

J Control Release. 2018 Nov 28;290:1-10. doi: 10.1016/j.jconrel.2018.09.031. Epub 2018 Oct 2.


Therapeutic inhibition of spleen tyrosine kinase in inflammatory macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis.

Kurniawan DW, Jajoriya AK, Dhawan G, Mishra D, Argemi J, Bataller R, Storm G, Mishra DP, Prakash J, Bansal R.

J Control Release. 2018 Oct 28;288:227-238. doi: 10.1016/j.jconrel.2018.09.004. Epub 2018 Sep 13.


From design to the clinic: practical guidelines for translating cardiovascular nanomedicine.

Cicha I, Chauvierre C, Texier I, Cabella C, Metselaar JM, Szebeni J, Dézsi L, Alexiou C, Rouzet F, Storm G, Stroes E, Bruce D, MacRitchie N, Maffia P, Letourneur D.

Cardiovasc Res. 2018 Nov 1;114(13):1714-1727. doi: 10.1093/cvr/cvy219. Review.


Preclinical evaluation of thermosensitive poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate)-grafted liposomes for cancer thermochemotherapy.

van Elk M, van den Dikkenberg JB, Storm G, Hennink WE, Vermonden T, Heger M.

Int J Pharm. 2018 Oct 25;550(1-2):190-199. doi: 10.1016/j.ijpharm.2018.08.027. Epub 2018 Aug 18.


Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.

Hua S, de Matos MBC, Metselaar JM, Storm G.

Front Pharmacol. 2018 Jul 17;9:790. doi: 10.3389/fphar.2018.00790. eCollection 2018. Review.


Environmental impact of switching from the synthetic glucocorticoid prednisolone to the natural alkaloid berberine.

Allijn IE, Oldenkamp R, Storm G, Ragas AMJ, Schiffelers RM.

PLoS One. 2018 Jun 14;13(6):e0199095. doi: 10.1371/journal.pone.0199095. eCollection 2018.


Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors.

Theek B, Baues M, Gremse F, Pola R, Pechar M, Negwer I, Koynov K, Weber B, Barz M, Jahnen-Dechent W, Storm G, Kiessling F, Lammers T.

J Control Release. 2018 Jul 28;282:25-34. doi: 10.1016/j.jconrel.2018.05.002. Epub 2018 May 4.


Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis.

Wong CW, Czarny B, Metselaar JM, Ho C, Ng SR, Barathi AV, Storm G, Wong TT.

Sci Rep. 2018 Apr 26;8(1):6604. doi: 10.1038/s41598-018-24545-2.


Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing.

Gauthier A, Fisch A, Seuwen K, Baumgarten B, Ruffner H, Aebi A, Rausch M, Kiessling F, Bartneck M, Weiskirchen R, Tacke F, Storm G, Lammers T, Ludwig MG.

Biomaterials. 2018 Sep;178:481-495. doi: 10.1016/j.biomaterials.2018.04.006. Epub 2018 Apr 5.


Local sustained delivery of bupivacaine HCl from a new castor oil-based nanoemulsion system.

Rachmawati H, Arvin YA, Asyarie S, Anggadiredja K, Tjandrawinata RR, Storm G.

Drug Deliv Transl Res. 2018 Jun;8(3):515-524. doi: 10.1007/s13346-018-0497-5.


Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities.

Belfiore L, Saunders DN, Ranson M, Thurecht KJ, Storm G, Vine KL.

J Control Release. 2018 May 10;277:1-13. doi: 10.1016/j.jconrel.2018.02.040. Epub 2018 Mar 1. Review.


Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery.

Schnittert J, Bansal R, Storm G, Prakash J.

Adv Drug Deliv Rev. 2018 Apr;129:37-53. doi: 10.1016/j.addr.2018.01.020. Epub 2018 Feb 4. Review.


Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer.

Schnittert J, Heinrich MA, Kuninty PR, Storm G, Prakash J.

Cancer Lett. 2018 Apr 28;420:247-258. doi: 10.1016/j.canlet.2018.01.072. Epub 2018 Feb 21.


Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis.

van der Geest T, Roeleveld DM, Walgreen B, Helsen MM, Nayak TK, Klein C, Hegen M, Storm G, Metselaar JM, van den Berg WB, van der Kraan PM, Laverman P, Boerman OC, Koenders MI.

Rheumatology (Oxford). 2018 Apr 1;57(4):737-747. doi: 10.1093/rheumatology/kex456.


Critical evaluation of quantification methods for oligonucleotides formulated in lipid nanoparticles.

Oude Blenke E, Evers MJW, Baumann V, Winkler J, Storm G, Mastrobattista E.

Int J Pharm. 2018 Sep 15;548(2):793-802. doi: 10.1016/j.ijpharm.2017.12.035. Epub 2017 Dec 21.


Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12.

Akcora BÖ, Storm G, Bansal R.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):804-818. doi: 10.1016/j.bbadis.2017.12.001. Epub 2017 Dec 5.


Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model: Correlation with physicochemical features and clinical information.

Fülöp T, Nemes R, Mészáros T, Urbanics R, Kok RJ, Jackman JA, Cho NJ, Storm G, Szebeni J.

J Control Release. 2018 Jan 28;270:268-274. doi: 10.1016/j.jconrel.2017.11.043. Epub 2017 Dec 2.


Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases.

Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, Song WM, Goossens N, Watanabe H, Beasley MB, Powell CA, Storm G, Kaminski N, van Goor H, Friedman SL, Hoshida Y, Prakash J.

Exp Mol Med. 2017 Nov 17;49(11):e396. doi: 10.1038/emm.2017.213.


Relationship between polarities of antibiotic and polymer matrix on nanoparticle formulations based on aliphatic polyesters.

Ritsema JAS, Herschberg EMA, Borgos SE, Løvmo C, Schmid R, Te Welscher YM, Storm G, van Nostrum CF.

Int J Pharm. 2018 Sep 15;548(2):730-739. doi: 10.1016/j.ijpharm.2017.11.017. Epub 2017 Nov 11.


Influence of cholesterol inclusion on the doxorubicin release characteristics of lysolipid-based thermosensitive liposomes.

Sadeghi N, Deckers R, Ozbakir B, Akthar S, Kok RJ, Lammers T, Storm G.

Int J Pharm. 2018 Sep 15;548(2):778-782. doi: 10.1016/j.ijpharm.2017.11.002. Epub 2017 Nov 7.


Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative.

Goh WJ, Zou S, Ong WY, Torta F, Alexandra AF, Schiffelers RM, Storm G, Wang JW, Czarny B, Pastorin G.

Sci Rep. 2017 Oct 30;7(1):14322. doi: 10.1038/s41598-017-14725-x.


Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer.

Binnemars-Postma K, Bansal R, Storm G, Prakash J.

FASEB J. 2018 Feb;32(2):969-978. doi: 10.1096/fj.201700629R. Epub 2018 Jan 3.


E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells.

Gholizadeh S, Visweswaran GRR, Storm G, Hennink WE, Kamps JAAM, Kok RJ.

Int J Pharm. 2018 Sep 15;548(2):759-770. doi: 10.1016/j.ijpharm.2017.10.027. Epub 2017 Oct 13.


Lipogels responsive to near-infrared light for the triggered release of therapeutic agents.

Martín-Saavedra F, Ruiz-Hernández E, Escudero-Duch C, Prieto M, Arruebo M, Sadeghi N, Deckers R, Storm G, Hennink WE, Santamaría J, Vilaboa N.

Acta Biomater. 2017 Oct 1;61:54-65. doi: 10.1016/j.actbio.2017.08.010. Epub 2017 Aug 8.


A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis.

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G.

J Control Release. 2017 Sep 28;262:47-57. doi: 10.1016/j.jconrel.2017.07.013. Epub 2017 Jul 9.


Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors.

Ojha T, Pathak V, Shi Y, Hennink WE, Moonen CTW, Storm G, Kiessling F, Lammers T.

Adv Drug Deliv Rev. 2017 Sep 15;119:44-60. doi: 10.1016/j.addr.2017.07.007. Epub 2017 Jul 8. Review.

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