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Items: 28

1.

Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity.

Mallik M, Catinozzi M, Hug CB, Zhang L, Wagner M, Bussmann J, Bittern J, Mersmann S, Klämbt C, Drexler HCA, Huynen MA, Vaquerizas JM, Storkebaum E.

J Cell Biol. 2018 Nov 5;217(11):3947-3964. doi: 10.1083/jcb.201802151. Epub 2018 Sep 12.

2.

Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila.

Rode S, Ohm H, Anhäuser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S.

Cell Rep. 2018 Aug 28;24(9):2287-2299.e4. doi: 10.1016/j.celrep.2018.07.074.

3.

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.

Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A.

Nat Commun. 2018 Jan 23;9(1):335. doi: 10.1038/s41467-017-02299-1.

4.

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.

Scekic-Zahirovic J, Oussini HE, Mersmann S, Drenner K, Wagner M, Sun Y, Allmeroth K, Dieterlé S, Sinniger J, Dirrig-Grosch S, René F, Dormann D, Haass C, Ludolph AC, Lagier-Tourenne C, Storkebaum E, Dupuis L.

Acta Neuropathol. 2017 Jun;133(6):887-906. doi: 10.1007/s00401-017-1687-9. Epub 2017 Feb 28.

5.

Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models.

Bussmann J, Storkebaum E.

Curr Opin Genet Dev. 2017 Jun;44:61-73. doi: 10.1016/j.gde.2017.01.011. Epub 2017 Feb 16. Review.

6.

Vascular endothelial growth factor: a neurovascular target in neurological diseases.

Lange C, Storkebaum E, de Almodóvar CR, Dewerchin M, Carmeliet P.

Nat Rev Neurol. 2016 Aug;12(8):439-54. doi: 10.1038/nrneurol.2016.88. Epub 2016 Jul 1. Review.

PMID:
27364743
7.

Peripheral neuropathy via mutant tRNA synthetases: Inhibition of protein translation provides a possible explanation.

Storkebaum E.

Bioessays. 2016 Sep;38(9):818-29. doi: 10.1002/bies.201600052. Epub 2016 Jun 28. Review.

8.

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L.

EMBO J. 2016 May 17;35(10):1077-97. doi: 10.15252/embj.201592559. Epub 2016 Mar 7.

9.

Corrigendum: Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.

Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E.

Nat Commun. 2016 Jan 21;7:10497. doi: 10.1038/ncomms10497. No abstract available.

10.

Cell-selective labelling of proteomes in Drosophila melanogaster.

Erdmann I, Marter K, Kobler O, Niehues S, Abele J, Müller A, Bussmann J, Storkebaum E, Ziv T, Thomas U, Dieterich DC.

Nat Commun. 2015 Jul 3;6:7521. doi: 10.1038/ncomms8521.

11.

Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.

Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, Wagner M, Schäfer K, Wang G, Koerdt SN, Stum M, Jaiswal S, RajBhandary UL, Thomas U, Aberle H, Burgess RW, Yang XL, Dieterich D, Storkebaum E.

Nat Commun. 2015 Jul 3;6:7520. doi: 10.1038/ncomms8520. Erratum in: Nat Commun. 2016;7:10497. Jaiswal, Sumit [Added].

12.

Highly efficient cell-type-specific gene inactivation reveals a key function for the Drosophila FUS homolog cabeza in neurons.

Frickenhaus M, Wagner M, Mallik M, Catinozzi M, Storkebaum E.

Sci Rep. 2015 Mar 16;5:9107. doi: 10.1038/srep09107.

13.

Cerebrovascular disorders: molecular insights and therapeutic opportunities.

Storkebaum E, Quaegebeur A, Vikkula M, Carmeliet P.

Nat Neurosci. 2011 Oct 26;14(11):1390-7. doi: 10.1038/nn.2947. Review.

PMID:
22030550
14.

Paracrine control of vascular innervation in health and disease.

Storkebaum E, Carmeliet P.

Acta Physiol (Oxf). 2011 Sep;203(1):61-86. doi: 10.1111/j.1748-1716.2011.02333.x. Epub 2011 Jul 30. Review.

PMID:
21689379
15.

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.

Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chédotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C.

J Neurosci. 2010 Nov 10;30(45):15052-66. doi: 10.1523/JNEUROSCI.0477-10.2010.

16.

Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery.

Storkebaum E, Ruiz de Almodovar C, Meens M, Zacchigna S, Mazzone M, Vanhoutte G, Vinckier S, Miskiewicz K, Poesen K, Lambrechts D, Janssen GM, Fazzi GE, Verstreken P, Haigh J, Schiffers PM, Rohrer H, Van der Linden A, De Mey JG, Carmeliet P.

Circulation. 2010 Jul 20;122(3):273-81. doi: 10.1161/CIRCULATIONAHA.109.929364. Epub 2010 Jul 6.

PMID:
20606119
17.

Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.

Storkebaum E, Leitão-Gonçalves R, Godenschwege T, Nangle L, Mejia M, Bosmans I, Ooms T, Jacobs A, Van Dijck P, Yang XL, Schimmel P, Norga K, Timmerman V, Callaerts P, Jordanova A.

Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11782-7. doi: 10.1073/pnas.0905339106. Epub 2009 Jun 26.

18.

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmitz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P.

Nat Neurosci. 2005 Jan;8(1):85-92. Epub 2004 Nov 28.

19.

VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection.

Storkebaum E, Lambrechts D, Carmeliet P.

Bioessays. 2004 Sep;26(9):943-54. Review.

PMID:
15351965
20.

Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration.

Van Den Bosch L, Storkebaum E, Vleminckx V, Moons L, Vanopdenbosch L, Scheveneels W, Carmeliet P, Robberecht W.

Neurobiol Dis. 2004 Oct;17(1):21-8.

PMID:
15350962
21.

VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?

Lambrechts D, Storkebaum E, Carmeliet P.

Trends Mol Med. 2004 Jun;10(6):275-82. Review.

PMID:
15177192
22.

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.

Azzouz M, Ralph GS, Storkebaum E, Walmsley LE, Mitrophanous KA, Kingsman SM, Carmeliet P, Mazarakis ND.

Nature. 2004 May 27;429(6990):413-7.

PMID:
15164063
23.

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W Jr, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP.

Cancer Res. 2004 May 1;64(9):3350-6. No abstract available.

24.

VEGF: a critical player in neurodegeneration.

Storkebaum E, Carmeliet P.

J Clin Invest. 2004 Jan;113(1):14-8. Review.

25.

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.

Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, Wyns S, Thijs V, Andersson J, van Marion I, Al-Chalabi A, Bornes S, Musson R, Hansen V, Beckman L, Adolfsson R, Pall HS, Prats H, Vermeire S, Rutgeerts P, Katayama S, Awata T, Leigh N, Lang-Lazdunski L, Dewerchin M, Shaw C, Moons L, Vlietinck R, Morrison KE, Robberecht W, Van Broeckhoven C, Collen D, Andersen PM, Carmeliet P.

Nat Genet. 2003 Aug;34(4):383-94.

PMID:
12847526
26.

Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders.

Carmeliet P, Storkebaum E.

Semin Cell Dev Biol. 2002 Feb;13(1):39-53. Review.

PMID:
11969370
27.

Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.

Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert JM, Collen D, Carmeliet P.

Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):499-505.

PMID:
11884297
28.

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Cashman N, Fujisawa H, Drost MR, Sciot R, Bruyninckx F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, Carmeliet P.

Nat Genet. 2001 Jun;28(2):131-8.

PMID:
11381259

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