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Items: 43

1.

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition.

Cavalloro V, Russo K, Vasile F, Pignataro L, Torretta A, Donini S, Semrau MS, Storici P, Rossi D, Rapetti F, Brullo C, Parisini E, Bruno O, Collina S.

Molecules. 2020 Feb 19;25(4). pii: E935. doi: 10.3390/molecules25040935.

2.

A consensus protocol for the in silico optimisation of antibody fragments.

Soler MA, Medagli B, Semrau MS, Storici P, Bajc G, de Marco A, Laio A, Fortuna S.

Chem Commun (Camb). 2019 Nov 19;55(93):14043-14046. doi: 10.1039/c9cc06182g.

PMID:
31690899
3.

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action.

Rosa B, Marchetti M, Paredi G, Amenitsch H, Franko N, Benoni R, Giabbai B, De Marino MG, Mozzarelli A, Ronda L, Storici P, Campanini B, Bettati S.

Int J Mol Sci. 2019 Oct 21;20(20). pii: E5219. doi: 10.3390/ijms20205219.

4.

Comparative analysis of fusion tags used to functionalize recombinant antibodies.

Veggiani G, Giabbai B, Semrau MS, Medagli B, Riccio V, Bajc G, Storici P, de Marco A.

Protein Expr Purif. 2020 Feb;166:105505. doi: 10.1016/j.pep.2019.105505. Epub 2019 Sep 26.

PMID:
31563543
5.

Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations.

Gobbo D, Piretti V, Di Martino RMC, Tripathi SK, Giabbai B, Storici P, Demitri N, Girotto S, Decherchi S, Cavalli A.

J Chem Theory Comput. 2019 Aug 13;15(8):4646-4659. doi: 10.1021/acs.jctc.9b00104. Epub 2019 Jul 12.

PMID:
31246463
6.

A Triazolotriazine-Based Dual GSK-3β/CK-1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition.

Redenti S, Marcovich I, De Vita T, Pérez C, De Zorzi R, Demitri N, Perez DI, Bottegoni G, Bisignano P, Bissaro M, Moro S, Martinez A, Storici P, Spalluto G, Cavalli A, Federico S.

ChemMedChem. 2019 Feb 5;14(3):310-314. doi: 10.1002/cmdc.201800778. Epub 2019 Jan 15.

PMID:
30548443
7.

Structure-Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR.

Carlino L, Christodoulou MS, Restelli V, Caporuscio F, Foschi F, Semrau MS, Costanzi E, Tinivella A, Pinzi L, Lo Presti L, Battistutta R, Storici P, Broggini M, Passarella D, Rastelli G.

ChemMedChem. 2018 Dec 20;13(24):2627-2634. doi: 10.1002/cmdc.201800687. Epub 2018 Nov 20.

8.

Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity.

Raboni S, Revtovich S, Demitri N, Giabbai B, Storici P, Cocconcelli C, Faggiano S, Rosini E, Pollegioni L, Galati S, Buschini A, Morozova E, Kulikova V, Nikulin A, Gabellieri E, Cioni P, Demidkina T, Mozzarelli A.

Biochim Biophys Acta Proteins Proteom. 2018 Dec;1866(12):1260-1270. doi: 10.1016/j.bbapap.2018.09.011. Epub 2018 Sep 27.

9.

Identification of small-molecule EGFR allosteric inhibitors by high-throughput docking.

Caporuscio F, Tinivella A, Restelli V, Semrau MS, Pinzi L, Storici P, Broggini M, Rastelli G.

Future Med Chem. 2018 Jul 1;10(13):1545-1553. doi: 10.4155/fmc-2018-0063. Epub 2018 May 16.

PMID:
29766737
10.

Molecular Bases of PDE4D Inhibition by Memory-Enhancing GEBR Library Compounds.

Prosdocimi T, Mollica L, Donini S, Semrau MS, Lucarelli AP, Aiolfi E, Cavalli A, Storici P, Alfei S, Brullo C, Bruno O, Parisini E.

Biochemistry. 2018 May 15;57(19):2876-2888. doi: 10.1021/acs.biochem.8b00288. Epub 2018 May 1.

PMID:
29652483
11.

Baculovirus-driven protein expression in insect cells: A benchmarking study.

Stolt-Bergner P, Benda C, Bergbrede T, Besir H, Celie PHN, Chang C, Drechsel D, Fischer A, Geerlof A, Giabbai B, van den Heuvel J, Huber G, Knecht W, Lehner A, Lemaitre R, Nordén K, Pardee G, Racke I, Remans K, Sander A, Scholz J, Stadnik M, Storici P, Weinbruch D, Zaror I, Lua LHL, Suppmann S.

J Struct Biol. 2018 Aug;203(2):71-80. doi: 10.1016/j.jsb.2018.03.004. Epub 2018 Mar 12.

PMID:
29545204
12.

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.

Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B, Cucchi U, Pippione AC, Lolli ML, Giabbai B, Storici P, Carloni P, Rossetti G, Benvenuti F, Bello E, D'Incalci M, Cappuzzello E, Rosato A, Del Sal G.

Nat Commun. 2017 Jun 9;8:15772. doi: 10.1038/ncomms15772.

13.

Structural basis of the specificity of USP18 toward ISG15.

Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G.

Nat Struct Mol Biol. 2017 Mar;24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6.

14.

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs.

Kenig S, Faoro V, Bourkoula E, Podergajs N, Ius T, Vindigni M, Skrap M, Lah T, Cesselli D, Storici P, Vindigni A.

Cancer Cell Int. 2016 Jul 26;16:58. doi: 10.1186/s12935-016-0339-9. eCollection 2016.

15.

Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation.

Kenig S, Bedolla DE, Birarda G, Faoro V, Mitri E, Vindigni A, Storici P, Vaccari L.

Biophys Chem. 2015 Dec;207:90-6. doi: 10.1016/j.bpc.2015.09.005. Epub 2015 Sep 25.

PMID:
26426146
16.

From protein structure to function via single crystal optical spectroscopy.

Ronda L, Bruno S, Bettati S, Storici P, Mozzarelli A.

Front Mol Biosci. 2015 Apr 28;2:12. doi: 10.3389/fmolb.2015.00012. eCollection 2015. Review.

17.

Soft X-Ray Microscopy Radiation Damage On Fixed Cells Investigated With Synchrotron Radiation FTIR Microscopy.

Gianoncelli A, Vaccari L, Kourousias G, Cassese D, Bedolla DE, Kenig S, Storici P, Lazzarino M, Kiskinova M.

Sci Rep. 2015 May 14;5:10250. doi: 10.1038/srep10250.

18.

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

Cersosimo U, Sgorbissa A, Foti C, Drioli S, Angelica R, Tomasella A, Picco R, Semrau MS, Storici P, Benedetti F, Berti F, Brancolini C.

J Med Chem. 2015 Feb 26;58(4):1691-704. doi: 10.1021/jm501336h. Epub 2015 Feb 12.

PMID:
25639862
19.

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

Bindi S, Fancelli D, Alli C, Berta D, Bertrand JA, Cameron AD, Cappella P, Carpinelli P, Cervi G, Croci V, D'Anello M, Forte B, Giorgini ML, Marsiglio A, Moll J, Pesenti E, Pittalà V, Pulici M, Riccardi-Sirtori F, Roletto F, Soncini C, Storici P, Varasi M, Volpi D, Zugnoni P, Vianello P.

Bioorg Med Chem. 2010 Oct 1;18(19):7113-20. doi: 10.1016/j.bmc.2010.07.048. Epub 2010 Jul 25.

PMID:
20817473
20.

Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.

Beria I, Ballinari D, Bertrand JA, Borghi D, Bossi RT, Brasca MG, Cappella P, Caruso M, Ceccarelli W, Ciavolella A, Cristiani C, Croci V, De Ponti A, Fachin G, Ferguson RD, Lansen J, Moll JK, Pesenti E, Posteri H, Perego R, Rocchetti M, Storici P, Volpi D, Valsasina B.

J Med Chem. 2010 May 13;53(9):3532-51. doi: 10.1021/jm901713n.

PMID:
20397705
21.

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

Carpinelli P, Ceruti R, Giorgini ML, Cappella P, Gianellini L, Croci V, Degrassi A, Texido G, Rocchetti M, Vianello P, Rusconi L, Storici P, Zugnoni P, Arrigoni C, Soncini C, Alli C, Patton V, Marsiglio A, Ballinari D, Pesenti E, Fancelli D, Moll J.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3158-68.

22.

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Fancelli D, Moll J, Varasi M, Bravo R, Artico R, Berta D, Bindi S, Cameron A, Candiani I, Cappella P, Carpinelli P, Croci W, Forte B, Giorgini ML, Klapwijk J, Marsiglio A, Pesenti E, Rocchetti M, Roletto F, Severino D, Soncini C, Storici P, Tonani R, Zugnoni P, Vianello P.

J Med Chem. 2006 Nov 30;49(24):7247-51.

PMID:
17125279
23.

Crystal structure of osmoporin OmpC from E. coli at 2.0 A.

Baslé A, Rummel G, Storici P, Rosenbusch JP, Schirmer T.

J Mol Biol. 2006 Oct 6;362(5):933-42. Epub 2006 Aug 3.

PMID:
16949612
24.

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML, Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J.

Clin Cancer Res. 2006 Jul 1;12(13):4080-9.

25.

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.

Fancelli D, Berta D, Bindi S, Cameron A, Cappella P, Carpinelli P, Catana C, Forte B, Giordano P, Giorgini ML, Mantegani S, Marsiglio A, Meroni M, Moll J, Pittalà V, Roletto F, Severino D, Soncini C, Storici P, Tonani R, Varasi M, Vulpetti A, Vianello P.

J Med Chem. 2005 Apr 21;48(8):3080-4.

PMID:
15828847
27.

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.

Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T.

J Biol Chem. 2004 Jan 2;279(1):363-73. Epub 2003 Oct 8.

28.

Inhibitor affinity chromatography: profiling the specific reactivity of the proteome with immobilized molecules.

Lolli G, Thaler F, Valsasina B, Roletto F, Knapp S, Uggeri M, Bachi A, Matafora V, Storici P, Stewart A, Kalisz HM, Isacchi A.

Proteomics. 2003 Jul;3(7):1287-98.

PMID:
12872229
30.

Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene.

Capitani G, Hohenester E, Feng L, Storici P, Kirsch JF, Jansonius JN.

J Mol Biol. 1999 Dec 3;294(3):745-56.

PMID:
10610793
31.

Crystallization and preliminary crystallographic investigations of rhodanese from Azotobacter vinelandii.

Bordo D, Colnaghi R, Deriu D, Carpen A, Storici P, Pagani S, Bolognesi M.

Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1471-3.

PMID:
10417419
32.

Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy.

Storici P, Capitani G, De Biase D, Moser M, John RA, Jansonius JN, Schirmer T.

Biochemistry. 1999 Jul 6;38(27):8628-34.

PMID:
10393538
33.

Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.

Storici P, Capitani G, Müller R, Schirmer T, Jansonius JN.

J Mol Biol. 1999 Jan 8;285(1):297-309.

PMID:
9878407
34.

An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides.

Tossi A, Scocchi M, Zanetti M, Gennaro R, Storici P, Romeo D.

Methods Mol Biol. 1997;78:133-50. No abstract available.

PMID:
9276302
35.

Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.

Storici P, Tossi A, Lenarcic B, Romeo D.

Eur J Biochem. 1996 Jun 15;238(3):769-76.

36.

PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.

Tossi A, Scocchi M, Zanetti M, Storici P, Gennaro R.

Eur J Biochem. 1995 Mar 15;228(3):941-6.

37.

Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.

Zanetti M, Storici P, Tossi A, Scocchi M, Gennaro R.

J Biol Chem. 1994 Mar 18;269(11):7855-8.

38.

Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA.

Storici P, Scocchi M, Tossi A, Gennaro R, Zanetti M.

FEBS Lett. 1994 Jan 17;337(3):303-7.

39.

A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with a cathelin-like pro-sequence.

Storici P, Zanetti M.

Biochem Biophys Res Commun. 1993 Nov 15;196(3):1363-8.

PMID:
8250892
40.

A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39.

Storici P, Zanetti M.

Biochem Biophys Res Commun. 1993 Nov 15;196(3):1058-65.

PMID:
8250863
41.
42.

cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils.

Storici P, Del Sal G, Schneider C, Zanetti M.

FEBS Lett. 1992 Dec 14;314(2):187-90.

43.

cDNA cloning of the neutrophil bactericidal peptide indolicidin.

Del Sal G, Storici P, Schneider C, Romeo D, Zanetti M.

Biochem Biophys Res Commun. 1992 Aug 31;187(1):467-72.

PMID:
1520337

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