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Items: 18


Breach of autoreactive B cell tolerance by post-translationally modified proteins.

Dekkers JS, Verheul MK, Stoop JN, Liu B, Ioan-Facsinay A, van Veelen PA, de Ru AH, Janssen GMC, Hegen M, Rapecki S, Huizinga TWJ, Trouw LA, Toes REM.

Ann Rheum Dis. 2017 Aug;76(8):1449-1457. doi: 10.1136/annrheumdis-2016-210772. Epub 2017 Apr 25.


Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.

van der Velden D, Lagraauw HM, Wezel A, Launay P, Kuiper J, Huizinga TW, Toes RE, Bot I, Stoop JN.

Arthritis Res Ther. 2016 Jun 13;18(1):138. doi: 10.1186/s13075-016-1036-8.


Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.

Jansen DT, el Bannoudi H, Arens R, Habets KL, Hameetman M, Huizinga TW, Stoop JN, Toes RE.

Arthritis Res Ther. 2015 Aug 20;17:220. doi: 10.1186/s13075-015-0731-1.


Anticarbamylated protein antibodies can be detected in animal models of arthritis that require active involvement of the adaptive immune system.

Stoop JN, Fischer A, Hayer S, Hegen M, Huizinga TW, Steiner G, Trouw LA, Toes RE.

Ann Rheum Dis. 2015 May;74(5):949-50. doi: 10.1136/annrheumdis-2014-206797. Epub 2015 Feb 4. No abstract available.


Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis.

Stoop JN, Liu BS, Shi J, Jansen DT, Hegen M, Huizinga TW, Trouw LA, Toes RE.

PLoS One. 2014 Jul 15;9(7):e102163. doi: 10.1371/journal.pone.0102163. eCollection 2014.


Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells.

Suurmond J, Stoop JN, Rivellese F, Bakker AM, Huizinga TW, Toes RE.

Eur J Immunol. 2014 Feb;44(2):386-96. doi: 10.1002/eji.201343617. Epub 2013 Nov 13.


IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-κB pathway in human B cells to boost antibody production.

Liu BS, Stoop JN, Huizinga TW, Toes RE.

J Immunol. 2013 Oct 15;191(8):4086-94. doi: 10.4049/jimmunol.1300765. Epub 2013 Sep 16.


DX5+ CD4+ T cells modulate CD4+ T-cell response via inhibition of IL-12 production by DCs.

el Bannoudi H, Han WG, Stoop JN, Louis-Plence P, Huizinga TW, Toes RE.

Eur J Immunol. 2013 Feb;43(2):439-46. doi: 10.1002/eji.201242796.


The choice of adjuvant determines the cytokine profile of T cells in proteoglycan-induced arthritis but does not influence disease severity.

Stoop JN, Tibbitt CA, van Eden W, Robinson JH, Hilkens CM.

Immunology. 2013 Jan;138(1):68-75. doi: 10.1111/imm.12019.


Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models?

Stoop JN, Robinson JH, Hilkens CM.

Ann Rheum Dis. 2011 Sep;70(9):1526-33. doi: 10.1136/ard.2011.151654. Review.


Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.

Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, Hilkens CM.

Arthritis Rheum. 2010 Dec;62(12):3656-65. doi: 10.1002/art.27756.


Low-strength T-cell activation promotes Th17 responses.

Purvis HA, Stoop JN, Mann J, Woods S, Kozijn AE, Hambleton S, Robinson JH, Isaacs JD, Anderson AE, Hilkens CM.

Blood. 2010 Dec 2;116(23):4829-37. doi: 10.1182/blood-2010-03-272153. Epub 2010 Aug 16.


Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients.

Stoop JN, Claassen MA, Woltman AM, Binda RS, Kuipers EJ, Janssen HL, van der Molen RG, Boonstra A.

Clin Immunol. 2008 Dec;129(3):419-27. doi: 10.1016/j.clim.2008.07.029. Epub 2008 Sep 26.


Induction of regulatory T-cells and interleukin-10-producing cells in non-responders to pegylated interferon-alpha therapy for chronic hepatitis B.

Sprengers D, Stoop JN, Binda RS, Kusters JG, Haagmans BL, Carotenuto P, Artsen A, van der Molen RG, Janssen HL.

Antivir Ther. 2007;12(7):1087-96.


Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response.

Stoop JN, Woltman AM, Biesta PJ, Kusters JG, Kuipers EJ, Janssen HL, van der Molen RG.

Hepatology. 2007 Sep;46(3):699-705.


Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B.

Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, Janssen HL.

Virology. 2007 Apr 25;361(1):141-8. Epub 2006 Dec 20.


Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection.

Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, Janssen HL.

Hepatology. 2005 Apr;41(4):771-8.


Coronaviruses as vectors: position dependence of foreign gene expression.

de Haan CA, van Genne L, Stoop JN, Volders H, Rottier PJ.

J Virol. 2003 Nov;77(21):11312-23.

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