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c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Scheri KC, Leonetti E, Laino L, Gigantino V, Gesualdi L, Grammatico P, Bizzari M, Franco R, Oosterhuis JW, Stoop H, Looijenga LHJ, Ricci G, Catizone A.

Oncotarget. 2018 Aug 7;9(61):31842-31860. doi: 10.18632/oncotarget.25867. eCollection 2018 Aug 7.


Concordance of PD-L1 expression in matched urothelial bladder cancer specimens.

de Jong JJ, Stoop H, Nieboer D, Boormans JL, van Leenders GJLH.

Histopathology. 2018 Jul 12. doi: 10.1111/his.13710. [Epub ahead of print]


Prognostic value of intra-tumoral CD8+ /FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis.

Sideras K, Galjart B, Vasaturo A, Pedroza-Gonzalez A, Biermann K, Mancham S, Nigg AL, Hansen BE, Stoop HA, Zhou G, Verhoef C, Sleijfer S, Sprengers D, Kwekkeboom J, Bruno MJ.

J Surg Oncol. 2018 Jul;118(1):68-76. doi: 10.1002/jso.25091. Epub 2018 Jun 7.


Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor.

Kenswil KJG, Jaramillo AC, Ping Z, Chen S, Hoogenboezem RM, Mylona MA, Adisty MN, Bindels EMJ, Bos PK, Stoop H, Lam KH, van Eerden B, Cupedo T, Raaijmakers MHGP.

Cell Rep. 2018 Jan 16;22(3):666-678. doi: 10.1016/j.celrep.2017.12.070.


Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development.

Baetens D, Güran T, Mendonca BB, Gomes NL, De Cauwer L, Peelman F, Verdin H, Vuylsteke M, Van der Linden M; ESR2 STUDY GROUP, Atay Z, Bereket A, de Krijger RR, Preter K, Domenice S, Turan S, Stoop H, Looijenga LH, De Bosscher K, Cools M, De Baere E.

Genet Med. 2018 Jul;20(7):717-727. doi: 10.1038/gim.2017.163. Epub 2017 Oct 26.


Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

Cools M, Wolffenbuttel KP, Hersmus R, Mendonca BB, Kaprová J, Drop SLS, Stoop H, Gillis AJM, Oosterhuis JW, Costa EMF, Domenice S, Nishi MY, Wunsch L, Quigley CA, T'Sjoen G, Looijenga LHJ.

Hum Reprod. 2017 Dec 1;32(12):2561-2573. doi: 10.1093/humrep/dex300.


VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract.

Boellaard WPA, Stoop H, Gillis AJM, Oosterhuis JW, Looijenga LHJ.

Medicine (Baltimore). 2017 Jul;96(30):e7489. doi: 10.1097/MD.0000000000007489.


Gene Expression Differences between Ductal Carcinoma in Situ with and without Progression to Invasive Breast Cancer.

Doebar SC, Sieuwerts AM, de Weerd V, Stoop H, Martens JWM, van Deurzen CHM.

Am J Pathol. 2017 Jul;187(7):1648-1655. doi: 10.1016/j.ajpath.2017.03.012.


Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.

Halim D, Brosens E, Muller F, Wangler MF, Beaudet AL, Lupski JR, Akdemir ZHC, Doukas M, Stoop HJ, de Graaf BM, Brouwer RWW, van Ijcken WFJ, Oury JF, Rosenblatt J, Burns AJ, Tibboel D, Hofstra RMW, Alves MM.

Am J Hum Genet. 2017 Jul 6;101(1):123-129. doi: 10.1016/j.ajhg.2017.05.011. Epub 2017 Jun 8.


Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer.

Sideras K, Biermann K, Yap K, Mancham S, Boor PPC, Hansen BE, Stoop HJA, Peppelenbosch MP, van Eijck CH, Sleijfer S, Kwekkeboom J, Bruno MJ.

Int J Cancer. 2017 Aug 1;141(3):572-582. doi: 10.1002/ijc.30760. Epub 2017 May 19.


Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2739-E2747. doi: 10.1073/pnas.1620507114. Epub 2017 Mar 14.


P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy.

van Olphen SH, Biermann K, Shapiro J, Wijnhoven BP, Toxopeus EL, van der Gaast A, Stoop HA, van Lanschot JJ, Spaander MC, Bruno MJ, Looijenga LH.

Ann Surg. 2017 Feb;265(2):347-355. doi: 10.1097/SLA.0000000000001625.


Value of cyclin A immunohistochemistry for cancer risk stratification in Barrett esophagus surveillance: A multicenter case-control study.

van Olphen SH, Ten Kate FJ, Doukas M, Kastelein F, Steyerberg EW, Stoop HA, Spaander MC, Looijenga LH, Bruno MJ, Biermann K; ProBar-Study Group.

Medicine (Baltimore). 2016 Nov;95(47):e5402.


Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management.

Wolffenbuttel KP, Hersmus R, Stoop H, Biermann K, Hoebeke P, Cools M, Looijenga LH.

J Pediatr Urol. 2016 Dec;12(6):411-416. doi: 10.1016/j.jpurol.2016.08.015. Epub 2016 Oct 8. Review.


Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis.

Papathomas TG, Duregon E, Korpershoek E, Restuccia DF, van Marion R, Cappellesso R, Sturm N, Rossi G, Coli A, Zucchini N, Stoop H, Oosterhuis W, Ventura L, Volante M, Fassina A, Dinjens WN, Papotti M, de Krijger RR.

Hum Pathol. 2016 Dec;58:113-122. doi: 10.1016/j.humpath.2016.08.006. Epub 2016 Aug 31.


NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.

Baetens D, Stoop H, Peelman F, Todeschini AL, Rosseel T, Coppieters F, Veitia RA, Looijenga LH, De Baere E, Cools M.

Genet Med. 2017 Apr;19(4):367-376. doi: 10.1038/gim.2016.118. Epub 2016 Aug 4.


Ductal carcinoma in situ diagnosed by breast needle biopsy: Predictors of invasion in the excision specimen.

Doebar SC, de Monyé C, Stoop H, Rothbarth J, Willemsen SP, van Deurzen CH.

Breast. 2016 Jun;27:15-21. doi: 10.1016/j.breast.2016.02.014. Epub 2016 Mar 20.


Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.

Spiller CM, Gillis AJ, Burnet G, Stoop H, Koopman P, Bowles J, Looijenga LH.

Mol Oncol. 2016 Apr;10(4):526-37. doi: 10.1016/j.molonc.2015.11.003. Epub 2015 Nov 18.


SOX2 as a novel marker to predict neoplastic progression in Barrett's esophagus.

van Olphen S, Biermann K, Spaander MC, Kastelein F, Steyerberg EW, Stoop HA, Bruno MJ, Looijenga LH.

Am J Gastroenterol. 2015 Oct;110(10):1420-8. doi: 10.1038/ajg.2015.260. Epub 2015 Sep 1.


Immunohistochemical expression of stem cell markers in pheochromocytomas/paragangliomas is associated with SDHx mutations.

Oudijk L, Neuhofer CM, Lichtenauer UD, Papathomas TG, Korpershoek E, Stoop H, Oosterhuis JW, Smid M, Restuccia DF, Robledo M, de Cubas AA, Mannelli M, Gimenez-Roqueplo AP, Dinjens WN, Beuschlein F, de Krijger RR.

Eur J Endocrinol. 2015 Jul;173(1):43-52. doi: 10.1530/EJE-14-1164. Epub 2015 Apr 27.


Testicular cancer: biology and biomarkers.

Looijenga LH, Stoop H, Biermann K.

Virchows Arch. 2014 Mar;464(3):301-13. doi: 10.1007/s00428-013-1522-1. Epub 2014 Feb 1. Review.


Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

Mitchell RT, Camacho-Moll M, Macdonald J, Anderson RA, Kelnar CJ, O'Donnell M, Sharpe RM, Smith LB, Grigor KM, Wallace WHB, Stoop H, Wolffenbuttel KP, Donat R, Saunders PT, Looijenga LH.

Mod Pathol. 2014 Sep;27(9):1255-1266. doi: 10.1038/modpathol.2013.246. Epub 2014 Jan 24.


Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines.

Eini R, Stoop H, Gillis AJ, Biermann K, Dorssers LC, Looijenga LH.

PLoS One. 2014 Jan 3;9(1):e83585. doi: 10.1371/journal.pone.0083585. eCollection 2014.


Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology.

Kaprova-Pleskacova J, Stoop H, Brüggenwirth H, Cools M, Wolffenbuttel KP, Drop SL, Snajderova M, Lebl J, Oosterhuis JW, Looijenga LH.

Mod Pathol. 2014 May;27(5):721-30. doi: 10.1038/modpathol.2013.193. Epub 2013 Nov 1.


Value of α-methylacyl-CoA racemase immunochemistry for predicting neoplastic progression in Barrett's oesophagus.

Kastelein F, Biermann K, Steyerberg EW, Verheij J, Kalisvaart M, Looijenga LH, Stoop HA, Walter L, Kuipers EJ, Spaander MC, Bruno MJ; ProBar study group.

Histopathology. 2013 Nov;63(5):630-9. doi: 10.1111/his.12216. Epub 2013 Sep 5.


Role of epigenetics in the etiology of germ cell cancer.

Van Der Zwan YG, Stoop H, Rossello F, White SJ, Looijenga LH.

Int J Dev Biol. 2013;57(2-4):299-308. doi: 10.1387/ijdb.130017ll. Review.


Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept.

Oosterhuis JW, Peeters SH, Smit VT, Stoop H, Looijenga LH, Elzevier HW, Osanto S.

Int J Dev Biol. 2013;57(2-4):153-7. doi: 10.1387/ijdb.130141jo.


Mutations in LRRC50 predispose zebrafish and humans to seminomas.

Basten SG, Davis EE, Gillis AJ, van Rooijen E, Stoop H, Babala N, Logister I, Heath ZG, Jonges TN, Katsanis N, Voest EE, van Eeden FJ, Medema RH, Ketting RF, Schulte-Merker S, Looijenga LH, Giles RH.

PLoS Genet. 2013 Apr;9(4):e1003384. doi: 10.1371/journal.pgen.1003384. Epub 2013 Apr 11.


Gonadal malignancy in 13 consecutive collected patients with disorders of sex development (DSD) from Semarang (Indonesia).

Juniarto AZ, Setyawati BA, Miranti IP, Santosa A, Hersmus R, Stoop H, Cools M, Oosterhuis JW, Drop SL, Faradz SM, Looijenga LH.

J Clin Pathol. 2013 Mar;66(3):198-204. doi: 10.1136/jclinpath-2012-201062. Epub 2012 Dec 25.


Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus.

Kastelein F, Biermann K, Steyerberg EW, Verheij J, Kalisvaart M, Looijenga LH, Stoop HA, Walter L, Kuipers EJ, Spaander MC, Bruno MJ; ProBar-study group.

Gut. 2013 Dec;62(12):1676-83. doi: 10.1136/gutjnl-2012-303594. Epub 2012 Dec 20.


SRY mutation analysis by next generation (deep) sequencing in a cohort of chromosomal Disorders of Sex Development (DSD) patients with a mosaic karyotype.

Hersmus R, Stoop H, Turbitt E, Oosterhuis JW, Drop SL, Sinclair AH, White SJ, Looijenga LH.

BMC Med Genet. 2012 Nov 16;13:108. doi: 10.1186/1471-2350-13-108.


DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours.

de Boer CM, Eini R, Gillis AM, Stoop H, Looijenga LH, White SJ.

BMC Res Notes. 2012 Oct 15;5:569. doi: 10.1186/1756-0500-5-569.


Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas.

Hersmus R, Stoop H, van de Geijn GJ, Eini R, Biermann K, Oosterhuis JW, Dhooge C, Schneider DT, Meijssen IC, Dinjens WN, Dubbink HJ, Drop SL, Looijenga LH.

PLoS One. 2012;7(8):e43952. doi: 10.1371/journal.pone.0043952. Epub 2012 Aug 28.


A 46,XY female DSD patient with bilateral gonadoblastoma, a novel SRY missense mutation combined with a WT1 KTS splice-site mutation.

Hersmus R, van der Zwan YG, Stoop H, Bernard P, Sreenivasan R, Oosterhuis JW, Brüggenwirth HT, de Boer S, White S, Wolffenbuttel KP, Alders M, McElreavy K, Drop SL, Harley VR, Looijenga LH.

PLoS One. 2012;7(7):e40858. doi: 10.1371/journal.pone.0040858. Epub 2012 Jul 18.


c-KIT protein expression does not discriminate neoplastic from non-neoplastic intratubular germ cells.

Biermann K, Stoop H, Looijenga L.

Histopathology. 2012 May;60(6):1017-9. doi: 10.1111/j.1365-2559.2011.04157.x. Epub 2012 Feb 16. No abstract available.


Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors.

Hersmus R, Stoop H, White SJ, Drop SL, Oosterhuis JW, Incrocci L, Wolffenbuttel KP, Looijenga LH.

Int J Endocrinol. 2012;2012:671209. doi: 10.1155/2012/671209. Epub 2012 Jan 19.


A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.

Westerman BA, Braat AK, Taub N, Potman M, Vissers JH, Blom M, Verhoeven E, Stoop H, Gillis A, Velds A, Nijkamp W, Beijersbergen R, Huber LA, Looijenga LH, van Lohuizen M.

J Exp Med. 2011 Dec 19;208(13):2675-89. doi: 10.1084/jem.20102037. Epub 2011 Dec 5.


Pubertal androgenization and gonadal histology in two 46,XY adolescents with NR5A1 mutations and predominantly female phenotype at birth.

Cools M, Hoebeke P, Wolffenbuttel KP, Stoop H, Hersmus R, Barbaro M, Wedell A, Brüggenwirth H, Looijenga LH, Drop SL.

Eur J Endocrinol. 2012 Feb;166(2):341-9. doi: 10.1530/EJE-11-0392. Epub 2011 Nov 11.


Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.

Rijlaarsdam MA, van Herk HA, Gillis AJ, Stoop H, Jenster G, Martens J, van Leenders GJ, Dinjens W, Hoogland AM, Timmermans M, Looijenga LH.

Br J Cancer. 2011 Sep 6;105(6):854-63. doi: 10.1038/bjc.2011.270. Epub 2011 Aug 16. Erratum in: Br J Cancer. 2012 Feb 14;106(4):791.


A pathologist's view on the testis biopsy.

Oosterhuis JW, Stoop H, Dohle G, Boellaard W, van Casteren N, Wolffenbuttel K, Looijenga LH.

Int J Androl. 2011 Aug;34(4 Pt 2):e14-9; discussion e20. doi: 10.1111/j.1365-2605.2011.01204.x. Review.


Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis.

Gillis AJ, Stoop H, Biermann K, van Gurp RJ, Swartzman E, Cribbes S, Ferlinz A, Shannon M, Oosterhuis JW, Looijenga LH.

Int J Androl. 2011 Aug;34(4 Pt 2):e160-74. doi: 10.1111/j.1365-2605.2011.01148.x. Epub 2011 Jun 2.


Dissecting the molecular pathways of (testicular) germ cell tumour pathogenesis; from initiation to treatment-resistance.

Looijenga LH, Gillis AJ, Stoop H, Biermann K, Oosterhuis JW.

Int J Androl. 2011 Aug;34(4 Pt 2):e234-51. doi: 10.1111/j.1365-2605.2011.01157.x. Epub 2011 May 12. Review.


Gonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism.

Cools M, Pleskacova J, Stoop H, Hoebeke P, Van Laecke E, Drop SL, Lebl J, Oosterhuis JW, Looijenga LH, Wolffenbuttel KP; Mosaicism Collaborative Group.

J Clin Endocrinol Metab. 2011 Jul;96(7):E1171-80. doi: 10.1210/jc.2011-0232. Epub 2011 Apr 20.


Diagnosis of testicular carcinoma in situ '(intratubular and microinvasive)' seminoma and embryonal carcinoma using direct enzymatic alkaline phosphatase reactivity on frozen histological sections.

Stoop H, Kirkels W, Dohle GR, Gillis AJ, den Bakker MA, Biermann K, Oosterhuis W, Looijenga LH.

Histopathology. 2011 Feb;58(3):440-6. doi: 10.1111/j.1365-2559.2011.03767.x. Epub 2011 Feb 16.


Histopathological and molecular features of late relapses in non-seminomas.

Mayer F, Wermann H, Albers P, Stoop H, Gillis AJ, Hartmann JT, Bokemeyer CC, Oosterhuis JW, Looijenga LH, Honecker F.

BJU Int. 2011 Mar;107(6):936-43. doi: 10.1111/j.1464-410X.2010.09631.x. Epub 2010 Oct 18.


Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance.

Wermann H, Stoop H, Gillis AJ, Honecker F, van Gurp RJ, Ammerpohl O, Richter J, Oosterhuis JW, Bokemeyer C, Looijenga LH.

J Pathol. 2010 Aug;221(4):433-42. doi: 10.1002/path.2725.


Gonadal tumours and DSD.

Looijenga LH, Hersmus R, de Leeuw BH, Stoop H, Cools M, Oosterhuis JW, Drop SL, Wolffenbuttel KP.

Best Pract Res Clin Endocrinol Metab. 2010 Apr;24(2):291-310. doi: 10.1016/j.beem.2009.10.002. Review.


Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness.

Nuti F, Luciani P, Marinari E, Erdei E, Bak M, Deledda C, Rosati F, Mazzinghi B, Danza G, Stoop H, Looijenga LH, Peri A, Serio M, Krausz C.

J Pathol. 2009 Dec;219(4):491-500. doi: 10.1002/path.2622.


[A patient with an alpha-foetoprotein producing tumour].

van Roon AH, ter Borg PC, Zondervan PE, Stoop H, de Man RA.

Ned Tijdschr Geneeskd. 2009;153:A364. Dutch.


A novel SRY missense mutation affecting nuclear import in a 46,XY female patient with bilateral gonadoblastoma.

Hersmus R, de Leeuw BH, Stoop H, Bernard P, van Doorn HC, Brüggenwirth HT, Drop SL, Oosterhuis JW, Harley VR, Looijenga LH.

Eur J Hum Genet. 2009 Dec;17(12):1642-9. doi: 10.1038/ejhg.2009.96. Epub 2009 Jun 10.

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