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Structure-function analysis of the equine hepacivirus 5' untranslated region highlights the conservation of translational mechanisms across the hepaciviruses.

Lattimer J, Stewart H, Locker N, Tuplin A, Stonehouse NJ, Harris M.

J Gen Virol. 2019 Sep 6. doi: 10.1099/jgv.0.001316. [Epub ahead of print]


Structural and phenotypic analysis of Chikungunya virus RNA replication elements.

Kendall C, Khalid H, Müller M, Banda DH, Kohl A, Merits A, Stonehouse NJ, Tuplin A.

Nucleic Acids Res. 2019 Sep 26;47(17):9296-9312. doi: 10.1093/nar/gkz640.


The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication.

Herod MR, Adeyemi OO, Ward J, Bentley K, Harris M, Stonehouse NJ, Polyak SJ.

J Gen Virol. 2019 Sep;100(9):1293-1302. doi: 10.1099/jgv.0.001283. Epub 2019 Jun 4.


Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response.

Macleod T, Ward J, Alase AA, Bridgewood C, Wittmann M, Stonehouse NJ.

Front Immunol. 2019 Apr 24;10:857. doi: 10.3389/fimmu.2019.00857. eCollection 2019.


The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus.

Shawli GT, Adeyemi OO, Stonehouse NJ, Herod MR.

Viruses. 2019 Jan 24;11(2). pii: E97. doi: 10.3390/v11020097.


Involvement of a Nonstructural Protein in Poliovirus Capsid Assembly.

Adeyemi OO, Sherry L, Ward JC, Pierce DM, Herod MR, Rowlands DJ, Stonehouse NJ.

J Virol. 2019 Feb 19;93(5). pii: e01447-18. doi: 10.1128/JVI.01447-18. Print 2019 Mar 1.


An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells.

Lulla V, Dinan AM, Hosmillo M, Chaudhry Y, Sherry L, Irigoyen N, Nayak KM, Stonehouse NJ, Zilbauer M, Goodfellow I, Firth AE.

Nat Microbiol. 2019 Feb;4(2):280-292. doi: 10.1038/s41564-018-0297-1. Epub 2018 Nov 26.


Photodynamic inactivation of non-enveloped RNA viruses.

Majiya H, Adeyemi OO, Herod M, Stonehouse NJ, Millner P.

J Photochem Photobiol B. 2018 Dec;189:87-94. doi: 10.1016/j.jphotobiol.2018.10.009. Epub 2018 Oct 9.


Recombinant Expression of Tandem-HBc Virus-Like Particles (VLPs).

Stephen SL, Beales L, Peyret H, Roe A, Stonehouse NJ, Rowlands DJ.

Methods Mol Biol. 2018;1776:97-123. doi: 10.1007/978-1-4939-7808-3_7.


Photodynamic inactivation of bacteriophage MS2: The A-protein is the target of virus inactivation.

Majiya H, Adeyemi OO, Stonehouse NJ, Millner P.

J Photochem Photobiol B. 2018 Jan;178:404-411. doi: 10.1016/j.jphotobiol.2017.11.032. Epub 2017 Nov 26.


Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

Kazaks A, Lu IN, Farinelle S, Ramirez A, Crescente V, Blaha B, Ogonah O, Mukhopadhyay T, de Obanos MP, Krimer A, Akopjana I, Bogans J, Ose V, Kirsteina A, Kazaka T, Stonehouse NJ, Rowlands DJ, Muller CP, Tars K, Rosenberg WM.

BMC Biotechnol. 2017 Nov 10;17(1):79. doi: 10.1186/s12896-017-0396-8.


Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research.

Roberts GC, Zothner C, Remenyi R, Merits A, Stonehouse NJ, Harris M.

Sci Rep. 2017 Nov 7;7(1):14641. doi: 10.1038/s41598-017-15269-w.


Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.

Herod MR, Gold S, Lasecka-Dykes L, Wright C, Ward JC, McLean TC, Forrest S, Jackson T, Tuthill TJ, Rowlands DJ, Stonehouse NJ.

PLoS Pathog. 2017 Oct 2;13(10):e1006666. doi: 10.1371/journal.ppat.1006666. eCollection 2017 Oct.


Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.

Adeyemi OO, Nicol C, Stonehouse NJ, Rowlands DJ.

J Virol. 2017 Jan 31;91(4). pii: e01586-16. doi: 10.1128/JVI.01586-16. Print 2017 Feb 15.


Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases.

Loundras EA, Herod MR, Harris M, Stonehouse NJ.

J Gen Virol. 2016 Sep;97(9):2221-2230. doi: 10.1099/jgv.0.000527. Epub 2016 Jun 20.


Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.

Herod MR, Ferrer-Orta C, Loundras EA, Ward JC, Verdaguer N, Rowlands DJ, Stonehouse NJ.

J Virol. 2016 Jul 11;90(15):6864-6883. doi: 10.1128/JVI.00469-16. Print 2016 Aug 1.


Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.

Kelly JT, De Colibus L, Elliott L, Fry EE, Stuart DI, Rowlands DJ, Stonehouse NJ.

Antiviral Res. 2015 Dec;124:77-82. doi: 10.1016/j.antiviral.2015.10.006. Epub 2015 Oct 30.


Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication.

Herod MR, Loundras EA, Ward JC, Tulloch F, Rowlands DJ, Stonehouse NJ.

J Gen Virol. 2015 Dec;96(12):3507-18.


YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins.

Müller M, Wasson CW, Bhatia R, Boxall S, Millan D, Goh GY, Haas J, Stonehouse NJ, Macdonald A.

Sci Rep. 2015 Aug 3;5:12523. doi: 10.1038/srep12523.


The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers.

Cesur Ö, Nicol C, Groves H, Mankouri J, Blair GE, Stonehouse NJ.

Viruses. 2015 Jun 26;7(7):3443-61. doi: 10.3390/v7072780.


Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.

Holmes K, Shepherd DA, Ashcroft AE, Whelan M, Rowlands DJ, Stonehouse NJ.

J Biol Chem. 2015 Jun 26;290(26):16238-45. doi: 10.1074/jbc.M114.622035. Epub 2015 May 7.


Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins.

Peyret H, Gehin A, Thuenemann EC, Blond D, El Turabi A, Beales L, Clarke D, Gilbert RJ, Fry EE, Stuart DI, Holmes K, Stonehouse NJ, Whelan M, Rosenberg W, Lomonossoff GP, Rowlands DJ.

PLoS One. 2015 Apr 1;10(4):e0120751. doi: 10.1371/journal.pone.0120751. eCollection 2015.


FMDV replicons encoding green fluorescent protein are replication competent.

Tulloch F, Pathania U, Luke GA, Nicholson J, Stonehouse NJ, Rowlands DJ, Jackson T, Tuthill T, Haas J, Lamond AI, Ryan MD.

J Virol Methods. 2014 Dec;209:35-40. doi: 10.1016/j.jviromet.2014.08.020. Epub 2014 Sep 4.


Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore.

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ.

PLoS Pathog. 2014 Aug 7;10(8):e1004294. doi: 10.1371/journal.ppat.1004294. eCollection 2014 Aug.


Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.

Forrest S, Lear Z, Herod MR, Ryan M, Rowlands DJ, Stonehouse NJ.

J Gen Virol. 2014 Dec;95(Pt 12):2649-57. doi: 10.1099/vir.0.067751-0. Epub 2014 Aug 5.


An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein.

Belyaeva TA, Nicol C, Cesur O, Travé G, Blair GE, Stonehouse NJ.

Cancers (Basel). 2014 Jul 24;6(3):1553-69. doi: 10.3390/cancers6031553.


Probing bunyavirus N protein oligomerisation using mass spectrometry.

Shepherd DA, Ariza A, Edwards TA, Barr JN, Stonehouse NJ, Ashcroft AE.

Rapid Commun Mass Spectrom. 2014 Apr 15;28(7):793-800. doi: 10.1002/rcm.6841.


IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?

Doble R, McDermott MF, Cesur Ö, Stonehouse NJ, Wittmann M.

J Invest Dermatol. 2014 Mar;134(3):852-855. doi: 10.1038/jid.2013.399. Epub 2013 Sep 20. No abstract available.


Using ion mobility spectrometry-mass spectrometry to decipher the conformational and assembly characteristics of the hepatitis B capsid protein.

Shepherd DA, Holmes K, Rowlands DJ, Stonehouse NJ, Ashcroft AE.

Biophys J. 2013 Sep 3;105(5):1258-67. doi: 10.1016/j.bpj.2013.07.028.


An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.

Nicol C, Cesur Ö, Forrest S, Belyaeva TA, Bunka DH, Blair GE, Stonehouse NJ.

PLoS One. 2013 May 30;8(5):e64781. doi: 10.1371/journal.pone.0064781. Print 2013.


Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization.

Ariza A, Tanner SJ, Walter CT, Dent KC, Shepherd DA, Wu W, Matthews SV, Hiscox JA, Green TJ, Luo M, Elliott RM, Fooks AR, Ashcroft AE, Stonehouse NJ, Ranson NA, Barr JN, Edwards TA.

Nucleic Acids Res. 2013 Jun;41(11):5912-26. doi: 10.1093/nar/gkt268. Epub 2013 Apr 17.


Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activity.

Bentham M, Holmes K, Forrest S, Rowlands DJ, Stonehouse NJ.

J Virol. 2012 Feb;86(4):2371-4. doi: 10.1128/JVI.05696-11. Epub 2011 Dec 7.


Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.

Foster TL, Gallay P, Stonehouse NJ, Harris M.

J Virol. 2011 Jul;85(14):7460-4. doi: 10.1128/JVI.00393-11. Epub 2011 May 18.


Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.

Nicol C, Bunka DH, Blair GE, Stonehouse NJ.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):417-21. doi: 10.1016/j.bbrc.2011.01.044. Epub 2011 Jan 14.


RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry.

Morton VL, Burkitt W, O'Connor G, Stonehouse NJ, Stockley PG, Ashcroft AE.

Phys Chem Chem Phys. 2010 Nov 7;12(41):13468-75. doi: 10.1039/c0cp00817f. Epub 2010 Sep 28.


Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometry.

Knapman TW, Morton VL, Stonehouse NJ, Stockley PG, Ashcroft AE.

Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3033-3042. doi: 10.1002/rcm.4732.


The impact of viral RNA on assembly pathway selection.

Morton VL, Dykeman EC, Stonehouse NJ, Ashcroft AE, Twarock R, Stockley PG.

J Mol Biol. 2010 Aug 13;401(2):298-308. doi: 10.1016/j.jmb.2010.05.059. Epub 2010 Jun 1.


All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.

Foster TL, Belyaeva T, Stonehouse NJ, Pearson AR, Harris M.

J Virol. 2010 Sep;84(18):9267-77. doi: 10.1128/JVI.00616-10. Epub 2010 Jun 30.


Viral genomic single-stranded RNA directs the pathway toward a T=3 capsid.

Basnak G, Morton VL, Rolfsson O, Stonehouse NJ, Ashcroft AE, Stockley PG.

J Mol Biol. 2010 Feb 5;395(5):924-36. doi: 10.1016/j.jmb.2009.11.018. Epub 2009 Nov 12.


Insights into virus capsid assembly from non-covalent mass spectrometry.

Morton VL, Stockley PG, Stonehouse NJ, Ashcroft AE.

Mass Spectrom Rev. 2008 Nov-Dec;27(6):575-95. doi: 10.1002/mas.20176. Review.


A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid.

Stockley PG, Rolfsson O, Thompson GS, Basnak G, Francese S, Stonehouse NJ, Homans SW, Ashcroft AE.

J Mol Biol. 2007 Jun 1;369(2):541-52. Epub 2007 Mar 15.


Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.

Ellingham M, Bunka DH, Rowlands DJ, Stonehouse NJ.

RNA. 2006 Nov;12(11):1970-9. Epub 2006 Oct 3.


Affinity of molecular interactions in the bacteriophage phi29 DNA packaging motor.

Robinson MA, Wood JP, Capaldi SA, Baron AJ, Gell C, Smith DA, Stonehouse NJ.

Nucleic Acids Res. 2006 May 19;34(9):2698-709. Print 2006.


Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2.

Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG.

Structure. 2006 Mar;14(3):487-95.


Engineering thermal stability in RNA phage capsids via disulphide bonds.

Ashcroft AE, Lago H, Macedo JM, Horn WT, Stonehouse NJ, Stockley PG.

J Nanosci Nanotechnol. 2005 Dec;5(12):2034-41.


Investigating the structural basis of purine specificity in the structures of MS2 coat protein RNA translational operator hairpins.

Helgstrand C, Grahn E, Moss T, Stonehouse NJ, Tars K, Stockley PG, Liljas L.

Nucleic Acids Res. 2002 Jun 15;30(12):2678-85.


Structural basis of pyrimidine specificity in the MS2 RNA hairpin-coat-protein complex.

Grahn E, Moss T, Helgstrand C, Fridborg K, Sundaram M, Tars K, Lago H, Stonehouse NJ, Davis DR, Stockley PG, Liljas L.

RNA. 2001 Nov;7(11):1616-27.


Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface.

Grahn E, Stonehouse NJ, Adams CJ, Fridborg K, Beigelman L, Matulic-Adamic J, Warriner SL, Stockley PG, Liljas L.

Nucleic Acids Res. 2000 Dec 1;28(23):4611-6.

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