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Items: 1 to 50 of 153

1.

Melatonin receptor type 1A gene linked to Alzheimer's disease in old age.

Sulkava S, Muggalla P, Sulkava R, Ollila HM, Peuralinna T, Myllykangas L, Kaivola K, Stone DJ, Traynor BJ, Renton AE, Rivera AM, Helisalmi S, Soininen H, Polvikoski T, Hiltunen M, Tienari PJ, Huttunen HJ, Paunio T.

Sleep. 2018 Jul 1;41(7). doi: 10.1093/sleep/zsy103.

2.

Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.

Stopa EG, Tanis KQ, Miller MC, Nikonova EV, Podtelezhnikov AA, Finney EM, Stone DJ, Camargo LM, Parker L, Verma A, Baird A, Donahue JE, Torabi T, Eliceiri BP, Silverberg GD, Johanson CE.

Fluids Barriers CNS. 2018 May 31;15(1):18. doi: 10.1186/s12987-018-0102-9.

3.

Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database.

Feng M, McSparron JI, Kien DT, Stone DJ, Roberts DH, Schwartzstein RM, Vieillard-Baron A, Celi LA.

Intensive Care Med. 2018 Jun;44(6):884-892. doi: 10.1007/s00134-018-5208-7. Epub 2018 May 28.

PMID:
29806057
4.

One-year mortality after recovery from critical illness: A retrospective cohort study.

Lokhandwala S, McCague N, Chahin A, Escobar B, Feng M, Ghassemi MM, Stone DJ, Celi LA.

PLoS One. 2018 May 11;13(5):e0197226. doi: 10.1371/journal.pone.0197226. eCollection 2018.

5.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A; ITALSGEN Consortium, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L; Genomic Translation for ALS Care (GTAC) Consortium, Moreno CAM, Kamalakaran S, Goldstein DB; ALS Sequencing Consortium, Gitler AD, Harris T, Myers RM; NYGC ALS Consortium, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC; Answer ALS Foundation, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E; Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J; SLAGEN Consortium, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C; French ALS Consortium, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A; Project MinE ALS Sequencing Consortium, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH Jr, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE.

Neuron. 2018 Mar 21;97(6):1268-1283.e6. doi: 10.1016/j.neuron.2018.02.027.

PMID:
29566793
6.

Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+).

Mäkelä M, Kaivola K, Valori M, Paetau A, Polvikoski T, Singleton AB, Traynor BJ, Stone DJ, Peuralinna T, Tienari PJ, Tanskanen M, Myllykangas L.

Neurol Genet. 2018 Jan 18;4(1):e211. doi: 10.1212/NXG.0000000000000211. eCollection 2018 Feb.

7.

From Big Data to Artificial Intelligence: Harnessing Data Routinely Collected in the Process of Care.

Rush B, Stone DJ, Celi LA.

Crit Care Med. 2018 Feb;46(2):345-346. doi: 10.1097/CCM.0000000000002892. No abstract available.

PMID:
29337803
8.

A Comparative Analysis of Sepsis Identification Methods in an Electronic Database.

Johnson AEW, Aboab J, Raffa JD, Pollard TJ, Deliberato RO, Celi LA, Stone DJ.

Crit Care Med. 2018 Apr;46(4):494-499. doi: 10.1097/CCM.0000000000002965.

PMID:
29303796
9.

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, Lleo A, Morenas-Rodriguez E, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Serrano GE, Beach TG, Lesage S, Galasko D, Masliah E, Santana I, Pastor P, Diez-Fairen M, Aguilar M, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Pickering-Brown S, Mann D, Halliday GM, Hardy J, Trojanowski JQ, Dickson DW, Singleton A, Stone DJ, Bras J.

Lancet Neurol. 2018 Jan;17(1):64-74. doi: 10.1016/S1474-4422(17)30400-3. Epub 2017 Dec 16.

10.

Severity of Illness Scores May Misclassify Critically Ill Obese Patients.

Deliberato RO, Ko S, Komorowski M, Armengol de La Hoz MA, Frushicheva MP, Raffa JD, Johnson AEW, Celi LA, Stone DJ.

Crit Care Med. 2018 Mar;46(3):394-400. doi: 10.1097/CCM.0000000000002868.

PMID:
29194147
11.

Racial and Geographic Disparities in Interhospital ICU Transfers.

Tyler PD, Stone DJ, Geisler BP, McLennan S, Celi LA, Rush B.

Crit Care Med. 2018 Jan;46(1):e76-e80. doi: 10.1097/CCM.0000000000002776.

PMID:
29068859
12.

Outcomes of Ventilated Patients With Sepsis Who Undergo Interhospital Transfer: A Nationwide Linked Analysis.

Rush B, Tyler PD, Stone DJ, Geisler BP, Walley KR, Celi LA.

Crit Care Med. 2018 Jan;46(1):e81-e86. doi: 10.1097/CCM.0000000000002777.

PMID:
29068858
13.

The MIMIC Code Repository: enabling reproducibility in critical care research.

Johnson AE, Stone DJ, Celi LA, Pollard TJ.

J Am Med Inform Assoc. 2018 Jan 1;25(1):32-39. doi: 10.1093/jamia/ocx084.

PMID:
29036464
14.

Clinical Note Creation, Binning, and Artificial Intelligence.

Deliberato RO, Celi LA, Stone DJ.

JMIR Med Inform. 2017 Aug 3;5(3):e24. doi: 10.2196/medinform.7627.

15.

Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake.

Nikonova EV, Gilliland JD, Tanis KQ, Podtelezhnikov AA, Rigby AM, Galante RJ, Finney EM, Stone DJ, Renger JJ, Pack AI, Winrow CJ.

Sleep. 2017 Jun 1;40(6). doi: 10.1093/sleep/zsx059.

16.

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.

Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2389-2394. doi: 10.1073/pnas.1616332114. Epub 2017 Feb 13.

17.

Bridging the Health Data Divide.

Celi LA, Davidzon G, Johnson AE, Komorowski M, Marshall DC, Nair SS, Phillips CT, Pollard TJ, Raffa JD, Salciccioli JD, Salgueiro FM, Stone DJ.

J Med Internet Res. 2016 Dec 20;18(12):e325. doi: 10.2196/jmir.6400.

18.

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Kun-Rodrigues C, Ross OA, Orme T, Shepherd C, Parkkinen L, Darwent L, Hernandez D, Ansorge O, Clark LN, Honig LS, Marder K, Lemstra A, Scheltens P, van der Flier W, Louwersheimer E, Holstege H, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Holton J, Compta Y, Van Deerlin V, Trojanowski JQ, Serrano GE, Beach TG, Clarimon J, Lleó A, Morenas-Rodríguez E, Lesage S, Galasko D, Masliah E, Santana I, Diez M, Pastor P, Tienari PJ, Myllykangas L, Oinas M, Revesz T, Lees A, Boeve BF, Petersen RC, Ferman TJ, Escott-Price V, Graff-Radford N, Cairns NJ, Morris JC, Stone DJ, Pickering-Brown S, Mann D, Dickson DW, Halliday GM, Singleton A, Guerreiro R, Bras J.

Neurobiol Aging. 2017 Jan;49:214.e13-214.e15. doi: 10.1016/j.neurobiolaging.2016.08.023. Epub 2016 Sep 2.

19.

Species specific exome probes reveal new insights in positively selected genes in nonhuman primates.

Su Z, Zhang J, Kumar C, Molony C, Lu H, Chen R, Stone DJ, Ling F, Liu X.

Sci Rep. 2016 Sep 23;6:33876. doi: 10.1038/srep33876.

20.

Actuating critical care therapeutics.

Stone DJ, Csete M.

J Crit Care. 2016 Oct;35:90-5. doi: 10.1016/j.jcrc.2016.05.002. Epub 2016 May 10. Review.

PMID:
27481741
21.

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.

Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB; North American Brain Expression Consortium, Hardy JA, Troncoso JC, Scholz SW.

Neurobiol Dis. 2016 Oct;94:55-62. doi: 10.1016/j.nbd.2016.06.004. Epub 2016 Jun 14.

22.

A "datathon" model to support cross-disciplinary collaboration.

Aboab J, Celi LA, Charlton P, Feng M, Ghassemi M, Marshall DC, Mayaud L, Naumann T, McCague N, Paik KE, Pollard TJ, Resche-Rigon M, Salciccioli JD, Stone DJ.

Sci Transl Med. 2016 Apr 6;8(333):333ps8. doi: 10.1126/scitranslmed.aad9072. Review.

23.

Disrupting Electronic Health Records Systems: The Next Generation.

Celi LA, Marshall JD, Lai Y, Stone DJ.

JMIR Med Inform. 2015 Oct 23;3(4):e34. doi: 10.2196/medinform.4192.

24.

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.

Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB; Parkinson's Disease Biomarkers Program and Parkinson's Progression Marker Initiative investigators.

Lancet Neurol. 2015 Oct;14(10):1002-9. doi: 10.1016/S1474-4422(15)00178-7. Epub 2015 Aug 10.

25.

Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI).

Nalls MA, Keller MF, Hernandez DG, Chen L, Stone DJ, Singleton AB; Parkinson's Progression Marker Initiative (PPMI) investigators.

Mov Disord. 2016 Jan;31(1):79-85. doi: 10.1002/mds.26374. Epub 2015 Aug 13.

26.

Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing.

Camargo LM, Zhang XD, Loerch P, Caceres RM, Marine SD, Uva P, Ferrer M, de Rinaldis E, Stone DJ, Majercak J, Ray WJ, Yi-An C, Shearman MS, Mizuguchi K.

PLoS One. 2015 Jun 1;10(6):e0129641. doi: 10.1371/journal.pone.0129641. eCollection 2015. No abstract available.

27.

State of the art review: the data revolution in critical care.

Ghassemi M, Celi LA, Stone DJ.

Crit Care. 2015 Mar 16;19:118. doi: 10.1186/s13054-015-0801-4. Review.

28.

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing.

Camargo LM, Zhang XD, Loerch P, Caceres RM, Marine SD, Uva P, Ferrer M, de Rinaldis E, Stone DJ, Majercak J, Ray WJ, Yi-An C, Shearman MS, Mizuguchi K.

PLoS One. 2015 Feb 27;10(2):e0115369. doi: 10.1371/journal.pone.0115369. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129641.

29.

Preparing a New Generation of Clinicians for the Era of Big Data.

Moskowitz A, McSparron J, Stone DJ, Celi LA.

Harv Med Stud Rev. 2015 Jan;2(1):24-27.

30.

Engineering control into medicine.

Stone DJ, Celi LA, Csete M.

J Crit Care. 2015 Jun;30(3):652.e1-7. doi: 10.1016/j.jcrc.2015.01.019. Epub 2015 Jan 30. Review.

31.

Metadata correction: making big data useful for health care: a summary of the inaugural mit critical data conference.

Badawi O, Brennan T, Celi LA, Feng M, Ghassemi M, Ippolito A, Johnson A, Mark RG, Mayaud L, Moody G, Moses C, Naumann T, Nikore V, Pimentel M, Pollard TJ, Santos M, Stone DJ, Zimolzak A; MIT Critical Data Conference 2014 Organizing Committee.

JMIR Med Inform. 2015 Jan 21;3(1):e6. doi: 10.2196/medinform.4226. No abstract available.

32.

Dynamic clinical data mining: search engine-based decision support.

Celi LA, Zimolzak AJ, Stone DJ.

JMIR Med Inform. 2014 Jun 23;2(1):e13. doi: 10.2196/medinform.3110.

33.

Making big data useful for health care: a summary of the inaugural mit critical data conference.

Badawi O, Brennan T, Celi LA, Feng M, Ghassemi M, Ippolito A, Johnson A, Mark RG, Mayaud L, Moody G, Moses C, Naumann T, Pimentel M, Pollard TJ, Santos M, Stone DJ, Zimolzak A; MIT Critical Data Conference 2014 Organizing Committee.

JMIR Med Inform. 2014 Aug 22;2(2):e22. doi: 10.2196/medinform.3447.

34.

Beyond open big data: addressing unreliable research.

Moseley ET, Hsu DJ, Stone DJ, Celi LA.

J Med Internet Res. 2014 Nov 11;16(11):e259. doi: 10.2196/jmir.3871.

35.

Crowdsourcing knowledge discovery and innovations in medicine.

Celi LA, Ippolito A, Montgomery RA, Moses C, Stone DJ.

J Med Internet Res. 2014 Sep 19;16(9):e216. doi: 10.2196/jmir.3761.

36.

Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.

Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi RC, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI.

Sleep. 2014 Oct 1;37(10):1589-600. doi: 10.5665/sleep.4064.

37.

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.

Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J.

Mol Syst Biol. 2014 Jul 30;10:743. doi: 10.15252/msb.20145304.

38.

Leveraging a critical care database: selective serotonin reuptake inhibitor use prior to ICU admission is associated with increased hospital mortality.

Ghassemi M, Marshall J, Singh N, Stone DJ, Celi LA.

Chest. 2014 Apr;145(4):745-752. doi: 10.1378/chest.13-1722.

39.

Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1.

Hazra S, Stepps V, Bhatwadekar AD, Caballero S, Boulton ME, Higgins PJ, Nikonova EV, Pepine CJ, Thut C, Finney EM, Stone DJ, Bartelmez SH, Grant MB.

PLoS One. 2013 Nov 1;8(11):e79067. doi: 10.1371/journal.pone.0079067. eCollection 2013.

40.

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.

Shen L, Thompson PM, Potkin SG, Bertram L, Farrer LA, Foroud TM, Green RC, Hu X, Huentelman MJ, Kim S, Kauwe JS, Li Q, Liu E, Macciardi F, Moore JH, Munsie L, Nho K, Ramanan VK, Risacher SL, Stone DJ, Swaminathan S, Toga AW, Weiner MW, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative.

Brain Imaging Behav. 2014 Jun;8(2):183-207. doi: 10.1007/s11682-013-9262-z. Review.

41.

"Big data" in the intensive care unit. Closing the data loop.

Celi LA, Mark RG, Stone DJ, Montgomery RA.

Am J Respir Crit Care Med. 2013 Jun 1;187(11):1157-60. doi: 10.1164/rccm.201212-2311ED. No abstract available.

42.

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V.

Cell. 2013 Apr 25;153(3):707-20. doi: 10.1016/j.cell.2013.03.030.

43.

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.

Zhu B, Xia M, Xu X, Ludovici DW, Tennakoon M, Youngman MA, Matthews JM, Dax SL, Colburn RW, Qin N, Hutchinson TL, Lubin ML, Brandt MR, Stone DJ, Flores CM, Macielag MJ.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2234-7. doi: 10.1016/j.bmcl.2013.01.062. Epub 2013 Feb 4.

PMID:
23411075
44.

Systems biology approach for new target and biomarker identification.

Wang IM, Stone DJ, Nickle D, Loboda A, Puig O, Roberts C.

Curr Top Microbiol Immunol. 2013;363:169-99. doi: 10.1007/82_2012_252. Review.

PMID:
22903568
45.

Transcriptional architecture of the primate neocortex.

Bernard A, Lubbers LS, Tanis KQ, Luo R, Podtelezhnikov AA, Finney EM, McWhorter MM, Serikawa K, Lemon T, Morgan R, Copeland C, Smith K, Cullen V, Davis-Turak J, Lee CK, Sunkin SM, Loboda AP, Levine DM, Stone DJ, Hawrylycz MJ, Roberts CJ, Jones AR, Geschwind DH, Lein ES.

Neuron. 2012 Mar 22;73(6):1083-99. doi: 10.1016/j.neuron.2012.03.002. Epub 2012 Mar 21.

46.

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, Flores CM.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2922-6. doi: 10.1016/j.bmcl.2012.02.060. Epub 2012 Feb 27.

PMID:
22421018
47.

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging.

Podtelezhnikov AA, Tanis KQ, Nebozhyn M, Ray WJ, Stone DJ, Loboda AP.

PLoS One. 2011;6(12):e29610. doi: 10.1371/journal.pone.0029610. Epub 2011 Dec 28.

48.

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.

Nikonova EV, Xiong Y, Tanis KQ, Dawson VL, Vogel RL, Finney EM, Stone DJ, Reynolds IJ, Kern JT, Dawson TM.

Hum Mol Genet. 2012 Jan 1;21(1):163-74. doi: 10.1093/hmg/ddr451. Epub 2011 Oct 4.

49.

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Parks DJ, Parsons WH, Colburn RW, Meegalla SK, Ballentine SK, Illig CR, Qin N, Liu Y, Hutchinson TL, Lubin ML, Stone DJ Jr, Baker JF, Schneider CR, Ma J, Damiano BP, Flores CM, Player MR.

J Med Chem. 2011 Jan 13;54(1):233-47. doi: 10.1021/jm101075v. Epub 2010 Dec 3.

PMID:
21128593
50.

Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.

Codd EE, Baker J, Brandt MR, Bryant S, Cai C, Carson JR, Chevalier KM, Colburn RW, Coogan TP, Dax SL, Decorte B, Kemmerer M, Legrand EK, Lenhard JM, Leone AM, Lin L, Mabus JR, McDonnell ME, McMillian MK, McNally JJ, Stone DJ Jr, Wang CY, Zhang SP, Flores CM.

Toxicol Sci. 2010 Oct;117(2):493-504. doi: 10.1093/toxsci/kfq200. Epub 2010 Jul 8.

PMID:
20616206

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