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Items: 1 to 50 of 181

1.

Novel AAV-mediated gene delivery system corrects CFTR function in pigs.

Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL.

Am J Respir Cell Mol Biol. 2019 Jun 11. doi: 10.1165/rcmb.2019-0006OC. [Epub ahead of print]

PMID:
31184507
2.

Erratum for Caves et al., "Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells".

Caves EA, Cook SA, Lee N, Stoltz D, Watkins S, Shair KHY.

mSphere. 2019 Apr 17;4(2). pii: e00247-19. doi: 10.1128/mSphere.00247-19. No abstract available.

3.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.

Fischer AJ, Pino-Argumedo MI, Hilkin BM, Shanrock CR, Gansemer ND, Chaly AL, Zarei K, Allen PD, Ostedgaard LS, Hoffman EA, Stoltz DA, Welsh MJ, Abou Alaiwa MH.

JCI Insight. 2019 Jan 10;4(1). pii: 124863. doi: 10.1172/jci.insight.124863. [Epub ahead of print]

4.

Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways.

Xie Y, Ostedgaard L, Abou Alaiwa MH, Lu L, Fischer AJ, Stoltz DA.

Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S171-S176. doi: 10.1513/AnnalsATS.201805-308AW.

PMID:
30431346
5.

CFTR Heterozygotes Are at Increased Risk of Respiratory Infections: A Population-Based Study.

Polgreen PM, Brown GD, Hornick DB, Ahmad F, London B, Stoltz DA, Comellas AP.

Open Forum Infect Dis. 2018 Nov 1;5(11):ofy219. doi: 10.1093/ofid/ofy219. eCollection 2018 Nov.

6.

Glycogen depletion can increase the specificity of mucin detection in airway tissues.

Meyerholz DK, Beck AP, Goeken JA, Leidinger MR, Ofori-Amanfo GK, Brown HC, Businga TR, Stoltz DA, Reznikov LR, Flaherty HA.

BMC Res Notes. 2018 Oct 25;11(1):763. doi: 10.1186/s13104-018-3855-y.

7.

Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.

Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL.

Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773.

8.

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.

Abou Alaiwa MH, Launspach JL, Grogan B, Carter S, Zabner J, Stoltz DA, Singh PK, McKone EF, Welsh MJ.

JCI Insight. 2018 Aug 9;3(15). pii: 121468. doi: 10.1172/jci.insight.121468. eCollection 2018 Aug 9.

9.

Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells.

Caves EA, Cook SA, Lee N, Stoltz D, Watkins S, Shair KHY.

mSphere. 2018 Jul 18;3(4). pii: e00152-18. doi: 10.1128/mSphere.00152-18. Erratum in: mSphere. 2019 Apr 17;4(2):.

10.

Superior Hypertension Management in Pediatric Kidney Transplant Patients After Native Nephrectomy.

Brubaker AL, Stoltz DJ, Chaudhuri A, Maestretti L, Grimm PC, Concepcion W, Gallo AE.

Transplantation. 2018 Jul;102(7):1172-1178. doi: 10.1097/TP.0000000000002093.

PMID:
29953422
11.

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity.

Reznikov LR, Meyerholz DK, Abou Alaiwa M, Kuan SP, Liao YJ, Bormann NL, Bair TB, Price M, Stoltz DA, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L133-L148. doi: 10.1152/ajplung.00557.2017. Epub 2018 Apr 5.

12.

Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs.

Meyerholz DK, Stoltz DA, Gansemer ND, Ernst SE, Cook DP, Strub MD, LeClair EN, Barker CK, Adam RJ, Leidinger MR, Gibson-Corley KN, Karp PH, Welsh MJ, McCray PB Jr.

Lab Invest. 2018 Jun;98(6):825-838. doi: 10.1038/s41374-018-0026-7. Epub 2018 Feb 21.

13.

A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury.

Cregg JM, Chu KA, Hager LE, Maggard RSJ, Stoltz DR, Edmond M, Alilain WJ, Philippidou P, Landmesser LT, Silver J.

Cell Rep. 2017 Oct 17;21(3):654-665. doi: 10.1016/j.celrep.2017.09.076.

14.

Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs.

Li X, Vargas Buonfiglio LG, Adam RJ, Stoltz DA, Zabner J, Comellas AP.

Crit Care Med. 2017 Dec;45(12):e1240-e1246. doi: 10.1097/CCM.0000000000002720.

15.

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ.

Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15.

16.

CF airway smooth muscle transcriptome reveals a role for PYK2.

Cook DP, Adam RJ, Zarei K, Deonovic B, Stroik MR, Gansemer ND, Meyerholz DK, Au KF, Stoltz DA.

JCI Insight. 2017 Sep 7;2(17). pii: 95332. doi: 10.1172/jci.insight.95332. eCollection 2017 Sep 7.

17.

Postnatal airway growth in cystic fibrosis piglets.

Adam RJ, Abou Alaiwa MH, Bouzek DC, Cook DP, Gansemer ND, Taft PJ, Powers LS, Stroik MR, Hoegger MJ, McMenimen JD, Hoffman EA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA.

J Appl Physiol (1985). 2017 Sep 1;123(3):526-533. doi: 10.1152/japplphysiol.00263.2017. Epub 2017 Jun 15.

18.

Gel-forming mucins form distinct morphologic structures in airways.

Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.

19.

Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth.

Paemka L, McCullagh BN, Abou Alaiwa MH, Stoltz DA, Dong Q, Randak CO, Gray RD, McCray PB Jr.

J Cyst Fibros. 2017 Jul;16(4):471-474. doi: 10.1016/j.jcf.2017.03.007. Epub 2017 Apr 1.

20.

Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections.

Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher CG, Bruce JE, Stoltz DA, Welsh MJ, Hoffman LR, McKone EF, Singh PK.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1617-1628. doi: 10.1164/rccm.201609-1954OC.

21.

Mounier-Kuhn syndrome: a case of tracheal smooth muscle remodeling.

Cook DP, Adam RJ, Abou Alaiwa MH, Eberlein M, Klesney-Tait JA, Parekh KR, Meyerholz DK, Stoltz DA.

Clin Case Rep. 2016 Dec 29;5(2):93-96. doi: 10.1002/ccr3.794. eCollection 2017 Feb.

22.

Novel High-throughput Approach for Purification of Infectious Virions.

James KT, Cooney B, Agopsowicz K, Trevors MA, Mohamed A, Stoltz D, Hitt M, Shmulevitz M.

Sci Rep. 2016 Nov 9;6:36826. doi: 10.1038/srep36826.

23.

Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.

Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ.

PLoS One. 2016 Nov 7;11(11):e0166089. doi: 10.1371/journal.pone.0166089. eCollection 2016.

24.

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728.

25.

Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.

Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.

JCI Insight. 2016 Sep 8;1(14). pii: 88730. doi: 10.1172/jci.insight.88730.

26.

Repurposing tromethamine as inhaled therapy to treat CF airway disease.

Abou Alaiwa MH, Launspach JL, Sheets KA, Rivera JA, Gansemer ND, Taft PJ, Thorne PS, Welsh MJ, Stoltz DA, Zabner J.

JCI Insight. 2016 Jun 2;1(8). pii: 87535. doi: 10.1172/jci.insight.87535.

27.

Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities.

Adam RJ, Hisert KB, Dodd JD, Grogan B, Launspach JL, Barnes JK, Gallagher CG, Sieren JP, Gross TJ, Fischer AJ, Cavanaugh JE, Hoffman EA, Singh PK, Welsh MJ, McKone EF, Stoltz DA.

JCI Insight. 2016 Apr 7;1(4):e86183. doi: 10.1172/jci.insight.86183.

28.

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.

Bartlett JA, Ramachandran S, Wohlford-Lenane CL, Barker CK, Pezzulo AA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA, McCray PB Jr.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):845-854.

29.

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ.

Science. 2016 Jan 29;351(6272):503-7. doi: 10.1126/science.aad5589.

30.

Acidic pH increases airway surface liquid viscosity in cystic fibrosis.

Tang XX, Ostedgaard LS, Hoegger MJ, Moninger TO, Karp PH, McMenimen JD, Choudhury B, Varki A, Stoltz DA, Welsh MJ.

J Clin Invest. 2016 Mar 1;126(3):879-91. doi: 10.1172/JCI83922. Epub 2016 Jan 25.

31.

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.

Li X, Tang XX, Vargas Buonfiglio LG, Comellas AP, Thornell IM, Ramachandran S, Karp PH, Taft PJ, Sheets K, Abou Alaiwa MH, Welsh MJ, Meyerholz DK, Stoltz DA, Zabner J.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L670-9. doi: 10.1152/ajplung.00422.2015. Epub 2016 Jan 22.

32.

Immunohistochemical Detection of Markers for Translational Studies of Lung Disease in Pigs and Humans.

Meyerholz DK, Lambertz AM, Reznikov LR, Ofori-Amanfo GK, Karp PH, McCray PB Jr, Welsh MJ, Stoltz DA.

Toxicol Pathol. 2016 Apr;44(3):434-41. doi: 10.1177/0192623315609691. Epub 2015 Oct 27.

33.

Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility.

Cook DP, Rector MV, Bouzek DC, Michalski AS, Gansemer ND, Reznikov LR, Li X, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow CY, Stoltz DA.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):417-26. doi: 10.1164/rccm.201508-1562OC.

34.

Genomic and Proteomic Analyses Indicate that Banchine and Campoplegine Polydnaviruses Have Similar, if Not Identical, Viral Ancestors.

Béliveau C, Cohen A, Stewart D, Periquet G, Djoumad A, Kuhn L, Stoltz D, Boyle B, Volkoff AN, Herniou EA, Drezen JM, Cusson M.

J Virol. 2015 Sep;89(17):8909-21. doi: 10.1128/JVI.01001-15. Epub 2015 Jun 17.

35.

Origins of cystic fibrosis lung disease.

Stoltz DA, Meyerholz DK, Welsh MJ.

N Engl J Med. 2015 Apr 16;372(16):1574-5. doi: 10.1056/NEJMc1502191. No abstract available.

PMID:
25875271
36.

Sonographic evidence of abnormal tracheal cartilage ring structure in cystic fibrosis.

Diwakar A, Adam RJ, Michalski AS, Tamegnon MM, Fischer AJ, Launspach JL, Horan RA, Kao SC, Chaloner K, Meyerholz DK, Stoltz DA.

Laryngoscope. 2015 Oct;125(10):2398-404. doi: 10.1002/lary.25255. Epub 2015 Mar 30.

37.

Origins of cystic fibrosis lung disease.

Stoltz DA, Meyerholz DK, Welsh MJ.

N Engl J Med. 2015 Jan 22;372(4):351-62. doi: 10.1056/NEJMra1300109. Review. No abstract available.

38.

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.

Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18703-8. doi: 10.1073/pnas.1422091112. Epub 2014 Dec 15.

39.

Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.

Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J.

Int Forum Allergy Rhinol. 2015 Feb;5(2):178-81. doi: 10.1002/alr.21440. Epub 2014 Oct 31.

40.

The ReactorSTM: atomically resolved scanning tunneling microscopy under high-pressure, high-temperature catalytic reaction conditions.

Herbschleb CT, van der Tuijn PC, Roobol SB, Navarro V, Bakker JW, Liu Q, Stoltz D, Cañas-Ventura ME, Verdoes G, van Spronsen MA, Bergman M, Crama L, Taminiau I, Ofitserov A, van Baarle GJ, Frenken JW.

Rev Sci Instrum. 2014 Aug;85(8):083703. doi: 10.1063/1.4891811.

PMID:
25173272
41.

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW.

Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059.

42.

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.

Hoegger MJ, Fischer AJ, McMenimen JD, Ostedgaard LS, Tucker AJ, Awadalla MA, Moninger TO, Michalski AS, Hoffman EA, Zabner J, Stoltz DA, Welsh MJ.

Science. 2014 Aug 15;345(6198):818-22. doi: 10.1126/science.1255825.

43.

A viral aphrodisiac in the cricket Gryllus texensis.

Adamo SA, Kovalko I, Easy RH, Stoltz D.

J Exp Biol. 2014 Jun 1;217(Pt 11):1970-6. doi: 10.1242/jeb.103408. Epub 2014 Mar 13.

44.

Antibacterial properties of the CFTR potentiator ivacaftor.

Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer ND, Diekema DJ, Stoltz DA, Welsh MJ.

J Cyst Fibros. 2014 Sep;13(5):515-9. doi: 10.1016/j.jcf.2014.02.004. Epub 2014 Mar 5.

45.

Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs.

Hoegger MJ, Awadalla M, Namati E, Itani OA, Fischer AJ, Tucker AJ, Adam RJ, McLennan G, Hoffman EA, Stoltz DA, Welsh MJ.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2355-60. doi: 10.1073/pnas.1323633111. Epub 2014 Jan 28.

46.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

Abou Alaiwa MH, Beer AM, Pezzulo AA, Launspach JL, Horan RA, Stoltz DA, Starner TD, Welsh MJ, Zabner J.

J Cyst Fibros. 2014 Jul;13(4):373-7. doi: 10.1016/j.jcf.2013.12.006. Epub 2014 Jan 11.

47.

Role of PON in anoxia-reoxygenation injury: a Drosophila melanogaster transgenic model.

Caraballo JC, Borcherding J, Rector M, Hornick E, Stoltz D, Zabner J, Comellas AP.

PLoS One. 2014 Jan 6;9(1):e84434. doi: 10.1371/journal.pone.0084434. eCollection 2014.

48.

Early airway structural changes in cystic fibrosis pigs as a determinant of particle distribution and deposition.

Awadalla M, Miyawaki S, Abou Alaiwa MH, Adam RJ, Bouzek DC, Michalski AS, Fuld MK, Reynolds KJ, Hoffman EA, Lin CL, Stoltz DA.

Ann Biomed Eng. 2014 Apr;42(4):915-27. doi: 10.1007/s10439-013-0955-7. Epub 2013 Dec 6.

49.

Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets.

Guo JJ, Stoltz DA, Zhu V, Volk KA, Segar JL, McCray PB Jr, Roghair RD.

J Cyst Fibros. 2014 May;13(3):251-9. doi: 10.1016/j.jcf.2013.10.009. Epub 2013 Oct 31.

50.

Air trapping and airflow obstruction in newborn cystic fibrosis piglets.

Adam RJ, Michalski AS, Bauer C, Abou Alaiwa MH, Gross TJ, Awadalla MS, Bouzek DC, Gansemer ND, Taft PJ, Hoegger MJ, Diwakar A, Ochs M, Reinhardt JM, Hoffman EA, Beichel RR, Meyerholz DK, Stoltz DA.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1434-41. doi: 10.1164/rccm.201307-1268OC.

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