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Items: 10

1.

The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids.

Ginsel C, Plitzko B, Froriep D, Stolfa DA, Jung M, Kubitza C, Scheidig AJ, Havemeyer A, Clement B.

Drug Metab Dispos. 2018 Oct;46(10):1396-1402. doi: 10.1124/dmd.118.082453. Epub 2018 Jul 25.

PMID:
30045842
2.

Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.

Porcelli L, Guida G, Quatrale AE, Cocco T, Sidella L, Maida I, Iacobazzi RM, Ferretta A, Stolfa DA, Strippoli S, Guida S, Tommasi S, Guida M, Azzariti A.

J Transl Med. 2015 Jan 27;13:26. doi: 10.1186/s12967-015-0385-4.

3.

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.

Tardia P, Stefanachi A, Niso M, Stolfa DA, Mangiatordi GF, Alberga D, Nicolotti O, Lattanzi G, Carotti A, Leonetti F, Perrone R, Berardi F, Azzariti A, Colabufo NA, Cellamare S.

J Med Chem. 2014 Aug 14;57(15):6403-18. doi: 10.1021/jm500697c. Epub 2014 Aug 5.

PMID:
25093931
4.

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M.

J Mol Biol. 2014 Oct 9;426(20):3442-53. doi: 10.1016/j.jmb.2014.03.007. Epub 2014 Mar 20.

5.

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.

Marek M, Kannan S, Hauser AT, Moraes MourĂ£o M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C.

PLoS Pathog. 2013;9(9):e1003645. doi: 10.1371/journal.ppat.1003645. Epub 2013 Sep 26.

6.

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M.

ACS Med Chem Lett. 2012 Oct 6;3(12):1050-3. doi: 10.1021/ml3002709. eCollection 2012 Dec 13.

7.

Current trends in epigenetic drug discovery.

Stolfa DA, Einsle O, Sippl W, Jung M.

Future Med Chem. 2012 Oct;4(16):2029-37. doi: 10.4155/fmc.12.144.

PMID:
23157236
8.

Design, synthesis, and biological evaluation of 2-aminobenzanilide derivatives as potent and selective HDAC inhibitors.

Stolfa DA, Stefanachi A, Gajer JM, Nebbioso A, Altucci L, Cellamare S, Jung M, Carotti A.

ChemMedChem. 2012 Jul;7(7):1256-66. doi: 10.1002/cmdc.201200193. Epub 2012 May 24.

PMID:
22628266
9.

Carbamate prodrug concept for hydroxamate HDAC inhibitors.

Schlimme S, Hauser AT, Carafa V, Heinke R, Kannan S, Stolfa DA, Cellamare S, Carotti A, Altucci L, Jung M, Sippl W.

ChemMedChem. 2011 Jul 4;6(7):1193-8. doi: 10.1002/cmdc.201100007. Epub 2011 Mar 17. No abstract available.

PMID:
21416613
10.

Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro.

Cellamare S, Stefanachi A, Stolfa DA, Basile T, Catto M, Campagna F, Sotelo E, Acquafredda P, Carotti A.

Bioorg Med Chem. 2008 May 1;16(9):4810-22. doi: 10.1016/j.bmc.2008.03.052. Epub 2008 Mar 25.

PMID:
18406152

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