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Items: 16


Differential contribution of pyruvate carboxylation to anaplerosis and cataplerosis during non-gluconeogenic and gluconeogenic conditions in HepG2 cells.

Wattanavanitchakorn S, Ansari IH, El Azzouny M, Longacre MJ, Stoker SW, MacDonald MJ, Jitrapakdee S.

Arch Biochem Biophys. 2019 Nov 15;676:108124. doi: 10.1016/ Epub 2019 Oct 2.


Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.

Ansari IH, Longacre MJ, Stoker SW, Kendrick MA, O'Neill LM, Zitur LJ, Fernandez LA, Ntambi JM, MacDonald MJ.

Arch Biochem Biophys. 2017 Mar 15;618:32-43. doi: 10.1016/ Epub 2017 Feb 11.


Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes.

MacDonald MJ, Hasan NM, Ansari IU, Longacre MJ, Kendrick MA, Stoker SW.

Diabetes. 2016 Jul;65(7):2051-9. doi: 10.2337/db16-0099. Epub 2016 Apr 5.


Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.

Ansari IU, Longacre MJ, Paulusma CC, Stoker SW, Kendrick MA, MacDonald MJ.

J Biol Chem. 2015 Sep 18;290(38):23110-23. doi: 10.1074/jbc.M115.655027. Epub 2015 Aug 3.


Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.

MacDonald MJ, Ade L, Ntambi JM, Ansari IU, Stoker SW.

J Biol Chem. 2015 Apr 24;290(17):11075-92. doi: 10.1074/jbc.M114.628420. Epub 2015 Mar 11.


Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, MacDonald MJ.

Mol Endocrinol. 2015 Mar;29(3):396-410. doi: 10.1210/me.2014-1249. Epub 2015 Jan 16.


Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.

MacDonald MJ, Brown LJ, Longacre MJ, Stoker SW, Kendrick MA, Hasan NM.

Biochim Biophys Acta. 2013 Nov;1830(11):5104-11. doi: 10.1016/j.bbagen.2013.07.013. Epub 2013 Jul 20. Erratum in: Biochim Biophys Acta. 2013. doi: 10.1016/j.bbagen.2013.09.024. Hasan, Noaman M [added]. Biochim Biophys Acta. 2015 Jun;1850(6):1343.


Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells.

MacDonald MJ, Hasan NM, Dobrzyn A, Stoker SW, Ntambi JM, Liu X, Sampath H.

Arch Biochem Biophys. 2013 Apr 1;532(1):23-31. doi: 10.1016/ Epub 2013 Jan 25.


Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, Druckenbrod NR, Laychock SG, Mastrandrea LD, MacDonald MJ.

Arch Biochem Biophys. 2012 Feb 1;518(1):23-30. doi: 10.1016/ Epub 2011 Dec 4.


Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J.

J Biol Chem. 2011 May 27;286(21):18383-96. doi: 10.1074/jbc.M111.241182. Epub 2011 Mar 22.


Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

Brown LJ, Longacre MJ, Hasan NM, Kendrick MA, Stoker SW, Macdonald MJ.

J Biol Chem. 2009 Dec 18;284(51):35359-67. doi: 10.1074/jbc.M109.040394.


Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

Hasan NM, Longacre MJ, Stoker SW, Boonsaen T, Jitrapakdee S, Kendrick MA, Wallace JC, MacDonald MJ.

J Biol Chem. 2008 Oct 17;283(42):28048-59. doi: 10.1074/jbc.M804170200. Epub 2008 Aug 12.


Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria.

MacDonald MJ, Stoker SW, Hasan NM.

Mol Cell Biochem. 2008 Jun;313(1-2):195-202. doi: 10.1007/s11010-008-9757-x. Epub 2008 Apr 15.


Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.

MacDonald MJ, Longacre MJ, Stoker SW, Brown LJ, Hasan NM, Kendrick MA.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C442-50. Epub 2007 Dec 26.


The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells.

MacDonald MJ, Dobrzyn A, Ntambi J, Stoker SW.

Arch Biochem Biophys. 2008 Feb 15;470(2):153-62. Epub 2007 Dec 3.

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