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Items: 1 to 50 of 90

1.

Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells.

Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA.

Mol Metab. 2019 Aug;26:45-56. doi: 10.1016/j.molmet.2019.05.009. Epub 2019 May 24.

2.

JUND regulates pancreatic β cell survival during metabolic stress.

Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA.

Mol Metab. 2019 Jul;25:95-106. doi: 10.1016/j.molmet.2019.04.007. Epub 2019 Apr 11.

3.

A Call for Improved Reporting of Human Islet Characteristics in Research Articles.

Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.

Diabetes. 2019 Feb;68(2):239-240. doi: 10.2337/dbi18-0055. Epub 2018 Dec 14. No abstract available.

4.

A call for improved reporting of human islet characteristics in research articles.

Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.

Diabetologia. 2019 Feb;62(2):209-211. doi: 10.1007/s00125-018-4784-y. Epub 2018 Dec 14. No abstract available.

PMID:
30547229
5.

A PDX1-ATF transcriptional complex governs β cell survival during stress.

Juliana CA, Yang J, Cannon CE, Good AL, Haemmerle MW, Stoffers DA.

Mol Metab. 2018 Nov;17:39-48. doi: 10.1016/j.molmet.2018.07.007. Epub 2018 Aug 1.

6.

Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.

Kropp PA, Dunn JC, Carboneau BA, Stoffers DA, Gannon M.

Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E308-E321. doi: 10.1152/ajpendo.00260.2017. Epub 2017 Dec 12.

7.

The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.

Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E651-E662. doi: 10.1152/ajpendo.00113.2017. Epub 2017 Aug 15.

8.

Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

Rozo AV, Babu DA, Suen PA, Groff DN, Seeley RJ, Simmons RA, Seale P, Ahima RS, Stoffers DA.

Mol Metab. 2017 May 15;6(7):748-759. doi: 10.1016/j.molmet.2017.05.006. eCollection 2017 Jul.

9.

Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion.

Remsberg JR, Ediger BN, Ho WY, Damle M, Li Z, Teng C, Lanzillotta C, Stoffers DA, Lazar MA.

Mol Metab. 2016 Nov 22;6(1):30-37. doi: 10.1016/j.molmet.2016.11.007. eCollection 2017 Jan.

10.

ATF5 regulates β-cell survival during stress.

Juliana CA, Yang J, Rozo AV, Good A, Groff DN, Wang SZ, Green MR, Stoffers DA.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1341-1346. doi: 10.1073/pnas.1620705114. Epub 2017 Jan 23.

11.

Single cell transcriptomic profiling of mouse pancreatic progenitors.

Stanescu DE, Yu R, Won KJ, Stoffers DA.

Physiol Genomics. 2017 Feb 1;49(2):105-114. doi: 10.1152/physiolgenomics.00114.2016. Epub 2016 Dec 23.

12.

LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity.

Loyd C, Liu Y, Kim T, Holleman C, Galloway J, Bethea M, Ediger BN, Swain TA, Tang Y, Stoffers DA, Rowe GC, Young M, Steele C, Habegger KM, Hunter CS.

Endocrinology. 2017 May 1;158(5):1289-1297. doi: 10.1210/en.2016-1791.

13.

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA.

J Clin Invest. 2017 Jan 3;127(1):215-229. doi: 10.1172/JCI88016. Epub 2016 Dec 12.

14.

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.

Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Diabetes. 2017 Feb;66(2):372-384. doi: 10.2337/db16-1102. Epub 2016 Dec 1.

15.

Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.

Henley KD, Stanescu DE, Kropp PA, Wright CVE, Won KJ, Stoffers DA, Gannon M.

Cell Rep. 2016 Jun 21;15(12):2637-2650. doi: 10.1016/j.celrep.2016.05.040. Epub 2016 Jun 9.

16.

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.

Soleimanpour SA, Ferrari AM, Raum JC, Groff DN, Yang J, Kaufman BA, Stoffers DA.

Diabetes. 2015 Oct;64(10):3475-84. doi: 10.2337/db15-0376. Epub 2015 Jun 17.

17.

Tshz1 Regulates Pancreatic β-Cell Maturation.

Raum JC, Soleimanpour SA, Groff DN, Coré N, Fasano L, Garratt AN, Dai C, Powers AC, Stoffers DA.

Diabetes. 2015 Aug;64(8):2905-14. doi: 10.2337/db14-1443. Epub 2015 Apr 27.

18.

Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.

Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M.

Cell Stem Cell. 2015 Apr 2;16(4):386-99. doi: 10.1016/j.stem.2015.02.013.

19.

The Polycomb protein, Bmi1, regulates insulin sensitivity.

Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA.

Mol Metab. 2014 Aug 27;3(8):794-802. doi: 10.1016/j.molmet.2014.08.002. eCollection 2014 Nov.

20.

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection.

Ussher JR, Baggio LL, Campbell JE, Mulvihill EE, Kim M, Kabir MG, Cao X, Baranek BM, Stoffers DA, Seeley RJ, Drucker DJ.

Mol Metab. 2014 May 9;3(5):507-17. doi: 10.1016/j.molmet.2014.04.009. eCollection 2014 Aug.

21.

Islet-1 Is essential for pancreatic β-cell function.

Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL.

Diabetes. 2014 Dec;63(12):4206-17. doi: 10.2337/db14-0096. Epub 2014 Jul 15.

22.

The diabetes susceptibility gene Clec16a regulates mitophagy.

Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA.

Cell. 2014 Jun 19;157(7):1577-90. doi: 10.1016/j.cell.2014.05.016.

23.

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.

Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2319-28. doi: 10.1073/pnas.1323066111. Epub 2014 May 19.

24.

The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.

Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA.

Cell Metab. 2014 Jun 3;19(6):1050-7. doi: 10.1016/j.cmet.2014.04.005. Epub 2014 May 15.

25.

Pdx1 maintains β cell identity and function by repressing an α cell program.

Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, Yang C, Pannikar A, Doliba N, Zhang T, Stoffers DA, Edlund H, Matschinsky F, Stein R, Stanger BZ.

Cell Metab. 2014 Feb 4;19(2):259-71. doi: 10.1016/j.cmet.2013.12.002.

26.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H.

Nat Biotechnol. 2014 Jan;32(1):76-83. doi: 10.1038/nbt.2747. Epub 2013 Nov 17.

27.

The pancreatic β cell and type 1 diabetes: innocent bystander or active participant?

Soleimanpour SA, Stoffers DA.

Trends Endocrinol Metab. 2013 Jul;24(7):324-31. doi: 10.1016/j.tem.2013.03.005. Epub 2013 May 3.

28.

MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells.

Wang Y, Liu J, Liu C, Naji A, Stoffers DA.

Diabetes. 2013 Mar;62(3):887-95. doi: 10.2337/db12-0451. Epub 2012 Dec 6.

29.

Research resource: the pdx1 cistrome of pancreatic islets.

Khoo C, Yang J, Weinrott SA, Kaestner KH, Naji A, Schug J, Stoffers DA.

Mol Endocrinol. 2012 Mar;26(3):521-33. doi: 10.1210/me.2011-1231. Epub 2012 Feb 9.

30.

Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.

Pinney SE, Jaeckle Santos LJ, Han Y, Stoffers DA, Simmons RA.

Diabetologia. 2011 Oct;54(10):2606-14. doi: 10.1007/s00125-011-2250-1. Epub 2011 Jul 21.

31.

Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.

Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA.

Endocrinology. 2011 Jul;152(7):2599-608. doi: 10.1210/en.2010-1420. Epub 2011 May 3.

32.

Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence.

Pinney SE, Oliver-Krasinski J, Ernst L, Hughes N, Patel P, Stoffers DA, Russo P, De León DD.

J Clin Endocrinol Metab. 2011 Jul;96(7):1960-5. doi: 10.1210/jc.2011-0029. Epub 2011 Apr 13.

33.

Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene.

Yang Y, Gurung B, Wu T, Wang H, Stoffers DA, Hua X.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20358-63. doi: 10.1073/pnas.1012257107. Epub 2010 Nov 8.

34.

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.

Liu J, Wang Y, Birnbaum MJ, Stoffers DA.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20494-9. doi: 10.1073/pnas.1007001107. Epub 2010 Nov 8.

35.

Calcineurin signaling regulates human islet {beta}-cell survival.

Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA.

J Biol Chem. 2010 Dec 17;285(51):40050-9. doi: 10.1074/jbc.M110.154955. Epub 2010 Oct 13.

36.

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.

Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA.

J Clin Invest. 2010 Oct;120(10):3713-21. doi: 10.1172/JCI40440. Epub 2010 Sep 1.

37.

A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency.

Nicolino M, Claiborn KC, Senée V, Boland A, Stoffers DA, Julier C.

Diabetes. 2010 Mar;59(3):733-40. doi: 10.2337/db09-1284. Epub 2009 Dec 15.

38.

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19090-5. doi: 10.1073/pnas.0904849106. Epub 2009 Oct 23.

39.

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats.

Raab EL, Vuguin PM, Stoffers DA, Simmons RA.

Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1785-94. doi: 10.1152/ajpregu.00519.2009. Epub 2009 Oct 21.

40.

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.

Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA.

J Clin Invest. 2009 Jul;119(7):1888-98. doi: 10.1172/JCI37028.

41.

Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF.

Ham JN, Crutchlow MF, Desai BM, Simmons RA, Stoffers DA.

Pediatr Res. 2009 Jul;66(1):42-6. doi: 10.1203/PDR.0b013e3181a282a5.

42.

Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion.

Sachdeva MM, Stoffers DA.

Mol Endocrinol. 2009 Jun;23(6):747-58. doi: 10.1210/me.2008-0400. Epub 2009 Feb 5. Review.

43.

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.

Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. doi: 10.1073/pnas.0810097105. Epub 2008 Nov 21.

44.

Toward a cell-based cure for diabetes: advances in production and transplant of beta cells.

Claiborn KC, Stoffers DA.

Mt Sinai J Med. 2008 Aug;75(4):362-71. doi: 10.1002/msj.20058. Review.

PMID:
18729181
45.

On the origin of the beta cell.

Oliver-Krasinski JM, Stoffers DA.

Genes Dev. 2008 Aug 1;22(15):1998-2021. doi: 10.1101/gad.1670808. Review.

46.

Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.

J Biol Chem. 2008 Sep 19;283(38):25786-93. doi: 10.1074/jbc.M804372200. Epub 2008 Jul 17.

47.

Exendin-4 does not promote Beta-cell proliferation or survival during the early post-islet transplant period in mice.

Crutchlow MF, Yu M, Bae YS, Deng S, Stoffers DA.

Transplant Proc. 2008 Jun;40(5):1650-7. doi: 10.1016/j.transproceed.2008.03.161. Erratum in: Transplant Proc. 2009 Jan-Feb;41(1):450.

48.

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

Park JH, Stoffers DA, Nicholls RD, Simmons RA.

J Clin Invest. 2008 Jun;118(6):2316-24. doi: 10.1172/JCI33655.

49.

Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, Leach SD, Stoffers DA.

J Clin Invest. 2007 Apr;117(4):971-7.

50.

Maximizing endogenous β-cell regeneration.

Crutchlow MF, Stoffers DA.

Curr Opin Organ Transplant. 2007 Feb;12(1):55-62.

PMID:
27792090

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