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Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products.

Franken A, Driemel C, Behrens B, Meier-Stiegen F, Endris V, Stenzinger A, Niederacher D, Fischer JC, Stoecklein NH, Ruckhaeberle E, Fehm T, Neubauer H.

Clin Chem. 2019 Feb 8. pii: clinchem.2018.296814. doi: 10.1373/clinchem.2018.296814. [Epub ahead of print]


Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Fehm TN, Meier-Stiegen F, Driemel C, Jäger B, Reinhardt F, Naskou J, Franken A, Neubauer H, Neves RPL, van Dalum G, Ruckhäberle E, Niederacher D, Rox JM, Fischer JC, Stoecklein NH.

Cytometry A. 2018 Dec;93(12):1213-1219. doi: 10.1002/cyto.a.23669.


Minimal Residual Disease in Head and Neck Cancer and Esophageal Cancer.

Sproll C, Fluegen G, Stoecklein NH.

Adv Exp Med Biol. 2018;1100:55-82. doi: 10.1007/978-3-319-97746-1_4.


BRAFV600E mutation: A promising target in colorectal neuroendocrine carcinoma.

Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M, Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A.

Int J Cancer. 2019 Mar 15;144(6):1379-1390. doi: 10.1002/ijc.31828. Epub 2018 Oct 30.


Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis.

Lambros MB, Seed G, Sumanasuriya S, Gil V, Crespo M, Fontes M, Chandler R, Mehra N, Fowler G, Ebbs B, Flohr P, Miranda S, Yuan W, Mackay A, Ferreira A, Pereira R, Bertan C, Figueiredo I, Riisnaes R, Rodrigues DN, Sharp A, Goodall J, Boysen G, Carreira S, Bianchini D, Rescigno P, Zafeiriou Z, Hunt J, Moloney D, Hamilton L, Neves RP, Swennenhuis J, Andree K, Stoecklein NH, Terstappen LWMM, de Bono JS.

Clin Cancer Res. 2018 Nov 15;24(22):5635-5644. doi: 10.1158/1078-0432.CCR-18-0862. Epub 2018 Aug 9.


Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap).

Andree KC, Mentink A, Zeune LL, Terstappen LWMM, Stoecklein NH, Neves RP, Driemel C, Lampignano R, Yang L, Neubauer H, Fehm T, Fischer JC, Rossi E, Manicone M, Basso U, Marson P, Zamarchi R, Loriot Y, Lapierre V, Faugeroux V, Oulhen M, Farace F, Fowler G, Sousa Fontes M, Ebbs B, Lambros M, Crespo M, Flohr P, de Bono JS.

Int J Cancer. 2018 Nov 15;143(10):2584-2591. doi: 10.1002/ijc.31752. Epub 2018 Sep 19.


ACGH detects distinct genomic alterations of primary intrahepatic cholangiocarcinomas and matched lymph node metastases and identifies a poor prognosis subclass.

Jansen R, Moehlendick B, Bartenhagen C, Tóth C, Lehwald N, Stoecklein NH, Knoefel WT, Lachenmayer A.

Sci Rep. 2018 Jul 13;8(1):10637. doi: 10.1038/s41598-018-28941-6.


A streamlined workflow for single-cells genome-wide copy-number profiling by low-pass sequencing of LM-PCR whole-genome amplification products.

Ferrarini A, Forcato C, Buson G, Tononi P, Del Monaco V, Terracciano M, Bolognesi C, Fontana F, Medoro G, Neves R, Möhlendick B, Rihawi K, Ardizzoni A, Sumanasuriya S, Flohr P, Lambros M, de Bono J, Stoecklein NH, Manaresi N.

PLoS One. 2018 Mar 1;13(3):e0193689. doi: 10.1371/journal.pone.0193689. eCollection 2018.


Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer.

Dizdar L, Jünemann LM, Werner TA, Verde PE, Baldus SE, Stoecklein NH, Knoefel WT, Krieg A.

Oncol Lett. 2018 Mar;15(3):3779-3789. doi: 10.3892/ol.2018.7755. Epub 2018 Jan 9.


Isolation of circulating tumor cells from pancreatic cancer by automated filtration.

Brychta N, Drosch M, Driemel C, Fischer JC, Neves RP, Esposito I, Knoefel W, Möhlendick B, Hille C, Stresemann A, Krahn T, Kassack MU, Stoecklein NH, von Ahsen O.

Oncotarget. 2017 Sep 16;8(49):86143-86156. doi: 10.18632/oncotarget.21026. eCollection 2017 Oct 17.


Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

Rausch V, Krieg A, Camps J, Behrens B, Beier M, Wangsa D, Heselmeyer-Haddad K, Baldus SE, Knoefel WT, Ried T, Stoecklein NH.

BMC Res Notes. 2017 Nov 6;10(1):560. doi: 10.1186/s13104-017-2886-0.


Survivin and XIAP expression in distinct tumor compartments of surgically resected gastric cancer: XIAP as a prognostic marker in diffuse and mixed type adenocarcinomas.

Dizdar L, Tomczak M, Werner TA, Safi SA, Riemer JC, Verde PE, Stoecklein NH, Knoefel WT, Krieg A.

Oncol Lett. 2017 Dec;14(6):6847-6856. doi: 10.3892/ol.2017.6999. Epub 2017 Sep 19.


Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer.

Hoffmann M, Pasch S, Schamberger T, Maneck M, Möhlendick B, Schumacher S, Brockhoff G, Knoefel WT, Izbicki J, Polzer B, Stoecklein NH, Klein CA.

Int J Cancer. 2018 Feb 15;142(4):833-843. doi: 10.1002/ijc.31108. Epub 2017 Nov 30.


Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases.

Mohme M, Riethdorf S, Dreimann M, Werner S, Maire CL, Joosse SA, Bludau F, Mueller V, Neves RPL, Stoecklein NH, Lamszus K, Westphal M, Pantel K, Wikman H, Eicker SO.

Sci Rep. 2017 Aug 3;7(1):7196. doi: 10.1038/s41598-017-07649-z.


Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma.

Schumacher S, Bartenhagen C, Hoffmann M, Will D, Fischer JC, Baldus SE, Vay C, Fluegen G, Dizdar L, Vallböhmer D, Klein CA, Knoefel WT, Stoecklein NH, Möhlendick B.

Br J Cancer. 2017 Aug 22;117(5):725-733. doi: 10.1038/bjc.2017.233. Epub 2017 Jul 20.


Immunohistochemical detection of lymph node-DTCs in patients with node-negative HNSCC.

Sproll C, Freund AK, Hassel A, Hölbling M, Aust V, Storb SH, Handschel J, Teichmann C, Depprich R, Behrens B, Neves RP, Kübler NR, Kaiser P, Baldus SE, Tóth C, Kaisers W, Stoecklein NH.

Int J Cancer. 2017 May 1;140(9):2112-2124. doi: 10.1002/ijc.30617. Epub 2017 Feb 8.


Analysis of DNA methylation in single circulating tumor cells.

Pixberg CF, Raba K, Müller F, Behrens B, Honisch E, Niederacher D, Neubauer H, Fehm T, Goering W, Schulz WA, Flohr P, Boysen G, Lambros M, De Bono JS, Knoefel WT, Sproll C, Stoecklein NH, Neves RPL.

Oncogene. 2017 Jun 8;36(23):3223-3231. doi: 10.1038/onc.2016.480. Epub 2017 Jan 9.


Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia.

Dizdar L, Oesterwind KA, Riemer JC, Werner TA, Mersch S, Möhlendick B, Schütte SC, Verde PE, Raba K, Topp SA, Stoecklein NH, Esposito I, Knoefel WT, Krieg A.

Oncotarget. 2017 Jan 31;8(5):8369-8382. doi: 10.18632/oncotarget.14207.


Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion.

Wang H, Stoecklein NH, Lin PP, Gires O.

Oncotarget. 2017 Jan 3;8(1):1884-1912. doi: 10.18632/oncotarget.12242. Review.


Characterization of different CTC subpopulations in non-small cell lung cancer.

Hanssen A, Wagner J, Gorges TM, Taenzer A, Uzunoglu FG, Driemel C, Stoecklein NH, Knoefel WT, Angenendt S, Hauch S, Atanackovic D, Loges S, Riethdorf S, Pantel K, Wikman H.

Sci Rep. 2016 Jun 15;6:28010. doi: 10.1038/srep28010.


Correction: EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.

Schneck H, Gierke B, Uppenkamp F, Behrens B, Niederacher D, Stoecklein NH, Templin MF, Pawlak M, Fehm T, Neubauer H; Disseminated Cancer Cell Network (DCC Net) Duesseldorf.

PLoS One. 2016 Feb 9;11(2):e0149315. doi: 10.1371/journal.pone.0149315. eCollection 2016. No abstract available.


A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells.

Hvichia GE, Parveen Z, Wagner C, Janning M, Quidde J, Stein A, Müller V, Loges S, Neves RP, Stoecklein NH, Wikman H, Riethdorf S, Pantel K, Gorges TM.

Int J Cancer. 2016 Jun 15;138(12):2894-904. doi: 10.1002/ijc.30007. Epub 2016 Feb 26.


Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).

Tsaktanis T, Kremling H, Pavšič M, von Stackelberg R, Mack B, Fukumori A, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarčič B, Gires O.

J Biol Chem. 2016 Jan 1;291(1):425. doi: 10.1074/jbc.A115.662700. No abstract available.


EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.

Schneck H, Gierke B, Uppenkamp F, Behrens B, Niederacher D, Stoecklein NH, Templin MF, Pawlak M, Fehm T, Neubauer H; Disseminated Cancer Cell Network (DCC Net) Duesseldorf.

PLoS One. 2015 Dec 22;10(12):e0144535. doi: 10.1371/journal.pone.0144535. eCollection 2015. Erratum in: PLoS One. 2016;11(2):e0149315.


Serum microRNA profiles as prognostic or predictive markers in the multimodality treatment of patients with gastric cancer.

Sisic L, Vallböhmer D, Stoecklein NH, Blank S, Schmidt T, Driemel C, Möhlendick B, Knoefel WT, Odenthal M, Ott K.

Oncol Lett. 2015 Aug;10(2):869-874. Epub 2015 Jun 9.


Challenges for CTC-based liquid biopsies: low CTC frequency and diagnostic leukapheresis as a potential solution.

Stoecklein NH, Fischer JC, Niederacher D, Terstappen LW.

Expert Rev Mol Diagn. 2016;16(2):147-64. doi: 10.1586/14737159.2016.1123095. Epub 2015 Dec 16. Review.


Characterization of DNA Methylation in Circulating Tumor Cells.

Pixberg CF, Schulz WA, Stoecklein NH, Neves RP.

Genes (Basel). 2015 Oct 21;6(4):1053-75. doi: 10.3390/genes6041053. Review.


Laser Microdissection of FFPE Tissue Areas and Subsequent Whole Genome Amplification by Ampli1™.

Czyz ZT, Stoecklein NH, Polzer B.

Methods Mol Biol. 2015;1347:141-62. doi: 10.1007/978-1-4939-2990-0_11.


Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma.

Mersch S, Riemer JC, Schlünder PM, Ghadimi MP, Ashmawy H, Möhlendick B, Topp SA, Arent T, Kröpil P, Stoecklein NH, Gabbert HE, Knoefel WT, Krieg A.

Tumour Biol. 2016 Feb;37(2):2341-51. doi: 10.1007/s13277-015-4050-6. Epub 2015 Sep 15.


Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).

Tsaktanis T, Kremling H, Pavšič M, von Stackelberg R, Mack B, Fukumori A, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarčič B, Gires O.

J Biol Chem. 2015 Oct 2;290(40):24574-91. doi: 10.1074/jbc.M115.662700. Epub 2015 Aug 19. Erratum in: J Biol Chem. 2016 Jan 1;291(1):425.


Analysis of Copy-Number Alterations in Single Cells Using Microarray-Based Comparative Genomic Hybridization (aCGH).

Möhlendick B, Stoecklein NH.

Curr Protoc Cell Biol. 2014 Dec 1;65:22.19.1-23. doi: 10.1002/0471143030.cb2219s65. Review.


Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction.

Odenthal M, Hee J, Gockel I, Sisic L, Schmitz J, Stoecklein NH, Driemel C, Möhlendick B, Schmidt T, Knoefel WT, Lang H, Büttner R, Ott K, Vallböhmer D.

Int J Cancer. 2015 Jul 1;137(1):230-7. doi: 10.1002/ijc.29363. Epub 2014 Dec 3.


Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.

Vay C, Hosch SB, Stoecklein NH, Klein CA, Vallböhmer D, Link BC, Yekebas EF, Izbicki JR, Knoefel WT, Scheunemann P.

PLoS One. 2014 Nov 14;9(11):e109026. doi: 10.1371/journal.pone.0109026. eCollection 2014.


Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer.

Neves RP, Raba K, Schmidt O, Honisch E, Meier-Stiegen F, Behrens B, Möhlendick B, Fehm T, Neubauer H, Klein CA, Polzer B, Sproll C, Fischer JC, Niederacher D, Stoecklein NH.

Clin Chem. 2014 Oct;60(10):1290-7. doi: 10.1373/clinchem.2014.222331.


Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences.

Gires O, Stoecklein NH.

Cell Mol Life Sci. 2014 Nov;71(22):4393-402. doi: 10.1007/s00018-014-1693-1. Epub 2014 Aug 8. Review.


A new workflow for whole-genome sequencing of single human cells.

Binder V, Bartenhagen C, Okpanyi V, Gombert M, Moehlendick B, Behrens B, Klein HU, Rieder H, Ida Krell PF, Dugas M, Stoecklein NH, Borkhardt A.

Hum Mutat. 2014 Oct;35(10):1260-70. doi: 10.1002/humu.22625. Epub 2014 Aug 18.


Clinically staged cT2 adenocarcinomas of the gastroesophageal junction: accuracy of staging and therapeutic consequences.

Vallböhmer D, Sisic L, Blank S, Kraus S, Stoecklein NH, Knoefel WT, Büchler MW, Ott K.

Oncol Res Treat. 2014;37(3):97-104. doi: 10.1159/000360177. Epub 2014 Feb 21.


Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer.

Steinert G, Schölch S, Niemietz T, Iwata N, García SA, Behrens B, Voigt A, Kloor M, Benner A, Bork U, Rahbari NN, Büchler MW, Stoecklein NH, Weitz J, Koch M.

Cancer Res. 2014 Mar 15;74(6):1694-704. doi: 10.1158/0008-5472.CAN-13-1885. Epub 2014 Mar 5.


New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines.

Krieg A, Mersch S, Boeck I, Dizdar L, Weihe E, Hilal Z, Krausch M, Möhlendick B, Topp SA, Piekorz RP, Huckenbeck W, Stoecklein NH, Anlauf M, Knoefel WT.

PLoS One. 2014 Feb 14;9(2):e88713. doi: 10.1371/journal.pone.0088713. eCollection 2014.


Context-dependent adaption of EpCAM expression in early systemic esophageal cancer.

Driemel C, Kremling H, Schumacher S, Will D, Wolters J, Lindenlauf N, Mack B, Baldus SA, Hoya V, Pietsch JM, Panagiotidou P, Raba K, Vay C, Vallböhmer D, Harréus U, Knoefel WT, Stoecklein NH, Gires O.

Oncogene. 2014 Oct 9;33(41):4904-15. doi: 10.1038/onc.2013.441. Epub 2013 Oct 21.


Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients.

Fischer JC, Niederacher D, Topp SA, Honisch E, Schumacher S, Schmitz N, Zacarias Föhrding L, Vay C, Hoffmann I, Kasprowicz NS, Hepp PG, Mohrmann S, Nitz U, Stresemann A, Krahn T, Henze T, Griebsch E, Raba K, Rox JM, Wenzel F, Sproll C, Janni W, Fehm T, Klein CA, Knoefel WT, Stoecklein NH.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16580-5. doi: 10.1073/pnas.1313594110. Epub 2013 Sep 24.


Role of survivin as prognostic and clinicopathological marker in gastric cancer: a meta-analysis.

Krieg A, Baseras B, Tomczak M, Verde PE, Stoecklein NH, Knoefel WT.

Mol Biol Rep. 2013 Sep;40(9):5501-11. doi: 10.1007/s11033-013-2650-z. Epub 2013 Aug 15.


Expression of TRAIL-splice variants in gastric carcinomas: identification of TRAIL-γ as a prognostic marker.

Krieg A, Mersch S, Wolf N, Stoecklein NH, Verde PE, am Esch JS 2nd, Heikaus S, Gabbert HE, Knoefel WT, Mahotka C.

BMC Cancer. 2013 Aug 12;13:384. doi: 10.1186/1471-2407-13-384.


Is minimal residual lymph node disease in papillary thyroid cancer of prognostic impact? An analysis of the epithelial cell adhesion molecule EpCAM in lymph nodes of 40 pN0 patients.

Rehders A, Anlauf M, Adamowsky I, Ghadimi MH, Klein S, Antke C, Cupisti K, Stoecklein NH, Knoefel WT.

Pathol Oncol Res. 2014 Jan;20(1):185-90. doi: 10.1007/s12253-013-9682-5. Epub 2013 Aug 6.


High EpCAM expression is linked to proliferation and lauren classification in gastric cancer.

Kroepil F, Dulian A, Vallböhmer D, Geddert H, Krieg A, Vay C, Topp SA, am Esch JS, Baldus SE, Gires O, Knoefel WT, Stoecklein NH.

BMC Res Notes. 2013 Jul 5;6:253. doi: 10.1186/1756-0500-6-253.


A robust method to analyze copy number alterations of less than 100 kb in single cells using oligonucleotide array CGH.

Möhlendick B, Bartenhagen C, Behrens B, Honisch E, Raba K, Knoefel WT, Stoecklein NH.

PLoS One. 2013 Jun 25;8(6):e67031. doi: 10.1371/journal.pone.0067031. Print 2013.


Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis.

Krieg A, Werner TA, Verde PE, Stoecklein NH, Knoefel WT.

PLoS One. 2013 Jun 3;8(6):e65338. doi: 10.1371/journal.pone.0065338. Print 2013.


Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.

Luca AC, Mersch S, Deenen R, Schmidt S, Messner I, Schäfer KL, Baldus SE, Huckenbeck W, Piekorz RP, Knoefel WT, Krieg A, Stoecklein NH.

PLoS One. 2013;8(3):e59689. doi: 10.1371/journal.pone.0059689. Epub 2013 Mar 26.


Snail1 expression in colorectal cancer and its correlation with clinical and pathological parameters.

Kroepil F, Fluegen G, Vallböhmer D, Baldus SE, Dizdar L, Raffel AM, Hafner D, Stoecklein NH, Knoefel WT.

BMC Cancer. 2013 Mar 22;13:145. doi: 10.1186/1471-2407-13-145.

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