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DNA replication licensing factor MCM2, geminin, and Ki67 define proliferative state and are linked with survival in oral squamous cell carcinoma.

Al-Hazmi N, Alhazzazi T, Williams G, Stoeber K, Al-Dabbagh R.

Eur J Oral Sci. 2018 Jun;126(3):186-196. doi: 10.1111/eos.12420.


Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome.

Sellar RS, Gale RE, Khwaja A, Garbowski M, Loddo M, Stoeber K, Williams GH, Linch DC.

Br J Haematol. 2018 May;181(4):486-494. doi: 10.1111/bjh.15211. Epub 2018 Apr 20.


p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress.

Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, Williams GH.

Cell Cycle. 2016 Nov;15(21):2958-2972. Epub 2016 Sep 9.


Spatial Cross-Talk between Oxidative Stress and DNA Replication in Human Fibroblasts.

Radulovic M, Baqader NO, Stoeber K, Godovac-Zimmermann J.

J Proteome Res. 2016 Jun 3;15(6):1907-38. doi: 10.1021/acs.jproteome.6b00101. Epub 2016 May 24.


Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment.

Sellar RS, Fraser L, Khwaja A, Gale RE, Marafioti T, Akarca A, Hubank M, Brooks T, Stoeber K, Williams G, Linch DC.

Br J Haematol. 2016 Jul;174(2):275-9. doi: 10.1111/bjh.14055. Epub 2016 Apr 8.


Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint.

Huggett MT, Tudzarova S, Proctor I, Loddo M, Keane MG, Stoeber K, Williams GH, Pereira SP.

Oncotarget. 2016 Apr 5;7(14):18495-507. doi: 10.18632/oncotarget.7611.


Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress.

Baqader NO, Radulovic M, Crawford M, Stoeber K, Godovac-Zimmermann J.

J Proteome Res. 2014 Oct 3;13(10):4398-423. doi: 10.1021/pr500638h. Epub 2014 Sep 3.


Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer.

Loddo M, Andryszkiewicz J, Rodriguez-Acebes S, Stoeber K, Jones A, Dafou D, Apostolidou S, Wollenschlaeger A, Widschwendter M, Sainsbury R, Tudzarova S, Williams GH.

J Pathol. 2014 Aug;233(4):344-56. doi: 10.1002/path.4393.


Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint.

Mulvey CM, Tudzarova S, Crawford M, Williams GH, Stoeber K, Godovac-Zimmermann J.

J Proteome Res. 2013 Mar 1;12(3):1436-53. doi: 10.1021/pr3010919. Epub 2013 Feb 6.


Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22.

Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, Robson W, Leung HY, Vasdev N, Pickard RS, Williams GH, Stoeber K.

PLoS One. 2012;7(7):e40305. doi: 10.1371/journal.pone.0040305. Epub 2012 Jul 9.


The cell cycle and cancer.

Williams GH, Stoeber K.

J Pathol. 2012 Jan;226(2):352-64. doi: 10.1002/path.3022. Epub 2011 Oct 28. Review.


Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA.

Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL.

Chem Biol Drug Des. 2012 Jan;79(1):9-21. doi: 10.1111/j.1747-0285.2011.01249.x. Epub 2011 Nov 4.


Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle.

Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5278-83. doi: 10.1073/pnas.1102247108. Epub 2011 Mar 14.


Molecular architecture of the DNA replication origin activation checkpoint.

Tudzarova S, Trotter MW, Wollenschlaeger A, Mulvey C, Godovac-Zimmermann J, Williams GH, Stoeber K.

EMBO J. 2010 Oct 6;29(19):3381-94. doi: 10.1038/emboj.2010.201. Epub 2010 Aug 20.


Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.

Rodriguez-Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, Prevost AT, Sainsbury R, Stoeber K, Williams GH.

Am J Pathol. 2010 Oct;177(4):2034-45. doi: 10.2353/ajpath.2010.100421. Epub 2010 Aug 19.


Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.

Mulvey C, Tudzarova S, Crawford M, Williams GH, Stoeber K, Godovac-Zimmermann J.

J Proteome Res. 2010 Oct 1;9(10):5445-60. doi: 10.1021/pr100678k.


Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

Dudderidge TJ, Kelly JD, Wollenschlaeger A, Okoturo O, Prevost T, Robson W, Leung HY, Williams GH, Stoeber K.

Br J Cancer. 2010 Aug 24;103(5):701-7. doi: 10.1038/sj.bjc.6605785. Epub 2010 Jul 20.


Biomarkers in bladder cancer.

Proctor I, Stoeber K, Williams GH.

Histopathology. 2010 Jul;57(1):1-13. doi: 10.1111/j.1365-2559.2010.03592.x. Epub 2010 Jun 23. Review.


DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma.

Kayes OJ, Loddo M, Patel N, Patel P, Minhas S, Ambler G, Freeman A, Wollenschlaeger A, Ralph DJ, Stoeber K, Williams GH.

Clin Cancer Res. 2009 Dec 1;15(23):7335-44. doi: 10.1158/1078-0432.CCR-09-0882. Epub 2009 Nov 17.


Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.

Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH.

Clin Cancer Res. 2009 Apr 1;15(7):2417-25. doi: 10.1158/1078-0432.CCR-08-1276. Epub 2009 Mar 24.


Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer.

Loddo M, Kingsbury SR, Rashid M, Proctor I, Holt C, Young J, El-Sheikh S, Falzon M, Eward KL, Prevost T, Sainsbury R, Stoeber K, Williams GH.

Br J Cancer. 2009 Mar 24;100(6):959-70. doi: 10.1038/sj.bjc.6604924. Epub 2009 Feb 24.


Identification of an arginine-rich motif in human papillomavirus type 1 E1;E4 protein necessary for E4-mediated inhibition of cellular DNA synthesis in vitro and in cells.

Roberts S, Kingsbury SR, Stoeber K, Knight GL, Gallimore PH, Williams GH.

J Virol. 2008 Sep;82(18):9056-64. doi: 10.1128/JVI.01080-08. Epub 2008 Jul 16.


Modular assembly using sequential palladium coupling gives easy access to the SMoC class of cellular transporters.

Rebstock AS, Visintin C, Leo E, Garcia Posada C, Kingsbury SR, Williams GH, Stoeber K, Selwood DL.

Chembiochem. 2008 Jul 21;9(11):1787-96. doi: 10.1002/cbic.200800153.


Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates.

Ayaru L, Stoeber K, Webster GJ, Hatfield AR, Wollenschlaeger A, Okoturo O, Rashid M, Williams G, Pereira SP.

Br J Cancer. 2008 May 6;98(9):1548-54. doi: 10.1038/sj.bjc.6604342. Epub 2008 Apr 15.


Cell cycle markers in clinical oncology.

Williams GH, Stoeber K.

Curr Opin Cell Biol. 2007 Dec;19(6):672-9. Epub 2007 Nov 26. Review.


Microglial activation in white matter lesions and nonlesional white matter of ageing brains.

Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.

Neuropathol Appl Neurobiol. 2007 Dec;33(6):670-83.


DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.

Kulkarni AA, Loddo M, Leo E, Rashid M, Eward KL, Fanshawe TR, Butcher J, Frost A, Ledermann JA, Williams GH, Stoeber K.

Clin Cancer Res. 2007 Oct 15;13(20):6153-61.


Hexameric ring structure of human MCM10 DNA replication factor.

Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH.

EMBO Rep. 2007 Oct;8(10):925-30. Epub 2007 Sep 7.


Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation.

Barkley LR, Hong HK, Kingsbury SR, James M, Stoeber K, Williams GH.

Exp Cell Res. 2007 Oct 15;313(17):3789-99. Epub 2007 Jul 14.


Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer.

Dudderidge TJ, McCracken SR, Loddo M, Fanshawe TR, Kelly JD, Neal DE, Leung HY, Williams GH, Stoeber K.

Br J Cancer. 2007 May 7;96(9):1384-93. Epub 2007 Apr 3.


Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells.

Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL.

Nat Methods. 2007 Feb;4(2):153-9. Epub 2007 Jan 14.


Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells.

Wharton SB, Maltby E, Jellinek DA, Levy D, Atkey N, Hibberd S, Crimmins D, Stoeber K, Williams GH.

Acta Neuropathol. 2007 Feb;113(2):119-27. Epub 2006 Dec 9.


Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma.

Quaglia A, McStay M, Stoeber K, Loddo M, Caplin M, Fanshawe T, Williams G, Dhillon A.

Liver Int. 2006 May;26(4):424-32.


Mcm2 labelling of balloon cells in focal cortical dysplasia.

Thom M, Martinian L, Sisodiya SM, Cross JH, Williams G, Stoeber K, Harkness W, Harding BN.

Neuropathol Appl Neurobiol. 2005 Dec;31(6):580-8.


DNA replication licensing and cell cycle kinetics of normal and neoplastic breast.

Shetty A, Loddo M, Fanshawe T, Prevost AT, Sainsbury R, Williams GH, Stoeber K.

Br J Cancer. 2005 Nov 28;93(11):1295-300.


Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells.

Kingsbury SR, Loddo M, Fanshawe T, Obermann EC, Prevost AT, Stoeber K, Williams GH.

Exp Cell Res. 2005 Sep 10;309(1):56-67.


Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology.

Wharton SB, Williams GH, Stoeber K, Gelsthorpe CH, Baxter L, Johnson AL, Ince PG; MRC-CFAS.

Neurosci Lett. 2005 Jul 22-29;383(1-2):33-8. Epub 2005 Apr 26.


Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma.

Dudderidge TJ, Stoeber K, Loddo M, Atkinson G, Fanshawe T, Griffiths DF, Williams GH.

Clin Cancer Res. 2005 Apr 1;11(7):2510-7.


Cell proliferation and granule cell dispersion in human hippocampal sclerosis.

Thom M, Martinian L, Williams G, Stoeber K, Sisodiya SM.

J Neuropathol Exp Neurol. 2005 Mar;64(3):194-201.


DNA replication licensing in peripheral B-cell lymphoma.

Obermann EC, Eward KL, Dogan A, Paul EA, Loddo M, Munson P, Williams GH, Stoeber K.

J Pathol. 2005 Feb;205(3):318-28.


DNA replication licensing in somatic and germ cells.

Eward KL, Obermann EC, Shreeram S, Loddo M, Fanshawe T, Williams C, Jung HI, Prevost AT, Blow JJ, Stoeber K, Williams GH.

J Cell Sci. 2004 Nov 15;117(Pt 24):5875-86. Epub 2004 Nov 2.


Characterization of peptides corresponding to the seven transmembrane domains of human adenosine A2a receptor.

Lazarova T, Brewin KA, Stoeber K, Robinson CR.

Biochemistry. 2004 Oct 12;43(40):12945-54.


Molecular structure of human geminin.

Okorokov AL, Orlova EV, Kingsbury SR, Bagneris C, Gohlke U, Williams GH, Stoeber K.

Nat Struct Mol Biol. 2004 Oct;11(10):1021-2. Epub 2004 Sep 19.


Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.

Chen JH, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, Hales CN.

J Biol Chem. 2004 Nov 19;279(47):49439-46. Epub 2004 Sep 16.


Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates.

Williams GH, Swinn R, Prevost AT, De Clive-Lowe P, Halsall I, Going JJ, Hales CN, Stoeber K, Middleton SJ.

Br J Cancer. 2004 Aug 16;91(4):714-9.


DNA replication licensing and cell cycle kinetics of oligodendroglial tumours.

Wharton SB, Hibberd S, Eward KL, Crimmins D, Jellinek DA, Levy D, Stoeber K, Williams GH.

Br J Cancer. 2004 Jul 19;91(2):262-9.


Commitment point during G0-->G1 that controls entry into the cell cycle.

Lea NC, Orr SJ, Stoeber K, Williams GH, Lam EW, Ibrahim MA, Mufti GJ, Thomas NS.

Mol Cell Biol. 2003 Apr;23(7):2351-61.


Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.

Stoeber K, Swinn R, Prevost AT, de Clive-Lowe P, Halsall I, Dilworth SM, Marr J, Turner WH, Bullock N, Doble A, Hales CN, Williams GH.

J Natl Cancer Inst. 2002 Jul 17;94(14):1071-9.


Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.

Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD.

Clin Cancer Res. 2001 Sep;7(9):2712-8.

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