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Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice.

Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA.

Viruses. 2019 Mar 13;11(3). pii: E256. doi: 10.3390/v11030256.


Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.

Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ.

PLoS Pathog. 2018 Feb 22;14(2):e1006856. doi: 10.1371/journal.ppat.1006856. eCollection 2018 Feb.


Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ.

Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG.

J Histochem Cytochem. 2018 Jun;66(6):427-446. doi: 10.1369/0022155418756848. Epub 2018 Feb 20.


Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.

Rose R, Nolan DJ, Maidji E, Stoddart CA, Singer EJ, Lamers SL, McGrath MS.

AIDS Res Hum Retroviruses. 2018 Jan;34(1):3-8. doi: 10.1089/AID.2017.0072. Epub 2017 Aug 7. Review.


Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction.

Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA.

PLoS Pathog. 2017 Feb 27;13(2):e1006202. doi: 10.1371/journal.ppat.1006202. eCollection 2017 Feb.


HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads.

Lamers SL, Rose R, Maidji E, Agsalda-Garcia M, Nolan DJ, Fogel GB, Salemi M, Garcia DL, Bracci P, Yong W, Commins D, Said J, Khanlou N, Hinkin CH, Sueiras MV, Mathisen G, Donovan S, Shiramizu B, Stoddart CA, McGrath MS, Singer EJ.

J Virol. 2016 Sep 29;90(20):8968-83. doi: 10.1128/JVI.00674-16. Print 2016 Oct 15.


HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer.

Rose R, Lamers SL, Nolan DJ, Maidji E, Faria NR, Pybus OG, Dollar JJ, Maruniak SA, McAvoy AC, Salemi M, Stoddart CA, Singer EJ, McGrath MS.

J Virol. 2016 Sep 29;90(20):8984-93. doi: 10.1128/JVI.00684-16. Print 2016 Oct 15.


Inhibition of Heat Shock Protein 90 Prevents HIV Rebound.

Joshi P, Maidji E, Stoddart CA.

J Biol Chem. 2016 May 6;291(19):10332-46. doi: 10.1074/jbc.M116.717538. Epub 2016 Mar 8.


Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.

Ghosn EE, Waters J, Phillips M, Yamamoto R, Long BR, Yang Y, Gerstein R, Stoddart CA, Nakauchi H, Herzenberg LA.

Stem Cell Reports. 2016 Jan 12;6(1):137-49. doi: 10.1016/j.stemcr.2015.11.011. Epub 2015 Dec 24.


The meningeal lymphatic system: a route for HIV brain migration?

Lamers SL, Rose R, Ndhlovu LC, Nolan DJ, Salemi M, Maidji E, Stoddart CA, McGrath MS.

J Neurovirol. 2016 Jun;22(3):275-81. doi: 10.1007/s13365-015-0399-y. Epub 2015 Nov 16. Review.


Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque.

Stoddart CA, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA.

Antimicrob Agents Chemother. 2015 Jul;59(7):4190-8. doi: 10.1128/AAC.05036-14. Epub 2015 May 4.


CD8-positive lymphocytes in graft-versus-host disease of humanized NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ mice.

Laing ST, Griffey SM, Moreno ME, Stoddart CA.

J Comp Pathol. 2015 Feb-Apr;152(2-3):238-42. doi: 10.1016/j.jcpa.2014.12.010. Epub 2015 Feb 7.


Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice.

Stoddart CA, Galkina SA, Joshi P, Kosikova G, Long BR, Maidji E, Moreno ME, Rivera JM, Sanford UR, Sloan B, Cieplak W, Wrin T, Chan-Hui PY.

Virology. 2014 Aug;462-463:115-25. doi: 10.1016/j.virol.2014.05.036. Epub 2014 Jun 25.


Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores.

Joshi P, Sloan B, Torbett BE, Stoddart CA.

Virology. 2013 Feb 5;436(1):162-72. doi: 10.1016/j.virol.2012.11.005. Epub 2012 Nov 30.


Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection.

Maidji E, Kosikova G, Joshi P, Stoddart CA.

J Virol. 2012 Dec;86(23):12795-805. doi: 10.1128/JVI.01054-12. Epub 2012 Sep 12.


OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice.

Long BR, Stoddart CA.

Cytometry A. 2012 Aug;81(8):646-8. doi: 10.1002/cyto.a.22074. Epub 2012 May 31. No abstract available.


Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice.

Stoddart CA, Nault G, Galkina SA, Bousquet-Gagnon N, Bridon D, Quraishi O.

Antimicrob Agents Chemother. 2012 Apr;56(4):2162-5. doi: 10.1128/AAC.05015-11. Epub 2012 Jan 17.


Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice.

Long BR, Stoddart CA.

J Virol. 2012 Mar;86(6):3327-36. doi: 10.1128/JVI.06676-11. Epub 2012 Jan 11.


Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies.

Vyas GN, Stoddart CA, Killian MS, Brennan TV, Goldberg T, Ziman A, Bryson Y.

Biologicals. 2012 Jan;40(1):15-20. doi: 10.1016/j.biologicals.2011.11.005. Epub 2011 Dec 20.


Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.

Baum PD, Sullam PM, Stoddart CA, McCune JM.

AIDS. 2011 Nov 28;25(18):2243-8. doi: 10.1097/QAD.0b013e32834d3cc3.


Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ(-/-) (NSG) BLT mice.

Stoddart CA, Maidji E, Galkina SA, Kosikova G, Rivera JM, Moreno ME, Sloan B, Joshi P, Long BR.

Virology. 2011 Aug 15;417(1):154-60. doi: 10.1016/j.virol.2011.05.013.


Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1.

Joshi P, Stoddart CA.

J Biol Chem. 2011 Jul 15;286(28):24581-92. doi: 10.1074/jbc.M111.248021. Epub 2011 May 20.


HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells.

Favre D, Stoddart CA, Emu B, Hoh R, Martin JN, Hecht FM, Deeks SG, McCune JM.

Blood. 2011 Feb 17;117(7):2189-99. doi: 10.1182/blood-2010-06-288035. Epub 2011 Jan 3.


Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.

Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM.

Science. 2010 Dec 17;330(6011):1695-9. doi: 10.1126/science.1196509. Erratum in: Science. 2011 Feb 4;331(6017):534.


IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.

Stoddart CA, Keir ME, McCune JM.

PLoS Pathog. 2010 Feb 19;6(2):e1000766. doi: 10.1371/journal.ppat.1000766.


Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice.

Stoddart CA, Nault G, Galkina SA, Thibaudeau K, Bakis P, Bousquet-Gagnon N, Robitaille M, Bellomo M, Paradis V, Liscourt P, Lobach A, Rivard ME, Ptak RG, Mankowski MK, Bridon D, Quraishi O.

J Biol Chem. 2008 Dec 5;283(49):34045-52. doi: 10.1074/jbc.M805536200. Epub 2008 Sep 22.


Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Stoddart CA, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE.

PLoS One. 2007 Nov 28;2(11):e1251.


Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.

Stoddart CA, Bales CA, Bare JC, Chkhenkeli G, Galkina SA, Kinkade AN, Moreno ME, Rivera JM, Ronquillo RE, Sloan B, Black PL.

PLoS One. 2007 Aug 1;2(7):e655.


Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ.

Lymphat Res Biol. 2006;4(4):229-42. No abstract available.


Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum.

Chen JL, Kernan MR, Jolad SD, Stoddart CA, Bogan M, Cooper R.

J Nat Prod. 2007 Feb;70(2):312-5.


Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ.

J Clin Invest. 2006 Oct;116(10):2643-52. Epub 2006 Sep 21.


Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells.

Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart CA, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA.

J Biol Chem. 2005 Dec 2;280(48):40293-300. Epub 2005 Sep 30.


Coxsackievirus B4 infection of human fetal thymus cells.

Brilot F, Geenen V, Hober D, Stoddart CA.

J Virol. 2004 Sep;78(18):9854-61.


Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7.

Sandberg JK, Stoddart CA, Brilot F, Jordan KA, Nixon DF.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7058-63. Epub 2004 Apr 26.


Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice.

Napolitano LA, Stoddart CA, Hanley MB, Wieder E, McCune JM.

J Immunol. 2003 Jul 15;171(2):645-54.


Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.

Stoddart CA, Geleziunas R, Ferrell S, Linquist-Stepps V, Moreno ME, Bare C, Xu W, Yonemoto W, Bresnahan PA, McCune JM, Greene WC.

J Virol. 2003 Feb;77(3):2124-33.


Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus.

Keir ME, Rosenberg MG, Sandberg JK, Jordan KA, Wiznia A, Nixon DF, Stoddart CA, McCune JM.

J Immunol. 2002 Sep 1;169(5):2788-96.


IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus.

Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM.

J Immunol. 2002 Jan 1;168(1):325-31.


SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.

Strizki JM, Xu S, Wagner NE, Wojcik L, Liu J, Hou Y, Endres M, Palani A, Shapiro S, Clader JW, Greenlee WJ, Tagat JR, McCombie S, Cox K, Fawzi AB, Chou CC, Pugliese-Sivo C, Davies L, Moreno ME, Ho DD, Trkola A, Stoddart CA, Moore JP, Reyes GR, Baroudy BM.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23. Epub 2001 Oct 16.


Impaired replication of protease inhibitor-resistant HIV-1 in human thymus.

Stoddart CA, Liegler TJ, Mammano F, Linquist-Stepps VD, Hayden MS, Deeks SG, Grant RM, Clavel F, McCune JM.

Nat Med. 2001 Jun;7(6):712-8.


Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.

Gobbi A, Stoddart CA, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P.

J Virol. 2000 Sep;74(18):8726-31.


Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.

Stoddart CA, Moreno ME, Linquist-Stepps VD, Bare C, Bogan MR, Gobbi A, Buckheit RW Jr, Bedard J, Rando RF, McCune JM.

Antimicrob Agents Chemother. 2000 Mar;44(3):783-6.


R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.

Berkowitz RD, van't Wout AB, Kootstra NA, Moreno ME, Linquist-Stepps VD, Bare C, Stoddart CA, Schuitemaker H, McCune JM.

J Virol. 1999 Sep;73(9):7817-22.


Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice.

Gobbi A, Stoddart CA, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM.

J Exp Med. 1999 Jun 21;189(12):1953-60.


CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.

Berkowitz RD, Alexander S, Bare C, Linquist-Stepps V, Bogan M, Moreno ME, Gibson L, Wieder ED, Kosek J, Stoddart CA, McCune JM.

J Virol. 1998 Dec;72(12):10108-17.


New iridoids from the medicinal plant Barleria prionitis with potent activity against respiratory syncytial virus.

Chen JL, Blanc P, Stoddart CA, Bogan M, Rozhon EJ, Parkinson N, Ye Z, Cooper R, Balick M, Nanakorn W, Kernan MR.

J Nat Prod. 1998 Oct;61(10):1295-7.


Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.

Stoddart CA, Rabin L, Hincenbergs M, Moreno M, Linquist-Stepps V, Leeds JM, Truong LA, Wyatt JR, Ecker DJ, McCune JM.

Antimicrob Agents Chemother. 1998 Aug;42(8):2113-5.


Antiviral phenylpropanoid glycosides from the medicinal plant Markhamia lutea.

Kernan MR, Amarquaye A, Chen JL, Chan J, Sesin DF, Parkinson N, Ye Z, Barrett M, Bales C, Stoddart CA, Sloan B, Blanc P, Limbach C, Mrisho S, Rozhon EJ.

J Nat Prod. 1998 May;61(5):564-70.


UV irradiation of polystyrene pipets releases PCR inhibitors.

Linquist V, Stoddart CA, McCune JM.

Biotechniques. 1998 Jan;24(1):50-2. No abstract available.


Two new lignans with activity against influenza virus from the medicinal plant Rhinacanthus nasutus.

Kernan MR, Sendl A, Chen JL, Jolad SD, Blanc P, Murphy JT, Stoddart CA, Nanakorn W, Balick MJ, Rozhon EJ.

J Nat Prod. 1997 Jun;60(6):635-7.


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