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Items: 1 to 50 of 63

1.

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

Jayaraman K, Morley AN, Szöllősi D, Wassenaar TA, Sitte HH, Stockner T.

PLoS Comput Biol. 2018 Jun 6;14(6):e1006229. doi: 10.1371/journal.pcbi.1006229. eCollection 2018 Jun.

2.

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Lichtenegger M, Tiapko O, Svobodova B, Stockner T, Glasnov TN, Schreibmayer W, Platzer D, de la Cruz GG, Krenn S, Schober R, Shrestha N, Schindl R, Romanin C, Groschner K.

Nat Chem Biol. 2018 Apr;14(4):396-404. doi: 10.1038/s41589-018-0015-6. Epub 2018 Mar 19.

PMID:
29556099
3.

Dissecting the Forces that Dominate Dimerization of the Nucleotide Binding Domains of ABCB1.

Szöllősi D, Szakács G, Chiba P, Stockner T.

Biophys J. 2018 Jan 23;114(2):331-342. doi: 10.1016/j.bpj.2017.11.022.

4.

A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron.

Hunter T, Bonetta R, Sacco A, Vella M, Sultana PM, Trinh CH, Fadia HBR, Borowski T, Garcia-Fandiño R, Stockner T, Hunter GJ.

Chemistry. 2018 Apr 6;24(20):5303-5308. doi: 10.1002/chem.201704655. Epub 2017 Dec 12.

5.

Comparison of mechanistic transport cycle models of ABC exporters.

Szöllősi D, Rose-Sperling D, Hellmich UA, Stockner T.

Biochim Biophys Acta. 2018 Apr;1860(4):818-832. doi: 10.1016/j.bbamem.2017.10.028. Epub 2017 Oct 31. Review.

6.

SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71.

PMID:
29086036
7.

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion.

Khunweeraphong N, Stockner T, Kuchler K.

Sci Rep. 2017 Oct 23;7(1):13767. doi: 10.1038/s41598-017-11794-w.

8.

An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.

9.

Molecular Mechanism of Taurocholate Transport by the Bile Salt Export Pump, an ABC Transporter Associated with Intrahepatic Cholestasis.

Sohail MI, Schmid D, Wlcek K, Spork M, Szakács G, Trauner M, Stockner T, Chiba P.

Mol Pharmacol. 2017 Oct;92(4):401-413. doi: 10.1124/mol.117.108688. Epub 2017 Aug 7.

PMID:
28784620
10.

Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.

PMID:
28619473
11.

Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.

Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T.

Pharmacol Res Perspect. 2017 May 26;5(3):e00325. doi: 10.1002/prp2.325. eCollection 2017 Jun.

12.

Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter.

Anderluh A, Hofmaier T, Klotzsch E, Kudlacek O, Stockner T, Sitte HH, Schütz GJ.

Nat Commun. 2017 Jan 19;8:14089. doi: 10.1038/ncomms14089.

13.

Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.

Sweeney CG, Tremblay BP, Stockner T, Sitte HH, Melikian HE.

J Biol Chem. 2017 Jan 27;292(4):1302-1309. doi: 10.1074/jbc.M116.762872. Epub 2016 Dec 16.

14.

Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.

Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF.

Mol Inform. 2017 May;36(5-6). doi: 10.1002/minf.201600094. Epub 2016 Nov 8.

PMID:
27860344
15.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

16.

Adhesion of Escherichia coli under flow conditions reveals potential novel effects of FimH mutations.

Feenstra T, Thøgersen MS, Wieser E, Peschel A, Ball MJ, Brandes R, Satchell SC, Stockner T, Aarestrup FM, Rees AJ, Kain R.

Eur J Clin Microbiol Infect Dis. 2017 Mar;36(3):467-478. doi: 10.1007/s10096-016-2820-8. Epub 2016 Nov 5.

17.

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1.

18.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.

19.

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH.

Mol Pharmacol. 2016 Jan;89(1):165-75. doi: 10.1124/mol.115.101394. Epub 2015 Oct 30.

20.

Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications.

Stockner T, Mullen A, MacMillan F.

Biochem Soc Trans. 2015 Oct;43(5):1023-32. doi: 10.1042/BST20150138. Review.

PMID:
26517918
21.

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.

22.

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.

23.

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.

24.

A refined atomic scale model of the Saccharomyces cerevisiae K+-translocation protein Trk1p combined with experimental evidence confirms the role of selectivity filter glycines and other key residues.

Zayats V, Stockner T, Pandey SK, Wörz K, Ettrich R, Ludwig J.

Biochim Biophys Acta. 2015 May;1848(5):1183-95. doi: 10.1016/j.bbamem.2015.02.007. Epub 2015 Feb 14.

25.

A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).

Jurik A, Zdrazil B, Holy M, Stockner T, Sitte HH, Ecker GF.

J Med Chem. 2015 Mar 12;58(5):2149-58. doi: 10.1021/jm5015428. Epub 2015 Feb 26.

26.

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function.

Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH.

Neuropsychopharmacology. 2015 May;40(6):1321-31. doi: 10.1038/npp.2014.325. Epub 2014 Dec 15.

27.

Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.

Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR.

Biochemistry. 2014 Aug 26;53(33):5444-60. doi: 10.1021/bi500637f. Epub 2014 Aug 15.

28.

Pharmacological correction of misfolding of ABC proteins.

Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P.

Drug Discov Today Technol. 2014 Jun;12:e87-94. doi: 10.1016/j.ddtec.2014.03.009. Review.

29.

Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.

Burtscher V, Schicker K, Novikova E, Pöhn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, Koschak A.

Biochim Biophys Acta. 2014 Aug;1838(8):2053-65. doi: 10.1016/j.bbamem.2014.04.023. Epub 2014 May 4.

30.

Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients.

Singer J, Fazekas J, Wang W, Weichselbaumer M, Matz M, Mader A, Steinfellner W, Meitz S, Mechtcheriakova D, Sobanov Y, Willmann M, Stockner T, Spillner E, Kunert R, Jensen-Jarolim E.

Mol Cancer Ther. 2014 Jul;13(7):1777-1790. doi: 10.1158/1535-7163.MCT-13-0288. Epub 2014 Apr 22.

31.

Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs.

Dönmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P.

Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23.

32.

Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters.

Chiba P, Freissmuth M, Stockner T.

Pharmacol Res. 2014 May;83:63-73. doi: 10.1016/j.phrs.2013.11.009. Epub 2013 Dec 6. Review.

33.

Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters.

Hofmaier T, Luf A, Seddik A, Stockner T, Holy M, Freissmuth M, Ecker GF, Schmid R, Sitte HH, Kudlacek O.

Neurochem Int. 2014 Jul;73:32-41. doi: 10.1016/j.neuint.2013.11.010. Epub 2013 Dec 1.

34.

Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates.

Baumann MH, Bulling S, Benaderet TS, Saha K, Ayestas MA, Partilla JS, Ali SF, Stockner T, Rothman RB, Sandtner W, Sitte HH.

Neuropsychopharmacology. 2014 May;39(6):1355-65. doi: 10.1038/npp.2013.331. Epub 2013 Nov 28.

35.

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

Lichtenegger M, Stockner T, Poteser M, Schleifer H, Platzer D, Romanin C, Groschner K.

Cell Calcium. 2013 Sep;54(3):175-85. doi: 10.1016/j.ceca.2013.05.010. Epub 2013 Jun 22.

36.

Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate.

Buchmayer F, Schicker K, Steinkellner T, Geier P, Stübiger G, Hamilton PJ, Jurik A, Stockner T, Yang JW, Montgomery T, Holy M, Hofmaier T, Kudlacek O, Matthies HJ, Ecker GF, Bochkov V, Galli A, Boehm S, Sitte HH.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11642-7. doi: 10.1073/pnas.1220552110. Epub 2013 Jun 24.

37.

Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model.

Stockner T, Montgomery TR, Kudlacek O, Weissensteiner R, Ecker GF, Freissmuth M, Sitte HH.

PLoS Comput Biol. 2013;9(2):e1002909. doi: 10.1371/journal.pcbi.1002909. Epub 2013 Feb 21.

38.

Insights into the molecular evolution of oxytocin receptor ligand binding.

Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW.

Biochem Soc Trans. 2013 Feb 1;41(1):197-204. doi: 10.1042/BST20120256. Review.

39.

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.

Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M.

J Biol Chem. 2013 Feb 22;288(8):5330-41. doi: 10.1074/jbc.M112.408237. Epub 2013 Jan 3.

40.

What can naturally occurring mutations tell us about Ca(v)1.x channel function?

Stockner T, Koschak A.

Biochim Biophys Acta. 2013 Jul;1828(7):1598-607. doi: 10.1016/j.bbamem.2012.11.026. Epub 2012 Dec 4. Review.

41.

Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain.

Zayats V, Samad A, Minofar B, Roelofs KE, Stockner T, Ettrich R.

J Mol Model. 2013 Nov;19(11):4689-700. doi: 10.1007/s00894-012-1505-1. Epub 2012 Jul 3.

PMID:
22752543
42.

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters.

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 May 25;287(22):18524-34. doi: 10.1074/jbc.M112.343681. Epub 2012 Mar 26.

43.

Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting.

Singer J, Weichselbaumer M, Stockner T, Mechtcheriakova D, Sobanov Y, Bajna E, Wrba F, Horvat R, Thalhammer JG, Willmann M, Jensen-Jarolim E.

Mol Immunol. 2012 Apr;50(4):200-9. doi: 10.1016/j.molimm.2012.01.002.

44.

Unifying concept of serotonin transporter-associated currents.

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W.

J Biol Chem. 2012 Jan 2;287(1):438-45. doi: 10.1074/jbc.M111.304261. Epub 2011 Nov 9.

45.

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes.

Poteser M, Schleifer H, Lichtenegger M, Schernthaner M, Stockner T, Kappe CO, Glasnov TN, Romanin C, Groschner K.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10556-61. doi: 10.1073/pnas.1106183108. Epub 2011 Jun 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13876-8.

46.

Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery.

Strawn R, Stockner T, Melichercik M, Jin L, Xue WF, Carey J, Ettrich R.

Methods Enzymol. 2011;492:151-88. doi: 10.1016/B978-0-12-381268-1.00017-3.

PMID:
21333791
47.

Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein.

Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P.

Mol Pharmacol. 2011 Mar;79(3):443-52. doi: 10.1124/mol.110.067611. Epub 2010 Dec 21.

48.

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.

Plochberger B, Stockner T, Chiantia S, Brameshuber M, Weghuber J, Hermetter A, Schwille P, Schütz GJ.

Langmuir. 2010 Nov 16;26(22):17322-9. doi: 10.1021/la1026202. Epub 2010 Oct 13.

49.

Solution structure and membrane binding of the toxin fst of the par addiction module.

Göbl C, Kosol S, Stockner T, Rückert HM, Zangger K.

Biochemistry. 2010 Aug 10;49(31):6567-75. doi: 10.1021/bi1005128.

50.

Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein.

Klepsch F, Stockner T, Erker T, Müller M, Chiba P, Ecker GF.

Curr Top Med Chem. 2010;10(17):1769-74. Review.

PMID:
20645918

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