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Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P Jr, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M.

Cell Stem Cell. 2019 Oct 3;25(4):531-541.e6. doi: 10.1016/j.stem.2019.09.003.


A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.


Neuronal vulnerability and multilineage diversity in multiple sclerosis.

Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH.

Nature. 2019 Sep;573(7772):75-82. doi: 10.1038/s41586-019-1404-z. Epub 2019 Jul 17.


A Novel, non-invasive Test Enabling Bladder Cancer Detection in Urine Sediment of Patients Presenting with Haematuria-A Prospective Multicentre Performance Evaluation of ADXBLADDER.

Dudderidge T, Stockley J, Nabi G, Mom J, Umez-Eronini N, Hrouda D, Cresswell J, McCracken SRC.

Eur Urol Oncol. 2020 Feb;3(1):42-46. doi: 10.1016/j.euo.2019.06.006. Epub 2019 Jul 13.


New Recipes for Myelinating Oligodendrocytes.

Nobuta H, Stockley JH, Rowitch DH.

Cell Stem Cell. 2018 Oct 4;23(4):464-465. doi: 10.1016/j.stem.2018.09.011.


Infection and wound breakdown in spontaneous second-degree perineal tears: An exploratory mixed methods study.

Wiseman O, Rafferty AM, Stockley J, Murrells T, Bick D.

Birth. 2019 Mar;46(1):80-89. doi: 10.1111/birt.12389. Epub 2018 Aug 22.


Small airways disease: time for a revisit?

Stockley JA, Cooper BG, Stockley RA, Sapey E.

Int J Chron Obstruct Pulmon Dis. 2017 Aug 7;12:2343-2353. doi: 10.2147/COPD.S138540. eCollection 2017. Review.


Surpassing light-induced cell damage in vitro with novel cell culture media.

Stockley JH, Evans K, Matthey M, Volbracht K, Agathou S, Mukanowa J, Burrone J, Káradóttir RT.

Sci Rep. 2017 Apr 12;7(1):849. doi: 10.1038/s41598-017-00829-x.


Maximal mid-expiratory flow detects early lung disease in α1-antitrypsin deficiency.

Stockley JA, Ismail AM, Hughes SM, Edgar R, Stockley RA, Sapey E.

Eur Respir J. 2017 Mar 29;49(3). pii: 1602055. doi: 10.1183/13993003.02055-2016. Print 2017 Mar.


Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD?

Walton GM, Stockley JA, Griffiths D, Sadhra CS, Purvis T, Sapey E.

J Clin Med. 2016 Oct 11;5(10). pii: E89. Review.


Pulmonary Physiology of Chronic Obstructive Pulmonary Disease, Cystic Fibrosis, and Alpha-1 Antitrypsin Deficiency.

Stockley JA, Stockley RA.

Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S118-22. doi: 10.1513/AnnalsATS.201504-224KV.


Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.

Stockley J, Nisar SP, Leo VC, Sabi E, Cunningham MR, Eikenboom JC, Lethagen S, Schneppenheim R, Goodeve AC, Watson SP, Mundell SJ, Daly ME; GAPP Study in Collaboration with the MCMDM-1VWD Study Group.

PLoS One. 2015 Dec 2;10(12):e0143913. doi: 10.1371/journal.pone.0143913. eCollection 2015.


The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.

Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J, Leung HY, Rajan P.

Sci Rep. 2015 Aug 27;5:13426. doi: 10.1038/srep13426.


Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination.

Zhao C, Ma D, Zawadzka M, Fancy SP, Elis-Williams L, Bouvier G, Stockley JH, de Castro GM, Wang B, Jacobs S, Casaccia P, Franklin RJ.

J Neurosci. 2015 Aug 19;35(33):11482-99. doi: 10.1523/JNEUROSCI.3655-14.2015. Erratum in: J Neurosci. 2017 Sep 20;37(38):9345.


Feasibility study of a randomized controlled trial comparing docetaxel chemotherapy and androgen deprivation therapy with sequential prostatic biopsies from patients with advanced non-castration-resistant prostate cancer.

Rajan P, Frew JA, Wilson JM, Azzabi AS, McMenemin RM, Stockley J, Soomro NA, Durkan G, Pedley ID, Leung HY.

Urol Oncol. 2015 Aug;33(8):337.e1-6. doi: 10.1016/j.urolonc.2015.05.012. Epub 2015 Jun 16.


Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.

Rajan P, Stockley J, Sudbery IM, Fleming JT, Hedley A, Kalna G, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY.

BMC Cancer. 2014 Dec 18;14:977. doi: 10.1186/1471-2407-14-977.


The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.

Wade MA, Jones D, Wilson L, Stockley J, Coffey K, Robson CN, Gaughan L.

Nucleic Acids Res. 2015 Jan;43(1):196-207. doi: 10.1093/nar/gku1298. Epub 2014 Dec 8.


The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer.

Stockley J, Villasevil ME, Nixon C, Ahmad I, Leung HY, Rajan P.

RNA Biol. 2014;11(6):755-65. Epub 2014 Apr 24.


Oligodendrocyte progenitors: adult stem cells of the central nervous system?

Crawford AH, Stockley JH, Tripathi RB, Richardson WD, Franklin RJ.

Exp Neurol. 2014 Oct;260:50-5. doi: 10.1016/j.expneurol.2014.04.027. Epub 2014 May 5. Review.


A novel mutation in the P2Y12 receptor and a function-reducing polymorphism in protease-activated receptor 1 in a patient with chronic bleeding.

Patel YM, Lordkipanidzé M, Lowe GC, Nisar SP, Garner K, Stockley J, Daly ME, Mitchell M, Watson SP, Austin SK, Mundell SJ.

J Thromb Haemost. 2014 May;12(5):716-25. doi: 10.1111/jth.12539.


Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ; Charles Ffrench-Constant, Attwell D, Káradóttir RT.

PLoS Biol. 2013 Dec;11(12):e1001743. doi: 10.1371/journal.pbio.1001743. Epub 2013 Dec 31.


We must use antibiotics wisely to maintain their effectiveness.

Stockley J.

Nurs Times. 2013 Nov 13-19;109(45):11. No abstract available.


Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression.

Laguerre M, Sabi E, Daly M, Stockley J, Nurden P, Pillois X, Nurden AT.

PLoS One. 2013 Nov 13;8(11):e78683. doi: 10.1371/journal.pone.0078683. eCollection 2013.


Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects.

Stockley J, Morgan NV, Bem D, Lowe GC, Lordkipanidzé M, Dawood B, Simpson MA, Macfarlane K, Horner K, Leo VC, Talks K, Motwani J, Wilde JT, Collins PW, Makris M, Watson SP, Daly ME; UK Genotyping and Phenotyping of Platelets Study Group.

Blood. 2013 Dec 12;122(25):4090-3. doi: 10.1182/blood-2013-06-506873. Epub 2013 Oct 7.


Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target.

Stockley JA, Walton GM, Lord JM, Sapey E.

Int Immunopharmacol. 2013 Dec;17(4):1211-7. doi: 10.1016/j.intimp.2013.05.035. Epub 2013 Aug 27. Review.


KDM4B is a master regulator of the estrogen receptor signalling cascade.

Gaughan L, Stockley J, Coffey K, O'Neill D, Jones DL, Wade M, Wright J, Moore M, Tse S, Rogerson L, Robson CN.

Nucleic Acids Res. 2013 Aug;41(14):6892-904. doi: 10.1093/nar/gkt469. Epub 2013 May 30.


The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.

Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN.

Nucleic Acids Res. 2013 Apr;41(8):4433-46. doi: 10.1093/nar/gkt106. Epub 2013 Feb 21.


Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies.

Holme J, Stockley JA, Stockley RA.

Respir Med. 2013 Mar;107(3):387-93. doi: 10.1016/j.rmed.2012.12.003. Epub 2012 Dec 29.


European Antibiotic Awareness Day 2012: getting smart about antibiotics, a public-professional partnership.

Stockley JM.

J Infect. 2012 Nov;65(5):377-9. doi: 10.1016/j.jinf.2012.08.017. Epub 2012 Sep 4.


Deconstructing myelination: it all comes down to size.

Káradóttir RT, Stockley JH.

Nat Methods. 2012 Sep;9(9):883-4. doi: 10.1038/nmeth.2145. No abstract available.


BIA position paper on Lyme borreliosis is evidence based.

Cowling P, Stockley J, Moss P, Miller A.

BMJ. 2012 Aug 21;345:e5364. doi: 10.1136/bmj.e5364. No abstract available.


Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells?

Bennett HL, Stockley J, Fleming JT, Mandal R, O'Prey J, Ryan KM, Robson CN, Leung HY.

BJU Int. 2013 Apr;111(4):672-82. doi: 10.1111/j.1464-410X.2012.11409.x. Epub 2012 Aug 16.


Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ.

PLoS One. 2011;6(12):e29088. doi: 10.1371/journal.pone.0029088. Epub 2011 Dec 14.


Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.

Sapey E, Stockley JA, Greenwood H, Ahmad A, Bayley D, Lord JM, Insall RH, Stockley RA.

Am J Respir Crit Care Med. 2011 May 1;183(9):1176-86. doi: 10.1164/rccm.201008-1285OC. Epub 2011 Jan 21.


Regulation of the androgen receptor by SET9-mediated methylation.

Gaughan L, Stockley J, Wang N, McCracken SR, Treumann A, Armstrong K, Shaheen F, Watt K, McEwan IJ, Wang C, Pestell RG, Robson CN.

Nucleic Acids Res. 2011 Mar;39(4):1266-79. doi: 10.1093/nar/gkq861. Epub 2010 Oct 19. Erratum in: Nucleic Acids Res. 2013 Jul;41(13):6783.


European Antibiotic Awareness Day 2010: why doesn't promoting antibiotic awareness always work?

Stockley JM.

J Infect. 2010 Nov;61(5):361-3. doi: 10.1016/j.jinf.2010.09.003. Epub 2010 Sep 17. No abstract available.


Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition.

Wiltshire C, Singh BL, Stockley J, Fleming J, Doyle B, Barnetson R, Robson CN, Kozielski F, Leung HY.

Mol Cancer Ther. 2010 Jun;9(6):1730-9. doi: 10.1158/1535-7163.MCT-09-1103. Epub 2010 Jun 1.


Fever in returned travellers presenting in the United Kingdom: recommendations for investigation and initial management.

Johnston V, Stockley JM, Dockrell D, Warrell D, Bailey R, Pasvol G, Klein J, Ustianowski A, Jones M, Beeching NJ, Brown M, Chapman AL, Sanderson F, Whitty CJ; British Infection Society and the Hospital for Tropical Diseases.

J Infect. 2009 Jul;59(1):1-18. doi: 10.1016/j.jinf.2009.05.005. Epub 2009 May 27.


Rate of progression of lung function impairment in alpha1-antitrypsin deficiency.

Dawkins PA, Dawkins CL, Wood AM, Nightingale PG, Stockley JA, Stockley RA.

Eur Respir J. 2009 Jun;33(6):1338-44. doi: 10.1183/09031936.00061208. Epub 2009 Jan 22.


Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease.

Stockley JH, O'Neill C.

Cell Mol Life Sci. 2008 Oct;65(20):3265-89. doi: 10.1007/s00018-008-8271-3. Review.


Fabry Perot etalon with polymer cholesteric liquid-crystal mirrors.

Stockley JE, Sharp GD, Johnson KM.

Opt Lett. 1999 Jan 1;24(1):55-7.


Expression of GnRH type II is regulated by the androgen receptor in prostate cancer.

Darby S, Stockley J, Khan MM, Robson CN, Leung HY, Gnanapragasam VJ.

Endocr Relat Cancer. 2007 Sep;14(3):613-24.


The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

Stockley JH, O'Neill C.

Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. Review.


Therapy myths.

Stockley J.

Br Dent J. 2007 May 12;202(9):508. No abstract available.


Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.

Stockley JH, Ravid R, O'Neill C.

FEBS Lett. 2006 Dec 11;580(28-29):6550-60. Epub 2006 Nov 13.


Building new hospitals: a UK infection control perspective.

Stockley JM, Constantine CE, Orr KE; Association Of Medical Microbiologists' New Hospital Developments Project Group.

J Hosp Infect. 2006 Mar;62(3):285-99. Epub 2005 Dec 6.


Analog optical phase modulator based on chiral smectic and polymer cholesteric liquid crystals.

Stockley JE, Sharp GD, Serati SA, Johnson KM.

Opt Lett. 1995 Dec 1;20(23):2441. No abstract available.


High-speed analog achromatic intensity modulator.

Stockley JE, Sharp GD, Doroski D, Johnson KM.

Opt Lett. 1994 May 15;19(10):758-60.


Nurses work. Catching the first post.

Stockley J.

Nurs Stand. 1993 Feb 17-23;7(22):22-3. No abstract available.


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