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Items: 23


Regulation of regulatory T cells in cancer.

Stockis J, Roychoudhuri R, Halim TYF.

Immunology. 2019 Jul;157(3):219-231. doi: 10.1111/imm.13064. Epub 2019 May 22. Review.


Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.

Liénart S, Merceron R, Vanderaa C, Lambert F, Colau D, Stockis J, van der Woning B, De Haard H, Saunders M, Coulie PG, Savvides SN, Lucas S.

Science. 2018 Nov 23;362(6417):952-956. doi: 10.1126/science.aau2909. Epub 2018 Oct 25.


Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.

Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10161-E10168. doi: 10.1073/pnas.1710680114. Epub 2017 Nov 6.


Role of GARP in the activation of latent TGF-β1.

Stockis J, Dedobbeleer O, Lucas S.

Mol Biosyst. 2017 Sep 26;13(10):1925-1935. doi: 10.1039/c7mb00251c. Review.


Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA.

Dedobbeleer O, Stockis J, van der Woning B, Coulie PG, Lucas S.

J Immunol. 2017 Jul 15;199(2):391-396. doi: 10.4049/jimmunol.1601882. Epub 2017 Jun 12.


Targeting immunosuppression by Tregs with monoclonal antibodies against GARP.

Liénart S, Stockis J, Dedobbeleer O, Lucas S.

Oncoimmunology. 2016 Feb 23;5(3):e1074379. eCollection 2016 Mar.


Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.

Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie PG, Lucas S.

J Biol Chem. 2015 Aug 14;290(33):20105-16. doi: 10.1074/jbc.M115.655340. Epub 2015 Jun 30.


Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.

Cuende J, Liénart S, Dedobbeleer O, van der Woning B, De Boeck G, Stockis J, Huygens C, Colau D, Somja J, Delvenne P, Hannon M, Baron F, Dumoutier L, Renauld JC, De Haard H, Saunders M, Coulie PG, Lucas S.

Sci Transl Med. 2015 Apr 22;7(284):284ra56. doi: 10.1126/scitranslmed.aaa1983.


PDGF-D expression is down-regulated by TGFβ in fibroblasts.

Charni Chaabane S, Coomans de Brachène A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB.

PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014.


Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells.

Valenzuela M, Glorieux C, Stockis J, Sid B, Sandoval JM, Felipe KB, Kviecinski MR, Verrax J, Buc Calderon P.

Br J Cancer. 2014 Aug 26;111(5):874-82. doi: 10.1038/bjc.2014.380. Epub 2014 Jul 8.


GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.

Gauthy E, Cuende J, Stockis J, Huygens C, Lethé B, Collet JF, Bommer G, Coulie PG, Lucas S.

PLoS One. 2013 Sep 30;8(9):e76186. doi: 10.1371/journal.pone.0076186. eCollection 2013.


Isomerizing olefin metathesis as a strategy to access defined distributions of unsaturated compounds from fatty acids.

Ohlmann DM, Tschauder N, Stockis JP, Goossen K, Dierker M, Goossen LJ.

J Am Chem Soc. 2012 Aug 22;134(33):13716-29. doi: 10.1021/ja303822c. Epub 2012 Aug 9.


Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors.

Diepart C, Karroum O, Magat J, Feron O, Verrax J, Calderon PB, Grégoire V, Leveque P, Stockis J, Dauguet N, Jordan BF, Gallez B.

Cancer Res. 2012 Jan 15;72(2):482-90. doi: 10.1158/0008-5472.CAN-11-1755. Epub 2011 Dec 2.


Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: results from an intervention study.

Bakuradze T, Boehm N, Janzowski C, Lang R, Hofmann T, Stockis JP, Albert FW, Stiebitz H, Bytof G, Lantz I, Baum M, Eisenbrand G.

Mol Nutr Food Res. 2011 May;55(5):793-7. doi: 10.1002/mnfr.201100093. Epub 2011 Apr 4.


Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents.

de Vries IJ, Castelli C, Huygens C, Jacobs JF, Stockis J, Schuler-Thurner B, Adema GJ, Punt CJ, Rivoltini L, Schuler G, Coulie PG, Lucas S.

Clin Cancer Res. 2011 Feb 15;17(4):841-8. doi: 10.1158/1078-0432.CCR-10-2227. Epub 2010 Dec 21.


Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.

Stockis J, Colau D, Coulie PG, Lucas S.

Eur J Immunol. 2009 Dec;39(12):3315-22. doi: 10.1002/eji.200939684.


The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.

François V, Ottaviani S, Renkvist N, Stockis J, Schuler G, Thielemans K, Colau D, Marchand M, Boon T, Lucas S, van der Bruggen P.

Cancer Res. 2009 May 15;69(10):4335-45. doi: 10.1158/0008-5472.CAN-08-3726. Epub 2009 May 12.


Comparison of stable human Treg and Th clones by transcriptional profiling.

Stockis J, Fink W, François V, Connerotte T, de Smet C, Knoops L, van der Bruggen P, Boon T, Coulie PG, Lucas S.

Eur J Immunol. 2009 Mar;39(3):869-82. doi: 10.1002/eji.200838807.


Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis.

Spormann TM, Albert FW, Rath T, Dietrich H, Will F, Stockis JP, Eisenbrand G, Janzowski C.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3372-80. doi: 10.1158/1055-9965.EPI-08-0364.


An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands.

Weisel T, Baum M, Eisenbrand G, Dietrich H, Will F, Stockis JP, Kulling S, Rüfer C, Johannes C, Janzowski C.

Biotechnol J. 2006 Apr;1(4):388-97.


Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

Verrax J, Stockis J, Tison A, Taper HS, Calderon PB.

Biochem Pharmacol. 2006 Sep 14;72(6):671-80. Epub 2006 Jul 7.


Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients.

Müller C, Eisenbrand G, Gradinger M, Rath T, Albert FW, Vienken J, Singh R, Farmer PB, Stockis JP, Janzowski C.

Free Radic Res. 2004 Oct;38(10):1093-100.


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