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Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.

Yan R, Zhang J, Park HJ, Park ES, Oh S, Zheng H, Junn E, Voronkov M, Stock JB, Mouradian MM.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12053-E12062. doi: 10.1073/pnas.1813365115. Epub 2018 Dec 3.


SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated.

Fernández JR, Webb C, Rouzard K, Voronkov M, Huber KL, Stock JB, Healy J, Tamura M, Stock M, Armbrister W, Gordon JS, Pérez E.

J Cosmet Dermatol. 2018 Nov 19. doi: 10.1111/jocd.12825. [Epub ahead of print]


SIG1459: A novel phytyl-cysteine derived TLR2 modulator with in vitro and clinical anti-acne activity.

Fernández JR, Webb C, Rouzard K, Healy J, Tamura M, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Pérez E.

Exp Dermatol. 2018 Sep;27(9):993-999. doi: 10.1111/exd.13692. Epub 2018 Jul 25.


Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease.

Park HJ, Lee KW, Oh S, Yan R, Zhang J, Beach TG, Adler CH, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.

J Neuropathol Exp Neurol. 2018 Feb 1;77(2):139-148. doi: 10.1093/jnen/nlx110.


Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.

Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE.

PLoS One. 2017 Dec 18;12(12):e0189413. doi: 10.1371/journal.pone.0189413. eCollection 2017.


N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes.

Fernández JR, Webb C, Rouzard K, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Perez E.

Arch Dermatol Res. 2017 Mar;309(2):103-110. doi: 10.1007/s00403-016-1708-x. Epub 2016 Dec 17.


Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies.

Park HJ, Lee KW, Park ES, Oh S, Yan R, Zhang J, Beach TG, Adler CH, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.

Ann Clin Transl Neurol. 2016 Sep 7;3(10):769-780. eCollection 2016 Oct.


In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities.

Fernández JR, Rouzard K, Voronkov M, Huber KL, Webb C, Stock JB, Stock M, Gordon JS, Pérez E.

J Cosmet Dermatol. 2016 Jun;15(2):150-7. doi: 10.1111/jocd.12206. Epub 2016 Jan 11.


Anti-inflammatory and anti-bacterial properties of tetramethylhexadecenyl succinyl cysteine (TSC): a skin-protecting cosmetic functional ingredient.

Fernandéz JR, Rouzard K, Voronkov M, Huber KL, Stock JB, Stock M, Gordon JS, Pérez E.

Int J Cosmet Sci. 2015 Feb;37(1):129-33. doi: 10.1111/ics.12166. Epub 2014 Oct 22.


Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.

Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K.

Neurobiol Aging. 2014 Dec;35(12):2701-2712. doi: 10.1016/j.neurobiolaging.2014.06.012. Epub 2014 Jun 17.


The biochemistry of memory.

Stock JB, Zhang S.

Curr Biol. 2013 Sep 9;23(17):R741-5. doi: 10.1016/j.cub.2013.08.011.


Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease.

Lee KW, Im JY, Woo JM, Grosso H, Kim YS, Cristovao AC, Sonsalla PK, Schuster DS, Jalbut MM, Fernandez JR, Voronkov M, Junn E, Braithwaite SP, Stock JB, Mouradian MM.

Neurotherapeutics. 2013 Jan;10(1):143-53. doi: 10.1007/s13311-012-0165-2.


SIG1273: a new cosmetic functional ingredient to reduce blemishes and Propionibacterium acnes in acne prone skin.

Fernandéz JR, Rouzard K, Voronkov M, Feng X, Stock JB, Stock M, Gordon JS, Shroot B, Christensen MS, Pérez E.

J Cosmet Dermatol. 2012 Dec;11(4):272-8. doi: 10.1111/jocd.12002.


α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.

Braithwaite SP, Stock JB, Mouradian MM.

Rev Neurosci. 2012 Mar 21;23(2):191-8. doi: 10.1515/revneuro-2011-0067. Review.


Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson's disease.

Braithwaite SP, Voronkov M, Stock JB, Mouradian MM.

Neurochem Int. 2012 Nov;61(6):899-906. doi: 10.1016/j.neuint.2012.01.031. Epub 2012 Feb 8. Review.


Protein phosphatases and Alzheimer's disease.

Braithwaite SP, Stock JB, Lombroso PJ, Nairn AC.

Prog Mol Biol Transl Sci. 2012;106:343-79. doi: 10.1016/B978-0-12-396456-4.00012-2. Review.


Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease.

Voronkov M, Braithwaite SP, Stock JB.

Future Med Chem. 2011 May;3(7):821-33. doi: 10.4155/fmc.11.47. Review.


Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model.

Lee KW, Chen W, Junn E, Im JY, Grosso H, Sonsalla PK, Feng X, Ray N, Fernandez JR, Chao Y, Masliah E, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.

J Neurosci. 2011 May 11;31(19):6963-71. doi: 10.1523/JNEUROSCI.6513-10.2011.


Protein carboxyl methylation and the biochemistry of memory.

Li Z, Stock JB.

Biol Chem. 2009 Nov;390(11):1087-96. doi: 10.1515/BC.2009.133. Review.


Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.

Cell. 2008 Apr 4;133(1):154-63. doi: 10.1016/j.cell.2008.02.041.


Signal transduction: networks and integrated circuits in bacterial cognition.

Baker MD, Stock JB.

Curr Biol. 2007 Dec 4;17(23):R1021-4.


Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.

Gordon JS, Wolanin PM, Gonzalez AV, Fela DA, Sarngadharan G, Rouzard K, Perez E, Stock JB, Stock MB.

J Invest Dermatol. 2008 Mar;128(3):643-54. Epub 2007 Sep 20.


Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum.

Chen Y, McQuade KJ, Guan XJ, Thomason PA, Wert MS, Stock JB, Cox EC.

Mol Biol Cell. 2007 Oct;18(10):4106-18. Epub 2007 Aug 15.


Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.

Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y.

Nat Struct Mol Biol. 2007 Jun;14(6):527-34. Epub 2007 May 27.


Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.

Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y.

Cell. 2006 Oct 20;127(2):341-53.


Self-assembly of receptor/signaling complexes in bacterial chemotaxis.

Wolanin PM, Baker MD, Francis NR, Thomas DR, DeRosier DJ, Stock JB.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14313-8. Epub 2006 Sep 14.


Structure and mechanism of the phosphotyrosyl phosphatase activator.

Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y.

Mol Cell. 2006 Aug;23(4):535-46.


Systems biology of bacterial chemotaxis.

Baker MD, Wolanin PM, Stock JB.

Curr Opin Microbiol. 2006 Apr;9(2):187-92. Epub 2006 Mar 9. Review.


The histidine kinase homologue DhkK/Sombrero controls morphogenesis in Dictyostelium.

Thomason PA, Sawai S, Stock JB, Cox EC.

Dev Biol. 2006 Apr 15;292(2):358-70. Epub 2006 Feb 13.


Signal transduction in bacterial chemotaxis.

Baker MD, Wolanin PM, Stock JB.

Bioessays. 2006 Jan;28(1):9-22. Review.


Three-dimensional structure and organization of a receptor/signaling complex.

Francis NR, Wolanin PM, Stock JB, Derosier DJ, Thomas DR.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17480-5. Epub 2004 Nov 30.


Modulated receptor interactions in bacterial transmembrane signaling.

Webre DJ, Wolanin PM, Stock JB.

Trends Cell Biol. 2004 Sep;14(9):478-82. Review.


Bacterial chemosensing: cooperative molecular logic.

Wolanin PM, Stock JB.

Curr Biol. 2004 Jun 22;14(12):R486-7. Review.


Mechanism of phosphatase activity in the chemotaxis response regulator CheY.

Wolanin PM, Webre DJ, Stock JB.

Biochemistry. 2003 Dec 2;42(47):14075-82.


Influence of topology on bacterial social interaction.

Park S, Wolanin PM, Yuzbashyan EA, Lin H, Darnton NC, Stock JB, Silberzan P, Austin R.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13910-5. Epub 2003 Nov 17.


Motion to form a quorum.

Park S, Wolanin PM, Yuzbashyan EA, Silberzan P, Stock JB, Austin RH.

Science. 2003 Jul 11;301(5630):188. No abstract available.


Intramolecular rearrangements as a consequence of the dephosphorylation of phosphoaspartate residues in proteins.

Napper S, Wolanin PM, Webre DJ, Kindrachuk J, Waygood B, Stock JB.

FEBS Lett. 2003 Mar 13;538(1-3):77-80.


Bacterial chemotaxis.

Webre DJ, Wolanin PM, Stock JB.

Curr Biol. 2003 Jan 21;13(2):R47-9. No abstract available.


Histidine protein kinases: key signal transducers outside the animal kingdom.

Wolanin PM, Thomason PA, Stock JB.

Genome Biol. 2002 Sep 25;3(10):REVIEWS3013. Epub 2002 Sep 25. Review.


Receptor methylation controls the magnitude of stimulus-response coupling in bacterial chemotaxis.

Levit MN, Stock JB.

J Biol Chem. 2002 Sep 27;277(39):36760-5. Epub 2002 Jul 15.


Subunit organization in a soluble complex of tar, CheW, and CheA by electron microscopy.

Francis NR, Levit MN, Shaikh TR, Melanson LA, Stock JB, DeRosier DJ.

J Biol Chem. 2002 Sep 27;277(39):36755-9. Epub 2002 Jul 15.


Organization of the receptor-kinase signaling array that regulates Escherichia coli chemotaxis.

Levit MN, Grebe TW, Stock JB.

J Biol Chem. 2002 Sep 27;277(39):36748-54. Epub 2002 Jul 15.


Signal transduction: receptor clusters as information processing arrays.

Thomason PA, Wolanin PM, Stock JB.

Curr Biol. 2002 Jun 4;12(11):R399-401. Review.


Information processing in bacterial chemotaxis.

Stock JB, Levit MN, Wolanin PM.

Sci STKE. 2002 May 14;2002(132):pe25. Review.


Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA.

Levit MN, Abramczyk BM, Stock JB, Postel EH.

J Biol Chem. 2002 Feb 15;277(7):5163-7. Epub 2001 Dec 12.


Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis.

Mourey L, Da Re S, Pédelacq JD, Tolstykh T, Faurie C, Guillet V, Stock JB, Samama JP.

J Biol Chem. 2001 Aug 17;276(33):31074-82. Epub 2001 May 31.


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