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Items: 1 to 50 of 162

1.

Vascular regeneration for ischemic retinopathies: Hope from cell therapies.

Bertelli PM, Pedrini E, Guduric-Fuchs J, Peixoto E, Pathak V, Stitt AW, Medina RJ.

Curr Eye Res. 2019 Oct 14. doi: 10.1080/02713683.2019.1681004. [Epub ahead of print]

PMID:
31609636
2.

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis.

O'Leary C, McGahon MK, Ashraf S, McNaughten J, Friedel T, Cincolà P, Barabas P, Fernandez JA, Stitt AW, McGeown JG, Curtis TM.

Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3297-3309. doi: 10.1167/iovs.18-26344.

PMID:
31369032
3.

The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy.

Caines R, Cochrane A, Kelaini S, Vila-Gonzalez M, Yang C, Eleftheriadou M, Moez A, Stitt AW, Zeng L, Grieve DJ, Margariti A.

J Cell Sci. 2019 Aug 15;132(16). pii: jcs230276. doi: 10.1242/jcs.230276.

PMID:
31331967
4.

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina.

Carroll LS, Uehara H, Fang D, Choi S, Zhang X, Singh M, Sandhu Z, Cummins PM, Curtis TM, Stitt AW, Archer BJ, Ambati BK.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2494-2502. doi: 10.1167/iovs.18-26182.

5.

The Placental Growth Factor Pathway and Its Potential Role in Macular Degenerative Disease.

Cunningham F, Van Bergen T, Canning P, Lengyel I, Feyen JHM, Stitt AW.

Curr Eye Res. 2019 Aug;44(8):813-822. doi: 10.1080/02713683.2019.1614197. Epub 2019 May 24.

PMID:
31055948
6.

Attenuating Diabetic Vascular and Neuronal Defects by Targeting P2rx7.

Pavlou S, Augustine J, Cunning R, Harkin K, Stitt AW, Xu H, Chen M.

Int J Mol Sci. 2019 Apr 29;20(9). pii: E2101. doi: 10.3390/ijms20092101.

7.

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation.

O'Neill KM, Campbell DC, Edgar KS, Gill EK, Moez A, McLoughlin KJ, O'Neill CL, Dellett M, Hargey CJ, Abudalo RA, O'Hare M, Doyle P, Toh T, Khoo J, Wong J, McCrudden CM, Meloni M, Brunssen C, Morawietz H, Yoder MC, McDonald DM, Watson CJ, Stitt AW, Margariti A, Medina RJ, Grieve DJ.

Cardiovasc Res. 2019 Apr 1. pii: cvz090. doi: 10.1093/cvr/cvz090. [Epub ahead of print]

PMID:
30937452
8.

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.

O'Leary OE, Canning P, Reid E, Bertelli PM, McKeown S, Brines M, Cerami A, Du X, Xu H, Chen M, Dutton L, Brazil DP, Medina RJ, Stitt AW.

Exp Eye Res. 2019 May;182:144-155. doi: 10.1016/j.exer.2019.03.001. Epub 2019 Mar 12.

PMID:
30876881
9.

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularization.

Ashraf S, Bell S, O'Leary C, Canning P, Micu I, Fernandez JA, O'Hare M, Barabas P, McCauley H, Brazil DP, Stitt AW, McGeown JG, Curtis TM.

JCI Insight. 2019 Mar 21;4(6). pii: 122442. doi: 10.1172/jci.insight.122442. eCollection 2019 Mar 21.

10.

The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies.

O'Neill CL, McLoughlin KJ, Chambers SEJ, Guduric-Fuchs J, Stitt AW, Medina RJ.

Front Med (Lausanne). 2018 Oct 16;5:273. doi: 10.3389/fmed.2018.00273. eCollection 2018. Review.

11.

The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases.

Van Bergen T, Etienne I, Cunningham F, Moons L, Schlingemann RO, Feyen JHM, Stitt AW.

Prog Retin Eye Res. 2019 Mar;69:116-136. doi: 10.1016/j.preteyeres.2018.10.006. Epub 2018 Oct 30. Review.

PMID:
30385175
12.

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling.

Vilà-González M, Kelaini S, Magee C, Caines R, Campbell D, Eleftheriadou M, Cochrane A, Drehmer D, Tsifaki M, O'Neill K, Pedrini E, Yang C, Medina R, McDonald D, Simpson D, Zampetaki A, Zeng L, Grieve D, Lois N, Stitt AW, Margariti A.

Stem Cells. 2019 Feb;37(2):226-239. doi: 10.1002/stem.2936. Epub 2018 Nov 17.

13.

Neurodegeneration in diabetic retinopathy: does it really matter?

Simó R, Stitt AW, Gardner TW.

Diabetologia. 2018 Sep;61(9):1902-1912. doi: 10.1007/s00125-018-4692-1. Epub 2018 Jul 20. Review.

14.

Follistatin-Like 3 Enhances the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Facilitating β-Catenin Nuclear Translocation Through Inhibition of Glycogen Synthase Kinase-3β Activity.

Kelaini S, Vilà-González M, Caines R, Campbell D, Eleftheriadou M, Tsifaki M, Magee C, Cochrane A, O'neill K, Yang C, Stitt AW, Zeng L, Grieve DJ, Margariti A.

Stem Cells. 2018 Jul;36(7):1033-1044. doi: 10.1002/stem.2820. Epub 2018 Apr 10.

15.

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β.

Chambers SEJ, O'Neill CL, Guduric-Fuchs J, McLoughlin KJ, Liew A, Egan AM, O'Brien T, Stitt AW, Medina RJ.

Stem Cells. 2018 Jun;36(6):834-843. doi: 10.1002/stem.2810. Epub 2018 Mar 9.

16.

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Greenwood J, Hammarlund-Udenaes M, Jones HC, Stitt AW, Vandenbroucke RE, Romero IA, Campbell M, Fricker G, Brodin B, Manninga H, Gaillard PJ, Schwaninger M, Webster C, Wicher KB, Khrestchatisky M.

Fluids Barriers CNS. 2018 Jan 12;15(1):3. doi: 10.1186/s12987-017-0086-x.

17.

Animal Models of Retinal Vein Occlusion.

Khayat M, Lois N, Williams M, Stitt AW.

Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6175-6192. doi: 10.1167/iovs.17-22788. Review.

PMID:
29222552
18.

Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies.

Reid E, Guduric-Fuchs J, O'Neill CL, Allen LD, Chambers SEJ, Stitt AW, Medina RJ.

Stem Cells Transl Med. 2018 Jan;7(1):59-67. doi: 10.1002/sctm.17-0187. Epub 2017 Nov 22.

19.

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Greenwood J, Hammarlund-Udenaes M, Jones HC, Stitt AW, Vandenbroucke RE, Romero IA, Campbell M, Fricker G, Brodin B, Manninga H, Gaillard PJ, Schwaninger M, Webster C, Wicher KB, Khrestchatisky M.

Fluids Barriers CNS. 2017 Nov 7;14(1):31. doi: 10.1186/s12987-017-0079-9. Erratum in: Fluids Barriers CNS. 2018 Jan 12;15(1):3.

20.

Diabetic retinopathy: current understanding, mechanisms, and treatment strategies.

Duh EJ, Sun JK, Stitt AW.

JCI Insight. 2017 Jul 20;2(14). pii: 93751. doi: 10.1172/jci.insight.93751. eCollection 2017 Jul 20. Review.

21.

MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy.

Dellett M, Brown ED, Guduric-Fuchs J, O'Connor A, Stitt AW, Medina RJ, Simpson DA.

J Cell Mol Med. 2017 Dec;21(12):3405-3419. doi: 10.1111/jcmm.13251. Epub 2017 Jun 20.

22.

The pathology associated with diabetic retinopathy.

Lechner J, O'Leary OE, Stitt AW.

Vision Res. 2017 Oct;139:7-14. doi: 10.1016/j.visres.2017.04.003. Epub 2017 Apr 29. Review.

23.

Endothelial Progenitors: A Consensus Statement on Nomenclature.

Medina RJ, Barber CL, Sabatier F, Dignat-George F, Melero-Martin JM, Khosrotehrani K, Ohneda O, Randi AM, Chan JKY, Yamaguchi T, Van Hinsbergh VWM, Yoder MC, Stitt AW.

Stem Cells Transl Med. 2017 May;6(5):1316-1320. doi: 10.1002/sctm.16-0360. Epub 2017 Mar 10. Review.

24.

Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis.

Cochrane A, Kelaini S, Tsifaki M, Bojdo J, Vilà-González M, Drehmer D, Caines R, Magee C, Eleftheriadou M, Hu Y, Grieve D, Stitt AW, Zeng L, Xu Q, Margariti A.

Stem Cells. 2017 Apr;35(4):952-966. doi: 10.1002/stem.2594. Epub 2017 Mar 5. Erratum in: Stem Cells. 2017 Jun;35(6):1654.

25.

Inhibition or deletion of 11β-HSD1 does not increase angiogenesis in ischemic retinopathy.

Davidson CT, Dover AR, McVicar CM, Megaw R, Glenn JV, Hadoke PWF, Stitt AW, Walker BR.

Diabetes Metab. 2017 Oct;43(5):480-483. doi: 10.1016/j.diabet.2016.12.001. Epub 2017 Jan 11. No abstract available.

26.

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.

Hookham MB, Ali IH, O'Neill CL, Hackett E, Lambe MH, Schmidt T, Medina RJ, Chamney S, Rao B, McLoone E, Sweet D, Stitt AW, Brazil DP.

Stem Cell Res Ther. 2016 Nov 29;7(1):173.

27.

Endothelial cell-derived pentraxin 3 limits the vasoreparative therapeutic potential of circulating angiogenic cells.

O'Neill CL, Guduric-Fuchs J, Chambers SE, O'Doherty M, Bottazzi B, Stitt AW, Medina RJ.

Cardiovasc Res. 2016 Dec;112(3):677-688. Epub 2016 Sep 22.

28.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes.

Canning P, Kenny BA, Prise V, Glenn J, Sarker MH, Hudson N, Brandt M, Lopez FJ, Gale D, Luthert PJ, Adamson P, Turowski P, Stitt AW.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7213-8. doi: 10.1073/pnas.1514213113. Epub 2016 Jun 13.

29.

Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis.

Reynolds AL, Alvarez Y, Sasore T, Waghorne N, Butler CT, Kilty C, Smith AJ, McVicar C, Wong VH, Galvin O, Merrigan S, Osman J, Grebnev G, Sjölander A, Stitt AW, Kennedy BN.

J Biol Chem. 2016 Apr 1;291(14):7242-55. doi: 10.1074/jbc.M115.710665. Epub 2016 Feb 4.

30.

Abnormal Glycogen Storage by Retinal Neurons in Diabetes.

Gardiner TA, Canning P, Tipping N, Archer DB, Stitt AW.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8008-18. doi: 10.1167/iovs.15-18441.

PMID:
26720448
31.

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders HJ.

J Am Soc Nephrol. 2016 Jun;27(6):1635-49. doi: 10.1681/ASN.2015020208. Epub 2015 Nov 13.

32.

Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.

Cahoon JM, Rai RR, Carroll LS, Uehara H, Zhang X, O'Neil CL, Medina RJ, Das SK, Muddana SK, Olson PR, Nielson S, Walker K, Flood MM, Messenger WB, Archer BJ, Barabas P, Krizaj D, Gibson CC, Li DY, Koh GY, Gao G, Stitt AW, Ambati BK.

Diabetes. 2015 Dec;64(12):4247-59. doi: 10.2337/db14-1030. Epub 2015 Sep 4.

33.

The progress in understanding and treatment of diabetic retinopathy.

Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes HP, Simó R, Lois N.

Prog Retin Eye Res. 2016 Mar;51:156-86. doi: 10.1016/j.preteyeres.2015.08.001. Epub 2015 Aug 18. Review.

PMID:
26297071
34.

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications.

Rajasekar P, O'Neill CL, Eeles L, Stitt AW, Medina RJ.

J Diabetes Res. 2015;2015:436879. doi: 10.1155/2015/436879. Epub 2015 May 28. Review.

35.

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.

McVicar CM, Ward M, Colhoun LM, Guduric-Fuchs J, Bierhaus A, Fleming T, Schlotterer A, Kolibabka M, Hammes HP, Chen M, Stitt AW.

Diabetologia. 2015 May;58(5):1129-37. doi: 10.1007/s00125-015-3523-x. Epub 2015 Feb 17.

36.

MicroRNA-199b Modulates Vascular Cell Fate During iPS Cell Differentiation by Targeting the Notch Ligand Jagged1 and Enhancing VEGF Signaling.

Chen T, Margariti A, Kelaini S, Cochrane A, Guha ST, Hu Y, Stitt AW, Zhang L, Xu Q.

Stem Cells. 2015 May;33(5):1405-18. doi: 10.1002/stem.1930.

37.

Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales' Disease patients.

Murugeswari P, Shukla D, Kim R, Namperumalsamy P, Stitt AW, Muthukkaruppan V.

PLoS One. 2014 Oct 13;9(10):e107551. doi: 10.1371/journal.pone.0107551. eCollection 2014.

38.

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.

Prasain N, Lee MR, Vemula S, Meador JL, Yoshimoto M, Ferkowicz MJ, Fett A, Gupta M, Rapp BM, Saadatzadeh MR, Ginsberg M, Elemento O, Lee Y, Voytik-Harbin SL, Chung HM, Hong KS, Reid E, O'Neill CL, Medina RJ, Stitt AW, Murphy MP, Rafii S, Broxmeyer HE, Yoder MC.

Nat Biotechnol. 2014 Nov;32(11):1151-1157. doi: 10.1038/nbt.3048. Epub 2014 Oct 12.

39.

Endothelial progenitor cells in diabetic retinopathy.

Lois N, McCarter RV, O'Neill C, Medina RJ, Stitt AW.

Front Endocrinol (Lausanne). 2014 Apr 9;5:44. doi: 10.3389/fendo.2014.00044. eCollection 2014. Review.

40.

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

Chen M, Glenn JV, Dasari S, McVicar C, Ward M, Colhoun L, Quinn M, Bierhaus A, Xu H, Stitt AW.

PLoS One. 2014 Feb 26;9(2):e89548. doi: 10.1371/journal.pone.0089548. eCollection 2014.

41.

The role of immune-related myeloid cells in angiogenesis.

Chambers SE, O'Neill CL, O'Doherty TM, Medina RJ, Stitt AW.

Immunobiology. 2013 Nov;218(11):1370-5. doi: 10.1016/j.imbio.2013.06.010. Epub 2013 Jul 8. Review.

PMID:
23932437
42.

Advanced glycation end products and diabetic retinopathy.

Chen M, Curtis TM, Stitt AW.

Curr Med Chem. 2013;20(26):3234-40. Review.

PMID:
23745547
43.

Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Medina RJ, O'Neill CL, O'Doherty TM, Chambers SE, Guduric-Fuchs J, Neisen J, Waugh DJ, Simpson DA, Stitt AW.

Stem Cells. 2013 Aug;31(8):1657-68. doi: 10.1002/stem.1414.

44.

Advances in our understanding of diabetic retinopathy.

Stitt AW, Lois N, Medina RJ, Adamson P, Curtis TM.

Clin Sci (Lond). 2013 Mar 13;125(1):1-17. doi: 10.1042/CS20120588. Review.

PMID:
23485060
45.

Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease.

McDowell RE, McGeown JG, Stitt AW, Curtis TM.

Future Med Chem. 2013 Feb;5(2):189-211. doi: 10.4155/fmc.12.202. Review.

PMID:
23360143
46.

Raman spectroscopy for the detection of AGEs/ALEs.

Beattie JR, McGarvey JJ, Stitt AW.

Methods Mol Biol. 2013;965:297-312. doi: 10.1007/978-1-62703-239-1_20.

PMID:
23296667
47.

Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors.

Jarajapu YP, Bhatwadekar AD, Caballero S, Hazra S, Shenoy V, Medina R, Kent D, Stitt AW, Thut C, Finney EM, Raizada MK, Grant MB.

Diabetes. 2013 Apr;62(4):1258-69. doi: 10.2337/db12-0808. Epub 2012 Dec 10.

48.

Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells.

O'Neill CL, O'Doherty MT, Wilson SE, Rana AA, Hirst CE, Stitt AW, Medina RJ.

Stem Cell Res Ther. 2012 Aug 16;3(4):31. doi: 10.1186/scrt122. Review.

49.

Bone marrow-CNS connections: implications in the pathogenesis of diabetic retinopathy.

Yellowlees Douglas J, Bhatwadekar AD, Li Calzi S, Shaw LC, Carnegie D, Caballero S, Li Q, Stitt AW, Raizada MK, Grant MB.

Prog Retin Eye Res. 2012 Sep;31(5):481-94. doi: 10.1016/j.preteyeres.2012.04.005. Epub 2012 May 15. Review.

50.

Endothelial progenitors as tools to study vascular disease.

Medina RJ, O'Neill CL, O'Doherty TM, Wilson SE, Stitt AW.

Stem Cells Int. 2012;2012:346735. doi: 10.1155/2012/346735. Epub 2012 Mar 15.

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