Sort by
Items per page

Send to

Choose Destination

Search results

Items: 41


R Loops and Their Composite Cancer Connections.

Wells JP, White J, Stirling PC.

Trends Cancer. 2019 Oct;5(10):619-631. doi: 10.1016/j.trecan.2019.08.006. Epub 2019 Oct 21. Review.


MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.

Chang EY, Tsai S, Aristizabal MJ, Wells JP, Coulombe Y, Busatto FF, Chan YA, Kumar A, Dan Zhu Y, Wang AY, Fournier LA, Hieter P, Kobor MS, Masson JY, Stirling PC.

Nat Commun. 2019 Sep 19;10(1):4265. doi: 10.1038/s41467-019-12271-w.


Splicing, genome stability and disease: splice like your genome depends on it!

Tam AS, Stirling PC.

Curr Genet. 2019 Aug;65(4):905-912. doi: 10.1007/s00294-019-00964-0. Epub 2019 Apr 5. Review.


Exonuclease domain mutants of yeast DIS3 display genome instability.

Milbury KL, Paul B, Lari A, Fowler C, Montpetit B, Stirling PC.

Nucleus. 2019 Dec;10(1):21-32. doi: 10.1080/19491034.2019.1578600.


Molecular characterization of an MLL1 fusion and its role in chromosomal instability.

Parameswaran S, Vizeacoumar FS, Kalyanasundaram Bhanumathy K, Qin F, Islam MF, Toosi BM, Cunningham CE, Mousseau DD, Uppalapati MC, Stirling PC, Wu Y, Bonham K, Freywald A, Li H, Vizeacoumar FJ.

Mol Oncol. 2019 Feb;13(2):422-440. doi: 10.1002/1878-0261.12423. Epub 2018 Dec 31.


Chromatin as a Platform for Modulating the Replication Stress Response.

Fournier LA, Kumar A, Stirling PC.

Genes (Basel). 2018 Dec 11;9(12). pii: E622. doi: 10.3390/genes9120622. Review.


Selective defects in gene expression control genome instability in yeast splicing mutants.

Tam AS, Sihota TS, Milbury KL, Zhang A, Mathew V, Stirling PC.

Mol Biol Cell. 2019 Jan 15;30(2):191-200. doi: 10.1091/mbc.E18-07-0439. Epub 2018 Nov 21.


Protein quality control meets transcriptome remodeling under stress.

Mathew V, Stirling PC.

Cell Stress. 2017 Nov 15;1(3):134-135. doi: 10.15698/cst2017.12.115.


The A-Like Faker Assay for Measuring Yeast Chromosome III Stability.

Novoa CA, Ang JS, Stirling PC.

Methods Mol Biol. 2018;1672:1-9. doi: 10.1007/978-1-4939-7306-4_1.


RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.

Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):3991-4005. doi: 10.1083/jcb.201703168. Epub 2017 Oct 17.


Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress.

Mathew V, Tam AS, Milbury KL, Hofmann AK, Hughes CS, Morin GB, Loewen CJR, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):4027-4040. doi: 10.1083/jcb.201612018. Epub 2017 Oct 4.


Genome-wide bisulfite sensitivity profiling of yeast suggests bisulfite inhibits transcription.

Segovia R, Mathew V, Tam AS, Stirling PC.

Mutat Res. 2017 Sep;821:13-19. doi: 10.1016/j.mrgentox.2017.06.004. Epub 2017 Jul 3.


CuboCube: Student creation of a cancer genetics e-textbook using open-access software for social learning.

Seid-Karbasi P, Ye XC, Zhang AW, Gladish N, Cheng SY, Rothe K, Pilsworth JA, Kang MA, Doolittle N, Jiang X, Stirling PC, Wasserman WW.

PLoS Biol. 2017 Mar 7;15(3):e2001192. doi: 10.1371/journal.pbio.2001192. eCollection 2017 Mar.


Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast.

Segovia R, Shen Y, Lujan SA, Jones SJ, Stirling PC.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2663-2668. doi: 10.1073/pnas.1618555114. Epub 2017 Feb 21.


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.


Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression.

Chang EY, Stirling PC.

Genes (Basel). 2017 Jan 14;8(1). pii: E33. doi: 10.3390/genes8010033. Review.


Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase.

Ang JS, Duffy S, Segovia R, Stirling PC, Hieter P.

Genetics. 2016 Nov;204(3):975-986. doi: 10.1534/genetics.116.192211. Epub 2016 Aug 31.


Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.

Stirling PC, Hieter P.

J Mol Biol. 2017 Oct 27;429(21):3132-3138. doi: 10.1016/j.jmb.2016.07.014. Epub 2016 Jul 22.


Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro.

Leung AW, Hung SS, Backstrom I, Ricaurte D, Kwok B, Poon S, McKinney S, Segovia R, Rawji J, Qadir MA, Aparicio S, Stirling PC, Steidl C, Bally MB.

PLoS One. 2016 Mar 3;11(3):e0150675. doi: 10.1371/journal.pone.0150675. eCollection 2016.


Navigating yeast genome maintenance with functional genomics.

Measday V, Stirling PC.

Brief Funct Genomics. 2016 Mar;15(2):119-29. doi: 10.1093/bfgp/elv033. Epub 2015 Aug 31. Review.


3'-Phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents.

Leung AW, Dragowska WH, Ricaurte D, Kwok B, Mathew V, Roosendaal J, Ahluwalia A, Warburton C, Laskin JJ, Stirling PC, Qadir MA, Bally MB.

Oncotarget. 2015 Jul 10;6(19):17161-77.


An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC.

G3 (Bethesda). 2015 Jul 14;5(9):1879-87. doi: 10.1534/g3.115.019174.


Dissecting genetic and environmental mutation signatures with model organisms.

Segovia R, Tam AS, Stirling PC.

Trends Genet. 2015 Aug;31(8):465-74. doi: 10.1016/j.tig.2015.04.001. Epub 2015 May 1. Review.


Mechanisms of genome instability induced by RNA-processing defects.

Chan YA, Hieter P, Stirling PC.

Trends Genet. 2014 Jun;30(6):245-53. doi: 10.1016/j.tig.2014.03.005. Epub 2014 May 1. Review.


Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.

Chan YA, Aristizabal MJ, Lu PY, Luo Z, Hamza A, Kobor MS, Stirling PC, Hieter P.

PLoS Genet. 2014 Apr 17;10(4):e1004288. doi: 10.1371/journal.pgen.1004288. eCollection 2014 Apr.


Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.

Stirling PC, Shen Y, Corbett R, Jones SJ, Hieter P.

Genetics. 2014 Feb;196(2):403-12. doi: 10.1534/genetics.113.159806. Epub 2013 Dec 13.


Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.

Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M.

Biochemistry. 2013 May 21;52(20):3532-42. doi: 10.1021/bi301705c. Epub 2013 May 8. Erratum in: Biochemistry. 2014 Jun 3;53(21):3520.


Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.

van Pel DM, Stirling PC, Minaker SW, Sipahimalani P, Hieter P.

G3 (Bethesda). 2013 Feb;3(2):273-82. doi: 10.1534/g3.112.004754. Epub 2013 Feb 1.


Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.

Minaker SW, Filiatrault MC, Ben-Aroya S, Hieter P, Stirling PC.

Genetics. 2013 Mar;193(3):853-64. doi: 10.1534/genetics.112.148726. Epub 2012 Dec 24.


R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.

Stirling PC, Chan YA, Minaker SW, Aristizabal MJ, Barrett I, Sipahimalani P, Kobor MS, Hieter P.

Genes Dev. 2012 Jan 15;26(2):163-75. doi: 10.1101/gad.179721.111.


Mutability and mutational spectrum of chromosome transmission fidelity genes.

Stirling PC, Crisp MJ, Basrai MA, Tucker CM, Dunham MJ, Spencer FA, Hieter P.

Chromosoma. 2012 Jun;121(3):263-75. doi: 10.1007/s00412-011-0356-3. Epub 2011 Dec 24.


The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.

Stirling PC, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li Z, Kofoed M, Ben-Aroya S, Myung K, Hieter P.

PLoS Genet. 2011 Apr;7(4):e1002057. doi: 10.1371/journal.pgen.1002057. Epub 2011 Apr 28.


Quality control of cytoskeletal proteins and human disease.

Lundin VF, Leroux MR, Stirling PC.

Trends Biochem Sci. 2010 May;35(5):288-97. doi: 10.1016/j.tibs.2009.12.007. Epub 2010 Jan 28. Review.


A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.

Carroll SY, Stirling PC, Stimpson HE, Giesselmann E, Schmitt MJ, Drubin DG.

Dev Cell. 2009 Oct;17(4):552-60. doi: 10.1016/j.devcel.2009.08.006.


The interaction network of the chaperonin CCT.

Dekker C, Stirling PC, McCormack EA, Filmore H, Paul A, Brost RL, Costanzo M, Boone C, Leroux MR, Willison KR.

EMBO J. 2008 Jul 9;27(13):1827-39. doi: 10.1038/emboj.2008.108. Epub 2008 May 29.


Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.

Stirling PC, Srayko M, Takhar KS, Pozniakovsky A, Hyman AA, Leroux MR.

Mol Biol Cell. 2007 Jun;18(6):2336-45. Epub 2007 Apr 11.


Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart.

Martín-Benito J, Gómez-Reino J, Stirling PC, Lundin VF, Gómez-Puertas P, Boskovic J, Chacón P, Fernández JJ, Berenguer J, Leroux MR, Valpuesta JM.

Structure. 2007 Jan;15(1):101-10.


Convergent evolution of clamp-like binding sites in diverse chaperones.

Stirling PC, Bakhoum SF, Feigl AB, Leroux MR.

Nat Struct Mol Biol. 2006 Oct;13(10):865-70. Review.


PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.

Stirling PC, Cuéllar J, Alfaro GA, El Khadali F, Beh CT, Valpuesta JM, Melki R, Leroux MR.

J Biol Chem. 2006 Mar 17;281(11):7012-21. Epub 2006 Jan 16.


Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin.

Lundin VF, Stirling PC, Gomez-Reino J, Mwenifumbo JC, Obst JM, Valpuesta JM, Leroux MR.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4367-72. Epub 2004 Mar 19.


Getting a grip on non-native proteins.

Stirling PC, Lundin VF, Leroux MR.

EMBO Rep. 2003 Jun;4(6):565-70. Review.

Supplemental Content

Loading ...
Support Center