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Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses.

Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshäuser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlöhner S, Köhler K, Stiewe T.

EMBO J. 2019 Sep 4:e102096. doi: 10.15252/embj.2019102096. [Epub ahead of print]


Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor.

Hannen R, Selmansberger M, Hauswald M, Pagenstecher A, Nist A, Stiewe T, Acker T, Carl B, Nimsky C, Bartsch JW.

Cancers (Basel). 2019 Jun 30;11(7). pii: E921. doi: 10.3390/cancers11070921.


Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression.

Riedlinger T, Bartkuhn M, Zimmermann T, Hake SB, Nist A, Stiewe T, Kracht M, Schmitz ML.

Cancers (Basel). 2019 Jun 25;11(6). pii: E883. doi: 10.3390/cancers11060883.


Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients.

Bauer M, Kantelhardt EJ, Stiewe T, Nist A, Mernberger M, Politt K, Hanf V, Lantzsch T, Uleer C, Peschel S, John J, Buchmann J, Weigert E, Bürrig KF, Wickenhauser C, Thomssen C, Bartel F, Vetter M.

Oncotarget. 2019 Mar 8;10(20):1975-1992. doi: 10.18632/oncotarget.26768. eCollection 2019 Mar 8.


SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells.

Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F, Nist A, Stiewe T, Mermoud JE.

Nat Commun. 2019 Mar 22;10(1):1335. doi: 10.1038/s41467-019-09078-0.


Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes.

Hundertmark T, Kreutz S, Merle N, Nist A, Lamp B, Stiewe T, Brehm A, Renkawitz-Pohl R, Rathke C.

PLoS One. 2019 Mar 7;14(3):e0213177. doi: 10.1371/journal.pone.0213177. eCollection 2019.


Downregulation of miR-503 in Activated Kidney Fibroblasts Disinhibits KCNN4 in an in Vitro Model of Kidney Fibrosis.

Mann C, Kaistha BP, Kacik M, Stiewe T, Hoyer J.

Kidney Blood Press Res. 2019;44(1):113-122. doi: 10.1159/000498875. Epub 2019 Feb 22.


The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes.

Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A.

Nat Commun. 2019 Feb 15;10(1):760. doi: 10.1038/s41467-019-08711-2.


ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H.

J Immunol. 2019 Feb 15;202(4):1099-1111. doi: 10.4049/jimmunol.1800269. Epub 2019 Jan 16.


NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.

Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML.

FASEB J. 2019 Mar;33(3):4188-4202. doi: 10.1096/fj.201801638R. Epub 2018 Dec 7.


Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.

Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R.

Mol Oncol. 2019 Feb;13(2):185-201. doi: 10.1002/1878-0261.12396. Epub 2018 Nov 15.


Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites.

Völkel S, Stielow B, Finkernagel F, Berger D, Stiewe T, Nist A, Suske G.

J Biol Chem. 2018 Dec 14;293(50):19250-19262. doi: 10.1074/jbc.RA118.005341. Epub 2018 Oct 18.


PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

Link S, Spitzer RMM, Sana M, Torrado M, Völker-Albert MC, Keilhauer EC, Burgold T, Pünzeler S, Low JKK, Lindström I, Nist A, Regnard C, Stiewe T, Hendrich B, Imhof A, Mann M, Mackay JP, Bartkuhn M, Hake SB.

Nat Commun. 2018 Oct 16;9(1):4300. doi: 10.1038/s41467-018-06665-5.


Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes.

Bouchard C, Sahu P, Meixner M, Nötzold RR, Rust MB, Kremmer E, Feederle R, Hart-Smith G, Finkernagel F, Bartkuhn M, Savai Pullamsetti S, Nist A, Stiewe T, Philipsen S, Bauer UM.

Cell Rep. 2018 Sep 18;24(12):3339-3352. doi: 10.1016/j.celrep.2018.08.052.


Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites.

Unger A, Finkernagel F, Hoffmann N, Neuhaus F, Joos B, Nist A, Stiewe T, Visekruna A, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R, Adhikary T.

Front Immunol. 2018 Jun 27;9:1425. doi: 10.3389/fimmu.2018.01425. eCollection 2018.


Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.

Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T.

Nucleic Acids Res. 2018 Sep 19;46(16):8197-8215. doi: 10.1093/nar/gky551.


How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance.

Stiewe T, Haran TE.

Drug Resist Updat. 2018 May;38:27-43. doi: 10.1016/j.drup.2018.05.001. Epub 2018 May 9. Review.


Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1.

Feld C, Sahu P, Frech M, Finkernagel F, Nist A, Stiewe T, Bauer UM, Neubauer A.

Nucleic Acids Res. 2018 Apr 20;46(7):3412-3428. doi: 10.1093/nar/gky119.


MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6.

Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G.

PLoS Genet. 2018 Jan 30;14(1):e1007193. doi: 10.1371/journal.pgen.1007193. eCollection 2018 Jan.


Miz1 Controls Schwann Cell Proliferation via H3K36me2 Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination.

Fuhrmann D, Mernberger M, Nist A, Stiewe T, Elsässer HP.

J Neurosci. 2018 Jan 24;38(4):858-877. doi: 10.1523/JNEUROSCI.0843-17.2017. Epub 2017 Dec 7.


Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.

Worzfeld T, Finkernagel F, Reinartz S, Konzer A, Adhikary T, Nist A, Stiewe T, Wagner U, Looso M, Graumann J, Müller R.

Mol Cell Proteomics. 2018 Feb;17(2):270-289. doi: 10.1074/mcp.RA117.000400. Epub 2017 Nov 15.


CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.

Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8035-E8044. doi: 10.1073/pnas.1702763114. Epub 2017 Sep 6.


ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.

Richter AM, Kiehl S, Köger N, Breuer J, Stiewe T, Dammann RH.

Clin Epigenetics. 2017 Jun 2;9:60. doi: 10.1186/s13148-017-0360-4. eCollection 2017.


p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.

Timofeev O, Stiewe T.

Mol Cell Oncol. 2017 Feb 3;4(2):e1288678. doi: 10.1080/23723556.2017.1288678. eCollection 2017.


Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients.

Adhikary T, Wortmann A, Finkernagel F, Lieber S, Nist A, Stiewe T, Wagner U, Müller-Brüsselbach S, Reinartz S, Müller R.

BMC Genomics. 2017 Mar 21;18(1):243. doi: 10.1186/s12864-017-3630-9.


Pro-metastatic p53 mutants control folding of N-glycoproteins.

Schneikert J, Stiewe T.

Cell Cycle. 2017 Apr 3;16(7):591-592. doi: 10.1080/15384101.2017.1291247. Epub 2017 Feb 6. No abstract available.


Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.

Vogiatzi F, Brandt DT, Schneikert J, Fuchs J, Grikscheit K, Wanzel M, Pavlakis E, Charles JP, Timofeev O, Nist A, Mernberger M, Kantelhardt EJ, Siebolts U, Bartel F, Jacob R, Rath A, Moll R, Grosse R, Stiewe T.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8433-E8442. doi: 10.1073/pnas.1612711114. Epub 2016 Dec 12.


Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance.

Voges Y, Michaelis M, Rothweiler F, Schaller T, Schneider C, Politt K, Mernberger M, Nist A, Stiewe T, Wass MN, Rödel F, Cinatl J.

Cell Death Dis. 2016 Oct 13;7(10):e2410. doi: 10.1038/cddis.2016.257.


The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.

Finkernagel F, Reinartz S, Lieber S, Adhikary T, Wortmann A, Hoffmann N, Bieringer T, Nist A, Stiewe T, Jansen JM, Wagner U, Müller-Brüsselbach S, Müller R.

Oncotarget. 2016 Nov 15;7(46):75339-75352. doi: 10.18632/oncotarget.12180.


Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion.

Kern L, Spreckels J, Nist A, Stiewe T, Skevaki C, Greene B, Mernberger M, Elsässer HP.

Cell Tissue Res. 2016 Dec;366(3):651-665. Epub 2016 Aug 23.


Galectin-3 interacts with components of the nuclear ribonucleoprotein complex.

Fritsch K, Mernberger M, Nist A, Stiewe T, Brehm A, Jacob R.

BMC Cancer. 2016 Jul 19;16:502. doi: 10.1186/s12885-016-2546-0.


A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome.

Reinartz S, Finkernagel F, Adhikary T, Rohnalter V, Schumann T, Schober Y, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Müller-Brüsselbach S, Müller R.

Genome Biol. 2016 May 23;17(1):108. doi: 10.1186/s13059-016-0956-6.


ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma.

Bretz AC, Gittler MP, Charles JP, Gremke N, Eckhardt I, Mernberger M, Mandic R, Thomale J, Nist A, Wanzel M, Stiewe T.

Nucleic Acids Res. 2016 Apr 20;44(7):3204-18. doi: 10.1093/nar/gkw036. Epub 2016 Jan 26.


CRISPR-Cas9-based target validation for p53-reactivating model compounds.

Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T.

Nat Chem Biol. 2016 Jan;12(1):22-8. doi: 10.1038/nchembio.1965. Epub 2015 Nov 23.


Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma.

Banat GA, Tretyn A, Pullamsetti SS, Wilhelm J, Weigert A, Olesch C, Ebel K, Stiewe T, Grimminger F, Seeger W, Fink L, Savai R.

PLoS One. 2015 Sep 28;10(9):e0139073. doi: 10.1371/journal.pone.0139073. eCollection 2015.


NFATc1 as a therapeutic target in FLT3-ITD-positive AML.

Metzelder SK, Michel C, von Bonin M, Rehberger M, Hessmann E, Inselmann S, Solovey M, Wang Y, Sohlbach K, Brendel C, Stiewe T, Charles J, Ten Haaf A, Ellenrieder V, Neubauer A, Gattenlöhner S, Bornhäuser M, Burchert A.

Leukemia. 2015 Jul;29(7):1470-7. doi: 10.1038/leu.2015.95. Epub 2015 Apr 14.


Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.

Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R.

Oncotarget. 2015 May 30;6(15):13416-33.


The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.

Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R.

Nucleic Acids Res. 2015 May 26;43(10):5033-51. doi: 10.1093/nar/gkv331. Epub 2015 Apr 30.


Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation.

Brendel C, Teichler S, Millahn A, Stiewe T, Krause M, Stabla K, Ross P, Huynh M, Illmer T, Mernberger M, Barckhausen C, Neubauer A.

PLoS One. 2015 Apr 22;10(4):e0123181. doi: 10.1371/journal.pone.0123181. eCollection 2015.


Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.

Völkel S, Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G.

PLoS Genet. 2015 Mar 20;11(3):e1005102. doi: 10.1371/journal.pgen.1005102. eCollection 2015 Mar.


Sorafenib induces paradoxical phosphorylation of the extracellular signal-regulated kinase pathway in acute myeloid leukemia cells lacking FLT3-ITD mutation.

Fouladi F, Jehn LB, Metzelder SK, Hub F, Henkenius K, Burchert A, Brendel C, Stiewe T, Neubauer A.

Leuk Lymphoma. 2015;56(9):2690-8. doi: 10.3109/10428194.2014.1003055. Epub 2015 Mar 3.


Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V.

EMBO J. 2015 Feb 12;34(4):517-30. doi: 10.15252/embj.201489574. Epub 2015 Jan 13.


A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.

Tonigold M, Rossmann A, Meinold M, Bette M, Märken M, Henkenius K, Bretz AC, Giel G, Cai C, Rodepeter FR, Beneš V, Grénman R, Carey TE, Lage H, Stiewe T, Neubauer A, Werner JA, Brendel C, Mandic R.

J Cancer Res Clin Oncol. 2014 Oct;140(10):1689-704. doi: 10.1007/s00432-014-1727-y. Epub 2014 Jun 10.


Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases.

Charles JP, Fuchs J, Hefter M, Vischedyk JB, Kleint M, Vogiatzi F, Schäfer JA, Nist A, Timofeev O, Wanzel M, Stiewe T.

Nat Commun. 2014 Jun 3;5:3981. doi: 10.1038/ncomms4981.


The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines.

Henrici A, Montalbano R, Neureiter D, Krause M, Stiewe T, Slater EP, Quint K, Ocker M, Di Fazio P.

Mol Carcinog. 2015 Aug;54(8):585-97. doi: 10.1002/mc.22122. Epub 2013 Dec 23.


Lung tumors on multimodal radiographs derived from grating-based X-ray imaging--a feasibility study.

Meinel FG, Schwab F, Yaroshenko A, Velroyen A, Bech M, Hellbach K, Fuchs J, Stiewe T, Yildirim AÖ, Bamberg F, Reiser MF, Pfeiffer F, Nikolaou K.

Phys Med. 2014 May;30(3):352-7. doi: 10.1016/j.ejmp.2013.11.001. Epub 2013 Dec 7.


Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

Schlereth K, Heyl C, Krampitz AM, Mernberger M, Finkernagel F, Scharfe M, Jarek M, Leich E, Rosenwald A, Stiewe T.

PLoS Genet. 2013;9(8):e1003726. doi: 10.1371/journal.pgen.1003726. Epub 2013 Aug 15.


A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y.

Cancer Cell. 2013 Aug 12;24(2):242-56. doi: 10.1016/j.ccr.2013.06.005. Epub 2013 Jul 25. Erratum in: Cancer Cell. 2015 Jun 8;27(6):877-8.


p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo.

Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsässer HP, Stiewe T.

Cell Rep. 2013 May 30;3(5):1512-25. doi: 10.1016/j.celrep.2013.04.008. Epub 2013 May 9.


iTRAQ analysis of a cell culture model for malignant transformation, including comparison with 2D-PAGE and SILAC.

Pütz SM, Boehm AM, Stiewe T, Sickmann A.

J Proteome Res. 2012 Apr 6;11(4):2140-53. doi: 10.1021/pr200881c. Epub 2012 Mar 23.


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