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Items: 1 to 50 of 171

1.

Inotropic interventions do not change the resting state of myosin motors during cardiac diastole.

Caremani M, Pinzauti F, Powers JD, Governali S, Narayanan T, Stienen GJM, Reconditi M, Linari M, Lombardi V, Piazzesi G.

J Gen Physiol. 2018 Dec 3. pii: jgp.201812196. doi: 10.1085/jgp.201812196. [Epub ahead of print]

PMID:
30510036
2.

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins.

van der Velden J, Stienen GJM.

Physiol Rev. 2019 Jan 1;99(1):381-426. doi: 10.1152/physrev.00040.2017.

PMID:
30379622
3.

A 3D diffusional-compartmental model of the calcium dynamics in cytosol, sarcoplasmic reticulum and mitochondria of murine skeletal muscle fibers.

Marcucci L, Canato M, Protasi F, Stienen GJM, Reggiani C.

PLoS One. 2018 Jul 26;13(7):e0201050. doi: 10.1371/journal.pone.0201050. eCollection 2018.

4.

The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration.

Pinzauti F, Pertici I, Reconditi M, Narayanan T, Stienen GJM, Piazzesi G, Lombardi V, Linari M, Caremani M.

J Physiol. 2018 Jul;596(13):2581-2596. doi: 10.1113/JP275579. Epub 2018 May 27.

PMID:
29714038
5.

Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.

Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, van der Velden J.

Biophys Rev. 2018 Jun;10(3):941. doi: 10.1007/s12551-018-0397-4.

6.

Successive contractile periods activate mitochondria at the onset of contractions in intact rat cardiac trabeculae.

Wüst RCI, Stienen GJM.

J Appl Physiol (1985). 2018 Apr 1;124(4):1003-1011. doi: 10.1152/japplphysiol.01010.2017. Epub 2018 Jan 11.

PMID:
29357483
7.

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Joureau B, de Winter JM, Conijn S, Bogaards SJP, Kovacevic I, Kalganov A, Persson M, Lindqvist J, Stienen GJM, Irving TC, Ma W, Yuen M, Clarke NF, Rassier DE, Malfatti E, Romero NB, Beggs AH, Ottenheijm CAC.

Ann Neurol. 2018 Feb;83(2):269-282. doi: 10.1002/ana.25144. Epub 2018 Feb 6.

PMID:
29328520
8.

The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.

Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke W, van der Velden J.

Biophys Rev. 2017 Aug;9(4):431-441. doi: 10.1007/s12551-017-0305-3. Epub 2017 Aug 14. Review. Erratum in: Biophys Rev. 2018 Feb 1;:.

9.

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1544-1558. doi: 10.1164/rccm.201703-0501OC.

PMID:
28787181
10.

Myosin filament activation in the heart is tuned to the mechanical task.

Reconditi M, Caremani M, Pinzauti F, Powers JD, Narayanan T, Stienen GJ, Linari M, Lombardi V, Piazzesi G.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3240-3245. doi: 10.1073/pnas.1619484114. Epub 2017 Mar 6.

11.

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

Wüst RC, Helmes M, Martin JL, van der Wardt TJ, Musters RJ, van der Velden J, Stienen GJ.

J Physiol. 2017 Mar 15;595(6):2001-2019. doi: 10.1113/JP273589. Epub 2017 Feb 22.

12.

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits.

Baartscheer A, Schumacher CA, Wüst RC, Fiolet JW, Stienen GJ, Coronel R, Zuurbier CJ.

Diabetologia. 2017 Mar;60(3):568-573. doi: 10.1007/s00125-016-4134-x. Epub 2016 Oct 17.

PMID:
27752710
13.

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure.

Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ.

Cardiovasc Res. 2016 Sep;111(4):362-72. doi: 10.1093/cvr/cvw176. Epub 2016 Jul 11.

PMID:
27402402
14.

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.

Manders E, Bonta PI, Kloek JJ, Symersky P, Bogaard HJ, Hooijman PE, Jasper JR, Malik FI, Stienen GJ, Vonk-Noordegraaf A, de Man FS, Ottenheijm CA.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L20-8. doi: 10.1152/ajplung.00113.2016. Epub 2016 May 17.

15.

Mutation-specific effects on thin filament length in thin filament myopathy.

Winter JM, Joureau B, Lee EJ, Kiss B, Yuen M, Gupta VA, Pappas CT, Gregorio CC, Stienen GJ, Edvardson S, Wallgren-Pettersson C, Lehtokari VL, Pelin K, Malfatti E, Romero NB, Engelen BG, Voermans NC, Donkervoort S, Bönnemann CG, Clarke NF, Beggs AH, Granzier H, Ottenheijm CA.

Ann Neurol. 2016 Jun;79(6):959-69. doi: 10.1002/ana.24654. Epub 2016 Apr 30.

16.

Size and speed of the working stroke of cardiac myosin in situ.

Caremani M, Pinzauti F, Reconditi M, Piazzesi G, Stienen GJ, Lombardi V, Linari M.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3675-80. doi: 10.1073/pnas.1525057113. Epub 2016 Mar 16.

17.

Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension.

Fowler ED, Benoist D, Drinkhill MJ, Stones R, Helmes M, Wüst RC, Stienen GJ, Steele DS, White E.

J Mol Cell Cardiol. 2015 Sep;86:1-8. doi: 10.1016/j.yjmcc.2015.06.016. Epub 2015 Jun 24.

18.

The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle.

Manders E, Rain S, Bogaard HJ, Handoko ML, Stienen GJ, Vonk-Noordegraaf A, Ottenheijm CA, de Man FS.

Eur Respir J. 2015 Sep;46(3):832-42. doi: 10.1183/13993003.02052-2014. Epub 2015 Jun 25. Review.

19.

Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness.

Sequeira V, Najafi A, McConnell M, Fowler ED, Bollen IA, Wüst RC, dos Remedios C, Helmes M, White E, Stienen GJ, Tardiff J, Kuster DW, van der Velden J.

J Physiol. 2015 Sep 1;593(17):3899-916. doi: 10.1113/JP270354. Epub 2015 Jul 14.

20.

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

de Winter JM, Joureau B, Sequeira V, Clarke NF, van der Velden J, Stienen GJ, Granzier H, Beggs AH, Ottenheijm CA.

Skelet Muscle. 2015 Apr 28;5:12. doi: 10.1186/s13395-015-0037-7. eCollection 2015.

21.

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J.

J Mol Cell Cardiol. 2015 May;82:93-103. doi: 10.1016/j.yjmcc.2015.03.006. Epub 2015 Mar 11.

22.

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

Hooijman PE, Beishuizen A, Witt CC, de Waard MC, Girbes AR, Spoelstra-de Man AM, Niessen HW, Manders E, van Hees HW, van den Brom CE, Silderhuis V, Lawlor MW, Labeit S, Stienen GJ, Hartemink KJ, Paul MA, Heunks LM, Ottenheijm CA.

Am J Respir Crit Care Med. 2015 May 15;191(10):1126-38. doi: 10.1164/rccm.201412-2214OC.

23.

Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension.

Manders E, Ruiter G, Bogaard HJ, Stienen GJ, Vonk-Noordegraaf A, de Man FS, Ottenheijm CA.

Eur Respir J. 2015 Jun;45(6):1737-40. doi: 10.1183/09031936.00205114. Epub 2015 Mar 5. No abstract available.

24.

Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity.

Wüst RC, Helmes M, Stienen GJ.

J Physiol. 2015 Apr 15;593(8):1829-40. doi: 10.1113/jphysiol.2014.286153. Epub 2015 Mar 13.

25.

Altered myocardial force generation in end-stage human heart failure.

Papp Z, van der Velden J, Borbély A, Édes I, Stienen GJM.

ESC Heart Fail. 2014 Dec;1(2):160-165. doi: 10.1002/ehf2.12020. Epub 2015 Jan 15.

PMID:
28834631
26.

Pathomechanisms in heart failure: the contractile connection.

Stienen GJ.

J Muscle Res Cell Motil. 2015 Feb;36(1):47-60. doi: 10.1007/s10974-014-9395-8. Epub 2014 Nov 7. Review.

PMID:
25376563
27.

Troponin I phosphorylation in human myocardium in health and disease.

Wijnker PJ, Murphy AM, Stienen GJ, van der Velden J.

Neth Heart J. 2014 Oct;22(10):463-9. doi: 10.1007/s12471-014-0590-4.

28.

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation.

Hooijman PE, Paul MA, Stienen GJ, Beishuizen A, Van Hees HW, Singhal S, Bashir M, Budak MT, Morgen J, Barsotti RJ, Levine S, Ottenheijm CA.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L460-70. doi: 10.1152/ajplung.00076.2014. Epub 2014 Jul 18.

29.

Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension.

Manders E, Bogaard HJ, Handoko ML, van de Veerdonk MC, Keogh A, Westerhof N, Stienen GJ, Dos Remedios CG, Humbert M, Dorfmüller P, Fadel E, Guignabert C, van der Velden J, Vonk-Noordegraaf A, de Man FS, Ottenheijm CA.

J Am Coll Cardiol. 2014 Jul 8;64(1):28-37. doi: 10.1016/j.jacc.2014.04.031.

30.

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation.

Witjas-Paalberends ER, Ferrara C, Scellini B, Piroddi N, Montag J, Tesi C, Stienen GJ, Michels M, Ho CY, Kraft T, Poggesi C, van der Velden J.

J Physiol. 2014 Aug 1;592(15):3257-72. doi: 10.1113/jphysiol.2014.274571. Epub 2014 Jun 13.

31.

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations.

Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AM, Christiaans I, Wilde AA, Dos Remedios C, Lammertsma AA, van Rossum AC, Stienen GJ, van Slegtenhorst M, Schinkel AF, Michels M, Ho CY, Poggesi C, van der Velden J.

Cardiovasc Res. 2014 Jul 15;103(2):248-57. doi: 10.1093/cvr/cvu127. Epub 2014 May 16.

PMID:
24835277
32.

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Arch Biochem Biophys. 2014 Jul 15;554:11-21. doi: 10.1016/j.abb.2014.04.017. Epub 2014 May 9.

33.

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Hooijman PE, Beishuizen A, de Waard MC, de Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, van Hees HW, Heunks LM, Dickhoff C, van der Peet DL, Girbes AR, Jasper JR, Malik FI, Stienen GJ, Hartemink KJ, Paul MA, Ottenheijm CA.

Am J Respir Crit Care Med. 2014 Apr 1;189(7):863-5. doi: 10.1164/rccm.201312-2260LE. No abstract available.

34.

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Wijnker PJ, Sequeira V, Foster DB, Li Y, Dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1171-81. doi: 10.1152/ajpheart.00580.2013. Epub 2014 Feb 28.

35.

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.

van Dijk SJ, Boontje NM, Heymans MW, Ten Cate FJ, Michels M, Dos Remedios C, Dooijes D, van Slegtenhorst MA, van der Velden J, Stienen GJ.

Pflugers Arch. 2014 Aug;466(8):1619-33. doi: 10.1007/s00424-013-1391-0. Epub 2013 Nov 2.

PMID:
24186209
36.

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Lassche S, Ottenheijm CA, Voermans NC, Westeneng HJ, Janssen BH, van der Maarel SM, Hopman MT, Padberg GW, Stienen GJ, van Engelen BG.

BMC Neurol. 2013 Oct 11;13:144. doi: 10.1186/1471-2377-13-144.

37.

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

Kooij V, Zhang P, Piersma SR, Sequeira V, Boontje NM, Wijnker PJ, Jiménez CR, Jaquet KE, dos Remedios C, Murphy AM, Van Eyk JE, van der Velden J, Stienen GJ.

PLoS One. 2013 Oct 7;8(10):e74847. doi: 10.1371/journal.pone.0074847. eCollection 2013.

38.

ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study).

Güçlü A, Germans T, Witjas-Paalberends ER, Stienen GJ, Brouwer WP, Harms HJ, Marcus JT, Vonk AB, Stooker W, Yilmaz A, Klein P, Ten Berg JM, Kluin J, Asselbergs FW, Lammertsma AA, Knaapen P, van Rossum AC, van der Velden J.

Neth Heart J. 2013 Dec;21(12):567-71. doi: 10.1007/s12471-013-0478-8.

39.

Mitochondrial Ca2+-handling in fast skeletal muscle fibers from wild type and calsequestrin-null mice.

Scorzeto M, Giacomello M, Toniolo L, Canato M, Blaauw B, Paolini C, Protasi F, Reggiani C, Stienen GJ.

PLoS One. 2013 Oct 3;8(10):e74919. doi: 10.1371/journal.pone.0074919. eCollection 2013.

40.

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension.

Rain S, Handoko ML, Trip P, Gan CT, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CA, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS.

Circulation. 2013 Oct 29;128(18):2016-25, 1-10. doi: 10.1161/CIRCULATIONAHA.113.001873. Epub 2013 Sep 20.

PMID:
24056688
41.

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H.

Brain. 2013 Jun;136(Pt 6):1718-31. doi: 10.1093/brain/awt113. Epub 2013 May 28.

42.

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy.

Witjas-Paalberends ER, Piroddi N, Stam K, van Dijk SJ, Oliviera VS, Ferrara C, Scellini B, Hazebroek M, ten Cate FJ, van Slegtenhorst M, dos Remedios C, Niessen HW, Tesi C, Stienen GJ, Heymans S, Michels M, Poggesi C, van der Velden J.

Cardiovasc Res. 2013 Aug 1;99(3):432-41. doi: 10.1093/cvr/cvt119. Epub 2013 May 13.

PMID:
23674513
43.

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.

de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H.

J Med Genet. 2013 Jun;50(6):383-92. doi: 10.1136/jmedgenet-2012-101470. Epub 2013 Apr 9.

44.

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.

Sequeira V, Wijnker PJ, Nijenkamp LL, Kuster DW, Najafi A, Witjas-Paalberends ER, Regan JA, Boontje N, Ten Cate FJ, Germans T, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, Dos Remedios C, Stienen GJ, Ho CY, Michels M, van der Velden J.

Circ Res. 2013 May 24;112(11):1491-505. doi: 10.1161/CIRCRESAHA.111.300436. Epub 2013 Mar 18. Erratum in: Circ Res. 2013 Sep 27;113(8):e87.

45.

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.

Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J.

Neuromuscul Disord. 2013 Apr;23(4):357-69. doi: 10.1016/j.nmd.2012.12.011. Epub 2013 Feb 1.

PMID:
23375831
46.

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy.

Lassche S, Stienen GJ, Irving TC, van der Maarel SM, Voermans NC, Padberg GW, Granzier H, van Engelen BG, Ottenheijm CA.

Neurology. 2013 Feb 19;80(8):733-7. doi: 10.1212/WNL.0b013e318282513b. Epub 2013 Jan 30.

47.

Familial hypertrophic cardiomyopathy: functional effects of myosin mutation R723G in cardiomyocytes.

Kraft T, Witjas-Paalberends ER, Boontje NM, Tripathi S, Brandis A, Montag J, Hodgkinson JL, Francino A, Navarro-Lopez F, Brenner B, Stienen GJ, van der Velden J.

J Mol Cell Cardiol. 2013 Apr;57:13-22. doi: 10.1016/j.yjmcc.2013.01.001. Epub 2013 Jan 11.

48.

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.

Wijnker PJ, Foster DB, Tsao AL, Frazier AH, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H260-8. doi: 10.1152/ajpheart.00498.2012. Epub 2012 Nov 9.

49.

Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.

Manders E, de Man FS, Handoko ML, Westerhof N, van Hees HW, Stienen GJ, Vonk-Noordegraaf A, Ottenheijm CA.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1070-8. doi: 10.1152/ajplung.00135.2012. Epub 2012 Sep 7.

50.

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.

van Heerebeek L, Hamdani N, Falcão-Pires I, Leite-Moreira AF, Begieneman MP, Bronzwaer JG, van der Velden J, Stienen GJ, Laarman GJ, Somsen A, Verheugt FW, Niessen HW, Paulus WJ.

Circulation. 2012 Aug 14;126(7):830-9. doi: 10.1161/CIRCULATIONAHA.111.076075. Epub 2012 Jul 17.

PMID:
22806632

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