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Use of controlled human infection models (CHIMs) to support vaccine development: US regulatory considerations.

Ramanathan R, Stibitz S, Pratt D, Roberts J.

Vaccine. 2019 Jul 18;37(31):4256-4261. doi: 10.1016/j.vaccine.2019.06.009. Epub 2019 Jun 21. Review.


In Vivo Gene Essentiality and Metabolism in Bordetella pertussis.

Gonyar LA, Gelbach PE, McDuffie DG, Koeppel AF, Chen Q, Lee G, Temple LM, Stibitz S, Hewlett EL, Papin JA, Damron FH, Eby JC.

mSphere. 2019 May 22;4(3). pii: e00694-18. doi: 10.1128/mSphere.00694-18.


The BvgASR virulence regulon of Bordetella pertussis.

Chen Q, Stibitz S.

Curr Opin Microbiol. 2019 Feb;47:74-81. doi: 10.1016/j.mib.2019.01.002. Epub 2019 Mar 11. Review.


Corynebacterium pseudodiphtheriticum Exploits Staphylococcus aureus Virulence Components in a Novel Polymicrobial Defense Strategy.

Hardy BL, Dickey SW, Plaut RD, Riggins DP, Stibitz S, Otto M, Merrell DS.

mBio. 2019 Jan 8;10(1). pii: e02491-18. doi: 10.1128/mBio.02491-18.


A Novel Bvg-Repressed Promoter Causes vrg-Like Transcription of fim3 but Does Not Result in the Production of Serotype 3 Fimbriae in Bvg- Mode Bordetella pertussis.

Chen Q, Lee G, Craig C, Ng V, Carlson PE Jr, Hinton DM, Stibitz S.

J Bacteriol. 2018 Sep 24;200(20). pii: e00175-18. doi: 10.1128/JB.00175-18. Print 2018 Oct 15.


Avirulent Bacillus anthracis Strain with Molecular Assay Targets as Surrogate for Irradiation-Inactivated Virulent Spores.

Plaut RD, Staab AB, Munson MA, Gebhardt JS, Klimko CP, Quirk AV, Cote CK, Buhr TL, Rossmaier RD, Bernhards RC, Love CE, Berk KL, Abshire TG, Rozak DA, Beck LC, Stibitz S, Goodwin BG, Smith MA, Sozhamannan S.

Emerg Infect Dis. 2018 Apr;24(4). doi: 10.3201/eid2404.171646.


Whole-Genome Sequences of Variants of Bacillus anthracis Sterne and Their Toxin Gene Deletion Mutants.

Staab A, Plaut RD, Pratt C, Lovett SP, Wiley MR, Biggs TD, Bernhards RC, Beck LC, Palacios GF, Stibitz S, Jones KL, Goodwin BG, Smith MA, Sozhamannan S.

Genome Announc. 2017 Nov 9;5(45). pii: e01231-17. doi: 10.1128/genomeA.01231-17.


Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.

Liu H, Archer NK, Dillen CA, Wang Y, Ashbaugh AG, Ortines RV, Kao T, Lee SK, Cai SS, Miller RJ, Marchitto MC, Zhang E, Riggins DP, Plaut RD, Stibitz S, Geha RS, Miller LS.

Cell Host Microbe. 2017 Nov 8;22(5):653-666.e5. doi: 10.1016/j.chom.2017.10.006.


Stable Chromosomal Expression of Shigella flexneri 2a and 3a O-Antigens in the Live Salmonella Oral Vaccine Vector Ty21a.

Dharmasena MN, Osorio M, Takeda K, Stibitz S, Kopecko DJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00181-17. doi: 10.1128/CVI.00181-17. Print 2017 Dec.


The BvgAS Regulon of Bordetella pertussis.

Moon K, Bonocora RP, Kim DD, Chen Q, Wade JT, Stibitz S, Hinton DM.

mBio. 2017 Oct 10;8(5). pii: e01526-17. doi: 10.1128/mBio.01526-17.


U.S. Regulatory Considerations for Development of Live Biotherapeutic Products as Drugs.

Dreher-Lesnick SM, Stibitz S, Carlson PE Jr.

Microbiol Spectr. 2017 Oct;5(5). doi: 10.1128/microbiolspec.BAD-0017-2017.


Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.

Chen Q, Ng V, Warfel JM, Merkel TJ, Stibitz S.

J Bacteriol. 2017 Oct 17;199(22). pii: e00475-17. doi: 10.1128/JB.00475-17. Print 2017 Nov 15.


Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract.

Bone MA, Wilk AJ, Perault AI, Marlatt SA, Scheller EV, Anthouard R, Chen Q, Stibitz S, Cotter PA, Julio SM.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1519-E1527. doi: 10.1073/pnas.1609565114. Epub 2017 Feb 6.


A simplified mycobacterial growth inhibition assay (MGIA) using direct infection of mouse splenocytes and the MGIT system.

Yang AL, Schmidt TE, Stibitz S, Derrick SC, Morris SL, Parra M.

J Microbiol Methods. 2016 Dec;131:7-9. doi: 10.1016/j.mimet.2016.09.010. Epub 2016 Sep 17.


Development of an Acid-Resistant Salmonella Typhi Ty21a Attenuated Vector For Improved Oral Vaccine Delivery.

Dharmasena MN, Feuille CM, Starke CE, Bhagwat AA, Stibitz S, Kopecko DJ.

PLoS One. 2016 Sep 27;11(9):e0163511. doi: 10.1371/journal.pone.0163511. eCollection 2016.


Stable expression of Shigella dysenteriae serotype 1 O-antigen genes integrated into the chromosome of live Salmonella oral vaccine vector Ty21a.

Dharmasena MN, Osorio M, Filipova S, Marsh C, Stibitz S, Kopecko DJ.

Pathog Dis. 2016 Nov;74(8). pii: ftw098. doi: 10.1093/femspd/ftw098. Epub 2016 Sep 20.


The multifaceted RisA regulon of Bordetella pertussis.

Coutte L, Huot L, Antoine R, Slupek S, Merkel TJ, Chen Q, Stibitz S, Hot D, Locht C.

Sci Rep. 2016 Sep 13;6:32774. doi: 10.1038/srep32774.


Development of Phage Lysin LysA2 for Use in Improved Purity Assays for Live Biotherapeutic Products.

Dreher-Lesnick SM, Schreier JE, Stibitz S.

Viruses. 2015 Dec 16;7(12):6675-88. doi: 10.3390/v7122965.


Improvements to a Markerless Allelic Exchange System for Bacillus anthracis.

Plaut RD, Stibitz S.

PLoS One. 2015 Dec 1;10(12):e0142758. doi: 10.1371/journal.pone.0142758. eCollection 2015.


Bordetella pertussis fim3 gene regulation by BvgA: phosphorylation controls the formation of inactive vs. active transcription complexes.

Boulanger A, Moon K, Decker KB, Chen Q, Knipling L, Stibitz S, Hinton DM.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E526-35. doi: 10.1073/pnas.1421045112. Epub 2015 Jan 26.


Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis.

Chen Q, Boulanger A, Hinton DM, Stibitz S.

Mol Microbiol. 2014 Aug;93(4):748-58. doi: 10.1111/mmi.12690. Epub 2014 Jul 13.


Genetic evidence for the involvement of the S-layer protein gene sap and the sporulation genes spo0A, spo0B, and spo0F in Phage AP50c infection of Bacillus anthracis.

Plaut RD, Beaber JW, Zemansky J, Kaur AP, George M, Biswas B, Henry M, Bishop-Lilly KA, Mokashi V, Hannah RM, Pope RK, Read TD, Stibitz S, Calendar R, Sozhamannan S.

J Bacteriol. 2014 Mar;196(6):1143-54. doi: 10.1128/JB.00739-13. Epub 2013 Dec 20.


Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging.

Plaut RD, Mocca CP, Prabhakara R, Merkel TJ, Stibitz S.

PLoS One. 2013;8(3):e59232. doi: 10.1371/journal.pone.0059232. Epub 2013 Mar 12.


In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA.

Boulanger A, Chen Q, Hinton DM, Stibitz S.

Mol Microbiol. 2013 Apr;88(1):156-72. doi: 10.1111/mmi.12177. Epub 2013 Mar 14.


Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Prabhakara R, Foreman O, De Pascalis R, Lee GM, Plaut RD, Kim SY, Stibitz S, Elkins KL, Merkel TJ.

Infect Immun. 2013 Apr;81(4):1306-15. doi: 10.1128/IAI.01304-12. Epub 2013 Feb 4.


Use of site-directed mutagenesis to model the effects of spontaneous deamidation on the immunogenicity of Bacillus anthracis protective antigen.

Verma A, McNichol B, Domínguez-Castillo RI, Amador-Molina JC, Arciniega JL, Reiter K, Meade BD, Ngundi MM, Stibitz S, Burns DL.

Infect Immun. 2013 Jan;81(1):278-84. doi: 10.1128/IAI.00863-12. Epub 2012 Oct 31.


Whole genome sequencing of phage resistant Bacillus anthracis mutants reveals an essential role for cell surface anchoring protein CsaB in phage AP50c adsorption.

Bishop-Lilly KA, Plaut RD, Chen PE, Akmal A, Willner KM, Butani A, Dorsey S, Mokashi V, Mateczun AJ, Chapman C, George M, Luu T, Read TD, Calendar R, Stibitz S, Sozhamannan S.

Virol J. 2012 Oct 26;9:246. doi: 10.1186/1743-422X-9-246.


Dissemination bottleneck in a murine model of inhalational anthrax.

Plaut RD, Kelly VK, Lee GM, Stibitz S, Merkel TJ.

Infect Immun. 2012 Sep;80(9):3189-93. doi: 10.1128/IAI.00515-12. Epub 2012 Jul 2.


The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA.

Decker KB, James TD, Stibitz S, Hinton DM.

Microbiology. 2012 Jul;158(Pt 7):1665-1676. doi: 10.1099/mic.0.058941-0. Epub 2012 May 24. Review.


Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells.

Tonry JH, McNichol BA, Ramarao N, Chertow DS, Kim KS, Stibitz S, Schneewind O, Kashanchi F, Bailey CL, Popov S, Chung MC.

Cell Microbiol. 2012 Aug;14(8):1219-30. doi: 10.1111/j.1462-5822.2012.01791.x. Epub 2012 Apr 17.


Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine.

Nicholson TL, Brockmeier SL, Loving CL, Register KB, Kehrli ME Jr, Stibitz SE, Shore SM.

Infect Immun. 2012 Mar;80(3):1025-36. doi: 10.1128/IAI.06016-11. Epub 2011 Dec 12.


Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis.

Crawford MA, Lowe DE, Fisher DJ, Stibitz S, Plaut RD, Beaber JW, Zemansky J, Mehrad B, Glomski IJ, Strieter RM, Hughes MA.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17159-64. doi: 10.1073/pnas.1108495108. Epub 2011 Sep 26.


Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB).

Decker KB, Chen Q, Hsieh ML, Boucher P, Stibitz S, Hinton DM.

J Mol Biol. 2011 Jun 24;409(5):692-709. doi: 10.1016/j.jmb.2011.04.017. Epub 2011 Apr 22.


Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA.

Chen Q, Decker KB, Boucher PE, Hinton D, Stibitz S.

Mol Microbiol. 2010 Sep;77(5):1326-40. doi: 10.1111/j.1365-2958.2010.07293.x.


Pertactin is required for Bordetella species to resist neutrophil-mediated clearance.

Inatsuka CS, Xu Q, Vujkovic-Cvijin I, Wong S, Stibitz S, Miller JF, Cotter PA.

Infect Immun. 2010 Jul;78(7):2901-9. doi: 10.1128/IAI.00188-10. Epub 2010 Apr 26.


Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress.

Cybulski RJ Jr, Sanz P, Alem F, Stibitz S, Bull RL, O'Brien AD.

Infect Immun. 2009 Jan;77(1):274-85. doi: 10.1128/IAI.00515-08. Epub 2008 Oct 27.


Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.

Loving CL, Khurana T, Osorio M, Lee GM, Kelly VK, Stibitz S, Merkel TJ.

Infect Immun. 2009 Jan;77(1):255-65. doi: 10.1128/IAI.00633-08. Epub 2008 Oct 27.


Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay.

Verma A, Wagner L, Stibitz S, Nguyen N, Guerengomba F, Burns DL.

Clin Vaccine Immunol. 2008 Nov;15(11):1737-41. doi: 10.1128/CVI.00081-08. Epub 2008 Sep 24.


O antigen protects Bordetella parapertussis from complement.

Goebel EM, Wolfe DN, Elder K, Stibitz S, Harvill ET.

Infect Immun. 2008 Apr;76(4):1774-80. doi: 10.1128/IAI.01629-07. Epub 2008 Feb 19.


c-di-GMP-mediated regulation of virulence and biofilm formation.

Cotter PA, Stibitz S.

Curr Opin Microbiol. 2007 Feb;10(1):17-23. Epub 2007 Jan 8. Review.


Routine markerless gene replacement in Bacillus anthracis.

Janes BK, Stibitz S.

Infect Immun. 2006 Mar;74(3):1949-53.


Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis.

Jones AM, Boucher PE, Williams CL, Stibitz S, Cotter PA.

Mol Microbiol. 2005 Nov;58(3):700-13.


BvgA functions as both an activator and a repressor to control Bvg phase expression of bipA in Bordetella pertussis.

Williams CL, Boucher PE, Stibitz S, Cotter PA.

Mol Microbiol. 2005 Apr;56(1):175-88.


Analysis of bvgR expression in Bordetella pertussis.

Merkel TJ, Boucher PE, Stibitz S, Grippe VK.

J Bacteriol. 2003 Dec;185(23):6902-12.


Genomic plasticity in natural populations of Bordetella pertussis.

Stibitz S, Yang MS.

J Bacteriol. 1999 Sep;181(17):5512-5.

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