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Items: 1 to 50 of 51

1.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.

Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, Nargan K, George JF, Ramdial PK, Agarwal A, Steyn AJC.

Cell Rep. 2019 Sep 17;28(12):3286. doi: 10.1016/j.celrep.2019.08.081. No abstract available.

2.

Remembering the Host in Tuberculosis Drug Development.

Frank DJ, Horne DJ, Dutta NK, Shaku MT, Madensein R, Hawn TR, Steyn AJC, Karakousis PC, Kana BD, Meintjes G, Laughon B, Tanvir Z.

J Infect Dis. 2019 Apr 19;219(10):1518-1524. doi: 10.1093/infdis/jiy712.

PMID:
30590592
3.

Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages.

Cumming BM, Addicott KW, Adamson JH, Steyn AJ.

Elife. 2018 Nov 16;7. pii: e39169. doi: 10.7554/eLife.39169.

4.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.

Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, Nargan K, George JF, Ramdial PK, Agarwal A, Steyn AJC.

Cell Rep. 2018 Nov 13;25(7):1938-1952.e5. doi: 10.1016/j.celrep.2018.10.073. Erratum in: Cell Rep. 2019 Sep 17;28(12):3286.

5.

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.

Foo CS, Lupien A, Kienle M, Vocat A, Benjak A, Sommer R, Lamprecht DA, Steyn AJC, Pethe K, Piton J, Altmann KH, Cole ST.

MBio. 2018 Oct 9;9(5). pii: e01276-18. doi: 10.1128/mBio.01276-18.

6.

Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.

Pacl HT, Reddy VP, Saini V, Chinta KC, Steyn AJC.

Pathog Dis. 2018 Jul 1;76(5). doi: 10.1093/femspd/fty036.

7.

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.

Reddy VP, Chinta KC, Saini V, Glasgow JN, Hull TD, Traylor A, Rey-Stolle F, Soares MP, Madansein R, Rahman MA, Barbas C, Nargan K, Naidoo T, Ramdial PK, George JF, Agarwal A, Steyn AJC.

Front Immunol. 2018 May 3;9:860. doi: 10.3389/fimmu.2018.00860. eCollection 2018.

8.

RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance.

Wang Z, Cumming BM, Mao C, Zhu Y, Lu P, Steyn AJC, Chen S, Hu Y.

Mol Microbiol. 2018 Jun;108(6):627-640. doi: 10.1111/mmi.13952. Epub 2018 Apr 6.

PMID:
29575247
9.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Finin PM, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE 3rd, Wyatt PG, Boshoff HIM.

ACS Infect Dis. 2018 Jun 8;4(6):954-969. doi: 10.1021/acsinfecdis.7b00275. Epub 2018 Mar 26.

10.

Role of Ergothioneine in Microbial Physiology and Pathogenesis.

Cumming BM, Chinta KC, Reddy VP, Steyn AJC.

Antioxid Redox Signal. 2018 Feb 20;28(6):431-444. doi: 10.1089/ars.2017.7300. Epub 2017 Sep 8. Review.

11.

Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01338-17. doi: 10.1128/AAC.01338-17. Print 2017 Oct.

12.

Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

Cumming BM, Rahman MA, Lamprecht DA, Rohde KH, Saini V, Adamson JH, Russell DG, Steyn AJC.

PLoS Pathog. 2017 Jul 14;13(7):e1006490. doi: 10.1371/journal.ppat.1006490. eCollection 2017 Jul.

13.

Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.

Cumming BM, Rahman MA, Lamprecht DA, Rohde KH, Saini V, Adamson JH, Russell DG, Steyn AJC.

PLoS Pathog. 2017 May 22;13(5):e1006389. doi: 10.1371/journal.ppat.1006389. eCollection 2017 May. Erratum in: PLoS Pathog. 2017 Jul 14;13(7):e1006490.

14.

Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections.

Surolia R, Karki S, Wang Z, Kulkarni T, Li FJ, Vohra S, Batra H, Nick JA, Duncan SR, Thannickal VJ, Steyn AJ, Agarwal A, Antony VB.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L928-L940. doi: 10.1152/ajplung.00397.2015. Epub 2016 Sep 30.

15.

Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.

Chen Z, Hu Y, Cumming BM, Lu P, Feng L, Deng J, Steyn AJ, Chen S.

Cell Rep. 2016 Aug 30;16(9):2512-24. doi: 10.1016/j.celrep.2016.07.080. Epub 2016 Aug 18.

16.

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.

Lamprecht DA, Finin PM, Rahman MA, Cumming BM, Russell SL, Jonnala SR, Adamson JH, Steyn AJ.

Nat Commun. 2016 Aug 10;7:12393. doi: 10.1038/ncomms12393.

17.

Cardiogenic shock: A look at acute functional mitral incompetence.

Steyn FA, Vosloo J, Naude H, Steyn AJ.

S Afr Med J. 2016 Jul 12;106(8):789-91. doi: 10.7196/SAMJ.2016.v106i8.10283.

PMID:
27499404
18.

The emerging role of gasotransmitters in the pathogenesis of tuberculosis.

Chinta KC, Saini V, Glasgow JN, Mazorodze JH, Rahman MA, Reddy D, Lancaster JR Jr, Steyn AJ.

Nitric Oxide. 2016 Sep 30;59:28-41. doi: 10.1016/j.niox.2016.06.009. Epub 2016 Jul 4. Review.

19.

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.

Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC.

Cell Rep. 2016 Jan 26;14(3):572-585. doi: 10.1016/j.celrep.2015.12.056. Epub 2016 Jan 7.

20.

Metabolic plasticity of central carbon metabolism protects mycobacteria.

Cumming BM, Steyn AJ.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13135-6. doi: 10.1073/pnas.1518171112. Epub 2015 Oct 19. No abstract available.

21.

Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.

Richard-Greenblatt M, Bach H, Adamson J, Peña-Diaz S, Li W, Steyn AJ, Av-Gay Y.

J Biol Chem. 2015 Sep 18;290(38):23064-76. doi: 10.1074/jbc.M115.648642. Epub 2015 Jul 30.

22.

The Physiology and Genetics of Oxidative Stress in Mycobacteria.

Cumming BM, Lamprecht DA, Wells RM, Saini V, Mazorodze JH, Steyn AJC.

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0019-2013. Review.

PMID:
26103972
23.

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.

Wang Y, Jin TH, Farhana A, Freeman J, Estell K, Zmijewski JW, Gaggar A, Thannickal VJ, Schwiebert LM, Steyn AJ, Deshane JS.

Lab Invest. 2014 Dec;94(12):1312-25. doi: 10.1038/labinvest.2014.126. Epub 2014 Nov 3.

24.

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.

Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna KC, Fallert Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46. doi: 10.1164/rccm.201304-0803OC.

25.

Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria.

Regev D, Surolia R, Karki S, Zolak J, Montes-Worboys A, Oliva O, Guroji P, Saini V, Steyn AJ, Agarwal A, Antony VB.

Lab Invest. 2012 Nov;92(11):1541-52. doi: 10.1038/labinvest.2012.125. Epub 2012 Sep 10.

26.

Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.

Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D, Steyn AJ, Singh A.

Mol Microbiol. 2012 Sep;85(6):1148-65. doi: 10.1111/j.1365-2958.2012.08165.x. Epub 2012 Jul 26.

27.

Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis.

Farhana A, Saini V, Kumar A, Lancaster JR Jr, Steyn AJ.

Antioxid Redox Signal. 2012 Nov 1;17(9):1232-45. doi: 10.1089/ars.2012.4613. Epub 2012 Jun 13. Review.

28.

Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis.

Saini V, Farhana A, Glasgow JN, Steyn AJ.

Curr Opin Chem Biol. 2012 Apr;16(1-2):45-53. doi: 10.1016/j.cbpa.2012.03.004. Epub 2012 Apr 4. Review.

29.

Redox homeostasis in mycobacteria: the key to tuberculosis control?

Kumar A, Farhana A, Guidry L, Saini V, Hondalus M, Steyn AJ.

Expert Rev Mol Med. 2011 Dec 16;13:e39. doi: 10.1017/S1462399411002079. Review.

30.

Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence.

Saini V, Farhana A, Steyn AJ.

Antioxid Redox Signal. 2012 Apr 1;16(7):687-97. doi: 10.1089/ars.2011.4341. Review.

31.

A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria.

Mai D, Jones J, Rodgers JW, Hartman JL 4th, Kutsch O, Steyn AJ.

Assay Drug Dev Technol. 2011 Jun;9(3):299-310. doi: 10.1089/adt.2010.0326. Epub 2011 Jan 31.

32.

Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence.

Farhana A, Guidry L, Srivastava A, Singh A, Hondalus MK, Steyn AJ.

Adv Microb Physiol. 2010;57:43-117. doi: 10.1016/B978-0-12-381045-8.00002-3. Review.

PMID:
21078441
33.

Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.

Callahan B, Nguyen K, Collins A, Valdes K, Caplow M, Crossman DK, Steyn AJ, Eisele L, Derbyshire KM.

J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.

34.

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.

Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, Renfrow MB, Steyn AJ.

PLoS Pathog. 2009 Aug;5(8):e1000545. doi: 10.1371/journal.ppat.1000545. Epub 2009 Aug 14.

35.

Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.

Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, Steyn AJ.

J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.

36.

A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis.

Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ.

Mol Microbiol. 2007 Nov;66(3):658-68. Epub 2007 Oct 4.

37.

Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival.

Singh A, Guidry L, Narasimhulu KV, Mai D, Trombley J, Redding KE, Giles GI, Lancaster JR Jr, Steyn AJ.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11562-7. Epub 2007 Jul 3.

38.

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor.

Kumar A, Toledo JC, Patel RP, Lancaster JR Jr, Steyn AJ.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11568-73. Epub 2007 Jul 3.

39.

Recent developments in mycobacterial research.

Steyn AJ, Chan J, Mehra V.

Curr Opin Infect Dis. 1999 Oct;12(5):415-24.

PMID:
17035806
40.

Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association.

Singh A, Mai D, Kumar A, Steyn AJ.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11346-51. Epub 2006 Jul 14.

41.
42.
43.

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.

Steyn AJ, Collins DM, Hondalus MK, Jacobs WR Jr, Kawakami RP, Bloom BR.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3147-52.

44.

Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.

Alland D, Steyn AJ, Weisbrod T, Aldrich K, Jacobs WR Jr.

J Bacteriol. 2000 Apr;182(7):1802-11.

45.
46.
48.

Expression of human P450c17 as an export protein in Saccharomyces cerevisiae.

Swart AC, Swart P, Roux SP, van der Merwe KJ, Pretorius IS, Steyn AJ.

Endocr Res. 1995 Feb-May;21(1-2):289-95.

PMID:
7588392
49.

Regional sequence homologies in starch-degrading enzymes.

Janse BJ, Steyn AJ, Pretorius IS.

Curr Genet. 1993 Nov;24(5):400-7.

PMID:
8299155
50.

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