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Items: 1 to 50 of 72

1.

Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss.

Jiang M, Li H, Johnson A, Karasawa T, Zhang Y, Meier WB, Taghizadeh F, Kachelmeier A, Steyger PS.

Sci Adv. 2019 Jul 17;5(7):eaaw1836. doi: 10.1126/sciadv.aaw1836. eCollection 2019 Jul.

2.

Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier.

Nyberg S, Abbott NJ, Shi X, Steyger PS, Dabdoub A.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaao0935. doi: 10.1126/scitranslmed.aao0935. Review.

PMID:
30842313
3.

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Kros CJ, Steyger PS.

Cold Spring Harb Perspect Med. 2018 Dec 17. pii: a033548. doi: 10.1101/cshperspect.a033548. [Epub ahead of print]

PMID:
30559254
4.

Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells.

Kachelmeier A, Shola T, Meier WB, Johnson A, Jiang M, Steyger PS.

PLoS One. 2018 Nov 1;13(11):e0206628. doi: 10.1371/journal.pone.0206628. eCollection 2018.

5.

Editorial: Cellular Mechanisms of Ototoxicity.

Steyger PS, Cunningham LL, Esquivel CR, Watts KL, Zuo J.

Front Cell Neurosci. 2018 Mar 27;12:75. doi: 10.3389/fncel.2018.00075. eCollection 2018. No abstract available.

6.

Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity.

Jiang M, Taghizadeh F, Steyger PS.

Front Cell Neurosci. 2017 Nov 21;11:362. doi: 10.3389/fncel.2017.00362. eCollection 2017. Review.

7.

Aminoglycoside-Induced Cochleotoxicity: A Review.

Jiang M, Karasawa T, Steyger PS.

Front Cell Neurosci. 2017 Oct 9;11:308. doi: 10.3389/fncel.2017.00308. eCollection 2017. Review.

8.

Monitoring neonates for ototoxicity.

Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS.

Int J Audiol. 2018 Sep;57(sup4):S41-S48. doi: 10.1080/14992027.2017.1339130. Epub 2017 Jun 22.

PMID:
28949262
9.

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study.

Garinis AC, Liao S, Cross CP, Galati J, Middaugh JL, Mace JC, Wood AM, McEvoy L, Moneta L, Lubianski T, Coopersmith N, Vigo N, Hart C, Riddle A, Ettinger O, Nold C, Durham H, MacArthur C, McEvoy C, Steyger PS.

Int J Pediatr Otorhinolaryngol. 2017 Jun;97:42-50. doi: 10.1016/j.ijporl.2017.03.025. Epub 2017 Mar 21.

10.

Community network for deaf scientists.

Adler HJ, Anbuhl KL, Atcherson SR, Barlow N, Brennan MA, Brigande JV, Buran BN, Fraenzer JT, Gale JE, Gallun FJ, Gluck SD, Goldsworthy RL, Heng J, Hight AE, Huyck JJ, Jacobson BD, Karasawa T, Kovačić D, Lim SR, Malone AK, Nolan LS, Pisano DV, Rao VRM, Raphael RM, Ratnanather JT, Reiss LAJ, Ruffin CV, Schwalje AT, Sinan M, Stahn P, Steyger PS, Tang SJ, Tejani VD, Wong V.

Science. 2017 Apr 28;356(6336):386-387. doi: 10.1126/science.aan2330. Epub 2017 Apr 27. No abstract available.

11.

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis.

Garinis AC, Cross CP, Srikanth P, Carroll K, Feeney MP, Keefe DH, Hunter LL, Putterman DB, Cohen DM, Gold JA, Steyger PS.

J Cyst Fibros. 2017 May;16(3):401-409. doi: 10.1016/j.jcf.2017.01.006. Epub 2017 Feb 24.

12.

Systemic Delivery and Biodistribution of Cisplatin in Vivo.

Chu YH, Sibrian-Vazquez M, Escobedo JO, Phillips AR, Dickey DT, Wang Q, Ralle M, Steyger PS, Strongin RM.

Mol Pharm. 2016 Aug 1;13(8):2677-82. doi: 10.1021/acs.molpharmaceut.6b00240. Epub 2016 Jun 24.

13.

Rhodamine analogues for molecular ruler applications.

Chu YH, Escobedo JO, Jiang M, Steyger PS, Strongin RM.

Dyes Pigm. 2016 Mar 1;126:46-53.

14.

Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure.

Cross CP, Liao S, Urdang ZD, Srikanth P, Garinis AC, Steyger PS.

Int J Pediatr Otorhinolaryngol. 2015 Nov;79(11):1915-9. doi: 10.1016/j.ijporl.2015.09.004. Epub 2015 Sep 9.

15.

An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus.

Jiang M, Steyger PS.

Expert Opin Ther Pat. 2015;25(11):1349-52. doi: 10.1517/13543776.2015.1076392. Epub 2015 Aug 6.

16.

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity.

Koo JW, Quintanilla-Dieck L, Jiang M, Liu J, Urdang ZD, Allensworth JJ, Cross CP, Li H, Steyger PS.

Sci Transl Med. 2015 Jul 29;7(298):298ra118. doi: 10.1126/scitranslmed.aac5546.

17.

An integrated view of cisplatin-induced nephrotoxicity and ototoxicity.

Karasawa T, Steyger PS.

Toxicol Lett. 2015 Sep 17;237(3):219-27. doi: 10.1016/j.toxlet.2015.06.012. Epub 2015 Jun 20. Review.

18.

Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles.

Yang Y, Chen F, Karasawa T, Ma KT, Guan BC, Shi XR, Li H, Steyger PS, Nuttall AL, Jiang ZG.

PLoS One. 2015 May 4;10(5):e0125266. doi: 10.1371/journal.pone.0125266. eCollection 2015.

19.

Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells.

Li H, Kachelmeier A, Furness DN, Steyger PS.

Front Cell Neurosci. 2015 Apr 14;9:130. doi: 10.3389/fncel.2015.00130. eCollection 2015.

20.

Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration.

Liu J, Kachelmeier A, Dai C, Li H, Steyger PS.

PLoS One. 2015 Mar 20;10(3):e0120612. doi: 10.1371/journal.pone.0120612. eCollection 2015.

21.

Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.

Jiang M, Wang Q, Karasawa T, Koo JW, Li H, Steyger PS.

PLoS One. 2014 Sep 30;9(9):e108941. doi: 10.1371/journal.pone.0108941. eCollection 2014.

22.

Preclinical and clinical studies of unrelieved aural fullness following intratympanic gentamicin injection in patients with intractable Ménière's disease.

Zhai F, Zhang R, Zhang T, Steyger PS, Dai CF.

Audiol Neurootol. 2013;18(5):297-306. doi: 10.1159/000351805. Epub 2013 Aug 30.

23.

Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds.

Karasawa T, Sibrian-Vazquez M, Strongin RM, Steyger PS.

PLoS One. 2013 Jun 3;8(6):e66220. doi: 10.1371/journal.pone.0066220. Print 2013.

24.

Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea: a pilot study.

Quintanilla-Dieck L, Larrain B, Trune D, Steyger PS.

Otolaryngol Head Neck Surg. 2013 Aug;149(2):301-3. doi: 10.1177/0194599813491712. Epub 2013 Jun 4.

25.

Aminoglycoside-induced hair cell death of inner ear organs causes functional deficits in adult zebrafish (Danio rerio).

Uribe PM, Sun H, Wang K, Asuncion JD, Wang Q, Chen CW, Steyger PS, Smith ME, Matsui JI.

PLoS One. 2013;8(3):e58755. doi: 10.1371/journal.pone.0058755. Epub 2013 Mar 22.

26.

Dimethyl sulfoxide (DMSO) exacerbates cisplatin-induced sensory hair cell death in zebrafish (Danio rerio).

Uribe PM, Mueller MA, Gleichman JS, Kramer MD, Wang Q, Sibrian-Vazquez M, Strongin RM, Steyger PS, Cotanche DA, Matsui JI.

PLoS One. 2013;8(2):e55359. doi: 10.1371/journal.pone.0055359. Epub 2013 Feb 1.

27.

Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs.

Zhang R, Zhang YB, Dai CF, Steyger PS.

Hear Res. 2013 Apr;298:49-59. doi: 10.1016/j.heares.2013.01.010. Epub 2013 Feb 1.

28.

Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels.

Wang T, Yang YQ, Karasawa T, Wang Q, Phillips A, Guan BC, Ma KT, Jiang M, Xie DH, Steyger PS, Jiang ZG.

Cell Biochem Biophys. 2013 Apr;65(3):381-98. doi: 10.1007/s12013-012-9442-2.

29.

Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale.

Brock PR, Knight KR, Freyer DR, Campbell KC, Steyger PS, Blakley BW, Rassekh SR, Chang KW, Fligor BJ, Rajput K, Sullivan M, Neuwelt EA.

J Clin Oncol. 2012 Jul 1;30(19):2408-17. doi: 10.1200/JCO.2011.39.1110. Epub 2012 Apr 30. Review.

30.

Live cell imaging of a fluorescent gentamicin conjugate.

Escobedo JO, Chu YH, Wang Q, Steyger PS, Strongin RM.

Nat Prod Commun. 2012 Mar;7(3):317-20.

31.

Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.

Li H, Steyger PS.

Sci Rep. 2011;1:159. doi: 10.1038/srep00159. Epub 2011 Nov 16.

32.

Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs.

Zhang YB, Zhang R, Zhang WF, Steyger PS, Dai CF.

Hear Res. 2012 Jan;283(1-2):169-79. doi: 10.1016/j.heares.2011.10.003. Epub 2011 Oct 31.

33.

TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells.

Stepanyan RS, Indzhykulian AA, Vélez-Ortega AC, Boger ET, Steyger PS, Friedman TB, Frolenkov GI.

J Assoc Res Otolaryngol. 2011 Dec;12(6):729-40. doi: 10.1007/s10162-011-0288-x. Epub 2011 Aug 31.

34.

Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity.

Alharazneh A, Luk L, Huth M, Monfared A, Steyger PS, Cheng AG, Ricci AJ.

PLoS One. 2011;6(7):e22347. doi: 10.1371/journal.pone.0022347. Epub 2011 Jul 26.

35.

Intracellular mechanisms of aminoglycoside-induced cytotoxicity.

Karasawa T, Steyger PS.

Integr Biol (Camb). 2011 Sep;3(9):879-86. doi: 10.1039/c1ib00034a. Epub 2011 Jul 29. Review.

36.

Calreticulin binds to gentamicin and reduces drug-induced ototoxicity.

Karasawa T, Wang Q, David LL, Steyger PS.

Toxicol Sci. 2011 Dec;124(2):378-87. doi: 10.1093/toxsci/kfr196. Epub 2011 Jul 23.

37.

Acoustic trauma increases cochlear and hair cell uptake of gentamicin.

Li H, Wang Q, Steyger PS.

PLoS One. 2011 Apr 28;6(4):e19130. doi: 10.1371/journal.pone.0019130.

38.

Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin.

Koo JW, Wang Q, Steyger PS.

Audiol Neurootol. 2011;16(6):347-58. doi: 10.1159/000322851. Epub 2010 Dec 30.

39.

Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window.

Zhang Y, Zhang R, Dai C, Steyger PS, Yu Y.

Laryngoscope. 2010 Oct;120(10):2054-60. doi: 10.1002/lary.21041.

40.

Competitive antagonism of fluorescent gentamicin uptake in the cochlea.

Wang Q, Kachelmeier A, Steyger PS.

Hear Res. 2010 Sep 1;268(1-2):250-9. doi: 10.1016/j.heares.2010.06.008. Epub 2010 Jun 16.

41.

Evidence-based modification of intratympanic gentamicin injections in patients with intractable vertigo.

Zhai F, Liu JP, Dai CF, Wang Q, Steyger PS.

Otol Neurotol. 2010 Jun;31(4):642-8. doi: 10.1097/MAO.0b013e3181dbb30e.

42.

CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity.

Karasawa T, Wang Q, David LL, Steyger PS.

Cell Death Dis. 2010 Nov 18;1:e102. doi: 10.1038/cddis.2010.80.

43.

Intra-cochlear trafficking of aminoglycosides.

Steyger PS, Karasawa T.

Commun Integr Biol. 2008;1(2):140-2.

44.

Metabolic imaging of the organ of corti--a window on cochlea bioenergetics.

Tiede L, Steyger PS, Nichols MG, Hallworth R.

Brain Res. 2009 Jun 24;1277:37-41. doi: 10.1016/j.brainres.2009.02.052. Epub 2009 Mar 6.

45.

Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics.

Li H, Steyger PS.

Noise Health. 2009 Jan-Mar;11(42):26-32.

46.

Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells.

Wang Q, Steyger PS.

J Assoc Res Otolaryngol. 2009 Jun;10(2):205-19. doi: 10.1007/s10162-009-0160-4. Epub 2009 Mar 3.

47.

Potentiation of Chemical Ototoxicity by Noise.

Steyger PS.

Semin Hear. 2009 Feb 1;30(1):38-46.

48.

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics.

Karasawa T, Wang Q, Fu Y, Cohen DM, Steyger PS.

J Cell Sci. 2008 Sep 1;121(Pt 17):2871-9. doi: 10.1242/jcs.023705. Epub 2008 Aug 5.

49.

A systemic gentamicin pathway across the stria vascularis.

Dai CF, Steyger PS.

Hear Res. 2008 Jan;235(1-2):114-24. Epub 2007 Nov 17.

50.

Closure of supporting cell scar formations requires dynamic actin mechanisms.

Hordichok AJ, Steyger PS.

Hear Res. 2007 Oct;232(1-2):1-19. Epub 2007 Jun 27.

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