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Items: 1 to 50 of 339

1.

Nanobodies to study protein conformational states.

Uchański T, Pardon E, Steyaert J.

Curr Opin Struct Biol. 2020 Feb 6;60:117-123. doi: 10.1016/j.sbi.2020.01.003. [Epub ahead of print] Review.

PMID:
32036243
2.

Ventral stream hierarchy underlying perceptual organization in adolescents with autism.

Sapey-Triomphe LA, Boets B, Van Eylen L, Noens I, Sunaert S, Steyaert J, Wagemans J.

Neuroimage Clin. 2020 Jan 25;25:102197. doi: 10.1016/j.nicl.2020.102197. [Epub ahead of print]

3.

Rapid neural categorization of angry and fearful faces is specifically impaired in boys with autism spectrum disorder.

Van der Donck S, Dzhelyova M, Vettori S, Mahdi SS, Claes P, Steyaert J, Boets B.

J Child Psychol Psychiatry. 2020 Jan 31. doi: 10.1111/jcpp.13201. [Epub ahead of print]

PMID:
32003011
4.

Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.

Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C.

Elife. 2020 Jan 28;9. pii: e51511. doi: 10.7554/eLife.51511.

5.

Combined frequency-tagging EEG and eye tracking reveal reduced social bias in boys with autism spectrum disorder.

Vettori S, Dzhelyova M, Van der Donck S, Jacques C, Van Wesemael T, Steyaert J, Rossion B, Boets B.

Cortex. 2019 Dec 28;125:135-148. doi: 10.1016/j.cortex.2019.12.013. [Epub ahead of print]

PMID:
31982699
6.

Adults with high functioning autism display idiosyncratic behavioral patterns, neural representations and connectivity of the 'Voice Area' while judging the appropriateness of emotional vocal reactions.

Pegado F, Hendriks MHA, Amelynck S, Daniels N, Steyaert J, Boets B, Op de Beeck H.

Cortex. 2019 Dec 5;125:90-108. doi: 10.1016/j.cortex.2019.11.008. [Epub ahead of print]

PMID:
31978745
7.

Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up.

Bernaerts S, Boets B, Bosmans G, Steyaert J, Alaerts K.

Mol Autism. 2020 Jan 15;11:6. doi: 10.1186/s13229-020-0313-1. eCollection 2020.

8.

TrichoGate: An Improved Vector System for a Large Scale of Functional Analysis of Trichoderma Genes.

Nogueira-López G, Padilla-Arizmendi F, Inwood S, Lyne S, Steyaert JM, Nieto-Jacobo MF, Stewart A, Mendoza-Mendoza A.

Front Microbiol. 2019 Dec 10;10:2794. doi: 10.3389/fmicb.2019.02794. eCollection 2019.

9.

Do Parental Interviews for ASD Converge with Clinical Diagnoses? An Empirical Comparison of the 3di and the DISCO in Children with ASD, a Clinically-Referred Group, and Typically Developing Children.

Evers K, Debbaut E, Maljaars J, Steyaert J, Noens I.

J Autism Dev Disord. 2020 Jan 6. doi: 10.1007/s10803-019-04344-y. [Epub ahead of print]

PMID:
31907731
10.

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.

Abskharon R, Wang F, Wohlkonig A, Ruan J, Soror S, Giachin G, Pardon E, Zou W, Legname G, Ma J, Steyaert J.

PLoS Pathog. 2019 Dec 9;15(12):e1008139. doi: 10.1371/journal.ppat.1008139. eCollection 2019 Dec.

11.

Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.

Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ.

Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y. Epub 2019 Nov 18.

PMID:
31740855
12.

Parents' views and experiences of the autism spectrum disorder diagnosis of their young child: a longitudinal interview study.

Jacobs D, Steyaert J, Dierickx K, Hens K.

Eur Child Adolesc Psychiatry. 2019 Nov 4. doi: 10.1007/s00787-019-01431-4. [Epub ahead of print]

PMID:
31686239
13.

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.

Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, Baenziger JE, Ulens C.

Nat Chem Biol. 2019 Dec;15(12):1156-1164. doi: 10.1038/s41589-019-0369-4. Epub 2019 Oct 7.

PMID:
31591563
14.

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C.

Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23.

PMID:
31548691
15.

Structures of influenza A virus RNA polymerase offer insight into viral genome replication.

Fan H, Walker AP, Carrique L, Keown JR, Serna Martin I, Karia D, Sharps J, Hengrung N, Pardon E, Steyaert J, Grimes JM, Fodor E.

Nature. 2019 Sep;573(7773):287-290. doi: 10.1038/s41586-019-1530-7. Epub 2019 Sep 4.

PMID:
31485076
16.

Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.

Van der Donck S, Dzhelyova M, Vettori S, Thielen H, Steyaert J, Rossion B, Boets B.

J Autism Dev Disord. 2019 Nov;49(11):4658-4673. doi: 10.1007/s10803-019-04172-0.

17.

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax.

Fioravanti A, Van Hauwermeiren F, Van der Verren SE, Jonckheere W, Goncalves A, Pardon E, Steyaert J, De Greve H, Lamkanfi M, Remaut H.

Nat Microbiol. 2019 Nov;4(11):1805-1814. doi: 10.1038/s41564-019-0499-1. Epub 2019 Jul 15.

PMID:
31308522
18.

[Adolescent with a schizophreniform disorder and recurrent 16p11.2 duplication].

Castelein L, Steyaert J, Peeters H, van Buggenhout G.

Tijdschr Psychiatr. 2019;61(6):421-425. Dutch.

19.

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C.

Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y.

20.

Physician View and Experience of the Diagnosis of Autism Spectrum Disorder in Young Children.

Jacobs D, Steyaert J, Dierickx K, Hens K.

Front Psychiatry. 2019 May 28;10:372. doi: 10.3389/fpsyt.2019.00372. eCollection 2019.

21.

Interrogating dense ligand chemical space with a forward-synthetic library.

Chevillard F, Stotani S, Karawajczyk A, Hristeva S, Pardon E, Steyaert J, Tzalis D, Kolb P.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11496-11501. doi: 10.1073/pnas.1818718116. Epub 2019 May 21.

22.

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.

Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I, Palacín M.

Nat Commun. 2019 Apr 18;10(1):1807. doi: 10.1038/s41467-019-09837-z.

23.

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.

Kuzina ES, Ung PM, Mohanty J, Tome F, Choi J, Pardon E, Steyaert J, Lax I, Schlessinger A, Schlessinger J, Lee S.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7819-7824. doi: 10.1073/pnas.1822055116. Epub 2019 Apr 3.

24.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
25.

Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Feb;566(7744):E8. doi: 10.1038/s41586-019-0929-5.

PMID:
30733619
26.

The NADPH Oxidases Nox1 and Nox2 Differentially Regulate Volatile Organic Compounds, Fungistatic Activity, Plant Growth Promotion and Nutrient Assimilation in Trichoderma atroviride.

Cruz-Magalhães V, Nieto-Jacobo MF, van Zijll de Jong E, Rostás M, Padilla-Arizmendi F, Kandula D, Kandula J, Hampton J, Herrera-Estrella A, Steyaert JM, Stewart A, Loguercio LL, Mendoza-Mendoza A.

Front Microbiol. 2019 Jan 23;9:3271. doi: 10.3389/fmicb.2018.03271. eCollection 2018.

27.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

28.

An improved yeast surface display platform for the screening of nanobody immune libraries.

Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J.

Sci Rep. 2019 Jan 23;9(1):382. doi: 10.1038/s41598-018-37212-3.

29.

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.

Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Löw C.

J Am Chem Soc. 2019 Feb 13;141(6):2404-2412. doi: 10.1021/jacs.8b11343. Epub 2019 Jan 31.

PMID:
30644743
30.

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.

Ruprecht JJ, King MS, Zögg T, Aleksandrova AA, Pardon E, Crichton PG, Steyaert J, Kunji ERS.

Cell. 2019 Jan 24;176(3):435-447.e15. doi: 10.1016/j.cell.2018.11.025. Epub 2019 Jan 2.

31.

GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):454-459. doi: 10.1038/s41586-018-0832-5. Epub 2019 Jan 2. Erratum in: Nature. 2019 Feb 7;:.

32.

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer.

Laverty D, Desai R, Uchański T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.

33.

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein.

Deyaert E, Leemans M, Singh RK, Gallardo R, Steyaert J, Kortholt A, Lauer J, Versées W.

Biochem J. 2019 Jan 7;476(1):51-66. doi: 10.1042/BCJ20180803.

PMID:
30538153
34.

Reduced neural sensitivity to rapid individual face discrimination in autism spectrum disorder.

Vettori S, Dzhelyova M, Van der Donck S, Jacques C, Steyaert J, Rossion B, Boets B.

Neuroimage Clin. 2019;21:101613. doi: 10.1016/j.nicl.2018.101613. Epub 2018 Nov 28.

35.

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.

PMID:
30504785
36.

Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools.

Bekesi A, Abdellaoui S, Holroyd N, Van Delm W, Pardon E, Pauwels J, Gevaert K, Steyaert J, Derveaux S, Borysik A, Tompa P.

Methods Enzymol. 2018;611:607-675. doi: 10.1016/bs.mie.2018.09.032. Epub 2018 Nov 3.

PMID:
30471702
37.

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

van Beusekom B, Heidebrecht T, Adamopoulos A, Fish A, Pardon E, Steyaert J, Joosten RP, Perrakis A.

Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):690-695. doi: 10.1107/S2053230X18010282. Epub 2018 Oct 16.

PMID:
30387773
38.

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.

Steyaert J, Scheveneels W, Vanneste J, Van Damme P, Robberecht W, Callaerts P, Bogaert E, Van Den Bosch L.

Hum Mol Genet. 2018 Dec 1;27(23):4103-4116. doi: 10.1093/hmg/ddy303.

39.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Erratum in: Nat Chem Biol. 2019 Feb;15(2):205.

40.

Implications of an Autism Spectrum Disorder Diagnosis: An Interview Study of How Physicians Experience the Diagnosis in a Young Child.

Jacobs D, Steyaert J, Dierickx K, Hens K.

J Clin Med. 2018 Oct 12;7(10). pii: E348. doi: 10.3390/jcm7100348.

41.

Crystal structure of human Mediator subunit MED23.

Monté D, Clantin B, Dewitte F, Lens Z, Rucktooa P, Pardon E, Steyaert J, Verger A, Villeret V.

Nat Commun. 2018 Aug 23;9(1):3389. doi: 10.1038/s41467-018-05967-y.

42.

Intact perceptual bias in autism contradicts the decreased normalization model.

Van de Cruys S, Vanmarcke S, Steyaert J, Wagemans J.

Sci Rep. 2018 Aug 22;8(1):12559. doi: 10.1038/s41598-018-31042-z.

43.

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8769-8774. doi: 10.1073/pnas.1801774115. Epub 2018 Aug 14.

44.

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.

45.

Advance care planning in dementia: recommendations for healthcare professionals.

Piers R, Albers G, Gilissen J, De Lepeleire J, Steyaert J, Van Mechelen W, Steeman E, Dillen L, Vanden Berghe P, Van den Block L.

BMC Palliat Care. 2018 Jun 21;17(1):88. doi: 10.1186/s12904-018-0332-2. Review.

46.

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern.

Castrec B, Dian C, Ciccone S, Ebert CL, Bienvenut WV, Le Caer JP, Steyaert JM, Giglione C, Meinnel T.

Nat Chem Biol. 2018 Jul;14(7):671-679. doi: 10.1038/s41589-018-0077-5. Epub 2018 Jun 11.

PMID:
29892081
47.

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

Icard P, Shulman S, Farhat D, Steyaert JM, Alifano M, Lincet H.

Drug Resist Updat. 2018 May;38:1-11. doi: 10.1016/j.drup.2018.03.001. Epub 2018 Mar 20. Review.

PMID:
29857814
48.

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.

49.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

50.

The Apoplastic Secretome of Trichoderma virens During Interaction With Maize Roots Shows an Inhibition of Plant Defence and Scavenging Oxidative Stress Secreted Proteins.

Nogueira-Lopez G, Greenwood DR, Middleditch M, Winefield C, Eaton C, Steyaert JM, Mendoza-Mendoza A.

Front Plant Sci. 2018 Apr 5;9:409. doi: 10.3389/fpls.2018.00409. eCollection 2018.

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