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Items: 1 to 50 of 323

1.

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax.

Fioravanti A, Van Hauwermeiren F, Van der Verren SE, Jonckheere W, Goncalves A, Pardon E, Steyaert J, De Greve H, Lamkanfi M, Remaut H.

Nat Microbiol. 2019 Jul 15. doi: 10.1038/s41564-019-0499-1. [Epub ahead of print]

PMID:
31308522
2.

[Adolescent with a schizophreniform disorder and recurrent 16p11.2 duplication].

Castelein L, Steyaert J, Peeters H, van Buggenhout G.

Tijdschr Psychiatr. 2019;61(6):421-425. Dutch.

3.

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C.

Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y.

4.

Physician View and Experience of the Diagnosis of Autism Spectrum Disorder in Young Children.

Jacobs D, Steyaert J, Dierickx K, Hens K.

Front Psychiatry. 2019 May 28;10:372. doi: 10.3389/fpsyt.2019.00372. eCollection 2019.

5.

Interrogating dense ligand chemical space with a forward-synthetic library.

Chevillard F, Stotani S, Karawajczyk A, Hristeva S, Pardon E, Steyaert J, Tzalis D, Kolb P.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11496-11501. doi: 10.1073/pnas.1818718116. Epub 2019 May 21.

PMID:
31113876
6.

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.

Errasti-Murugarren E, Fort J, Bartoccioni P, Díaz L, Pardon E, Carpena X, Espino-Guarch M, Zorzano A, Ziegler C, Steyaert J, Fernández-Recio J, Fita I, Palacín M.

Nat Commun. 2019 Apr 18;10(1):1807. doi: 10.1038/s41467-019-09837-z.

7.

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.

Kuzina ES, Ung PM, Mohanty J, Tome F, Choi J, Pardon E, Steyaert J, Lax I, Schlessinger A, Schlessinger J, Lee S.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7819-7824. doi: 10.1073/pnas.1822055116. Epub 2019 Apr 3.

PMID:
30944224
8.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
9.

Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Feb;566(7744):E8. doi: 10.1038/s41586-019-0929-5.

PMID:
30733619
10.

The NADPH Oxidases Nox1 and Nox2 Differentially Regulate Volatile Organic Compounds, Fungistatic Activity, Plant Growth Promotion and Nutrient Assimilation in Trichoderma atroviride.

Cruz-Magalhães V, Nieto-Jacobo MF, van Zijll de Jong E, Rostás M, Padilla-Arizmendi F, Kandula D, Kandula J, Hampton J, Herrera-Estrella A, Steyaert JM, Stewart A, Loguercio LL, Mendoza-Mendoza A.

Front Microbiol. 2019 Jan 23;9:3271. doi: 10.3389/fmicb.2018.03271. eCollection 2018.

11.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

PMID:
30675062
12.

An improved yeast surface display platform for the screening of nanobody immune libraries.

Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J.

Sci Rep. 2019 Jan 23;9(1):382. doi: 10.1038/s41598-018-37212-3.

13.

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1.

Ural-Blimke Y, Flayhan A, Strauss J, Rantos V, Bartels K, Nielsen R, Pardon E, Steyaert J, Kosinski J, Quistgaard EM, Löw C.

J Am Chem Soc. 2019 Feb 13;141(6):2404-2412. doi: 10.1021/jacs.8b11343. Epub 2019 Jan 31.

PMID:
30644743
14.

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier.

Ruprecht JJ, King MS, Zögg T, Aleksandrova AA, Pardon E, Crichton PG, Steyaert J, Kunji ERS.

Cell. 2019 Jan 24;176(3):435-447.e15. doi: 10.1016/j.cell.2018.11.025. Epub 2019 Jan 2.

15.

GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):454-459. doi: 10.1038/s41586-018-0832-5. Epub 2019 Jan 2. Erratum in: Nature. 2019 Feb 7;:.

16.

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer.

Laverty D, Desai R, Uchański T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.

17.

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein.

Deyaert E, Leemans M, Singh RK, Gallardo R, Steyaert J, Kortholt A, Lauer J, Versées W.

Biochem J. 2019 Jan 7;476(1):51-66. doi: 10.1042/BCJ20180803.

PMID:
30538153
18.

Reduced neural sensitivity to rapid individual face discrimination in autism spectrum disorder.

Vettori S, Dzhelyova M, Van der Donck S, Jacques C, Steyaert J, Rossion B, Boets B.

Neuroimage Clin. 2019;21:101613. doi: 10.1016/j.nicl.2018.101613. Epub 2018 Nov 28.

19.

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.

PMID:
30504785
20.

Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools.

Bekesi A, Abdellaoui S, Holroyd N, Van Delm W, Pardon E, Pauwels J, Gevaert K, Steyaert J, Derveaux S, Borysik A, Tompa P.

Methods Enzymol. 2018;611:607-675. doi: 10.1016/bs.mie.2018.09.032. Epub 2018 Nov 3.

PMID:
30471702
21.

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

van Beusekom B, Heidebrecht T, Adamopoulos A, Fish A, Pardon E, Steyaert J, Joosten RP, Perrakis A.

Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):690-695. doi: 10.1107/S2053230X18010282. Epub 2018 Oct 16.

PMID:
30387773
22.

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.

Steyaert J, Scheveneels W, Vanneste J, Van Damme P, Robberecht W, Callaerts P, Bogaert E, Van Den Bosch L.

Hum Mol Genet. 2018 Dec 1;27(23):4103-4116. doi: 10.1093/hmg/ddy303.

23.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Erratum in: Nat Chem Biol. 2019 Feb;15(2):205.

24.

Implications of an Autism Spectrum Disorder Diagnosis: An Interview Study of How Physicians Experience the Diagnosis in a Young Child.

Jacobs D, Steyaert J, Dierickx K, Hens K.

J Clin Med. 2018 Oct 12;7(10). pii: E348. doi: 10.3390/jcm7100348.

25.

Crystal structure of human Mediator subunit MED23.

Monté D, Clantin B, Dewitte F, Lens Z, Rucktooa P, Pardon E, Steyaert J, Verger A, Villeret V.

Nat Commun. 2018 Aug 23;9(1):3389. doi: 10.1038/s41467-018-05967-y.

26.

Intact perceptual bias in autism contradicts the decreased normalization model.

Van de Cruys S, Vanmarcke S, Steyaert J, Wagemans J.

Sci Rep. 2018 Aug 22;8(1):12559. doi: 10.1038/s41598-018-31042-z.

27.

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8769-8774. doi: 10.1073/pnas.1801774115. Epub 2018 Aug 14.

28.

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.

Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.

29.

Advance care planning in dementia: recommendations for healthcare professionals.

Piers R, Albers G, Gilissen J, De Lepeleire J, Steyaert J, Van Mechelen W, Steeman E, Dillen L, Vanden Berghe P, Van den Block L.

BMC Palliat Care. 2018 Jun 21;17(1):88. doi: 10.1186/s12904-018-0332-2. Review.

30.

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern.

Castrec B, Dian C, Ciccone S, Ebert CL, Bienvenut WV, Le Caer JP, Steyaert JM, Giglione C, Meinnel T.

Nat Chem Biol. 2018 Jul;14(7):671-679. doi: 10.1038/s41589-018-0077-5. Epub 2018 Jun 11.

PMID:
29892081
31.

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

Icard P, Shulman S, Farhat D, Steyaert JM, Alifano M, Lincet H.

Drug Resist Updat. 2018 May;38:1-11. doi: 10.1016/j.drup.2018.03.001. Epub 2018 Mar 20. Review.

PMID:
29857814
32.

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.

Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K.

Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0.

33.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

34.

The Apoplastic Secretome of Trichoderma virens During Interaction With Maize Roots Shows an Inhibition of Plant Defence and Scavenging Oxidative Stress Secreted Proteins.

Nogueira-Lopez G, Greenwood DR, Middleditch M, Winefield C, Eaton C, Steyaert JM, Mendoza-Mendoza A.

Front Plant Sci. 2018 Apr 5;9:409. doi: 10.3389/fpls.2018.00409. eCollection 2018.

35.

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function.

Peyrassol X, Laeremans T, Lahura V, Debulpaep M, El Hassan H, Steyaert J, Parmentier M, Langer I.

Front Endocrinol (Lausanne). 2018 Apr 5;9:153. doi: 10.3389/fendo.2018.00153. eCollection 2018.

36.

Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.

Joncour A, Desroy N, Housseman C, Bock X, Bienvenu N, Cherel L, Labeguere V, Peixoto C, Annoot D, Lepissier L, Heiermann J, Hengeveld WJ, Pilzak G, Monjardet A, Wakselman E, Roncoroni V, Le Tallec S, Galien R, David C, Vandervoort N, Christophe T, Conrath K, Jans M, Wohlkonig A, Soror S, Steyaert J, Touitou R, Fleury D, Vercheval L, Mollat P, Triballeau N, van der Aar E, Brys R, Heckmann B.

J Med Chem. 2018 May 10;61(9):4270. doi: 10.1021/acs.jmedchem.8b00579. Epub 2018 Apr 19. No abstract available.

PMID:
29672037
37.

The ethics of patenting autism genes.

Hens K, Noens I, Peeters H, Steyaert J.

Nat Rev Genet. 2018 May;19(5):247-248. doi: 10.1038/nrg.2018.17. Epub 2018 Mar 26. No abstract available.

PMID:
29576616
38.

Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.

Köhler M, Neff C, Perez C, Brunner C, Pardon E, Steyaert J, Schneider G, Locher KP, Zenobi R.

Anal Chem. 2018 Apr 17;90(8):5306-5313. doi: 10.1021/acs.analchem.8b00236. Epub 2018 Apr 4.

PMID:
29562137
39.

Insights on dying, dementia and death certificates.

Vandormael S, Meirschaert A, Steyaert J, De Lepeleire J.

Arch Public Health. 2018 Mar 12;76:16. doi: 10.1186/s13690-018-0263-7. eCollection 2018.

40.

Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.

Szpakowska M, Meyrath M, Reynders N, Counson M, Hanson J, Steyaert J, Chevigné A.

Biochem Pharmacol. 2018 Jul;153:299-309. doi: 10.1016/j.bcp.2018.03.007. Epub 2018 Mar 9.

PMID:
29530506
41.

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.

Pardon E, Betti C, Laeremans T, Chevillard F, Guillemyn K, Kolb P, Ballet S, Steyaert J.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295. doi: 10.1002/anie.201712581. Epub 2018 Mar 30.

PMID:
29469969
42.

Alterations in the inferior longitudinal fasciculus in autism and associations with visual processing: a diffusion-weighted MRI study.

Boets B, Van Eylen L, Sitek K, Moors P, Noens I, Steyaert J, Sunaert S, Wagemans J.

Mol Autism. 2018 Feb 8;9:10. doi: 10.1186/s13229-018-0188-6. eCollection 2018.

43.

Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands.

Chevillard F, Rimmer H, Betti C, Pardon E, Ballet S, van Hilten N, Steyaert J, Diederich WE, Kolb P.

J Med Chem. 2018 Feb 8;61(3):1118-1129. doi: 10.1021/acs.jmedchem.7b01558. Epub 2018 Jan 24.

PMID:
29364664
44.

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.

Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J.

Nature. 2018 Jan 25;553(7689):501-505. doi: 10.1038/nature25010. Epub 2018 Jan 17.

45.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.

Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4.

46.

Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice.

Levy Nogueira M, Hamraz M, Abolhassani M, Bigan E, Lafitte O, Steyaert JM, Dubois B, Schwartz L.

Alzheimers Dement. 2018 Apr;14(4):444-453. doi: 10.1016/j.jalz.2017.11.003. Epub 2017 Dec 12.

PMID:
29244999
47.

Structure of PINK1 in complex with its substrate ubiquitin.

Schubert AF, Gladkova C, Pardon E, Wagstaff JL, Freund SMV, Steyaert J, Maslen SL, Komander D.

Nature. 2017 Dec 7;552(7683):51-56. doi: 10.1038/nature24645. Epub 2017 Oct 30.

48.

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.

Guo W, Naujock M, Fumagalli L, Vandoorne T, Baatsen P, Boon R, Ordovás L, Patel A, Welters M, Vanwelden T, Geens N, Tricot T, Benoy V, Steyaert J, Lefebvre-Omar C, Boesmans W, Jarpe M, Sterneckert J, Wegner F, Petri S, Bohl D, Vanden Berghe P, Robberecht W, Van Damme P, Verfaillie C, Van Den Bosch L.

Nat Commun. 2017 Oct 11;8(1):861. doi: 10.1038/s41467-017-00911-y.

49.

Structural basis for GABAA receptor potentiation by neurosteroids.

Miller PS, Scott S, Masiulis S, De Colibus L, Pardon E, Steyaert J, Aricescu AR.

Nat Struct Mol Biol. 2017 Nov;24(11):986-992. doi: 10.1038/nsmb.3484. Epub 2017 Oct 9.

50.

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.

Abskharon R, Dang J, Elfarash A, Wang Z, Shen P, Zou LS, Hassan S, Wang F, Fujioka H, Steyaert J, Mulaj M, Surewicz WK, Castilla J, Wohlkonig A, Zou WQ.

Microb Cell Fact. 2017 Oct 4;16(1):170. doi: 10.1186/s12934-017-0782-x.

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