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Items: 27

1.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126610. doi: 10.1016/j.bmcl.2019.08.014. Epub 2019 Aug 9.

2.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):509-514. doi: 10.1016/j.bmcl.2018.11.039. Epub 2018 Nov 20.

3.

Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.

Tarr SJ, Díaz-Ingelmo O, Stewart LB, Hocking SE, Murray L, Duffy CW, Otto TD, Chappell L, Rayner JC, Awandare GA, Conway DJ.

BMC Genomics. 2018 Dec 10;19(1):894. doi: 10.1186/s12864-018-5257-x.

4.

Multi-population genomic analysis of malaria parasites indicates local selection and differentiation at the gdv1 locus regulating sexual development.

Duffy CW, Amambua-Ngwa A, Ahouidi AD, Diakite M, Awandare GA, Ba H, Tarr SJ, Murray L, Stewart LB, D'Alessandro U, Otto TD, Kwiatkowski DP, Conway DJ.

Sci Rep. 2018 Oct 25;8(1):15763. doi: 10.1038/s41598-018-34078-3.

5.

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Tsagris DJ, Birchall K, Bouloc N, Large JM, Merritt A, Smiljanic-Hurley E, Wheldon M, Ansell KH, Kettleborough C, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3168-3173. doi: 10.1016/j.bmcl.2018.08.028. Epub 2018 Aug 27.

6.

Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria.

Lee HJ, Georgiadou A, Walther M, Nwakanma D, Stewart LB, Levin M, Otto TD, Conway DJ, Coin LJ, Cunnington AJ.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaar3619. doi: 10.1126/scitranslmed.aar3619.

7.

Long read assemblies of geographically dispersed Plasmodium falciparum isolates reveal highly structured subtelomeres.

Otto TD, Böhme U, Sanders M, Reid A, Bruske EI, Duffy CW, Bull PC, Pearson RD, Abdi A, Dimonte S, Stewart LB, Campino S, Kekre M, Hamilton WL, Claessens A, Volkman SK, Ndiaye D, Amambua-Ngwa A, Diakite M, Fairhurst RM, Conway DJ, Franck M, Newbold CI, Berriman M.

Wellcome Open Res. 2018 May 3;3:52. doi: 10.12688/wellcomeopenres.14571.1. eCollection 2018.

8.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

9.

Multiplication rate variation in the human malaria parasite Plasmodium falciparum.

Murray L, Stewart LB, Tarr SJ, Ahouidi AD, Diakite M, Amambua-Ngwa A, Conway DJ.

Sci Rep. 2017 Jul 25;7(1):6436. doi: 10.1038/s41598-017-06295-9.

10.

Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity.

Bowyer PW, Stewart LB, Aspeling-Jones H, Mensah-Brown HE, Ahouidi AD, Amambua-Ngwa A, Awandare GA, Conway DJ.

Infect Immun. 2015 Jun;83(6):2575-82. doi: 10.1128/IAI.03009-14. Epub 2015 Apr 13.

11.

Analysis of Erythrocyte Invasion Mechanisms of Plasmodium falciparum Clinical Isolates Across 3 Malaria-Endemic Areas in Ghana.

Mensah-Brown HE, Amoako N, Abugri J, Stewart LB, Agongo G, Dickson EK, Ofori MF, Stoute JA, Conway DJ, Awandare GA.

J Infect Dis. 2015 Oct 15;212(8):1288-97. doi: 10.1093/infdis/jiv207. Epub 2015 Apr 2.

12.

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.

Preston MD, Campino S, Assefa SA, Echeverry DF, Ocholla H, Amambua-Ngwa A, Stewart LB, Conway DJ, Borrmann S, Michon P, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Pain A, Bousema T, Drakeley CJ, Fairhurst RM, Sutherland CJ, Roper C, Clark TG.

Nat Commun. 2014 Jun 13;5:4052. doi: 10.1038/ncomms5052.

13.

Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ.

PLoS Genet. 2012;8(11):e1002992. doi: 10.1371/journal.pgen.1002992. Epub 2012 Nov 1.

14.

Freshwater suspended sediments and sewage are reservoirs for enterotoxin-positive Clostridium perfringens.

Mueller-Spitz SR, Stewart LB, Klump JV, McLellan SL.

Appl Environ Microbiol. 2010 Aug;76(16):5556-62. doi: 10.1128/AEM.01702-09. Epub 2010 Jun 25.

15.

Allele frequency-based and polymorphism-versus-divergence indices of balancing selection in a new filtered set of polymorphic genes in Plasmodium falciparum.

Ochola LI, Tetteh KK, Stewart LB, Riitho V, Marsh K, Conway DJ.

Mol Biol Evol. 2010 Oct;27(10):2344-51. doi: 10.1093/molbev/msq119. Epub 2010 May 9.

16.

Reliability of mCP method for identification of Clostridium perfringens from faecal polluted aquatic environments.

Mueller-Spitz SR, Stewart LB, McLellan SL.

J Appl Microbiol. 2010 Jun;108(6):1994-2002. doi: 10.1111/j.1365-2672.2009.04605.x. Epub 2009 Oct 26.

17.

Gene copy number variation throughout the Plasmodium falciparum genome.

Cheeseman IH, Gomez-Escobar N, Carret CK, Ivens A, Stewart LB, Tetteh KK, Conway DJ.

BMC Genomics. 2009 Aug 4;10:353. doi: 10.1186/1471-2164-10-353.

18.

Prospective identification of malaria parasite genes under balancing selection.

Tetteh KK, Stewart LB, Ochola LI, Amambua-Ngwa A, Thomas AW, Marsh K, Weedall GD, Conway DJ.

PLoS One. 2009;4(5):e5568. doi: 10.1371/journal.pone.0005568. Epub 2009 May 15.

19.

Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.

Vivas L, Rattray L, Stewart LB, Robinson BL, Fugmann B, Haynes RK, Peters W, Croft SL.

J Antimicrob Chemother. 2007 Apr;59(4):658-65. Epub 2007 Mar 2.

PMID:
17337512
21.
23.
24.

The chemotherapy of rodent malaria. LX. The importance of formulation in evaluating the blood schizontocidal activity of some endoperoxide antimalarials.

Peters W, Fleck SL, Robinson BL, Stewart LB, Jefford CW.

Ann Trop Med Parasitol. 2002 Sep;96(6):559-73.

PMID:
12396319
26.

Knee kinematics: the effects of running on cambers.

Gehlsen GM, Stewart LB, Van Nelson C, Bratz JS.

Med Sci Sports Exerc. 1989 Aug;21(4):463-6. Review.

PMID:
2674598
27.

THE GENETIC DEFECT, NO. 18 TRISOMY.

STEWART LB, BOWLES AP.

J Natl Med Assoc. 1963 Nov;55:520-3. No abstract available.

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