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Items: 1 to 50 of 91

1.

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG.

Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr.

2.

Mitochondrial stress response triggered by defects in protein synthesis quality control.

Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ.

Life Sci Alliance. 2019 Jan 25;2(1). pii: e201800219. doi: 10.26508/lsa.201800219. Print 2019 Feb.

3.

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.

Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT.

Nat Med. 2018 Dec;24(12):1940. doi: 10.1038/s41591-018-0234-0.

PMID:
30291358
4.

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.

Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT.

Nat Med. 2018 Nov;24(11):1696-1700. doi: 10.1038/s41591-018-0166-8. Epub 2018 Sep 24. Erratum in: Nat Med. 2018 Oct 5;:.

5.

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, Zeviani M, Frezza C, Stewart JB, Minczuk M.

Nat Med. 2018 Nov;24(11):1691-1695. doi: 10.1038/s41591-018-0165-9. Epub 2018 Sep 24.

6.

Delivery of mtZFNs into Early Mouse Embryos.

McCann BJ, Cox A, Gammage PA, Stewart JB, Zernicka-Goetz M, Minczuk M.

Methods Mol Biol. 2018;1867:215-228. doi: 10.1007/978-1-4939-8799-3_16.

PMID:
30155826
7.

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.

Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG.

Nucleic Acids Res. 2018 Jul 27;46(13):6642-6669. doi: 10.1093/nar/gky456.

8.

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Simard ML, Mourier A, Greaves LC, Taylor RW, Stewart JB.

J Pathol. 2018 Jul;245(3):311-323. doi: 10.1002/path.5084. Epub 2018 May 14.

9.

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D.

Nat Commun. 2018 Mar 23;9(1):1202. doi: 10.1038/s41467-018-03552-x.

10.

Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.

Jiang M, Kauppila TES, Motori E, Li X, Atanassov I, Folz-Donahue K, Bonekamp NA, Albarran-Gutierrez S, Stewart JB, Larsson NG.

Cell Metab. 2017 Aug 1;26(2):429-436.e4. doi: 10.1016/j.cmet.2017.07.003.

11.

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB.

Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037.

12.

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A.

Cell Rep. 2016 Aug 16;16(7):1874-90. doi: 10.1016/j.celrep.2016.07.031. Epub 2016 Aug 4.

13.

Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division.

Jokinen R, Marttinen P, Stewart JB, Neil Dear T, Battersby BJ.

Hum Mol Genet. 2016 Feb 15;25(4):706-14. doi: 10.1093/hmg/ddv508. Epub 2015 Dec 17.

PMID:
26681804
14.

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG.

Nat Commun. 2015 Nov 10;6:8808. doi: 10.1038/ncomms9808.

15.

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease.

Stewart JB, Chinnery PF.

Nat Rev Genet. 2015 Sep;16(9):530-42. doi: 10.1038/nrg3966. Review.

PMID:
26281784
16.

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers.

Stewart JB, Alaei-Mahabadi B, Sabarinathan R, Samuelsson T, Gorodkin J, Gustafsson CM, Larsson E.

PLoS Genet. 2015 Jun 30;11(6):e1005333. doi: 10.1371/journal.pgen.1005333. eCollection 2015 Jun.

17.

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.

Macao B, Uhler JP, Siibak T, Zhu X, Shi Y, Sheng W, Olsson M, Stewart JB, Gustafsson CM, Falkenberg M.

Nat Commun. 2015 Jun 22;6:7303. doi: 10.1038/ncomms8303.

18.

Mitochondrial DNA: Radically free of free-radical driven mutations.

Kauppila JH, Stewart JB.

Biochim Biophys Acta. 2015 Nov;1847(11):1354-61. doi: 10.1016/j.bbabio.2015.06.001. Epub 2015 Jun 4. Review.

19.

Explosively driven air blast in a conical shock tube.

Stewart JB, Pecora C.

Rev Sci Instrum. 2015 Mar;86(3):035108. doi: 10.1063/1.4914898.

PMID:
25832276
20.

Keeping mtDNA in shape between generations.

Stewart JB, Larsson NG.

PLoS Genet. 2014 Oct 9;10(10):e1004670. doi: 10.1371/journal.pgen.1004670. eCollection 2014 Oct. Review.

21.

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans.

Baines HL, Stewart JB, Stamp C, Zupanic A, Kirkwood TB, Larsson NG, Turnbull DM, Greaves LC.

Mech Ageing Dev. 2014 Jul;139:22-30. doi: 10.1016/j.mad.2014.06.003. Epub 2014 Jun 7.

22.

Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L.

PLoS One. 2014 May 12;9(5):e96940. doi: 10.1371/journal.pone.0096940. eCollection 2014.

23.

The challenges of mitochondrial replacement.

Chinnery PF, Craven L, Mitalipov S, Stewart JB, Herbert M, Turnbull DM.

PLoS Genet. 2014 Apr 24;10(4):e1004315. doi: 10.1371/journal.pgen.1004315. eCollection 2014 Apr. No abstract available. Erratum in: PLoS Genet. 2014 Jun;10(6):e1004472.

24.

Characterization of the sea urchin mitochondrial transcription factor A reveals unusual features.

Deceglie S, Lionetti C, Stewart JB, Habermann B, Roberti M, Cantatore P, Loguercio Polosa P.

Mitochondrion. 2014 Jan;14(1):34-41. doi: 10.1016/j.mito.2013.10.003. Epub 2013 Nov 1.

25.

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline.

Hagström E, Freyer C, Battersby BJ, Stewart JB, Larsson NG.

Nucleic Acids Res. 2014 Jan;42(2):1111-6. doi: 10.1093/nar/gkt969. Epub 2013 Oct 25.

26.

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.

Ross JM, Stewart JB, Hagström E, Brené S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG.

Nature. 2013 Sep 19;501(7467):412-5. doi: 10.1038/nature12474. Epub 2013 Aug 21.

27.

MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.

Terzioglu M, Ruzzenente B, Harmel J, Mourier A, Jemt E, López MD, Kukat C, Stewart JB, Wibom R, Meharg C, Habermann B, Falkenberg M, Gustafsson CM, Park CB, Larsson NG.

Cell Metab. 2013 Apr 2;17(4):618-26. doi: 10.1016/j.cmet.2013.03.006.

28.

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.

Wanrooij S, Miralles Fusté J, Stewart JB, Wanrooij PH, Samuelsson T, Larsson NG, Gustafsson CM, Falkenberg M.

EMBO Rep. 2012 Dec;13(12):1130-7. doi: 10.1038/embor.2012.161. Epub 2012 Oct 23.

29.

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF.

Nat Genet. 2012 Nov;44(11):1282-5. doi: 10.1038/ng.2427. Epub 2012 Oct 7.

30.

Mitochondrial DNA deletions are associated with non-B DNA conformations.

Damas J, Carneiro J, Gonçalves J, Stewart JB, Samuels DC, Amorim A, Pereira F.

Nucleic Acids Res. 2012 Sep;40(16):7606-21. doi: 10.1093/nar/gks500. Epub 2012 May 31.

31.

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.

Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG.

EMBO J. 2012 Jan 18;31(2):443-56. doi: 10.1038/emboj.2011.392. Epub 2011 Nov 1.

32.

The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.

Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG.

PLoS Genet. 2011 Oct;7(10):e1002324. doi: 10.1371/journal.pgen.1002324. Epub 2011 Oct 13.

33.

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.

Ameur A, Stewart JB, Freyer C, Hagström E, Ingman M, Larsson NG, Gyllensten U.

PLoS Genet. 2011 Mar;7(3):e1002028. doi: 10.1371/journal.pgen.1002028. Epub 2011 Mar 24.

34.

Characterization of mature mitochondrial transcripts in Drosophila, and the implications for the tRNA punctuation model in arthropods.

Stewart JB, Beckenbach AT.

Gene. 2009 Sep 15;445(1-2):49-57. doi: 10.1016/j.gene.2009.06.006. Epub 2009 Jun 18.

PMID:
19540318
36.

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease.

Stewart JB, Freyer C, Elson JL, Larsson NG.

Nat Rev Genet. 2008 Sep;9(9):657-62. doi: 10.1038/nrg2396. Review.

PMID:
18695671
37.

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.

Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A.

Hum Mol Genet. 2008 Aug 1;17(15):2329-35. doi: 10.1093/hmg/ddn133. Epub 2008 Apr 22.

PMID:
18434326
38.

Strong purifying selection in transmission of mammalian mitochondrial DNA.

Stewart JB, Freyer C, Elson JL, Wredenberg A, Cansu Z, Trifunovic A, Larsson NG.

PLoS Biol. 2008 Jan;6(1):e10. doi: 10.1371/journal.pbio.0060010.

39.

Lessons from the Falklands campaign.

Crawford IP, Abraham P, Brown M, Stewart JB, Scott R.

J R Army Med Corps. 2007;153 Suppl 1:74-7. No abstract available.

PMID:
18214091
40.

Open-loop control of a MEMS deformable mirror for large-amplitude wavefront control.

Stewart JB, Diouf A, Zhou Y, Bifano TG.

J Opt Soc Am A Opt Image Sci Vis. 2007 Dec;24(12):3827-33.

PMID:
18059936
42.

Asian scientists and the "glass ceiling".

Stewart JB.

Science. 2005 Dec 16;310(5755):1767-8. No abstract available.

PMID:
16363029
44.

Novel algorithms for polarization imaging resulting in improved quantification of retinal blood vessels.

Elsner AE, Miura M, Stewart JB, Kairala MB, Burns SA.

Stud Health Technol Inform. 2003;94:59-61.

PMID:
15455864
45.

Topology of RbsC, the membrane component of the Escherichia coli ribose transporter.

Stewart JB, Hermodson MA.

J Bacteriol. 2003 Sep;185(17):5234-9.

46.
47.

Combined anticoagulant and antiselectin treatments prevent lethal intravascular coagulation.

Norman KE, Cotter MJ, Stewart JB, Abbitt KB, Ali M, Wagner BE, Wallace WA, Forlow SB, Hellewell PG.

Blood. 2003 Feb 1;101(3):921-8. Epub 2002 Sep 19.

PMID:
12393622
48.

Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation.

Prabhu KS, Zamamiri-Davis F, Stewart JB, Thompson JT, Sordillo LM, Reddy CC.

Biochem J. 2002 Aug 15;366(Pt 1):203-9.

49.
50.

Security and confidentiality in an electronic medical record.

Olson LA, Peters SG, Stewart JB.

Healthc Inf Manage. 1998 Spring;12(1):27-37.

PMID:
10179264

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