Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 187

1.

MYBL2 supports DNA double strand break repair in haematopoietic stem cells.

Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, Almaghrabi R, Gujar J, Reeve N, Raghavan M, Higgs MR, Stewart GS, Petermann E, Garcia P.

Cancer Res. 2018 Aug 6. pii: canres.0273.2018. doi: 10.1158/0008-5472.CAN-18-0273. [Epub ahead of print]

PMID:
30082276
2.

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS.

Mol Cell. 2018 Jul 5;71(1):25-41.e6. doi: 10.1016/j.molcel.2018.05.018. Epub 2018 Jun 21.

3.

Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1 (Tab182), following adenovirus infection.

Hagkarim NC, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ.

J Virol. 2018 Mar 28. pii: JVI.02034-17. doi: 10.1128/JVI.02034-17. [Epub ahead of print]

4.

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND.

Nat Commun. 2018 Feb 21;9(1):746. doi: 10.1038/s41467-018-03159-2.

5.

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

Hollingworth R, Horniblow RD, Forrest C, Stewart GS, Grand RJ.

J Virol. 2017 Oct 27;91(22). pii: e00930-17. doi: 10.1128/JVI.00930-17. Print 2017 Nov 15.

6.

The power of evolutionary rescue is constrained by genetic load.

Stewart GS, Morris MR, Genis AB, Szűcs M, Melbourne BA, Tavener SJ, Hufbauer RA.

Evol Appl. 2017 May 26;10(7):731-741. doi: 10.1111/eva.12489. eCollection 2017 Aug.

7.

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.

Agathanggelou A, Smith E, Davies NJ, Kwok M, Zlatanou A, Oldreive CE, Mao J, Da Costa D, Yadollahi S, Perry T, Kearns P, Skowronska A, Yates E, Parry H, Hillmen P, Reverdy C, Delansorne R, Paneesha S, Pratt G, Moss P, Taylor AMR, Stewart GS, Stankovic T.

Blood. 2017 Jul 13;130(2):156-166. doi: 10.1182/blood-2016-12-758219. Epub 2017 May 11.

8.

Novel 3q27.2-qter deletion in a patient with Diamond-Blackfan anemia and immunodeficiency: Case report and review of literature.

Alkhunaizi E, Schrewe B, Alizadehfar R, Vézina C, Stewart GS, Braverman N.

Am J Med Genet A. 2017 Jun;173(6):1514-1520. doi: 10.1002/ajmg.a.38208. Epub 2017 Apr 21.

PMID:
28432740
9.

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.

Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC.

Mol Cell. 2017 Mar 2;65(5):900-916.e7. doi: 10.1016/j.molcel.2017.01.019. Epub 2017 Feb 23.

10.

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altmüller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nürnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS.

Nat Genet. 2017 Apr;49(4):537-549. doi: 10.1038/ng.3790. Epub 2017 Feb 13.

11.

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.

Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R.

Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638.

12.

Damaged replication forks tolerate USP7 to maintain genome stability.

Zlatanou A, Stewart GS.

Mol Cell Oncol. 2015 Jul 6;3(1):e1063571. doi: 10.1080/23723556.2015.1063571. eCollection 2016 Jan.

13.

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.

Byrd PJ, Stewart GS, Smith A, Eaton C, Taylor AJ, Guy C, Eringyte I, Fooks P, Last JI, Horsley R, Oliver AW, Janic D, Dokmanovic L, Stankovic T, Taylor AM.

PLoS Genet. 2016 Mar 18;12(3):e1005945. doi: 10.1371/journal.pgen.1005945. eCollection 2016 Mar.

14.

Protection or resection: BOD1L as a novel replication fork protection factor.

Higgs MR, Stewart GS.

Nucleus. 2016;7(1):34-40. doi: 10.1080/19491034.2016.1143183. Epub 2016 Feb 18. Review.

15.

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie KJ, Reddy K, Halachev M, McGlasson S, Reijns MAM, Fluteau A, Martin CA, Sabbioneda S, Elcioglu NH, Altmüller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS, Jackson AP.

Nat Genet. 2016 Jan;48(1):36-43. doi: 10.1038/ng.3451. Epub 2015 Nov 23.

16.

UT-B Urea Transporter Localization in the Bovine Gastrointestinal Tract.

Coyle J, McDaid S, Walpole C, Stewart GS.

J Membr Biol. 2016 Apr;249(1-2):77-85. doi: 10.1007/s00232-015-9850-5. Epub 2015 Sep 24.

PMID:
26403526
17.

Alchemix, p53 and topoisomerase.

Grand RJ, Stewart GS.

Aging (Albany NY). 2015 Sep;7(9):601-2. No abstract available.

18.

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS.

Mol Cell. 2015 Aug 6;59(3):462-77. doi: 10.1016/j.molcel.2015.06.007. Epub 2015 Jul 9.

19.

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ.

Viruses. 2015 Jun 5;7(6):2908-27. doi: 10.3390/v7062752.

20.

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.

Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F, Vaziri C, Stewart GS.

Oncogene. 2016 Feb 25;35(8):965-76. doi: 10.1038/onc.2015.149. Epub 2015 May 11.

PMID:
25961918
21.

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.

Agathanggelou A, Weston VJ, Perry T, Davies NJ, Skowronska A, Payne DT, Fossey JS, Oldreive CE, Wei W, Pratt G, Parry H, Oscier D, Coles SJ, Hole PS, Darley RL, McMahon M, Hayes JD, Moss P, Stewart GS, Taylor AM, Stankovic T.

Haematologica. 2015 Aug;100(8):1076-85. doi: 10.3324/haematol.2014.115170. Epub 2015 Apr 3.

22.

Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP, Stewart GS, Bicknell LS.

Am J Hum Genet. 2015 Mar 5;96(3):412-24. doi: 10.1016/j.ajhg.2015.01.013. Epub 2015 Feb 26.

23.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.

Kocyłowski MK, Rey AJ, Stewart GS, Halazonetis TD.

Cell Cycle. 2015;14(11):1748-58. doi: 10.1080/15384101.2015.1010918.

24.

Expression and localization of a UT-B urea transporter in the human bladder.

Walpole C, Farrell A, McGrane A, Stewart GS.

Am J Physiol Renal Physiol. 2014 Nov 1;307(9):F1088-94. doi: 10.1152/ajprenal.00284.2014. Epub 2014 Sep 10.

25.

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.

Thomas A, Perry T, Berhane S, Oldreive C, Zlatanou A, Williams LR, Weston VJ, Stankovic T, Kearns P, Pors K, Grand RJ, Stewart GS.

Oncogene. 2015 Jun;34(25):3336-48. doi: 10.1038/onc.2014.266. Epub 2014 Aug 18.

PMID:
25132271
26.

BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.

Jones RM, Kotsantis P, Stewart GS, Groth P, Petermann E.

Mol Cancer Ther. 2014 Oct;13(10):2412-21. doi: 10.1158/1535-7163.MCT-13-0862. Epub 2014 Jul 22.

27.

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.

28.

Reply: A single strand that links multiple neuropathologies in human disease.

Reynolds JJ, Stewart GS.

Brain. 2014 Apr;137(Pt 4):e267. doi: 10.1093/brain/awt198. Epub 2013 Aug 5. No abstract available.

PMID:
23921167
29.

Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination.

Tikoo S, Madhavan V, Hussain M, Miller ES, Arora P, Zlatanou A, Modi P, Townsend K, Stewart GS, Sengupta S.

EMBO J. 2013 Jun 12;32(12):1778-92. doi: 10.1038/emboj.2013.117. Epub 2013 May 24.

30.

A nervous predisposition to unrepaired DNA double strand breaks.

Reynolds JJ, Stewart GS.

DNA Repair (Amst). 2013 Aug;12(8):588-99. doi: 10.1016/j.dnarep.2013.04.011. Epub 2013 May 17. Review.

PMID:
23684796
31.

A single strand that links multiple neuropathologies in human disease.

Reynolds JJ, Stewart GS.

Brain. 2013 Jan;136(Pt 1):14-27. doi: 10.1093/brain/aws310. Review.

PMID:
23365091
32.

Short communication: urea transporter protein UT-B in the bovine parotid gland.

Dix L, Ward DT, Stewart GS.

J Dairy Sci. 2013 Mar;96(3):1685-90. doi: 10.3168/jds.2012-6230. Epub 2013 Jan 26.

PMID:
23357018
33.

Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.

Sedgwick GG, Townsend K, Martin A, Shimwell NJ, Grand RJ, Stewart GS, Nilsson J, Turnell AS.

Oncogene. 2013 Sep 26;32(39):4622-33. doi: 10.1038/onc.2012.501. Epub 2012 Nov 19.

34.

Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.

Ogi T, Walker S, Stiff T, Hobson E, Limsirichaikul S, Carpenter G, Prescott K, Suri M, Byrd PJ, Matsuse M, Mitsutake N, Nakazawa Y, Vasudevan P, Barrow M, Stewart GS, Taylor AM, O'Driscoll M, Jeggo PA.

PLoS Genet. 2012;8(11):e1002945. doi: 10.1371/journal.pgen.1002945. Epub 2012 Nov 8.

35.

The demise of a TUDOR under stress opens a chromatin link to 53BP1.

Stewart GS.

EMBO J. 2012 Apr 18;31(8):1847-9. doi: 10.1038/emboj.2012.78. Epub 2012 Mar 27. No abstract available.

36.

Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AM, Turnell AS, Stewart GS, Grand RJ, Jackson SP.

Mol Cell. 2012 Feb 24;45(4):505-16. doi: 10.1016/j.molcel.2011.12.035.

37.

Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.

Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS.

J Virol. 2012 Mar;86(6):3167-79. doi: 10.1128/JVI.06583-11. Epub 2011 Dec 28.

38.

Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia.

Byrd PJ, Srinivasan V, Last JI, Smith A, Biggs P, Carney EF, Exley A, Abson C, Stewart GS, Izatt L, Taylor AM.

Br J Cancer. 2012 Jan 17;106(2):262-8. doi: 10.1038/bjc.2011.534. Epub 2011 Dec 6.

39.

The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells.

Zlatanou A, Despras E, Braz-Petta T, Boubakour-Azzouz I, Pouvelle C, Stewart GS, Nakajima S, Yasui A, Ishchenko AA, Kannouche PL.

Mol Cell. 2011 Aug 19;43(4):649-62. doi: 10.1016/j.molcel.2011.06.023.

40.

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.

PLoS Genet. 2011 Apr;7(4):e1001381. doi: 10.1371/journal.pgen.1001381. Epub 2011 Apr 28.

41.

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.

Blundred RM, Stewart GS.

Expert Rev Clin Immunol. 2011 Mar;7(2):169-85. doi: 10.1586/eci.10.93. Review.

PMID:
21426255
42.

Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.

Forrester NA, Sedgwick GG, Thomas A, Blackford AN, Speiseder T, Dobner T, Byrd PJ, Stewart GS, Turnell AS, Grand RJ.

J Virol. 2011 Mar;85(5):2201-11. doi: 10.1128/JVI.01748-10. Epub 2010 Dec 15.

43.

When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1.

Blackford AN, Stewart GS.

DNA Repair (Amst). 2011 Feb 7;10(2):245-9. doi: 10.1016/j.dnarep.2010.11.004. Epub 2010 Dec 3.

PMID:
21130715
44.

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Blackford AN, Patel RN, Forrester NA, Theil K, Groitl P, Stewart GS, Taylor AM, Morgan IM, Dobner T, Grand RJ, Turnell AS.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12251-6. doi: 10.1073/pnas.0914605107. Epub 2010 Jun 21.

45.

A PIAS-ed view of DNA double strand break repair focuses on SUMO.

Zlatanou A, Stewart GS.

DNA Repair (Amst). 2010 May 4;9(5):588-92. doi: 10.1016/j.dnarep.2010.02.003. Epub 2010 Mar 1. Review.

PMID:
20197240
46.

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.

Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.

Nat Cell Biol. 2010 Feb;12(2):177-84. doi: 10.1038/ncb2017. Epub 2010 Jan 17.

PMID:
20081839
47.

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.

Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD.

EMBO J. 2010 Mar 3;29(5):943-55. doi: 10.1038/emboj.2009.400. Epub 2010 Jan 14.

48.

Differential protein abundance and function of UT-B urea transporters in human colon.

Collins D, Winter DC, Hogan AM, Schirmer L, Baird AW, Stewart GS.

Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G345-51. doi: 10.1152/ajpgi.00405.2009. Epub 2009 Nov 19.

49.

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

Townsend K, Mason H, Blackford AN, Miller ES, Chapman JR, Sedgwick GG, Barone G, Turnell AS, Stewart GS.

J Biol Chem. 2009 Dec 4;284(49):33939-48. doi: 10.1074/jbc.M109.009191. Epub 2009 Oct 13.

50.

Dietary regulation of ruminal bovine UT-B urea transporter expression and localization.

Simmons NL, Chaudhry AS, Graham C, Scriven ES, Thistlethwaite A, Smith CP, Stewart GS.

J Anim Sci. 2009 Oct;87(10):3288-99. doi: 10.2527/jas.2008-1710. Epub 2009 Jul 2.

PMID:
19574570

Supplemental Content

Loading ...
Support Center