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A Pro - Con debate: Current Controversies in PAH Pathogenesis at the American Thoracic Society International Meeting in 2017.

Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart DJ, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E.

Am J Physiol Lung Cell Mol Physiol. 2018 Jun 7. doi: 10.1152/ajplung.00150.2018. [Epub ahead of print]


Circulating MicroRNAs Implicate Multiple Atherogenic Abnormalities in the Long-Term Cardiovascular Sequelae of Preeclampsia.

Dayan N, Schlosser K, Stewart DJ, Delles C, Kaur A, Pilote L.

Am J Hypertens. 2018 May 23. doi: 10.1093/ajh/hpy069. [Epub ahead of print]


Making Lung Cancer Clinical Trials More Inclusive: Recommendations for Expanding Eligibility Criteria.

Bonomi P, Blumenthal G, Ferris AS, Stewart DJ, Selig WKD, Krug LM, Allen J, Ison G, Langer CJ, Melemed A, Odogwu L, Basu Roy U, Sandler A.

J Thorac Oncol. 2018 Jun;13(6):748-751. doi: 10.1016/j.jtho.2018.02.013. No abstract available.


Cancer research in the United States: A critical review of current status and proposal for alternative models.

Kantarjian HM, Prat F, Steensma DP, Kurzrock R, Stewart DJ, Sekeres MA, Leveque J.

Cancer. 2018 May 14. doi: 10.1002/cncr.31522. [Epub ahead of print] No abstract available.


A Potential Role for Exosomal TCTP Export in Vascular Remodeling in Pulmonary Arterial Hypertension.

Ferrer E, Dunmore BJ, Hassan D, Ormiston ML, Moore S, Deighton J, Long L, Yang XD, Stewart DJ, Morrell NW.

Am J Respir Cell Mol Biol. 2018 Apr 20. doi: 10.1165/rcmb.2017-0129OC. [Epub ahead of print]


Deterministic Encapsulation of Human Cardiac Stem Cells in Variable Composition Nanoporous Gel Cocoons To Enhance Therapeutic Repair of Injured Myocardium.

Kanda P, Alarcon EI, Yeuchyk T, Parent S, de Kemp RA, Variola F, Courtman D, Stewart DJ, Davis DR.

ACS Nano. 2018 May 22;12(5):4338-4350. doi: 10.1021/acsnano.7b08881. Epub 2018 Apr 20.


The importance of greater speed in drug development for advanced malignancies.

Stewart DJ, Stewart AA, Wheatley-Price P, Batist G, Kantarjian HM, Schiller J, Clemons M, Bradford JP, Gillespie L, Kurzrock R.

Cancer Med. 2018 May;7(5):1824-1836. doi: 10.1002/cam4.1454. Epub 2018 Mar 30.


Taking the right ventricle to 'task' in pulmonary hypertension: role of TASK1/KCNK3 in RV dysfunction.

Chaudhary KR, Stewart DJ.

Cardiovasc Res. 2018 May 1;114(6):776-778. doi: 10.1093/cvr/cvy066. No abstract available.


Systematic Assessment of Strategies for Lung-targeted Delivery of MicroRNA Mimics.

Schlosser K, Taha M, Stewart DJ.

Theranostics. 2018 Feb 2;8(5):1213-1226. doi: 10.7150/thno.22912. eCollection 2018.


Regional process redesign of lung cancer care: a learning health system pilot project.

Fung-Kee-Fung M, Maziak DE, Pantarotto JR, Smylie J, Taylor L, Timlin T, Cacciotti T, Villeneuve PJ, Dennie C, Bornais C, Madore S, Aquino J, Wheatley-Price P, Ozer RS, Stewart DJ.

Curr Oncol. 2018 Feb;25(1):59-66. doi: 10.3747/co.25.3719. Epub 2018 Feb 28.


Go with the (back) flow: what can retrograde perfusion teach us about arterial remodeling in pulmonary arterial hypertension?

Chaudhary KR, Stewart DJ.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L797-L798. doi: 10.1152/ajplung.00065.2018. Epub 2018 Feb 8. No abstract available.


Systemic delivery of MicroRNA mimics with polyethylenimine elevates pulmonary microRNA levels, but lacks pulmonary selectivity.

Schlosser K, Taha M, Deng Y, Stewart DJ.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217750613. doi: 10.1177/2045893217750613. Epub 2017 Dec 18.


Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells.

Mayfield AE, Kanda P, Nantsios A, Parent S, Mount S, Dixit S, Ye B, Seymour R, Stewart DJ, Davis DR.

Theranostics. 2017 Oct 17;7(19):4850-4861. doi: 10.7150/thno.19435. eCollection 2017.


Clinical Features and Outcomes of Acute Coronary Syndrome in Women With Previous Pregnancy Complications.

Grand'Maison S, Pilote L, Schlosser K, Stewart DJ, Okano M, Dayan N.

Can J Cardiol. 2017 Dec;33(12):1683-1692. doi: 10.1016/j.cjca.2017.08.025. Epub 2017 Sep 11.


Macro- and micro-heterogeneity of lung endothelial cells: they may not be smooth, but they got the moves.

Taha M, Cadete VJ, Stewart DJ.

Pulm Circ. 2017 Oct-Dec;7(4):755-757. doi: 10.1177/2045893217743710. No abstract available.


Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol.

Barron CC, Lalu MM, Stewart DJ, Fergusson D, Yang H, Moher D, Liu P, Mazer D, Devereaux PJ, McIntyre L; Canadian Perioperative Anesthesia Clinical Trials Group.

Syst Rev. 2017 Nov 7;6(1):226. doi: 10.1186/s13643-017-0601-9.


Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.

Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW.

Circulation. 2017 Dec 19;136(25):2451-2467. doi: 10.1161/CIRCULATIONAHA.117.028034. Epub 2017 Sep 26.


Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial.

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. doi: 10.1164/rccm.201705-1006OC.


High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice.

Schlosser K, Taha M, Deng Y, McIntyre LA, Mei SHJ, Stewart DJ.

Thorax. 2018 Mar;73(3):248-261. doi: 10.1136/thoraxjnl-2017-210413. Epub 2017 Sep 25.


Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia.

Yougbaré I, Tai WS, Zdravic D, Oswald BE, Lang S, Zhu G, Leong-Poi H, Qu D, Yu L, Dunk C, Zhang J, Sled JG, Lye SJ, Brkić J, Peng C, Höglund P, Croy BA, Adamson SL, Wen XY, Stewart DJ, Freedman J, Ni H.

Nat Commun. 2017 Aug 9;8(1):224. doi: 10.1038/s41467-017-00269-1.


Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart.

Abdul-Ghani M, Suen C, Jiang B, Deng Y, Weldrick JJ, Putinski C, Brunette S, Fernando P, Lee TT, Flynn P, Leenen FHH, Burgon PG, Stewart DJ, Megeney LA.

Cell Res. 2017 Oct;27(10):1195-1215. doi: 10.1038/cr.2017.87. Epub 2017 Aug 8.


Photodriven Oxygen Removal via Chromophore-Mediated Singlet Oxygen Sensitization and Chemical Capture.

O'Donnell RM, Grusenmeyer TA, Stewart DJ, Ensley TR, Shensky WM 3rd, Haley JE, Shi J.

Inorg Chem. 2017 Aug 7;56(15):9273-9280. doi: 10.1021/acs.inorgchem.7b01226. Epub 2017 Jul 11.


Lack of elevation in plasma levels of pro-inflammatory cytokines in common rodent models of pulmonary arterial hypertension: questions of construct validity for human patients.

Schlosser K, Taha M, Deng Y, Jiang B, McIntyre LA, Mei SH, Stewart DJ.

Pulm Circ. 2017 Apr-Jun;7(2):476-485. doi: 10.1177/2045893217705878. Epub 2017 May 12.


Effect of steroid and serum starvation on a human breast cancer adenocarcinoma cell line.

Nakhjavani M, Stewart DJ, Shirazi FH.

J Exp Ther Oncol. 2017 May;12(1):25-34.


Proliferative Versus Degenerative Paradigms in Pulmonary Arterial Hypertension: Have We Put the Cart Before the Horse?

Chaudhary KR, Taha M, Cadete VJ, Godoy RS, Stewart DJ.

Circ Res. 2017 Apr 14;120(8):1237-1239. doi: 10.1161/CIRCRESAHA.116.310097. No abstract available.


Exploring the Benefit/Risk Associated with Antiangiogenic Agents for the Treatment of Non-Small Cell Lung Cancer Patients.

Kurzrock R, Stewart DJ.

Clin Cancer Res. 2017 Mar 1;23(5):1137-1148. doi: 10.1158/1078-0432.CCR-16-1968. Epub 2016 Dec 9. Review.


Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial.

Lalu MM, Sullivan KJ, Mei SH, Moher D, Straus A, Fergusson DA, Stewart DJ, Jazi M, MacLeod M, Winston B, Marshall J, Hutton B, Walley KR, McIntyre L.

Elife. 2016 Nov 17;5. pii: e17850. doi: 10.7554/eLife.17850.


Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers.

Schlosser K, Hanson J, Villeneuve PJ, Dimitroulakos J, McIntyre L, Pilote L, Stewart DJ.

Sci Rep. 2016 Nov 18;6:36596. doi: 10.1038/srep36596.


The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research.

Avey MT, Moher D, Sullivan KJ, Fergusson D, Griffin G, Grimshaw JM, Hutton B, Lalu MM, Macleod M, Marshall J, Mei SH, Rudnicki M, Stewart DJ, Turgeon AF, McIntyre L; Canadian Critical Care Translational Biology Group.

PLoS One. 2016 Nov 17;11(11):e0166733. doi: 10.1371/journal.pone.0166733. eCollection 2016.


DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis.

Amatullah H, Shan Y, Beauchamp BL, Gali PL, Gupta S, Maron-Gutierrez T, Speck ER, Fox-Robichaud AE, Tsang JL, Mei SH, Mak TW, Rocco PR, Semple JW, Zhang H, Hu P, Marshall JC, Stewart DJ, Harper ME, Liaw PC, Liles WC, Dos Santos CC; Canadian Critical Care Translational Biology Group.

Am J Respir Crit Care Med. 2017 Apr 1;195(7):889-905. doi: 10.1164/rccm.201604-0730OC.


Induction of Activating Transcription Factor 3 Is Associated with Cisplatin Responsiveness in Non-Small Cell Lung Carcinoma Cells.

Bar J, Hasim MS, Baghai T, Niknejad N, Perkins TJ, Stewart DJ, Sekhon HS, Villeneuve PJ, Dimitroulakos J.

Neoplasia. 2016 Sep;18(9):525-35. doi: 10.1016/j.neo.2016.07.004.


Advances in Stem Cell and Cell-Based Gene Therapy Approaches for Experimental Acute Lung Injury: A Review of Preclinical Studies.

Mei SH, Dos Santos CC, Stewart DJ.

Hum Gene Ther. 2016 Oct;27(10):802-812. Review.


Aerobic versus Anaerobic Microbial Degradation of Clothianidin under Simulated California Rice Field Conditions.

Mulligan RA, Tomco PL, Howard MW, Schempp TT, Stewart DJ, Stacey PM, Ball DB, Tjeerdema RS.

J Agric Food Chem. 2016 Sep 28;64(38):7059-67. doi: 10.1021/acs.jafc.6b02055. Epub 2016 Sep 13.


The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina.

Povsic TJ, Henry TD, Traverse JH, Fortuin FD, Schaer GL, Kereiakes DJ, Schatz RA, Zeiher AM, White CJ, Stewart DJ, Jolicoeur EM, Bass T, Henderson DA, Dignacco P, Gu Z, Al-Khalidi HR, Junge C, Nada A, Hunt AS, Losordo DW; RENEW Investigators.

JACC Cardiovasc Interv. 2016 Aug 8;9(15):1576-85. doi: 10.1016/j.jcin.2016.05.003.


Unravelling the life history of Amazonian fishes through otolith microchemistry.

Hermann TW, Stewart DJ, Limburg KE, Castello L.

R Soc Open Sci. 2016 Jun 8;3(6):160206. doi: 10.1098/rsos.160206. eCollection 2016 Jun.


Molecular Changes Associated with the Protective Effects of Angiopoietin-1 During Blood-Brain Barrier Breakdown Post-Injury.

Nag S, Manias JL, Kapadia A, Stewart DJ.

Mol Neurobiol. 2017 Aug;54(6):4232-4242. doi: 10.1007/s12035-016-9973-4. Epub 2016 Jun 22.


Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol.

Suen CM, Zhai A, Lalu MM, Welsh C, Levac BM, Fergusson D, McIntyre L, Stewart DJ.

Syst Rev. 2016 May 25;5:89. doi: 10.1186/s13643-016-0265-x. Review.


The impact of patient co-morbidities on the regenerative capacity of cardiac explant-derived stem cells.

Mayfield AE, Fitzpatrick ME, Latham N, Tilokee EL, Villanueva M, Mount S, Lam BK, Ruel M, Stewart DJ, Davis DR.

Stem Cell Res Ther. 2016 May 26;7(1):60. doi: 10.1186/s13287-016-0321-4.


Brief Report: Elastin Microfibril Interface 1 and Integrin-Linked Protein Kinase Are Novel Markers of Islet Regenerative Function in Human Multipotent Mesenchymal Stromal Cells.

Lavoie JR, Creskey MM, Muradia G, Bell GI, Sherman SE, Gao J, Stewart DJ, Cyr TD, Hess DA, Rosu-Myles M.

Stem Cells. 2016 Aug;34(8):2249-55. doi: 10.1002/stem.2385. Epub 2016 May 19.


Paracrine Engineering of Human Explant-Derived Cardiac Stem Cells to Over-Express Stromal-Cell Derived Factor 1α Enhances Myocardial Repair.

Tilokee EL, Latham N, Jackson R, Mayfield AE, Ye B, Mount S, Lam BK, Suuronen EJ, Ruel M, Stewart DJ, Davis DR.

Stem Cells. 2016 Jul;34(7):1826-35. doi: 10.1002/stem.2373. Epub 2016 Apr 21.


Transient Receptor Potential Melastatin 7 Cation Channel Kinase: New Player in Angiotensin II-Induced Hypertension.

Antunes TT, Callera GE, He Y, Yogi A, Ryazanov AG, Ryazanova LV, Zhai A, Stewart DJ, Shrier A, Touyz RM.

Hypertension. 2016 Apr;67(4):763-73. doi: 10.1161/HYPERTENSIONAHA.115.07021. Epub 2016 Feb 29.


Insurance Denial of Coverage for Patients Enrolled in Cancer Clinical Trials Is Still a Problem in the Affordable Care Act Era.

Jain N, Steensma D, Stewart DJ, Kantarjian H.

J Oncol Pract. 2016 Apr;12(4):283-5. doi: 10.1200/JOP.2015.010454. Epub 2016 Feb 23. No abstract available.


Steric hindrance inhibits excited-state relaxation and lowers the extent of intramolecular charge transfer in two-photon absorbing dyes.

Stewart DJ, Dalton MJ, Long SL, Kannan R, Yu Z, Cooper TM, Haley JE, Tan LS.

Phys Chem Chem Phys. 2016 Feb 21;18(7):5587-96. doi: 10.1039/c5cp07716h. Epub 2016 Feb 1.


Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review.

McIntyre LA, Moher D, Fergusson DA, Sullivan KJ, Mei SH, Lalu M, Marshall J, Mcleod M, Griffin G, Grimshaw J, Turgeon A, Avey MT, Rudnicki MA, Jazi M, Fishman J, Stewart DJ; Canadian Critical Care Translational Biology Group.

PLoS One. 2016 Jan 28;11(1):e0147170. doi: 10.1371/journal.pone.0147170. eCollection 2016. Review.


Click chemistry, 3D-printing, and omics: the future of drug development.

Kurzrock R, Stewart DJ.

Oncotarget. 2016 Jan 19;7(3):2155-8. doi: 10.18632/oncotarget.6787.


The Urgent Need for Clinical Research Reform to Permit Faster, Less Expensive Access to New Therapies for Lethal Diseases.

Stewart DJ, Batist G, Kantarjian HM, Bradford JP, Schiller JH, Kurzrock R.

Clin Cancer Res. 2015 Oct 15;21(20):4561-8. doi: 10.1158/1078-0432.CCR-14-3246.


Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair.

Jackson R, Tilokee EL, Latham N, Mount S, Rafatian G, Strydhorst J, Ye B, Boodhwani M, Chan V, Ruel M, Ruddy TD, Suuronen EJ, Stewart DJ, Davis DR.

J Am Heart Assoc. 2015 Sep 11;4(9):e002104. doi: 10.1161/JAHA.115.002104.


Marked Strain-Specific Differences in the SU5416 Rat Model of Severe Pulmonary Arterial Hypertension.

Jiang B, Deng Y, Suen C, Taha M, Chaudhary KR, Courtman DW, Stewart DJ.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):461-8. doi: 10.1165/rcmb.2014-0488OC.


Endothelial NO-Synthase Gene-Enhanced Progenitor Cell Therapy for Pulmonary Arterial Hypertension: The PHACeT Trial.

Granton J, Langleben D, Kutryk MB, Camack N, Galipeau J, Courtman DW, Stewart DJ.

Circ Res. 2015 Sep 11;117(7):645-54. doi: 10.1161/CIRCRESAHA.114.305951. Epub 2015 Jul 20.


Reversible pulmonary arterial hypertension associated with interferon-beta treatment for multiple sclerosis.

Gibbons E, Promislow S, Davies RA, Chandy G, Stewart DJ, Vladamir CD, Pugliese C, Dunne R, Mielniczuk LM.

Can Respir J. 2015 Sep-Oct;22(5):263-5. Epub 2015 Jun 17.

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