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Items: 36

1.

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.

Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C.

J Med Chem. 2019 Jan 10;62(1):276-287. doi: 10.1021/acs.jmedchem.8b00368. Epub 2018 Jul 23.

PMID:
29990428
2.

Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats.

Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C, Smoum R, Parker LA, Mechoulam R.

Br J Pharmacol. 2018 Jan;175(1):100-112. doi: 10.1111/bph.14073. Epub 2017 Dec 5.

3.

Big conductance calcium-activated potassium channel openers control spasticity without sedation.

Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI, Vanessa Ho WS, Jackson SJ, Williams TE, Al-Izki S, Sevastou I, Okuyama M, Graier WF, Stevenson LA, Tanner C, Ross R, Pertwee RG, Henstridge CM, Irving AJ, Schulman J, Powell K, Baker MD, Giovannoni G, Selwood DL.

Br J Pharmacol. 2017 Aug;174(16):2662-2681. doi: 10.1111/bph.13889. Epub 2017 Jul 7.

4.

Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor.

Laprairie RB, Kulkarni PM, Deschamps JR, Kelly MEM, Janero DR, Cascio MG, Stevenson LA, Pertwee RG, Kenakin TP, Denovan-Wright EM, Thakur GA.

ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203. doi: 10.1021/acschemneuro.6b00310. Epub 2017 Feb 7.

PMID:
28103441
5.

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA.

ACS Chem Neurosci. 2016 Jun 15;7(6):776-98. doi: 10.1021/acschemneuro.6b00041. Epub 2016 Apr 25.

6.

Host-specific thermal profiles affect fitness of a widespread pathogen.

Stevenson LA, Roznik EA, Alford RA, Pike DA.

Ecol Evol. 2014 Nov;4(21):4053-64. doi: 10.1002/ece3.1271. Epub 2014 Oct 3.

7.

Variation in thermal performance of a widespread pathogen, the amphibian chytrid fungus Batrachochytrium dendrobatidis.

Stevenson LA, Alford RA, Bell SC, Roznik EA, Berger L, Pike DA.

PLoS One. 2013 Sep 4;8(9):e73830. doi: 10.1371/journal.pone.0073830. eCollection 2013.

8.

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study.

Wisnivesky JP, Teitelbaum SL, Todd AC, Boffetta P, Crane M, Crowley L, de la Hoz RE, Dellenbaugh C, Harrison D, Herbert R, Kim H, Jeon Y, Kaplan J, Katz C, Levin S, Luft B, Markowitz S, Moline JM, Ozbay F, Pietrzak RH, Shapiro M, Sharma V, Skloot G, Southwick S, Stevenson LA, Udasin I, Wallenstein S, Landrigan PJ.

Lancet. 2011 Sep 3;378(9794):888-97. doi: 10.1016/S0140-6736(11)61180-X.

PMID:
21890053
9.

Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist.

Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee RG.

Br J Pharmacol. 2010 Jan;159(1):129-41. doi: 10.1111/j.1476-5381.2009.00515.x. Epub 2009 Dec 4.

10.

The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.

Pertwee RG, Thomas A, Stevenson LA, Ross RA, Varvel SA, Lichtman AH, Martin BR, Razdan RK.

Br J Pharmacol. 2007 Mar;150(5):586-94. Epub 2007 Jan 22.

11.

Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.

Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG.

Br J Pharmacol. 2005 Dec;146(7):917-26.

12.

Allosteric modulation of the cannabinoid CB1 receptor.

Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, Pertwee RG, Ross RA.

Mol Pharmacol. 2005 Nov;68(5):1484-95. Epub 2005 Aug 19.

PMID:
16113085
13.
14.

Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.

Pertwee RG, Thomas A, Stevenson LA, Maor Y, Mechoulam R.

Neuropharmacology. 2005 Jun;48(8):1139-46. Epub 2005 Mar 19.

PMID:
15910889
15.

Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations.

Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Barbee BD, Richards JH, Butenhoff JL, Stevenson LA, Lau C.

Toxicol Sci. 2003 Aug;74(2):369-81. Epub 2003 May 28. Erratum in: Toxicol Sci. 2004 Nov;82(1):359.

PMID:
12773773
16.

Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation.

Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, Stevenson LA.

Toxicol Sci. 2003 Aug;74(2):382-92. Epub 2003 May 28.

PMID:
12773772
17.

Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals.

Olsen GW, Hansen KJ, Stevenson LA, Burris JM, Mandel JH.

Environ Sci Technol. 2003 Mar 1;37(5):888-91.

PMID:
12666917
18.
19.

Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide.

Ross RA, Craib SJ, Stevenson LA, Pertwee RG, Henderson A, Toole J, Ellington HC.

J Pharmacol Exp Ther. 2002 Jun;301(3):900-7.

PMID:
12023517
20.

Sociodemographic correlates of indoor allergen sensitivity among United States children.

Stevenson LA, Gergen PJ, Hoover DR, Rosenstreich D, Mannino DM, Matte TD.

J Allergy Clin Immunol. 2001 Nov;108(5):747-52.

PMID:
11692099
21.

O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties.

Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR.

Br J Pharmacol. 2000 Apr;129(8):1577-84.

22.

Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.

Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG.

Br J Pharmacol. 1999 Oct;128(3):735-43.

23.

Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

Hillard CJ, Manna S, Greenberg MJ, DiCamelli R, Ross RA, Stevenson LA, Murphy V, Pertwee RG, Campbell WB.

J Pharmacol Exp Ther. 1999 Jun;289(3):1427-33.

PMID:
10336536
24.

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630.

Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG.

Br J Pharmacol. 1999 Feb;126(3):665-72.

25.

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

Reggio PH, Basu-Dutt S, Barnett-Norris J, Castro MT, Hurst DP, Seltzman HH, Roche MJ, Gilliam AF, Thomas BF, Stevenson LA, Pertwee RG, Abood ME.

J Med Chem. 1998 Dec 17;41(26):5177-87.

PMID:
9857088
26.
27.

Species markers for equine strongyles detected in intergenic rDNA by PCR-RFLP.

Gasser RB, Stevenson LA, Chilton NB, Nansen P, Bucknell DG, Beveridge I.

Mol Cell Probes. 1996 Oct;10(5):371-8.

PMID:
8910892
28.
29.

The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.

Reggio PH, Bramblett RD, Yuknavich H, Seltzman HH, Fleming DN, Fernando SR, Stevenson LA, Pertwee RG.

Life Sci. 1995;56(23-24):2025-32.

PMID:
7776828
30.

(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.

Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG, Makriyannis A.

J Med Chem. 1994 Jun 10;37(12):1889-93.

PMID:
8021930
31.

Species identification of trichostrongyle nematodes by PCR-linked RFLP.

Gasser RB, Chilton NB, Hoste H, Stevenson LA.

Int J Parasitol. 1994 Apr;24(2):291-3.

PMID:
7913087
32.

Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.

Pertwee RG, Stevenson LA, Griffin G.

Br J Pharmacol. 1993 Dec;110(4):1483-90. Erratum in: Br J Pharmacol 1994 Mar;111(3):968.

33.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R.

Science. 1992 Dec 18;258(5090):1946-9.

PMID:
1470919
34.
35.

The response of Winnipeg retail shops and restaurants to a bylaw regulating smoking in public place.

Stanwick RS, Thomson MP, Swerhone PM, Stevenson LA, Fish DG.

Can J Public Health. 1988 Jul-Aug;79(4):226-30. No abstract available.

PMID:
3167746
36.

The recognition of threatening facial stimuli.

Aronoff J, Barclay AM, Stevenson LA.

J Pers Soc Psychol. 1988 Apr;54(4):647-55.

PMID:
3367283

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