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Items: 1 to 50 of 401

1.

A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.

Li JC, Nastertorabi F, Xuan W, Han GW, Stevens RC, Schultz PG.

ACS Chem Biol. 2019 Jun 4. doi: 10.1021/acschembio.9b00002. [Epub ahead of print]

PMID:
31181898
2.

The structure-based traceless specific fluorescence labeling of the smoothened receptor.

Xue D, Ye L, Zheng J, Wu Y, Zhang X, Xu Y, Li T, Stevens RC, Xu F, Zhuang M, Zhao S, Zhao F, Tao H.

Org Biomol Chem. 2019 Jun 10. doi: 10.1039/c9ob00654k. [Epub ahead of print]

PMID:
31180094
3.

Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor.

Lu Y, Qin S, Zhang B, Dai A, Cai X, Ma M, Gao ZG, Yang D, Stevens RC, Jacobson KA, Wang MW, Shui W.

Anal Chem. 2019 Jun 12. doi: 10.1021/acs.analchem.9b00477. [Epub ahead of print]

PMID:
31094506
4.

Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor.

Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V.

Nature. 2019 May;569(7756):E6. doi: 10.1038/s41586-019-1209-0.

PMID:
31048811
5.

The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state.

Gutierrez MG, Deyell J, White KL, Dalle Ore LC, Cherezov V, Stevens RC, Malmstadt N.

Chem Commun (Camb). 2019 May 14;55(40):5724-5727. doi: 10.1039/c8cc10130b.

PMID:
31038495
6.

Structural basis of ligand recognition at the human MT1 melatonin receptor.

Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V.

Nature. 2019 May;569(7755):284-288. doi: 10.1038/s41586-019-1141-3. Epub 2019 Apr 24. Erratum in: Nature. 2019 May 3;:.

PMID:
31019306
7.

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.

Johansson LC, Stauch B, McCorvy JD, Han GW, Patel N, Huang XP, Batyuk A, Gati C, Slocum ST, Li C, Grandner JM, Hao S, Olsen RHJ, Tribo AR, Zaare S, Zhu L, Zatsepin NA, Weierstall U, Yous S, Stevens RC, Liu W, Roth BL, Katritch V, Cherezov V.

Nature. 2019 May;569(7755):289-292. doi: 10.1038/s41586-019-1144-0. Epub 2019 Apr 24.

PMID:
31019305
8.

A novel CRISPR/Cas9 associated technology for sequence-specific nucleic acid enrichment.

Stevens RC, Steele JL, Glover WR, Sanchez-Garcia JF, Simpson SD, O'Rourke D, Ramsdell JS, MacManes MD, Thomas WK, Shuber AP.

PLoS One. 2019 Apr 18;14(4):e0215441. doi: 10.1371/journal.pone.0215441. eCollection 2019.

9.

Advancing Chemokine GPCR Structure Based Drug Discovery.

Zhao S, Wu B, Stevens RC.

Structure. 2019 Mar 5;27(3):405-408. doi: 10.1016/j.str.2019.02.004.

PMID:
30840872
10.

De Novo Structural Pattern Mining in Cellular Electron Cryotomograms.

Xu M, Singla J, Tocheva EI, Chang YW, Stevens RC, Jensen GJ, Alber F.

Structure. 2019 Apr 2;27(4):679-691.e14. doi: 10.1016/j.str.2019.01.005. Epub 2019 Feb 7.

PMID:
30744995
11.

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.

Chen S, Lu M, Liu D, Yang L, Yi C, Ma L, Zhang H, Liu Q, Frimurer TM, Wang MW, Schwartz TW, Stevens RC, Wu B, Wüthrich K, Zhao Q.

Nat Commun. 2019 Feb 7;10(1):638. doi: 10.1038/s41467-019-08568-5.

12.

An online resource for GPCR structure determination and analysis.

Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE.

Nat Methods. 2019 Feb;16(2):151-162. doi: 10.1038/s41592-018-0302-x. Epub 2019 Jan 21. Review.

PMID:
30664776
13.

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10.

PMID:
30639103
14.

Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Feb;15(2):206. doi: 10.1038/s41589-018-0214-1.

PMID:
30573766
15.

Facile chemoenzymatic synthesis of a novel stable mimic of NAD.

Dai Z, Zhang XN, Nasertorabi F, Cheng Q, Pei H, Louie SG, Stevens RC, Zhang Y.

Chem Sci. 2018 Oct 15;9(44):8337-8342. doi: 10.1039/c8sc03899f. eCollection 2018 Nov 28.

16.

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.

Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC.

Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3. Erratum in: Nat Chem Biol. 2019 Feb;15(2):206.

17.

A2A adenosine receptor functional states characterized by 19F-NMR.

Sušac L, Eddy MT, Didenko T, Stevens RC, Wüthrich K.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12733-12738. doi: 10.1073/pnas.1813649115. Epub 2018 Nov 21.

18.

Emerging structural biology of lipid G protein-coupled receptors.

Audet M, Stevens RC.

Protein Sci. 2019 Feb;28(2):292-304. doi: 10.1002/pro.3509. Review.

PMID:
30239054
19.

Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F.

Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.

PMID:
30135577
20.

Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.

Liu X, Gao ZG, Wu Y, Stevens RC, Jacobson KA, Zhao S.

Sci Rep. 2018 Jul 24;8(1):11380. doi: 10.1038/s41598-018-29406-6.

21.

Computational design of thermostabilizing point mutations for G protein-coupled receptors.

Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V.

Elife. 2018 Jun 21;7. pii: e34729. doi: 10.7554/eLife.34729.

22.

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor.

Eddy MT, Gao ZG, Mannes P, Patel N, Jacobson KA, Katritch V, Stevens RC, Wüthrich K.

J Am Chem Soc. 2018 Jul 5;140(26):8228-8235. doi: 10.1021/jacs.8b03805. Epub 2018 Jun 20.

23.

Structural basis for signal recognition and transduction by platelet-activating-factor receptor.

Cao C, Tan Q, Xu C, He L, Yang L, Zhou Y, Zhou Y, Qiao A, Lu M, Yi C, Han GW, Wang X, Li X, Yang H, Rao Z, Jiang H, Zhao Y, Liu J, Stevens RC, Zhao Q, Zhang XC, Wu B.

Nat Struct Mol Biol. 2018 Jun;25(6):488-495. doi: 10.1038/s41594-018-0068-y. Epub 2018 May 28.

PMID:
29808000
24.

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.

Liu X, Gao ZG, Wu Y, Stevens RC, Jacobson KA, Zhao S.

Sci Rep. 2018 May 24;8(1):8084. doi: 10.1038/s41598-018-26577-0. Erratum in: Sci Rep. 2018 Jul 24;8(1):11380.

25.

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening.

Qin S, Meng M, Yang D, Bai W, Lu Y, Peng Y, Song G, Wu Y, Zhou Q, Zhao S, Huang X, McCorvy JD, Cai X, Dai A, Roth BL, Hanson MA, Liu ZJ, Wang MW, Stevens RC, Shui W.

Chem Sci. 2018 Feb 20;9(12):3192-3199. doi: 10.1039/c7sc04698g. eCollection 2018 Mar 28.

26.

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B.

Nature. 2018 Apr;556(7702):520-524. doi: 10.1038/s41586-018-0046-x. Epub 2018 Apr 18.

27.

Identification of natural products as novel ligands for the human 5-HT2C receptor.

Peng Y, Zhao S, Wu Y, Cao H, Xu Y, Liu X, Shui W, Cheng J, Zhao S, Shen L, Ma J, Quinn RJ, Stevens RC, Zhong G, Liu ZJ.

Biophys Rep. 2018;4(1):50-61. doi: 10.1007/s41048-018-0047-1. Epub 2018 Mar 9.

28.

Chemical Diversity in the G Protein-Coupled Receptor Superfamily.

Vass M, Kooistra AJ, Yang D, Stevens RC, Wang MW, de Graaf C.

Trends Pharmacol Sci. 2018 May;39(5):494-512. doi: 10.1016/j.tips.2018.02.004. Epub 2018 Mar 22. Review.

PMID:
29576399
29.

Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell.

Singla J, McClary KM, White KL, Alber F, Sali A, Stevens RC.

Cell. 2018 Mar 22;173(1):11-19. doi: 10.1016/j.cell.2018.03.014. Review.

30.

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ.

Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1.

31.

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.

White KL, Eddy MT, Gao ZG, Han GW, Lian T, Deary A, Patel N, Jacobson KA, Katritch V, Stevens RC.

Structure. 2018 Feb 6;26(2):259-269.e5. doi: 10.1016/j.str.2017.12.013. Epub 2018 Jan 27.

32.

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL.

Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4.

33.

Structure of the glucagon receptor in complex with a glucagon analogue.

Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B.

Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153.

PMID:
29300013
34.

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist.

Roach JJ, Sasano Y, Schmid CL, Zaidi S, Katritch V, Stevens RC, Bohn LM, Shenvi RA.

ACS Cent Sci. 2017 Dec 27;3(12):1329-1336. doi: 10.1021/acscentsci.7b00488. Epub 2017 Dec 13.

35.

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.

Eddy MT, Lee MY, Gao ZG, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wüthrich K.

Cell. 2018 Jan 11;172(1-2):68-80.e12. doi: 10.1016/j.cell.2017.12.004. Epub 2017 Dec 28.

36.

Psychological and Psychophysiological Effects of Recuperative Music Postexercise.

Karageorghis CI, Bruce AC, Pottratz ST, Stevens RC, Bigliassi M, Hamer M.

Med Sci Sports Exerc. 2018 Apr;50(4):739-746. doi: 10.1249/MSS.0000000000001497.

PMID:
29140897
37.

Extending the Structural View of Class B GPCRs.

de Graaf C, Song G, Cao C, Zhao Q, Wang MW, Wu B, Stevens RC.

Trends Biochem Sci. 2017 Dec;42(12):946-960. doi: 10.1016/j.tibs.2017.10.003. Epub 2017 Nov 11. Review.

PMID:
29132948
38.

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE.

Cell. 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.

39.

How Ligands Illuminate GPCR Molecular Pharmacology.

Wacker D, Stevens RC, Roth BL.

Cell. 2017 Jul 27;170(3):414-427. doi: 10.1016/j.cell.2017.07.009. Review.

40.

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.

Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, Cherezov V.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8223-8228. doi: 10.1073/pnas.1700891114. Epub 2017 Jul 17.

41.

Structure and Function of Peptide-Binding G Protein-Coupled Receptors.

Wu F, Song G, de Graaf C, Stevens RC.

J Mol Biol. 2017 Aug 18;429(17):2726-2745. doi: 10.1016/j.jmb.2017.06.022. Epub 2017 Jul 11. Review.

PMID:
28705763
42.

Crystal structures of agonist-bound human cannabinoid receptor CB1.

Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.

Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5.

43.

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.

Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM.

Immunity. 2017 Jun 20;46(6):1005-1017.e5. doi: 10.1016/j.immuni.2017.05.002.

44.

Structural Basis for Apelin Control of the Human Apelin Receptor.

Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F.

Structure. 2017 Jun 6;25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017 May 18.

45.

Structure of the full-length glucagon class B G-protein-coupled receptor.

Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B.

Nature. 2017 Jun 8;546(7657):259-264. doi: 10.1038/nature22363. Epub 2017 May 17.

46.

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han GW, Lau J, Wu B, Hanson MA, Liu ZJ, Wang MW, Stevens RC.

Nature. 2017 Jun 8;546(7657):312-315. doi: 10.1038/nature22378. Epub 2017 May 17.

PMID:
28514449
47.

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F.

Nat Commun. 2017 May 17;8:15383. doi: 10.1038/ncomms15383.

48.

A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.

Ye L, Ding K, Zhao F, Liu X, Wu Y, Liu Y, Xue D, Zhou F, Zhang X, Stevens RC, Xu F, Zhao S, Tao H.

Medchemcomm. 2017 Apr 28;8(6):1332-1336. doi: 10.1039/c7md00104e. eCollection 2017 Jun 1.

49.

Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.

Koh M, Nasertorabi F, Han GW, Stevens RC, Schultz PG.

J Am Chem Soc. 2017 Apr 26;139(16):5728-5731. doi: 10.1021/jacs.7b02273. Epub 2017 Apr 17.

PMID:
28413876
50.

Structural basis for selectivity and diversity in angiotensin II receptors.

Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V.

Nature. 2017 Apr 20;544(7650):327-332. doi: 10.1038/nature22035. Epub 2017 Apr 5.

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