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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.

Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P.

Arch Toxicol. 2020 Jan;94(1):205-217. doi: 10.1007/s00204-019-02630-3. Epub 2020 Jan 9.


Perioperative Oxidative Stress: The Unseen Enemy.

Stevens JL, Feelisch M, Martin DS.

Anesth Analg. 2019 Dec;129(6):1749-1760. doi: 10.1213/ANE.0000000000004455.


Perioperative Oxidative Stress: The Unseen Enemy.

Stevens JL, Feelisch M, Martin DS.

Anesth Analg. 2019 Oct 9. doi: 10.1213/ANE.0000000000004455. [Epub ahead of print]


Azteca ants maintain unique microbiomes across functionally distinct nest chambers.

Lucas JM, Madden AA, Penick CA, Epps MJ, Marting PR, Stevens JL, Fergus DJ, Dunn RR, Meineke EK.

Proc Biol Sci. 2019 Aug 14;286(1908):20191026. doi: 10.1098/rspb.2019.1026. Epub 2019 Aug 7.


A Novel Open Access Web Portal for Integrating Mechanistic and Toxicogenomic Study Results.

Sutherland JJ, Stevens JL, Johnson K, Elango N, Webster YW, Mills BJ, Robertson DH.

Toxicol Sci. 2019 Aug 1;170(2):296-309. doi: 10.1093/toxsci/kfz101.


Racial Disparities in the Receipt of Guideline Care and Cancer Deaths for Women with Ovarian Cancer.

Cronin KA, Howlader N, Stevens JL, Trimble EL, Harlan LC, Warren JL.

Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):539-545. doi: 10.1158/1055-9965.EPI-18-0285. Epub 2018 Nov 28.


Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.

Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, Rainbow L, Fang Y, Sutherland JJ, Ellis EC, Ingelman-Sundberg M, Fenwick SW, Goldring CE, van de Water B, Stevens JL, Park BK.

Arch Toxicol. 2019 Feb;93(2):385-399. doi: 10.1007/s00204-018-2354-1. Epub 2018 Nov 13.


Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells.

Spahr CS, Daris ME, Graham KC, Soriano BD, Stevens JL, Shi SD.

MAbs. 2018 Nov-Dec;10(8):1291-1300. doi: 10.1080/19420862.2018.1511197. Epub 2018 Sep 20.


Black/white differences in treatment and survival among women with stage IIIB-IV breast cancer at diagnosis: a US population-based study.

Enewold L, Penn DC, Stevens JL, Harlan LC.

Cancer Causes Control. 2018 Jul;29(7):657-665. doi: 10.1007/s10552-018-1045-9. Epub 2018 Jun 2.


Suicidality in High-Risk Psychiatric Patients: The Contribution of Protective Factors.

Tillman JG, Clemence AJ, Hopwood CJ, Lewis KC, Stevens JL.

Psychiatry. 2017 Winter;80(4):357-373. doi: 10.1080/00332747.2017.1296309.


Adoption of Sorafenib for the Treatment of Advanced-Stage Hepatocellular Carcinoma in Oncology Practices in the United States.

Parsons HM, Chu Q, Karlitz JJ, Stevens JL, Harlan LC.

Liver Cancer. 2017 Jun;6(3):216-226. doi: 10.1159/000473862. Epub 2017 Apr 28.


Treatment and survival of childhood neuroblastoma: Evidence from a population-based study in the United States.

Coughlan D, Gianferante M, Lynch CF, Stevens JL, Harlan LC.

Pediatr Hematol Oncol. 2017 Aug;34(5):320-330. doi: 10.1080/08880018.2017.1373315. Epub 2017 Oct 17.


Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response.

Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC.

J Biol Chem. 2017 Aug 25;292(34):14050-14065. doi: 10.1074/jbc.M117.799304. Epub 2017 Jul 14.


Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.

Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK.

Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28. Review.


The persistent shadow of suicide ideation and attempts in a high-risk group of psychiatric patients: A focus for intervention.

Tillman JG, Clemence AJ, Cree R, Lewis KC, Stevens JL, Reiss D.

Compr Psychiatry. 2017 Aug;77:20-26. doi: 10.1016/j.comppsych.2017.05.005. Epub 2017 May 18.


Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity.

Sutherland JJ, Webster YW, Willy JA, Searfoss GH, Goldstein KM, Irizarry AR, Hall DG, Stevens JL.

Pharmacogenomics J. 2018 May 22;18(3):377-390. doi: 10.1038/tpj.2017.17. Epub 2017 Apr 25.


Temporal patterns of care and outcomes of non-small cell lung cancer patients in the United States diagnosed in 1996, 2005, and 2010.

Kaniski F, Enewold L, Thomas A, Malik S, Stevens JL, Harlan LC.

Lung Cancer. 2017 Jan;103:66-74. doi: 10.1016/j.lungcan.2016.11.020. Epub 2016 Nov 29.


Validation of prostate-specific antigen laboratory values recorded in Surveillance, Epidemiology, and End Results registries.

National Cancer Institute Surveillance, Epidemiology, and End Results Prostate-Specific Antigen Working Group, Adamo MP, Boten JA, Coyle LM, Cronin KA, Lam CJ, Negoita S, Penberthy L, Stevens JL, Ward KC.

Cancer. 2017 Feb 15;123(4):697-703. doi: 10.1002/cncr.30401. Epub 2016 Oct 26.


Symbiosis in the Soil: Citizen Microbiology in Middle and High School Classrooms.

McKenney E, Flythe T, Millis C, Stalls J, Urban JM, Dunn RR, Stevens JL.

J Microbiol Biol Educ. 2016 Mar 1;17(1):60-2. doi: 10.1128/jmbe.v17i1.1016. eCollection 2016 Mar.


Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes.

Sutherland JJ, Jolly RA, Goldstein KM, Stevens JL.

PLoS Comput Biol. 2016 Mar 30;12(3):e1004847. doi: 10.1371/journal.pcbi.1004847. eCollection 2016 Mar.


Treatment of hepatocellular carcinoma in the community: disparities in standard therapy.

Harlan LC, Parsons HM, Wiggins CL, Stevens JL, Patt YZ.

Liver Cancer. 2015 Mar;4(1):70-83. doi: 10.1159/000367729.


CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis.

Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC.

Mol Biol Cell. 2015 Jun 15;26(12):2190-204. doi: 10.1091/mbc.E15-01-0036. Epub 2015 Apr 22.


Gastrointestinal stromal tumors: treatment patterns of a population-based sample.

Harlan LC, Eisenstein J, Russell MC, Stevens JL, Cardona K.

J Surg Oncol. 2015 May;111(6):702-7. doi: 10.1002/jso.23879.


Thyroid cancer presentation and treatment in the United States.

Enewold L, Harlan LC, Stevens JL, Sharon E.

Ann Surg Oncol. 2015;22(6):1789-97. doi: 10.1245/s10434-014-4209-1. Epub 2014 Nov 1.


ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.

Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP.

Development. 2014 Oct;141(20):3966-77. doi: 10.1242/dev.107755.


Developing microphysiological systems for use as regulatory tools--challenges and opportunities.

Andersen ME, Betts K, Dragan Y, Fitzpatrick S, Goodman JL, Hartung T, Himmelfarb J, Ingber DE, Jacobs A, Kavlock R, Kolaja K, Stevens JL, Tagle D, Lansing Taylor D, Throckmorton D.

ALTEX. 2014;31(3):364-7. doi: 10.14573/altex.1405151. No abstract available.


Do flow volume loops alter surgical management in patients with a goitre?

Stevens JL, Constantinides V, Todd J, Meeran K, Christakis I, Tolley NS, Palazzo FF.

Clin Endocrinol (Oxf). 2014 Dec;81(6):916-20. doi: 10.1111/cen.12539. Epub 2014 Aug 7.


Treatment of small cell lung cancer in academic and community settings: factors associated with receiving standard therapy and survival.

Parsons HM, Harlan LC, Stevens JL, Ullmann CD.

Cancer J. 2014 Mar-Apr;20(2):97-104. doi: 10.1097/PPO.0000000000000039.


An automated and reproducible workflow for running and analyzing neural simulations using Lancet and IPython Notebook.

Stevens JL, Elver M, Bednar JA.

Front Neuroinform. 2013 Dec 30;7:44. doi: 10.3389/fninf.2013.00044. eCollection 2013.


Hepatocolonic fistula: a rare consequence of retained gallstones after laparoscopic cholecystectomy.

Stevens JL, Laliotis A, Gould SW.

Ann R Coll Surg Engl. 2013 Nov;95(8):e139-41. doi: 10.1308/003588413X13629960048550.


Mechanisms for stable, robust, and adaptive development of orientation maps in the primary visual cortex.

Stevens JL, Law JS, Antolík J, Bednar JA.

J Neurosci. 2013 Oct 2;33(40):15747-66. doi: 10.1523/JNEUROSCI.1037-13.2013.


Slowing PCR ramp speed reduces chimera formation from environmental samples.

Stevens JL, Jackson RL, Olson JB.

J Microbiol Methods. 2013 Jun;93(3):203-5. doi: 10.1016/j.mimet.2013.03.013. Epub 2013 Mar 26.


Xenobiotic perturbation of ER stress and the unfolded protein response.

Lafleur MA, Stevens JL, Lawrence JW.

Toxicol Pathol. 2013 Feb;41(2):235-62. doi: 10.1177/0192623312470764. Epub 2013 Jan 18. Review.


Inhibition of WISE preserves renal allograft function.

Qian X, Yuan X, Vonderfecht S, Ge X, Lee J, Jurisch A, Zhang L, You A, Fitzpatrick VD, Williams A, Valente EG, Pretorius J, Stevens JL, Tipton B, Winters AG, Graham K, Harriss L, Baker DM, Damore M, Salimi-Moosavi H, Gao Y, Elkhal A, Paszty C, Simonet WS, Richards WG, Tullius SG.

J Am Soc Nephrol. 2013 Jan;24(1):66-76. doi: 10.1681/ASN.2012010012. Epub 2012 Nov 26.


Relating molecular properties and in vitro assay results to in vivo drug disposition and toxicity outcomes.

Sutherland JJ, Raymond JW, Stevens JL, Baker TK, Watson DE.

J Med Chem. 2012 Jul 26;55(14):6455-66. doi: 10.1021/jm300684u. Epub 2012 Jul 5.


A population-based study of therapy and survival for patients with head and neck cancer treated in the community.

Dansky Ullmann C, Harlan LC, Shavers VL, Stevens JL.

Cancer. 2012 Sep 15;118(18):4452-61. doi: 10.1002/cncr.27419. Epub 2012 Jan 17.


Clinical trial participation and time to treatment among adolescents and young adults with cancer: does age at diagnosis or insurance make a difference?

Parsons HM, Harlan LC, Seibel NL, Stevens JL, Keegan TH.

J Clin Oncol. 2011 Oct 20;29(30):4045-53. doi: 10.1200/JCO.2011.36.2954. Epub 2011 Sep 19.


Mixed methods research design for pragmatic psychoanalytic studies.

Tillman JG, Clemence AJ, Stevens JL.

J Am Psychoanal Assoc. 2011 Oct;59(5):1023-40. doi: 10.1177/0003065111418650. Epub 2011 Aug 31.


Ductal carcinoma in situ: trends in treatment over time in the US.

Zujewski JA, Harlan LC, Morrell DM, Stevens JL.

Breast Cancer Res Treat. 2011 May;127(1):251-7. doi: 10.1007/s10549-010-1198-z. Epub 2010 Oct 8.


Human and environmental health challenges for the next decade (2010–2020).

Bonnefoi MS, Belanger SE, Devlin DJ, Doerrer NG, Embry MR, Fukushima S, Harpur ES, Hines RN, Holsapple MP, Kim JH, MacDonald JS, O'Lone R, Pettit SD, Stevens JL, Takei AS, Tinkle SS, van der Laan JW.

Crit Rev Toxicol. 2010 Nov;40(10):893-911. doi: 10.3109/10408444.2010.506640. Review.


Toxicogenomics and cancer risk assessment: a framework for key event analysis and dose-response assessment for nongenotoxic carcinogens.

Bercu JP, Jolly RA, Flagella KM, Baker TK, Romero P, Stevens JL.

Regul Toxicol Pharmacol. 2010 Dec;58(3):369-81. doi: 10.1016/j.yrtph.2010.08.002. Epub 2010 Aug 27.


Age disparity in the dissemination of imatinib for treating chronic myeloid leukemia.

Wiggins CL, Harlan LC, Nelson HE, Stevens JL, Willman CL, Libby EN, Hromas RA.

Am J Med. 2010 Aug;123(8):764.e1-9. doi: 10.1016/j.amjmed.2010.03.018.


Breast cancer in men in the United States: a population-based study of diagnosis, treatment, and survival.

Harlan LC, Zujewski JA, Goodman MT, Stevens JL.

Cancer. 2010 Aug 1;116(15):3558-68. doi: 10.1002/cncr.25153.


An unusual case of rectal bleeding and hemospermia.

Stevens JL, Schon K, Mukhtar H.

Gastroenterology. 2010 Mar;138(3):826, 1216. doi: 10.1053/j.gastro.2009.06.066. Epub 2010 Jan 25. No abstract available.


Complexity in transcription control at the activation domain-mediator interface.

Balamotis MA, Pennella MA, Stevens JL, Wasylyk B, Belmont AS, Berk AJ.

Sci Signal. 2009 May 5;2(69):ra20. doi: 10.1126/scisignal.1164302. Erratum in: Sci Signal. 2009 Sep 22;2(89):er8.


Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.

Ermakov A, Stevens JL, Whitehill E, Robson JE, Pieles G, Brooker D, Goggolidou P, Powles-Glover N, Hacker T, Young SR, Dear N, Hirst E, Tymowska-Lalanne Z, Briscoe J, Bhattacharya S, Norris DP.

Dev Dyn. 2009 Mar;238(3):581-94. doi: 10.1002/dvdy.21874.


The future of drug safety testing: expanding the view and narrowing the focus.

Stevens JL, Baker TK.

Drug Discov Today. 2009 Feb;14(3-4):162-7. doi: 10.1016/j.drudis.2008.11.009. Epub 2009 Jan 3. Review.


Treatment of a population based sample of men diagnosed with testicular cancer in the United States.

Osswald M, Harlan LC, Penson D, Stevens JL, Clegg LX.

Urol Oncol. 2009 Nov-Dec;27(6):604-10. doi: 10.1016/j.urolonc.2008.06.004. Epub 2008 Sep 16.


Strategic applications of toxicogenomics in early drug discovery.

Ryan TP, Stevens JL, Thomas CE.

Curr Opin Pharmacol. 2008 Oct;8(5):654-60. doi: 10.1016/j.coph.2008.07.011. Epub 2008 Sep 17. Review.


Underlying mechanisms of pharmacology and toxicity of a novel PPAR agonist revealed using rodent and canine hepatocytes.

Guo Y, Jolly RA, Halstead BW, Baker TK, Stutz JP, Huffman M, Calley JN, West A, Gao H, Searfoss GH, Li S, Irizarry AR, Qian HR, Stevens JL, Ryan TP.

Toxicol Sci. 2007 Apr;96(2):294-309. Epub 2007 Jan 25.


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