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Items: 1 to 50 of 56

1.

Identification of common genetic risk variants for autism spectrum disorder.

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S, Dumont AL, Goldstein JI, Hansen CS, Hauberg ME, Hollegaard MV, Hope S, Howrigan DP, Huang H, Hultman CM, Klei L, Maller J, Martin J, Martin AR, Moran JL, Nyegaard M, Nærland T, Palmer DS, Palotie A, Pedersen CB, Pedersen MG, dPoterba T, Poulsen JB, Pourcain BS, Qvist P, Rehnström K, Reichenberg A, Reichert J, Robinson EB, Roeder K, Roussos P, Saemundsen E, Sandin S, Satterstrom FK, Davey Smith G, Stefansson H, Steinberg S, Stevens CR, Sullivan PF, Turley P, Walters GB, Xu X; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, Stefansson K, Geschwind DH, Nordentoft M, Hougaard DM, Werge T, Mors O, Mortensen PB, Neale BM, Daly MJ, Børglum AD.

Nat Genet. 2019 Mar;51(3):431-444. doi: 10.1038/s41588-019-0344-8. Epub 2019 Feb 25.

2.

Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro.

Sanchez-Schmitz G, Stevens CR, Bettencourt IA, Flynn PJ, Schmitz-Abe K, Metser G, Hamm D, Jensen KJ, Benn C, Levy O.

Front Immunol. 2018 Nov 20;9:2634. doi: 10.3389/fimmu.2018.02634. eCollection 2018.

3.

PSMD12 haploinsufficiency in a neurodevelopmental disorder with autistic features.

Khalil R, Kenny C, Hill RS, Mochida GH, Nasir R, Partlow JN, Barry BJ, Al-Saffar M, Egan C, Stevens CR, Gabriel SB, Barkovich AJ, Ellison JW, Al-Gazali L, Walsh CA, Chahrour MH.

Am J Med Genet B Neuropsychiatr Genet. 2018 Dec;177(8):736-745. doi: 10.1002/ajmg.b.32688. Epub 2018 Nov 13.

4.

Evolution of Osteocrin as an activity-regulated factor in the primate brain.

Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME.

Nature. 2016 Nov 10;539(7628):242-247. doi: 10.1038/nature20111.

5.

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Fowler SA, Ananthakrishnan AN, Gardet A, Stevens CR, Korzenik JR, Sands BE, Daly MJ, Xavier RJ, Yajnik V.

J Crohns Colitis. 2014 Aug;8(8):845-51. doi: 10.1016/j.crohns.2014.01.003. Epub 2014 Jan 24.

6.

Super resolution microscopy reveals that caveolin-1 is required for spatial organization of CRFB1 and subsequent antiviral signaling in zebrafish.

Gabor KA, Stevens CR, Pietraszewski MJ, Gould TJ, Shim J, Yoder JA, Lam SH, Gong Z, Hess ST, Kim CH.

PLoS One. 2013 Jul 9;8(7):e68759. doi: 10.1371/journal.pone.0068759. Print 2013.

7.

Using whole-exome sequencing to identify inherited causes of autism.

Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, Schmitz-Abe K, Harmin DA, Adli M, Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J, Nasir RH, Ware J, Joseph RM, Hill RS, Kwan BY, Al-Saffar M, Mukaddes NM, Hashmi A, Balkhy S, Gascon GG, Hisama FM, LeClair E, Poduri A, Oner O, Al-Saad S, Al-Awadi SA, Bastaki L, Ben-Omran T, Teebi AS, Al-Gazali L, Eapen V, Stevens CR, Rappaport L, Gabriel SB, Markianos K, State MW, Greenberg ME, Taniguchi H, Braverman NE, Morrow EM, Walsh CA.

Neuron. 2013 Jan 23;77(2):259-73. doi: 10.1016/j.neuron.2012.11.002.

8.

Exome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndrome.

Manzini MC, Tambunan DE, Hill RS, Yu TW, Maynard TM, Heinzen EL, Shianna KV, Stevens CR, Partlow JN, Barry BJ, Rodriguez J, Gupta VA, Al-Qudah AK, Eyaid WM, Friedman JM, Salih MA, Clark R, Moroni I, Mora M, Beggs AH, Gabriel SB, Walsh CA.

Am J Hum Genet. 2012 Sep 7;91(3):541-7. doi: 10.1016/j.ajhg.2012.07.009.

9.

Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism.

Chahrour MH, Yu TW, Lim ET, Ataman B, Coulter ME, Hill RS, Stevens CR, Schubert CR; ARRA Autism Sequencing Collaboration, Greenberg ME, Gabriel SB, Walsh CA.

PLoS Genet. 2012;8(4):e1002635. doi: 10.1371/journal.pgen.1002635. Epub 2012 Apr 12.

10.

Hypoxia in abdominal aortic aneurysm supports a role for HIF-1α and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells.

Erdozain OJ, Pegrum S, Winrow VR, Horrocks M, Stevens CR.

J Vasc Res. 2011;48(2):163-70. doi: 10.1159/000318806. Epub 2010 Oct 8.

11.

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK; NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M.

Nat Genet. 2010 Apr;42(4):332-7. doi: 10.1038/ng.549. Epub 2010 Mar 14. Erratum in: Nat Genet. 2011 Apr;43(4):388.

12.

Established genetic risk factors do not distinguish early and later onset Crohn's disease.

Essers JB, Lee JJ, Kugathasan S, Stevens CR, Grand RJ, Daly MJ; NIDDK IBD Genetics Consortium.

Inflamm Bowel Dis. 2009 Oct;15(10):1508-14. doi: 10.1002/ibd.20922.

13.

Defining the role of the MHC in autoimmunity: a review and pooled analysis.

Fernando MM, Stevens CR, Walsh EC, De Jager PL, Goyette P, Plenge RM, Vyse TJ, Rioux JD.

PLoS Genet. 2008 Apr 25;4(4):e1000024. doi: 10.1371/journal.pgen.1000024. Review.

14.

Identification of two independent risk factors for lupus within the MHC in United Kingdom families.

Fernando MM, Stevens CR, Sabeti PC, Walsh EC, McWhinnie AJ, Shah A, Green T, Rioux JD, Vyse TJ.

PLoS Genet. 2007 Nov;3(11):e192.

15.

Differential expression of TRAIL and its receptors relative to calcification in AAA.

Liu X, Winrow VR, Horrocks M, Stevens CR.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):18-23. Epub 2007 Apr 23.

PMID:
17490621
16.

What if Derek Willoughby were right? Cyclo-oxygenase is an anti-inflammatory enzyme.

Blake DR, Shenker N, Cohen H, Stevens CR.

Inflammopharmacology. 2005;12(5-6):465-71. No abstract available.

PMID:
16259713
17.

Vascular physiology and pathology of circulating xanthine oxidoreductase: from nucleotide sequence to functional enzyme.

Hewinson J, Stevens CR, Millar TM.

Redox Rep. 2004;9(2):71-9. Review. Erratum in: Redox Rep. 2005;10(5):270.

PMID:
15231061
18.

Xanthine oxidase mediates cytokine-induced, but not hormone-induced bone resorption.

Kanczler JM, Millar TM, Bodamyali T, Blake DR, Stevens CR.

Free Radic Res. 2003 Feb;37(2):179-87.

PMID:
12653206
19.

Xanthine oxidase is a peroxynitrite synthase: newly identified roles for a very old enzyme.

Millar TM, Kanczler JM, Bodamyali T, Blake DR, Stevens CR.

Redox Rep. 2002;7(2):65-70. Review. No abstract available.

PMID:
12189051
20.

Localization of 3-nitrotyrosine to rheumatoid and normal synovium.

Mapp PI, Klocke R, Walsh DA, Chana JK, Stevens CR, Gallagher PJ, Blake DR.

Arthritis Rheum. 2001 Jul;44(7):1534-9.

21.

Antibacterial properties of xanthine oxidase in human milk.

Stevens CR, Millar TM, Clinch JG, Kanczler JM, Bodamyali T, Blake DR.

Lancet. 2000 Sep 2;356(9232):829-30.

PMID:
11022933
22.

Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase.

Godber BL, Doel JJ, Sapkota GP, Blake DR, Stevens CR, Eisenthal R, Harrison R.

J Biol Chem. 2000 Mar 17;275(11):7757-63.

23.

Effect of faradic products on direct current-stimulated calvarial organ culture calcium levels.

Bodamyali T, Kanczler JM, Simon B, Blake DR, Stevens CR.

Biochem Biophys Res Commun. 1999 Nov 2;264(3):657-61.

PMID:
10543988
24.
25.

Influence of hypoxia in inflammatory synovitis.

Bodamyali T, Stevens CR, Billingham ME, Ohta S, Blake DR.

Ann Rheum Dis. 1998 Dec;57(12):703-10. Review. No abstract available.

26.

Biomechanics of A-to-T flap design.

Stevens CR, Tan L, Kassir R, Calhoun K.

Laryngoscope. 1999 Jan;109(1):113-7.

PMID:
9917051
27.

Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro.

Bodamyali T, Bhatt B, Hughes FJ, Winrow VR, Kanczler JM, Simon B, Abbott J, Blake DR, Stevens CR.

Biochem Biophys Res Commun. 1998 Sep 18;250(2):458-61.

PMID:
9753652
28.

Xanthine oxidoreductase in human mammary epithelial cells: activation in response to inflammatory cytokines.

Page S, Powell D, Benboubetra M, Stevens CR, Blake DR, Selase F, Wolstenholme AJ, Harrison R.

Biochim Biophys Acta. 1998 Jul 23;1381(2):191-202.

PMID:
9685639
29.

A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor.

Zhang Z, Blake DR, Stevens CR, Kanczler JM, Winyard PG, Symons MC, Benboubetra M, Harrison R.

Free Radic Res. 1998 Feb;28(2):151-64.

PMID:
9645392
30.

Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions.

Millar TM, Stevens CR, Benjamin N, Eisenthal R, Harrison R, Blake DR.

FEBS Lett. 1998 May 8;427(2):225-8.

31.

Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture.

Rouquette M, Page S, Bryant R, Benboubetra M, Stevens CR, Blake DR, Whish WD, Harrison R, Tosh D.

FEBS Lett. 1998 Apr 24;426(3):397-401.

32.

Elevated circulating plasma NADH oxidising activity of xanthine oxidoreductase in plasma.

Jawed S, Stevens CR, Harrison R, Blake DR.

Biochem Soc Trans. 1997 Aug;25(3):531S. No abstract available.

PMID:
9388747
33.

Xanthine oxidase can generate nitric oxide from nitrate in ischaemia.

Millar TM, Stevens CR, Blake DR.

Biochem Soc Trans. 1997 Aug;25(3):528S. No abstract available.

PMID:
9388744
34.

Human xanthine oxidase converts nitrite ions into nitric oxide (NO).

Zhang Z, Naughton DP, Blake DR, Benjamin N, Stevens CR, Winyard PG, Symons MC, Harrison R.

Biochem Soc Trans. 1997 Aug;25(3):524S. No abstract available.

PMID:
9388740
35.

Xanthine oxidase: four roles for the enzyme in rheumatoid pathology.

Blake DR, Stevens CR, Sahinoglu T, Ellis G, Gaffney K, Edmonds S, Benboubetra M, Harrison R, Jawed S, Kanczler J, Millar TM, Winyard PG, Zhang Z.

Biochem Soc Trans. 1997 Aug;25(3):812-6. Review. No abstract available.

PMID:
9388551
36.

Modified low density lipoprotein and cytokines mediate monocyte adhesion to smooth muscle cells.

Thorne SA, Abbot SE, Stevens CR, Winyard PG, Mills PG, Blake DR.

Atherosclerosis. 1996 Dec 20;127(2):167-76.

PMID:
9125306
37.

The Role of Reactive Oxygen Species in Inflammatory Disease: Evaluation of Methodology

Sahinoglu T, Stevens CR, Bhatt B, Blake DR.

Methods. 1996 Jun;9(3):628-34.

PMID:
8812717
38.

Pressure and vascular changes in mobile joints: implications for inflammatory joint disease.

Gaffney K, Edmonds SE, Stevens CR, Blake DR.

Scand J Rheumatol Suppl. 1995;101:21-6. Review. No abstract available.

PMID:
7747129
39.

The joint, a redox sensitive microenvironment?--an hypothesis.

Sahinoglu T, Stevens CR, Blake DR.

Scand J Rheumatol Suppl. 1995;101:131-6. Review.

PMID:
7747116
40.

Intestinal spirochaetosis in children.

da Cunha Ferreira RM, Phillips AD, Stevens CR, Hudson MJ, Rees HC, Walker-Smith JA.

J Pediatr Gastroenterol Nutr. 1993 Oct;17(3):333-6. No abstract available.

PMID:
8271139
41.

Oxidative stress and its control: a pathogenetic role in inflammatory joint disease.

Fairburn K, Stevens CR, Winyard PG, Kus M, Ward RJ, Cunningham J, Zaidi M, Blake DR.

Biochem Soc Trans. 1993 May;21(2):371-5. Review. No abstract available.

PMID:
8359499
42.

Exercise induced release of von Willebrand factor: evidence for hypoxic reperfusion microvascular injury in rheumatoid arthritis.

Farrell AJ, Williams RB, Stevens CR, Lawrie AS, Cox NL, Blake DR.

Ann Rheum Dis. 1992 Oct;51(10):1117-22.

43.
44.

Stimulation of osteoclastic bone resorption by hydrogen peroxide.

Bax BE, Alam AS, Banerji B, Bax CM, Bevis PJ, Stevens CR, Moonga BS, Blake DR, Zaidi M.

Biochem Biophys Res Commun. 1992 Mar 31;183(3):1153-8.

PMID:
1567393
45.

Application of methionine as a detector molecule for the assessment of oxygen radical generation by human neutrophils and endothelial cells.

Stevens CR, Bucurenci N, Abbot SE, Sahinoglu T, Blake DR, Naughton D, Grootveld MC.

Free Radic Res Commun. 1992;17(2):143-54.

PMID:
1468686
46.

Hypoxia-induced von Willebrand factor release is blocked by verapamil.

Wilkie ME, Stevens CR, Cunningham J, Blake D.

Miner Electrolyte Metab. 1992;18(2-5):141-4.

PMID:
1465048
47.

A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium.

Stevens CR, Blake DR, Merry P, Revell PA, Levick JR.

Arthritis Rheum. 1991 Dec;34(12):1508-13.

PMID:
1747135
48.

Localisation of xanthine oxidase to synovial endothelium.

Stevens CR, Benboubetra M, Harrison R, Sahinoglu T, Smith EC, Blake DR.

Ann Rheum Dis. 1991 Nov;50(11):760-2.

49.

Hypoxia and inflammatory synovitis: observations and speculation.

Stevens CR, Williams RB, Farrell AJ, Blake DR.

Ann Rheum Dis. 1991 Feb;50(2):124-32. Review. No abstract available.

50.

Influence of disodium aurothiomalate on the activities of xanthine dehydrogenase and xanthine oxidase in endothelial cells.

Sahinoglu T, Grootveld M, Stevens CR, Thompson SJ, Claxson AW, Blake DR.

Agents Actions Suppl. 1991;32:71-5.

PMID:
1906238

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