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Author Correction: Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder.

Stevens AJ, Purcell RV, Darling KA, Eggleston MJF, Kennedy MA, Rucklidge JJ.

Sci Rep. 2020 Jan 21;10(1):1180. doi: 10.1038/s41598-020-58141-0.


The Driver of Extreme Human-Specific Olduvai Repeat Expansion Remains Highly Active in the Human Genome.

Heft IE, Mostovoy Y, Levy-Sakin M, Ma W, Stevens AJ, Pastor S, McCaffrey J, Boffelli D, Martin DI, Xiao M, Kennedy MA, Kwok PY, Sikela JM.

Genetics. 2020 Jan;214(1):179-191. doi: 10.1534/genetics.119.302782. Epub 2019 Nov 21.


How can we meet the health needs of child refugees, asylum seekers and undocumented migrants?

Stevens AJ.

Arch Dis Child. 2020 Feb;105(2):191-196. doi: 10.1136/archdischild-2018-316614. Epub 2019 Oct 11. Review.


Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder.

Stevens AJ, Purcell RV, Darling KA, Eggleston MJF, Kennedy MA, Rucklidge JJ.

Sci Rep. 2019 Jul 12;9(1):10128. doi: 10.1038/s41598-019-46146-3. Erratum in: Sci Rep. 2020 Jan 21;10(1):1180.


Protein engineering through tandem transamidation.

Thompson RE, Stevens AJ, Muir TW.

Nat Chem. 2019 Aug;11(8):737-743. doi: 10.1038/s41557-019-0281-2. Epub 2019 Jul 1.


Aminoguanidines: New leads for treatment of Giardia duodenalis infection.

Abraham RJ, Abraham S, Stevens AJ, Page SW, McCluskey A, Trott DJ, O'Handley RM.

Int J Parasitol Drugs Drug Resist. 2019 Aug;10:38-44. doi: 10.1016/j.ijpddr.2019.04.003. Epub 2019 Apr 8.


Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables.

Rucklidge JJ, Eggleston MJF, Darling KA, Stevens AJ, Kennedy MA, Frampton CM.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:181-192. doi: 10.1016/j.pnpbp.2018.09.007. Epub 2018 Sep 12.


Comparative metabolism of xenobiotic chemicals by cytochrome P450s in the nematode Caenorhabditis elegans.

Harlow PH, Perry SJ, Stevens AJ, Flemming AJ.

Sci Rep. 2018 Sep 6;8(1):13333. doi: 10.1038/s41598-018-31215-w.


Methylomic changes in response to micronutrient supplementation and MTHFR genotype.

Stevens AJ, Rucklidge JJ, Darling KA, Eggleston MJ, Pearson JF, Kennedy MA.

Epigenomics. 2018 Sep;10(9):1201-1214. doi: 10.2217/epi-2018-0029. Epub 2018 Sep 5.


An Atypical Mechanism of Split Intein Molecular Recognition and Folding.

Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW.

J Am Chem Soc. 2018 Sep 19;140(37):11791-11799. doi: 10.1021/jacs.8b07334. Epub 2018 Sep 10.


Improved protein splicing using embedded split inteins.

Gramespacher JA, Stevens AJ, Thompson RE, Muir TW.

Protein Sci. 2018 Mar;27(3):614-619. doi: 10.1002/pro.3357. Epub 2018 Jan 17.


Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent.

Ogunniyi AD, Khazandi M, Stevens AJ, Sims SK, Page SW, Garg S, Venter H, Powell A, White K, Petrovski KR, Laven-Law G, Tótoli EG, Salgado HR, Pi H, Coombs GW, Shinabarger DL, Turnidge JD, Paton JC, McCluskey A, Trott DJ.

PLoS One. 2017 Sep 5;12(9):e0183457. doi: 10.1371/journal.pone.0183457. eCollection 2017.


A promiscuous split intein with expanded protein engineering applications.

Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8538-8543. doi: 10.1073/pnas.1701083114. Epub 2017 Jul 24.


An emerging model for life sciences commercialization.

Stevens AJ.

Nat Biotechnol. 2017 Jul 12;35(7):608-613. doi: 10.1038/nbt.3911. No abstract available.


Bridging Zirconia Nodes within a Metal-Organic Framework via Catalytic Ni-Hydroxo Clusters to Form Heterobimetallic Nanowires.

Platero-Prats AE, League AB, Bernales V, Ye J, Gallington LC, Vjunov A, Schweitzer NM, Li Z, Zheng J, Mehdi BL, Stevens AJ, Dohnalkova A, Balasubramanian M, Farha OK, Hupp JT, Browning ND, Fulton JL, Camaioni DM, Lercher JA, Truhlar DG, Gagliardi L, Cramer CJ, Chapman KW.

J Am Chem Soc. 2017 Aug 2;139(30):10410-10418. doi: 10.1021/jacs.7b04997. Epub 2017 Jul 24.


Methylated Cytosine Maintains G-Quadruplex Structures during Polymerase Chain Reaction and Contributes to Allelic Dropout.

Stevens AJ, Kennedy MA.

Biochemistry. 2017 Jul 25;56(29):3691-3698. doi: 10.1021/acs.biochem.7b00480. Epub 2017 Jul 10.


Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis.

Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW.

J Am Chem Soc. 2017 Jun 21;139(24):8074-8077. doi: 10.1021/jacs.7b02618. Epub 2017 Jun 7.


Epigenetics, nutrition and mental health. Is there a relationship?

Stevens AJ, Rucklidge JJ, Kennedy MA.

Nutr Neurosci. 2018 Nov;21(9):602-613. doi: 10.1080/1028415X.2017.1331524. Epub 2017 May 29. Review.


Allelic Dropout During Polymerase Chain Reaction due to G-Quadruplex Structures and DNA Methylation Is Widespread at Imprinted Human Loci.

Stevens AJ, Taylor MG, Pearce FG, Kennedy MA.

G3 (Bethesda). 2017 Mar 10;7(3):1019-1025. doi: 10.1534/g3.116.038687.


A systematic review of the analgesic efficacy of cannabinoid medications in the management of acute pain.

Stevens AJ, Higgins MD.

Acta Anaesthesiol Scand. 2017 Mar;61(3):268-280. doi: 10.1111/aas.12851. Epub 2017 Jan 16. Review.


Structural Analysis of G-Quadruplex Formation at the Human MEST Promoter.

Stevens AJ, Kennedy MA.

PLoS One. 2017 Jan 4;12(1):e0169433. doi: 10.1371/journal.pone.0169433. eCollection 2017.


Fluorescence Methods for Probing G-Quadruplex Structure in Single- and Double-Stranded DNA.

Stevens AJ, Kennedy HL, Kennedy MA.

Biochemistry. 2016 Jul 5;55(26):3714-25. doi: 10.1021/acs.biochem.6b00327. Epub 2016 Jun 16.


Circular replication-associated protein encoding DNA viruses identified in the faecal matter of various animals in New Zealand.

Steel O, Kraberger S, Sikorski A, Young LM, Catchpole RJ, Stevens AJ, Ladley JJ, Coray DS, Stainton D, Dayaram A, Julian L, van Bysterveldt K, Varsani A.

Infect Genet Evol. 2016 Sep;43:151-64. doi: 10.1016/j.meegid.2016.05.008. Epub 2016 May 20.


Design of a Split Intein with Exceptional Protein Splicing Activity.

Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW.

J Am Chem Soc. 2016 Feb 24;138(7):2162-5. doi: 10.1021/jacs.5b13528. Epub 2016 Feb 8.


Robenidine Analogues as Gram-Positive Antibacterial Agents.

Abraham RJ, Stevens AJ, Young KA, Russell C, Qvist A, Khazandi M, Wong HS, Abraham S, Ogunniyi AD, Page SW, O'Handley R, McCluskey A, Trott DJ.

J Med Chem. 2016 Mar 10;59(5):2126-38. doi: 10.1021/acs.jmedchem.5b01797. Epub 2016 Feb 10.


Trends in clinical development timeframes for antiviral drugs launched in the UK, 1981-2014: a retrospective observational study.

Ward DJ, Hammond E, Linden-Phillips L, Stevens AJ.

BMJ Open. 2015 Nov 16;5(11):e009333. doi: 10.1136/bmjopen-2015-009333.


Secular trends and evaluation of complex interventions: the rising tide phenomenon.

Chen YF, Hemming K, Stevens AJ, Lilford RJ.

BMJ Qual Saf. 2016 May;25(5):303-10. doi: 10.1136/bmjqs-2015-004372. Epub 2015 Oct 6. Review.


The effect of ondansetron on the efficacy of postoperative tramadol: a systematic review and meta-analysis of a drug interaction.

Stevens AJ, Woodman RJ, Owen H.

Anaesthesia. 2015 Feb;70(2):209-18. doi: 10.1111/anae.12948. Epub 2014 Dec 10. Review.


G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter.

Stevens AJ, Stuffrein-Roberts S, Cree SL, Gibb A, Miller AL, Doudney K, Aitchison A, Eccles MR, Joyce PR, Filichev VV, Kennedy MA.

PLoS One. 2014 Dec 1;9(12):e113955. doi: 10.1371/journal.pone.0113955. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0122940.


How innovative are new drugs launched in the UK? A retrospective study of new drugs listed in the British National Formulary (BNF) 2001-2012.

Ward DJ, Slade A, Genus T, Martino OI, Stevens AJ.

BMJ Open. 2014 Oct 24;4(10):e006235. doi: 10.1136/bmjopen-2014-006235.


The invisible soldiers: understanding how the life experiences of girl child soldiers impacts upon their health and rehabilitation needs.

Stevens AJ.

Arch Dis Child. 2014 May;99(5):458-62. doi: 10.1136/archdischild-2013-305240. Epub 2014 Jan 7. Review.


The combined influence of distance and neighbourhood deprivation on Emergency Department attendance in a large English population: a retrospective database study.

Rudge GM, Mohammed MA, Fillingham SC, Girling A, Sidhu K, Stevens AJ.

PLoS One. 2013 Jul 16;8(7):e67943. doi: 10.1371/journal.pone.0067943. Print 2013.


At the center of health care policy making: the use of health technology assessment at NICE.

Stevens AJ, Longson C.

Med Decis Making. 2013 Apr;33(3):320-4. doi: 10.1177/0272989X13480563.


A simple insightful approach to investigating a hospital standardised mortality ratio: an illustrative case-study.

Mohammed MA, Stevens AJ.

PLoS One. 2013;8(3):e57845. doi: 10.1371/journal.pone.0057845. Epub 2013 Mar 5.


Decline in new drug launches: myth or reality? Retrospective observational study using 30 years of data from the UK.

Ward DJ, Martino OI, Simpson S, Stevens AJ.

BMJ Open. 2013 Feb 20;3(2). pii: e002088. doi: 10.1136/bmjopen-2012-002088. Print 2013.


DNA polymerase λ inactivation by oxidized abasic sites.

Stevens AJ, Guan L, Bebenek K, Kunkel TA, Greenberg MM.

Biochemistry. 2013 Feb 5;52(5):975-83. doi: 10.1021/bi301592x. Epub 2013 Jan 18.


A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer.

Kordes S, Richel DJ, Klümpen HJ, Weterman MJ, Stevens AJ, Wilmink JW.

Invest New Drugs. 2013 Feb;31(1):85-91. doi: 10.1007/s10637-012-9802-1. Epub 2012 Feb 25.


The role of public-sector research in the discovery of drugs and vaccines.

Stevens AJ, Jensen JJ, Wyller K, Kilgore PC, Chatterjee S, Rohrbaugh ML.

N Engl J Med. 2011 Feb 10;364(6):535-41. doi: 10.1056/NEJMsa1008268.


Innovation: lessons from UK policy.

Stevens AJ.

Nature. 2011 Jan 13;469(7329):162. doi: 10.1038/469162b. No abstract available.


The Bayh-Dole Act turns 30.

Loise V, Stevens AJ.

Sci Transl Med. 2010 Oct 6;2(52):52cm27. doi: 10.1126/scitranslmed.3001481.


Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

Abdi MH, Beswick PJ, Billinton A, Chambers LJ, Charlton A, Collins SD, Collis KL, Dean DK, Fonfria E, Gleave RJ, Lejeune CL, Livermore DG, Medhurst SJ, Michel AD, Moses AP, Page L, Patel S, Roman SA, Senger S, Slingsby B, Steadman JG, Stevens AJ, Walter DS.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5080-4. doi: 10.1016/j.bmcl.2010.07.033. Epub 2010 Jul 14.


Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.

Beswick PJ, Billinton A, Chambers LJ, Dean DK, Fonfria E, Gleave RJ, Medhurst SJ, Michel AD, Moses AP, Patel S, Roman SA, Roomans S, Senger S, Stevens AJ, Walter DS.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4653-6. doi: 10.1016/j.bmcl.2010.05.107. Epub 2010 Jun 8.


Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.

Chambers LJ, Stevens AJ, Moses AP, Michel AD, Walter DS, Davies DJ, Livermore DG, Fonfria E, Demont EH, Vimal M, Theobald PJ, Beswick PJ, Gleave RJ, Roman SA, Senger S.

Bioorg Med Chem Lett. 2010 May 15;20(10):3161-4. doi: 10.1016/j.bmcl.2010.03.096. Epub 2010 Mar 30.



Hemmingson SL, Stevens AJ, Tanski JM, Getzler YD.

Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 17;66(Pt 8):m937. doi: 10.1107/S1600536810027212.


The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.

Bailey JM, Scott JS, Basilla JB, Bolton VJ, Boyfield I, Evans DG, Fleury E, Heightman TD, Jarvie EM, Lawless K, Matthews KL, McKay F, Mok H, Muir A, Orlek BS, Sanger GJ, Stemp G, Stevens AJ, Thompson M, Ward J, Vaidya K, Westaway SM.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6452-8. doi: 10.1016/j.bmcl.2009.09.027. Epub 2009 Sep 12.


The medicinal chemistry of dengue fever.

Stevens AJ, Gahan ME, Mahalingam S, Keller PA.

J Med Chem. 2009 Dec 24;52(24):7911-26. doi: 10.1021/jm900652e. Review. No abstract available.


Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

Swarbrick ME, Beswick PJ, Gleave RJ, Green RH, Bingham S, Bountra C, Carter MC, Chambers LJ, Chessell IP, Clayton NM, Collins SD, Corfield JA, Hartley CD, Kleanthous S, Lambeth PF, Lucas FS, Mathews N, Naylor A, Page LW, Payne JJ, Pegg NA, Price HS, Skidmore J, Stevens AJ, Stocker R, Stratton SC, Stuart AJ, Wiseman JO.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4504-8. doi: 10.1016/j.bmcl.2009.02.085. Epub 2009 Feb 26.


Evidence of methodological bias in hospital standardised mortality ratios: retrospective database study of English hospitals.

Mohammed MA, Deeks JJ, Girling A, Rudge G, Carmalt M, Stevens AJ, Lilford RJ.

BMJ. 2009 Mar 18;338:b780. doi: 10.1136/bmj.b780. Erratum in: BMJ. 2009 Apr 1. doi: 10.1136/bmj.b1348.

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