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Items: 1 to 50 of 310

1.

Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with supersized T=7 capsids.

Bayfield OW, Klimuk E, Winkler DC, Hesketh EL, Chechik M, Cheng N, Dykeman EC, Minakhin L, Ranson NA, Severinov K, Steven AC, Antson AA.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3556-3561. doi: 10.1073/pnas.1813204116. Epub 2019 Feb 8.

2.

Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.

Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC.

J Cell Biol. 2019 Mar 4;218(3):1027-1038. doi: 10.1083/jcb.201806148. Epub 2019 Jan 10.

PMID:
30630865
3.

A Computational Assay that Explores the Hemagglutinin/Neuraminidase Functional Balance Reveals the Neuraminidase Secondary Site as a Novel Anti-Influenza Target.

Amaro RE, Ieong PU, Huber G, Dommer A, Steven AC, Bush RM, Durrant JD, Votapka LW.

ACS Cent Sci. 2018 Nov 28;4(11):1570-1577. doi: 10.1021/acscentsci.8b00666. Epub 2018 Nov 9.

4.

Global Proteomic Profiling of Salmonella Infection by a Giant Phage.

Weintraub ST, Mohd Redzuan NH, Barton MK, Md Amin NA, Desmond MI, Adams LE, Ali B, Pardo S, Molleur D, Wu W, Newcomb WW, Osier MV, Black LW, Steven AC, Thomas JA.

J Virol. 2019 Feb 19;93(5). pii: e01833-18. doi: 10.1128/JVI.01833-18. Print 2019 Mar 1.

5.

Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation.

Novikova M, Adams LJ, Fontana J, Gres AT, Balasubramaniam M, Winkler DC, Kudchodkar SB, Soheilian F, Sarafianos SG, Steven AC, Freed EO.

MBio. 2018 Oct 16;9(5). pii: e01567-18. doi: 10.1128/mBio.01567-18.

6.

Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.

Eren E, Watts NR, Dearborn AD, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Oct 2;26(10):1314-1326.e4. doi: 10.1016/j.str.2018.06.012. Epub 2018 Aug 9.

PMID:
30100358
7.

The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein.

Mata CP, Mertens J, Fontana J, Luque D, Allende-Ballestero C, Reguera D, Trus BL, Steven AC, Carrascosa JL, Castón JR.

J Virol. 2018 Sep 12;92(19). pii: e00968-18. doi: 10.1128/JVI.00968-18. Print 2018 Oct 1.

8.

Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association.

Dearborn AD, Eren E, Watts NR, Palmer IW, Kaufman JD, Steven AC, Wingfield PT.

Structure. 2018 Sep 4;26(9):1187-1195.e4. doi: 10.1016/j.str.2018.06.001. Epub 2018 Jul 12.

PMID:
30017564
9.

A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.

Watts NR, Eren E, Zhuang X, Wang YX, Steven AC, Wingfield PT.

J Struct Biol. 2018 Aug;203(2):102-108. doi: 10.1016/j.jsb.2018.03.011. Epub 2018 Mar 29.

10.

Journal of Structural Biology - Paper of the year 2017.

Lupas AN, Steven AC.

J Struct Biol. 2018 Mar;201(3):185-186. doi: 10.1016/j.jsb.2018.01.008. Epub 2018 Jan 31. No abstract available.

PMID:
29410085
11.

Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy.

Zhuang X, Watts NR, Palmer IW, Kaufman JD, Dearborn AD, Trenbeath JL, Eren E, Steven AC, Rader C, Wingfield PT.

J Biol Chem. 2017 Oct 6;292(40):16760-16772. doi: 10.1074/jbc.M117.802272. Epub 2017 Aug 23.

12.

The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress.

Newcomb WW, Fontana J, Winkler DC, Cheng N, Heymann JB, Steven AC.

MBio. 2017 Jun 13;8(3). pii: e00825-17. doi: 10.1128/mBio.00825-17.

13.

Localization of the Houdinisome (Ejection Proteins) inside the Bacteriophage P22 Virion by Bubblegram Imaging.

Wu W, Leavitt JC, Cheng N, Gilcrease EB, Motwani T, Teschke CM, Casjens SR, Steven AC.

MBio. 2016 Aug 9;7(4). pii: e01152-16. doi: 10.1128/mBio.01152-16.

14.

The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

DiMattia MA, Watts NR, Cheng N, Huang R, Heymann JB, Grimes JM, Wingfield PT, Stuart DI, Steven AC.

Structure. 2016 Jul 6;24(7):1068-80. doi: 10.1016/j.str.2016.04.015. Epub 2016 Jun 2.

15.

Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin.

Ishitsuka Y, Huebner AJ, Rice RH, Koch PJ, Speransky VV, Steven AC, Roop DR.

J Invest Dermatol. 2016 Aug;136(8):1656-1663. doi: 10.1016/j.jid.2016.04.022. Epub 2016 May 7.

16.

Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.

Tolun G, Vijayasarathy C, Huang R, Zeng Y, Li Y, Steven AC, Sieving PA, Heymann JB.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5287-92. doi: 10.1073/pnas.1519048113. Epub 2016 Apr 25.

17.

Internal Proteins of the Procapsid and Mature Capsids of Herpes Simplex Virus 1 Mapped by Bubblegram Imaging.

Wu W, Newcomb WW, Cheng N, Aksyuk A, Winkler DC, Steven AC.

J Virol. 2016 Apr 29;90(10):5176-86. doi: 10.1128/JVI.03224-15. Print 2016 May 15.

18.

α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils.

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC.

J Biol Chem. 2016 Jan 29;291(5):2310-8. doi: 10.1074/jbc.M115.698787. Epub 2015 Dec 7.

19.

Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice.

Fontana J, Keller PW, Urano E, Ablan SD, Steven AC, Freed EO.

J Virol. 2015 Nov 4;90(2):972-8. doi: 10.1128/JVI.02204-15. Print 2016 Jan 15.

20.

Subassemblies and asymmetry in assembly of herpes simplex virus procapsid.

Aksyuk AA, Newcomb WW, Cheng N, Winkler DC, Fontana J, Heymann JB, Steven AC.

MBio. 2015 Oct 6;6(5):e01525-15. doi: 10.1128/mBio.01525-15.

21.

Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.

Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, Engelman AN, Steven AC.

J Virol. 2015 Oct;89(19):9765-80. doi: 10.1128/JVI.01522-15. Epub 2015 Jul 15.

22.

Influenza virus-mediated membrane fusion: Structural insights from electron microscopy.

Fontana J, Steven AC.

Arch Biochem Biophys. 2015 Sep 1;581:86-97. doi: 10.1016/j.abb.2015.04.011. Epub 2015 May 6. Review.

23.

Distribution of DNA-condensing protein complexes in the adenovirus core.

Pérez-Berná AJ, Marion S, Chichón FJ, Fernández JJ, Winkler DC, Carrascosa JL, Steven AC, Šiber A, San Martín C.

Nucleic Acids Res. 2015 Apr 30;43(8):4274-83. doi: 10.1093/nar/gkv187. Epub 2015 Mar 27.

24.

Metastable intermediates as stepping stones on the maturation pathways of viral capsids.

Cardone G, Duda RL, Cheng N, You L, Conway JF, Hendrix RW, Steven AC.

MBio. 2014 Nov 11;5(6):e02067. doi: 10.1128/mBio.02067-14.

25.

Maturation of the human papillomavirus 16 capsid.

Cardone G, Moyer AL, Cheng N, Thompson CD, Dvoretzky I, Lowy DR, Schiller JT, Steven AC, Buck CB, Trus BL.

MBio. 2014 Aug 5;5(4):e01104-14. doi: 10.1128/mBio.01104-14.

26.

Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F.

Cell. 2014 Jul 17;158(2):353-367. doi: 10.1016/j.cell.2014.05.037.

27.

Activated STING in a vascular and pulmonary syndrome.

Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R.

N Engl J Med. 2014 Aug 7;371(6):507-518. doi: 10.1056/NEJMoa1312625. Epub 2014 Jul 16.

28.

A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress.

McHugh CA, Fontana J, Nemecek D, Cheng N, Aksyuk AA, Heymann JB, Winkler DC, Lam AS, Wall JS, Steven AC, Hoiczyk E.

EMBO J. 2014 Sep 1;33(17):1896-911. doi: 10.15252/embj.201488566. Epub 2014 Jul 14.

29.

A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope.

Zhuang X, Stahl SJ, Watts NR, DiMattia MA, Steven AC, Wingfield PT.

J Biol Chem. 2014 Jul 18;289(29):20222-33. doi: 10.1074/jbc.M114.581090. Epub 2014 May 30.

30.

Conformational switching in PolyGln amyloid fibrils resulting from a single amino acid insertion.

Huang RK, Baxa U, Aldrian G, Ahmed AB, Wall JS, Mizuno N, Antzutkin O, Steven AC, Kajava AV.

Biophys J. 2014 May 20;106(10):2134-42. doi: 10.1016/j.bpj.2014.03.047.

31.

Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry.

Bereszczak JZ, Watts NR, Wingfield PT, Steven AC, Heck AJ.

Protein Sci. 2014 Jul;23(7):884-96. doi: 10.1002/pro.2470. Epub 2014 Apr 17.

32.

Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids.

Bereszczak JZ, Havlik M, Weiss VU, Marchetti-Deschmann M, van Duijn E, Watts NR, Wingfield PT, Allmaier G, Steven AC, Heck AJ.

Anal Bioanal Chem. 2014 Feb;406(5):1437-46. doi: 10.1007/s00216-013-7548-z. Epub 2013 Dec 20.

33.

Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B.

Cairns TM, Fontana J, Huang ZY, Whitbeck JC, Atanasiu D, Rao S, Shelly SS, Lou H, Ponce de Leon M, Steven AC, Eisenberg RJ, Cohen GH.

J Virol. 2014 Mar;88(5):2677-89. doi: 10.1128/JVI.03200-13. Epub 2013 Dec 18.

34.

Exploiting radiation damage to map proteins in nucleoprotein complexes: the internal structure of bacteriophage T7.

Cheng N, Wu W, Watts NR, Steven AC.

J Struct Biol. 2014 Mar;185(3):250-6. doi: 10.1016/j.jsb.2013.12.004. Epub 2013 Dec 15.

35.

A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.

Keller PW, Huang RK, England MR, Waki K, Cheng N, Heymann JB, Craven RC, Freed EO, Steven AC.

J Virol. 2013 Dec;87(24):13655-64. doi: 10.1128/JVI.01408-13. Epub 2013 Oct 9.

36.

One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions.

Cardone G, Heymann JB, Steven AC.

J Struct Biol. 2013 Nov;184(2):226-36. doi: 10.1016/j.jsb.2013.08.002. Epub 2013 Aug 14.

37.

Subunit folds and maturation pathway of a dsRNA virus capsid.

Nemecek D, Boura E, Wu W, Cheng N, Plevka P, Qiao J, Mindich L, Heymann JB, Hurley JH, Steven AC.

Structure. 2013 Aug 6;21(8):1374-83. doi: 10.1016/j.str.2013.06.007. Epub 2013 Jul 25.

38.

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition.

Mizuno N, Dramićanin M, Mizuuchi M, Adam J, Wang Y, Han YW, Yang W, Steven AC, Mizuuchi K, Ramón-Maiques S.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2441-50. doi: 10.1073/pnas.1309499110. Epub 2013 Jun 17.

39.

Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy.

Lin J, Cheng N, Hogle JM, Steven AC, Belnap DM.

J Immunol. 2013 Jul 15;191(2):884-91. doi: 10.4049/jimmunol.1202014. Epub 2013 Jun 14.

40.

Clathrin-coated vesicles from brain have small payloads: a cryo-electron tomographic study.

Heymann JB, Winkler DC, Yim YI, Eisenberg E, Greene LE, Steven AC.

J Struct Biol. 2013 Oct;184(1):43-51. doi: 10.1016/j.jsb.2013.05.006. Epub 2013 May 18.

41.

α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles.

Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R.

J Biol Chem. 2013 Jun 14;288(24):17620-30. doi: 10.1074/jbc.M113.476697. Epub 2013 Apr 22.

42.

Epitope-distal effects accompany the binding of two distinct antibodies to hepatitis B virus capsids.

Bereszczak JZ, Rose RJ, van Duijn E, Watts NR, Wingfield PT, Steven AC, Heck AJ.

J Am Chem Soc. 2013 May 1;135(17):6504-12. doi: 10.1021/ja402023x. Epub 2013 Apr 18.

43.

At low pH, influenza virus matrix protein M1 undergoes a conformational change prior to dissociating from the membrane.

Fontana J, Steven AC.

J Virol. 2013 May;87(10):5621-8. doi: 10.1128/JVI.00276-13. Epub 2013 Mar 6.

44.

Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.

DiMattia MA, Watts NR, Stahl SJ, Grimes JM, Steven AC, Stuart DI, Wingfield PT.

Structure. 2013 Jan 8;21(1):133-142. doi: 10.1016/j.str.2012.10.017. Epub 2012 Dec 6.

45.

Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure.

Wu W, Chen Z, Cheng N, Watts NR, Stahl SJ, Farci P, Purcell RH, Wingfield PT, Steven AC.

J Struct Biol. 2013 Jan;181(1):53-60. doi: 10.1016/j.jsb.2012.10.004. Epub 2012 Oct 16.

46.

Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis virus by cryo-electron tomography.

Cardone G, Brecher M, Fontana J, Winkler DC, Butan C, White JM, Steven AC.

J Virol. 2012 Nov;86(22):12129-37. doi: 10.1128/JVI.01880-12. Epub 2012 Aug 29.

47.

Packaging accessory protein P7 and polymerase P2 have mutually occluding binding sites inside the bacteriophage 6 procapsid.

Nemecek D, Qiao J, Mindich L, Steven AC, Heymann JB.

J Virol. 2012 Nov;86(21):11616-24. doi: 10.1128/JVI.01347-12. Epub 2012 Aug 15.

48.

Structure and assembly of a paramyxovirus matrix protein.

Battisti AJ, Meng G, Winkler DC, McGinnes LW, Plevka P, Steven AC, Morrison TG, Rossmann MG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13996-4000. doi: 10.1073/pnas.1210275109. Epub 2012 Aug 13.

49.

Cryo-electron tomography of rubella virus.

Battisti AJ, Yoder JD, Plevka P, Winkler DC, Prasad VM, Kuhn RJ, Frey TK, Steven AC, Rossmann MG.

J Virol. 2012 Oct;86(20):11078-85. Epub 2012 Aug 1.

50.

The role of capsid maturation on adenovirus priming for sequential uncoating.

Pérez-Berná AJ, Ortega-Esteban A, Menéndez-Conejero R, Winkler DC, Menéndez M, Steven AC, Flint SJ, de Pablo PJ, San Martín C.

J Biol Chem. 2012 Sep 7;287(37):31582-95. doi: 10.1074/jbc.M112.389957. Epub 2012 Jul 12.

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