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Items: 31


Human DNA-PK activates a STING-independent DNA sensing pathway.

Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB.

Sci Immunol. 2020 Jan 24;5(43). pii: eaba4219. doi: 10.1126/sciimmunol.aba4219.


Tight nuclear tethering of cGAS is essential for preventing autoreactivity.

Volkman HE, Cambier S, Gray EE, Stetson DB.

Elife. 2019 Dec 6;8. pii: e47491. doi: 10.7554/eLife.47491.


Editorial overview: Autoimmunity: A new frontier awaits.

Stetson DB.

Curr Opin Immunol. 2018 Dec;55:iii-iv. doi: 10.1016/j.coi.2018.11.005. No abstract available.


SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.

Crowl JT, Stetson DB.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6798-6803. doi: 10.1073/pnas.1802114115. Epub 2018 Jun 11.


Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling.

Brault M, Olsen TM, Martinez J, Stetson DB, Oberst A.

J Immunol. 2018 Apr 15;200(8):2748-2756. doi: 10.4049/jimmunol.1701492. Epub 2018 Mar 14.


The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.


Intracellular Nucleic Acid Detection in Autoimmunity.

Crowl JT, Gray EE, Pestal K, Volkman HE, Stetson DB.

Annu Rev Immunol. 2017 Apr 26;35:313-336. doi: 10.1146/annurev-immunol-051116-052331. Epub 2017 Jan 30. Review.


The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.

Gray EE, Winship D, Snyder JM, Child SJ, Geballe AP, Stetson DB.

Immunity. 2016 Aug 16;45(2):255-66. doi: 10.1016/j.immuni.2016.06.015. Epub 2016 Aug 2.


Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.

York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ.

Cell. 2015 Dec 17;163(7):1716-29. doi: 10.1016/j.cell.2015.11.045. Epub 2015 Dec 10.


Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.

Pestal K, Funk CC, Snyder JM, Price ND, Treuting PM, Stetson DB.

Immunity. 2015 Nov 17;43(5):933-44. doi: 10.1016/j.immuni.2015.11.001.


DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway.

Lau L, Gray EE, Brunette RL, Stetson DB.

Science. 2015 Oct 30;350(6260):568-71. doi: 10.1126/science.aab3291. Epub 2015 Sep 24.


Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.

Gray EE, Treuting PM, Woodward JJ, Stetson DB.

J Immunol. 2015 Sep 1;195(5):1939-43. doi: 10.4049/jimmunol.1500969. Epub 2015 Jul 29.


The SKIV2L RNA exosome limits activation of the RIG-I-like receptors.

Eckard SC, Rice GI, Fabre A, Badens C, Gray EE, Hartley JL, Crow YJ, Stetson DB.

Nat Immunol. 2014 Sep;15(9):839-45. doi: 10.1038/ni.2948. Epub 2014 Jul 27.


The enemy within: endogenous retroelements and autoimmune disease.

Volkman HE, Stetson DB.

Nat Immunol. 2014 May;15(5):415-22. doi: 10.1038/ni.2872. Review.


Endogenous retroelements and autoimmune disease.

Stetson DB.

Curr Opin Immunol. 2012 Dec;24(6):692-7. doi: 10.1016/j.coi.2012.09.007. Epub 2012 Oct 10. Review.


Extensive evolutionary and functional diversity among mammalian AIM2-like receptors.

Brunette RL, Young JM, Whitley DG, Brodsky IE, Malik HS, Stetson DB.

J Exp Med. 2012 Oct 22;209(11):1969-83. doi: 10.1084/jem.20121960. Epub 2012 Oct 8.


Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB.

Immunity. 2012 Jan 27;36(1):120-31. doi: 10.1016/j.immuni.2011.11.018.


Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.

Rice GI, Bond J, Asipu A, Brunette RL, Manfield IW, Carr IM, Fuller JC, Jackson RM, Lamb T, Briggs TA, Ali M, Gornall H, Couthard LR, Aeby A, Attard-Montalto SP, Bertini E, Bodemer C, Brockmann K, Brueton LA, Corry PC, Desguerre I, Fazzi E, Cazorla AG, Gener B, Hamel BC, Heiberg A, Hunter M, van der Knaap MS, Kumar R, Lagae L, Landrieu PG, Lourenco CM, Marom D, McDermott MF, van der Merwe W, Orcesi S, Prendiville JS, Rasmussen M, Shalev SA, Soler DM, Shinawi M, Spiegel R, Tan TY, Vanderver A, Wakeling EL, Wassmer E, Whittaker E, Lebon P, Stetson DB, Bonthron DT, Crow YJ.

Nat Genet. 2009 Jul;41(7):829-32. doi: 10.1038/ng.373. Epub 2009 Jun 14.


Connections between antiviral defense and autoimmunity.

Stetson DB.

Curr Opin Immunol. 2009 Jun;21(3):244-50. doi: 10.1016/j.coi.2009.05.005. Epub 2009 Jun 3. Review.


Trex1 prevents cell-intrinsic initiation of autoimmunity.

Stetson DB, Ko JS, Heidmann T, Medzhitov R.

Cell. 2008 Aug 22;134(4):587-98. doi: 10.1016/j.cell.2008.06.032.


T helper 17 cells get the NOD.

Stetson DB, Medzhitov R.

Immunity. 2007 Oct;27(4):546-8. Review.


Type I interferons in host defense.

Stetson DB, Medzhitov R.

Immunity. 2006 Sep;25(3):373-81. Review.


Antiviral defense: interferons and beyond.

Stetson DB, Medzhitov R.

J Exp Med. 2006 Aug 7;203(8):1837-41. Epub 2006 Jul 31. Erratum in: J Exp Med. 2006 Sep 4;203(9):2215.


Activation of the integrated stress response during T helper cell differentiation.

Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM.

Nat Immunol. 2006 Jun;7(6):644-51. Epub 2006 May 7.


Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.

Stetson DB, Medzhitov R.

Immunity. 2006 Jan;24(1):93-103.


Th2 cells: orchestrating barrier immunity.

Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM.

Adv Immunol. 2004;83:163-89. Review. No abstract available.


Leishmania major LACK antigen is required for efficient vertebrate parasitization.

Kelly BL, Stetson DB, Locksley RM.

J Exp Med. 2003 Dec 1;198(11):1689-98.


Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM.

J Exp Med. 2003 Oct 6;198(7):1069-76.


Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.

Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8395-400. Epub 2003 Jun 26.


Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo.

Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM.

Immunity. 2002 Aug;17(2):191-200.


Development and maintenance of a B220- memory B cell compartment.

Driver DJ, McHeyzer-Williams LJ, Cool M, Stetson DB, McHeyzer-Williams MG.

J Immunol. 2001 Aug 1;167(3):1393-405.

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