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Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase.

Chen Z, Gutowski S, Sternweis PC.

Data Brief. 2018 Feb 20;17:356-362. doi: 10.1016/j.dib.2018.01.024. eCollection 2018 Apr.


Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.

Dada O, Gutowski S, Brautigam CA, Chen Z, Sternweis PC.

J Struct Biol. 2018 Apr;202(1):13-24. doi: 10.1016/j.jsb.2017.11.014. Epub 2017 Nov 28.


Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.

Pascoe HG, Gutowski S, Chen H, Brautigam CA, Chen Z, Sternweis PC, Zhang X.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14852-7. doi: 10.1073/pnas.1508931112. Epub 2015 Nov 16.


Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).

Carter AM, Gutowski S, Sternweis PC.

J Biol Chem. 2014 Jul 11;289(28):19737-46. doi: 10.1074/jbc.M114.564930. Epub 2014 May 22.


Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.

Medina F, Carter AM, Dada O, Gutowski S, Hadas J, Chen Z, Sternweis PC.

J Biol Chem. 2013 Apr 19;288(16):11325-33. doi: 10.1074/jbc.M113.450056. Epub 2013 Mar 14.


Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway.

Jiang LI, Wang JE, Sternweis PC.

Mol Pharmacol. 2013 Mar;83(3):587-93. doi: 10.1124/mol.112.082446. Epub 2012 Dec 10.


Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation.

Jiang LI, Sternweis PC, Wang JE.

Mol Immunol. 2013 May;54(1):14-22. doi: 10.1016/j.molimm.2012.10.027. Epub 2012 Nov 22.


Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.

Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC.

J Biol Chem. 2012 Jul 20;287(30):25490-500. doi: 10.1074/jbc.M111.333716. Epub 2012 Jun 1.


Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.

Chen Z, Guo L, Sprang SR, Sternweis PC.

Protein Sci. 2011 Jan;20(1):107-17. doi: 10.1002/pro.542.


Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice.

Duan B, Davis R, Sadat EL, Collins J, Sternweis PC, Yuan D, Jiang LI.

J Immunol. 2010 Jul 1;185(1):335-44. doi: 10.4049/jimmunol.0903474. Epub 2010 May 26.


Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC.

J Biol Chem. 2010 Jul 2;285(27):21070-81. doi: 10.1074/jbc.M110.122549. Epub 2010 Apr 29.


Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage.

Callender HL, Horn MA, DeCamp DL, Sternweis PC, Alex Brown H.

J Theor Biol. 2010 Feb 21;262(4):679-90. doi: 10.1016/j.jtbi.2009.10.030. Epub 2009 Oct 31.


Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.

Wall EA, Zavzavadjian JR, Chang MS, Randhawa B, Zhu X, Hsueh RC, Liu J, Driver A, Bao XR, Sternweis PC, Simon MI, Fraser ID.

Sci Signal. 2009 Jun 16;2(75):ra28. doi: 10.1126/scisignal.2000202.


Deciphering signaling outcomes from a system of complex networks.

Hsueh RC, Natarajan M, Fraser I, Pond B, Liu J, Mumby S, Han H, Jiang LI, Simon MI, Taussig R, Sternweis PC.

Sci Signal. 2009 May 19;2(71):ra22. doi: 10.1126/scisignal.2000054.


Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.

Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR.

Structure. 2008 Oct 8;16(10):1532-43. doi: 10.1016/j.str.2008.07.009.


Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.

Jiang LI, Collins J, Davis R, Fraser ID, Sternweis PC.

J Biol Chem. 2008 Aug 22;283(34):23429-39. doi: 10.1074/jbc.M803281200. Epub 2008 Jun 9.


Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.

Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE.

J Biol Chem. 2008 Jun 20;283(25):17351-61. doi: 10.1074/jbc.M800907200. Epub 2008 Apr 14.


Regulation of Rho guanine nucleotide exchange factors by G proteins.

Sternweis PC, Carter AM, Chen Z, Danesh SM, Hsiung YF, Singer WD.

Adv Protein Chem. 2007;74:189-228. Review.


Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.

Jiang LI, Collins J, Davis R, Lin KM, DeCamp D, Roach T, Hsueh R, Rebres RA, Ross EM, Taussig R, Fraser I, Sternweis PC.

J Biol Chem. 2007 Apr 6;282(14):10576-84. Epub 2007 Feb 5.


A global analysis of cross-talk in a mammalian cellular signalling network.

Natarajan M, Lin KM, Hsueh RC, Sternweis PC, Ranganathan R.

Nat Cell Biol. 2006 Jun;8(6):571-80. Epub 2006 May 14.


Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.

Chen Z, Singer WD, Sternweis PC, Sprang SR.

Nat Struct Mol Biol. 2005 Feb;12(2):191-7. Epub 2005 Jan 16.


Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.

Wang Q, Liu M, Kozasa T, Rothestein JD, Sternweis PC, Neubig RR.

Methods Enzymol. 2004;389:244-65. Review.


Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.

Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR.

J Biol Chem. 2004 Jul 9;279(28):28831-4. Epub 2004 May 13.


RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.

Gallagher ED, Gutowski S, Sternweis PC, Cobb MH.

J Biol Chem. 2004 Jan 16;279(3):1872-7. Epub 2003 Oct 27.


Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.

Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC.

J Biol Chem. 2003 Mar 14;278(11):9912-9. Epub 2003 Jan 13.


Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.


p115 Rho GTPase activating protein interacts with MEKK1.

Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, Cobb MH.

J Cell Physiol. 2002 Aug;192(2):200-8.


Mechanisms for reversible regulation between G13 and Rho exchange factors.

Wells CD, Liu MY, Jackson M, Gutowski S, Sternweis PM, Rothstein JD, Kozasa T, Sternweis PC.

J Biol Chem. 2002 Jan 11;277(2):1174-81. Epub 2001 Nov 6.


Functional characterization of p115 RhoGEF.

Wells C, Jiang X, Gutowski S, Sternweis PC.

Methods Enzymol. 2002;345:371-82. No abstract available.


Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase D.

Jiang X, Gutowski S, Singer WD, Sternweis PC.

Methods Enzymol. 2002;345:328-34. No abstract available.


Structure of the rgRGS domain of p115RhoGEF.

Chen Z, Wells CD, Sternweis PC, Sprang SR.

Nat Struct Biol. 2001 Sep;8(9):805-9.


Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor.

Wells CD, Gutowski S, Bollag G, Sternweis PC.

J Biol Chem. 2001 Aug 3;276(31):28897-905. Epub 2001 May 30.


Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.

Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD.

Nature. 2001 Mar 1;410(6824):89-93.


The C terminus of mammalian phospholipase D is required for catalytic activity.

Liu MY, Gutowski S, Sternweis PC.

J Biol Chem. 2001 Feb 23;276(8):5556-62. Epub 2000 Nov 16.


The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae.

Faulkner A, Chen X, Rush J, Horazdovsky B, Waechter CJ, Carman GM, Sternweis PC.

J Biol Chem. 1999 May 21;274(21):14831-7.


Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects.

Xie Z, Fang M, Rivas MP, Faulkner AJ, Sternweis PC, Engebrecht JA, Bankaitis VA.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12346-51.


Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G.

Science. 1998 Jun 26;280(5372):2112-4.


p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.

Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC.

Science. 1998 Jun 26;280(5372):2109-11.


The role of lipid signaling in constitutive membrane traffic.

Roth MG, Sternweis PC.

Curr Opin Cell Biol. 1997 Aug;9(4):519-26. Review.


Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997).

Taylor P, Ross EM, Sternweis PC, Neubig RR, McCammon JA.

Mol Pharmacol. 1997 Jul;52(1):1-5. No abstract available.


The monomeric G-proteins Rac1 and/or Cdc42 are required for the inhibition of voltage-dependent calcium current by bradykinin.

Wilk-Blaszczak MA, Singer WD, Quill T, Miller B, Frost JA, Sternweis PC, Belardetti F.

J Neurosci. 1997 Jun 1;17(11):4094-100.


Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.

Singer WD, Brown HA, Sternweis PC.

Annu Rev Biochem. 1997;66:475-509. Review.


Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

Ktistakis NT, Brown HA, Waters MG, Sternweis PC, Roth MG.

J Cell Biol. 1996 Jul;134(2):295-306.


Resolved phospholipase D activity is modulated by cytosolic factors other than Arf.

Singer WD, Brown HA, Bokoch GM, Sternweis PC.

J Biol Chem. 1995 Jun 23;270(25):14944-50.


Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain.

Brown HA, Gutowski S, Kahn RA, Sternweis PC.

J Biol Chem. 1995 Jun 23;270(25):14935-43.


Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

Ktistakis NT, Brown HA, Sternweis PC, Roth MG.

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4952-6.


Stimulation of phospholipase D by ADP-ribosylation factor.

Brown HA, Sternweis PC.

Methods Enzymol. 1995;257:313-24. No abstract available.


The G protein G13 mediates inhibition of voltage-dependent calcium current by bradykinin.

Wilk-Blaszczak MA, Singer WD, Gutowski S, Sternweis PC, Belardetti F.

Neuron. 1994 Nov;13(5):1215-24.


Purification and characterization of the alpha subunit of G13.

Singer WD, Miller RT, Sternweis PC.

J Biol Chem. 1994 Aug 5;269(31):19796-802.

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