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Items: 26


USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.

Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I.

Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5. doi: 10.1016/j.chembiol.2017.09.004. Epub 2017 Oct 19.


Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity.

Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, Han R, Samanta A, Beier UH, Akimova T, Bhatti TR, Nicholson B, Kodrasov MP, Agarwal S, Sterner DE, Gu W, Weinstock J, Butt TR, Albelda SM, Hancock WW.

EBioMedicine. 2016 Nov;13:99-112. doi: 10.1016/j.ebiom.2016.10.018. Epub 2016 Oct 15.


Process for Assembly and Transformation into Saccharomyces cerevisiae of a Synthetic Yeast Artificial Chromosome Containing a Multigene Cassette to Express Enzymes That Enhance Xylose Utilization Designed for an Automated Platform.

Hughes SR, Cox EJ, Bang SS, Pinkelman RJ, López-Núñez JC, Saha BC, Qureshi N, Gibbons WR, Fry MR, Moser BR, Bischoff KM, Liu S, Sterner DE, Butt TR, Riedmuller SB, Jones MA, Riaño-Herrera NM.

J Lab Autom. 2015 Dec;20(6):621-35. doi: 10.1177/2211068215573188. Epub 2015 Feb 26.


Discovery of Therapeutic Deubiquitylase Effector Molecules: Current Perspectives.

Nicholson B, Kumar S, Agarwal S, Eddins MJ, Marblestone JG, Wu J, Kodrasov MP, LaRocque JP, Sterner DE, Mattern MR.

J Biomol Screen. 2014 Aug;19(7):989-99. doi: 10.1177/1087057114527312. Epub 2014 Mar 14. Review.


Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases.

Marblestone JG, Butt S, McKelvey DM, Sterner DE, Mattern MR, Nicholson B, Eddins MJ.

Cell Biochem Biophys. 2013 Sep;67(1):161-7. doi: 10.1007/s12013-013-9627-3.


Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p.

Mallory MJ, Law MJ, Sterner DE, Berger SL, Strich R.

Mol Biol Cell. 2012 May;23(9):1609-17. doi: 10.1091/mbc.E11-06-0536. Epub 2012 Mar 21.


Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy.

Eddins MJ, Marblestone JG, Suresh Kumar KG, Leach CA, Sterner DE, Mattern MR, Nicholson B.

Cell Biochem Biophys. 2011 Jun;60(1-2):113-8. doi: 10.1007/s12013-011-9175-7.


Novel approach for characterizing ubiquitin E3 ligase function.

Marblestone JG, Suresh Kumar KG, Eddins MJ, Leach CA, Sterner DE, Mattern MR, Nicholson B.

J Biomol Screen. 2010 Dec;15(10):1220-8. doi: 10.1177/1087057110380456. Epub 2010 Sep 23.


Engineered Saccharomyces cerevisiae strain for improved xylose utilization with a three-plasmid SUMO yeast expression system.

Hughes SR, Sterner DE, Bischoff KM, Hector RE, Dowd PF, Qureshi N, Bang SS, Grynaviski N, Chakrabarty T, Johnson ET, Dien BS, Mertens JA, Caughey RJ, Liu S, Butt TR, LaBaer J, Cotta MA, Rich JO.

Plasmid. 2009 Jan;61(1):22-38. doi: 10.1016/j.plasmid.2008.09.001. Epub 2008 Oct 26.


Lycotoxin-1 insecticidal peptide optimized by amino acid scanning mutagenesis and expressed as a coproduct in an ethanologenic Saccharomyces cerevisiae strain.

Hughes SR, Dowd PF, Hector RE, Panavas T, Sterner DE, Qureshi N, Bischoff KM, Bang SS, Mertens JA, Johnson ET, Li XL, Jackson JS, Caughey RJ, Riedmuller SB, Bartolett S, Liu S, Rich JO, Farrelly PJ, Butt TR, Labaer J, Cotta MA.

J Pept Sci. 2008 Sep;14(9):1039-50. doi: 10.1002/psc.1040.


Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.

Nicholson B, Leach CA, Goldenberg SJ, Francis DM, Kodrasov MP, Tian X, Shanks J, Sterner DE, Bernal A, Mattern MR, Wilkinson KD, Butt TR.

Protein Sci. 2008 Jun;17(6):1035-43. doi: 10.1110/ps.083450408. Epub 2008 Apr 18.


Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.

Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR, Dokmanovic M, Dorsey JA, Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger SL.

Genes Dev. 2006 Apr 15;20(8):966-76. Epub 2006 Apr 5.


Sumoylation of the yeast Gcn5 protein.

Sterner DE, Nathan D, Reindle A, Johnson ES, Berger SL.

Biochemistry. 2006 Jan 24;45(3):1035-42.


Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity.

Arnold JJ, Bernal A, Uche U, Sterner DE, Butt TR, Cameron CE, Mattern MR.

Anal Biochem. 2006 Mar 15;350(2):214-21. Epub 2005 Nov 17.


Expression and purification of SARS coronavirus proteins using SUMO-fusions.

Zuo X, Mattern MR, Tan R, Li S, Hall J, Sterner DE, Shoo J, Tran H, Lim P, Sarafianos SG, Kazi L, Navas-Martin S, Weiss SR, Butt TR.

Protein Expr Purif. 2005 Jul;42(1):100-10. Epub 2005 Feb 23.


Histone modifications: Now summoning sumoylation.

Nathan D, Sterner DE, Berger SL.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20. Epub 2003 Nov 3. No abstract available.


SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Sterner DE, Belotserkovskaya R, Berger SL.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11622-7. Epub 2002 Aug 19.


The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.

Sterner DE, Wang X, Bloom MH, Simon GM, Berger SL.

J Biol Chem. 2002 Mar 8;277(10):8178-86. Epub 2002 Jan 2.


Acetylation of histones and transcription-related factors.

Sterner DE, Berger SL.

Microbiol Mol Biol Rev. 2000 Jun;64(2):435-59. Review.


Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters.

Belotserkovskaya R, Sterner DE, Deng M, Sayre MH, Lieberman PM, Berger SL.

Mol Cell Biol. 2000 Jan;20(2):634-47.


The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.

Eberharter A, Sterner DE, Schieltz D, Hassan A, Yates JR 3rd, Berger SL, Workman JL.

Mol Cell Biol. 1999 Oct;19(10):6621-31.


Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.

Trievel RC, Rojas JR, Sterner DE, Venkataramani RN, Wang L, Zhou J, Allis CD, Berger SL, Marmorstein R.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8931-6.


Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.

Sterner DE, Grant PA, Roberts SM, Duggan LJ, Belotserkovskaya R, Pacella LA, Winston F, Workman JL, Berger SL.

Mol Cell Biol. 1999 Jan;19(1):86-98.


The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes.

Grant PA, Sterner DE, Duggan LJ, Workman JL, Berger SL.

Trends Cell Biol. 1998 May;8(5):193-7. Review.


Assaying CTD kinases in vitro and phosphorylation-modulated properties of RNA polymerase II in vivo.

Morris DP, Lee JM, Sterner DE, Brickey WJ, Greenleaf AL.

Methods. 1997 Jul;12(3):264-75. Review.


The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex.

Sterner DE, Lee JM, Hardin SE, Greenleaf AL.

Mol Cell Biol. 1995 Oct;15(10):5716-24.

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