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Items: 1 to 20 of 200

1.

Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.

Kneuttinger AC, Zwisele S, Straub K, Bruckmann A, Busch F, Kinateder T, Gaim B, Wysocki VH, Merkl R, Sterner R.

Int J Mol Sci. 2019 Oct 15;20(20). pii: E5106. doi: 10.3390/ijms20205106.

2.

Library Selection with a Randomized Repertoire of (βα)8-Barrel Enzymes Results in Unexpected Induction of Gene Expression.

Rohweder B, Lehmann G, Eichner N, Polen T, Rajendran C, Ruperti F, Linde M, Treiber T, Jung O, Dettmer K, Meister G, Bott M, Gronwald W, Sterner R.

Biochemistry. 2019 Oct 15;58(41):4207-4217. doi: 10.1021/acs.biochem.9b00579. Epub 2019 Oct 7.

PMID:
31557000
3.

Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids.

Kneuttinger AC, Straub K, Bittner P, Simeth NA, Bruckmann A, Busch F, Rajendran C, Hupfeld E, Wysocki VH, Horinek D, König B, Merkl R, Sterner R.

Cell Chem Biol. 2019 Sep 4. pii: S2451-9456(19)30271-5. doi: 10.1016/j.chembiol.2019.08.006. [Epub ahead of print]

PMID:
31495713
4.

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells.

Sterner RM, Cox MJ, Sakemura R, Kenderian SS.

J Vis Exp. 2019 Jul 22;(149). doi: 10.3791/59629.

PMID:
31380838
5.

Prediction of quaternary structure by analysis of hot spot residues in protein-protein interfaces: the case of anthranilate phosphoribosyltransferases.

Schlee S, Straub K, Schwab T, Kinateder T, Merkl R, Sterner R.

Proteins. 2019 Oct;87(10):815-825. doi: 10.1002/prot.25744. Epub 2019 Jun 10.

PMID:
31134642
6.

Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase.

Semmelmann F, Straub K, Nazet J, Rajendran C, Merkl R, Sterner R.

J Mol Biol. 2019 Jul 12;431(15):2718-2728. doi: 10.1016/j.jmb.2019.05.021. Epub 2019 May 21.

PMID:
31121180
7.

A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases.

Semmelmann F, Hupfeld E, Heizinger L, Merkl R, Sterner R.

Biochemistry. 2019 Jun 4;58(22):2584-2588. doi: 10.1021/acs.biochem.9b00286. Epub 2019 May 23.

PMID:
31117390
8.

Generation of a Stand-Alone Tryptophan Synthase α-Subunit by Mimicking an Evolutionary Blueprint.

Schupfner M, Busch F, Wysocki VH, Sterner R.

Chembiochem. 2019 Nov 4;20(21):2747-2751. doi: 10.1002/cbic.201900323. Epub 2019 Aug 28.

PMID:
31090986
9.

Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia.

Semmelmann F, Kabeya N, Malcicka M, Bruckmann A, Broschwitz B, Straub K, Merkl R, Monroig O, Sterner R, Ruther J, Ellers J.

J Exp Biol. 2019 May 16;222(Pt 10). pii: jeb201038. doi: 10.1242/jeb.201038.

10.

Tale of Two Storms: Impact of Extreme Rain Events on the Biogeochemistry of Lake Superior.

Cooney EM, McKinney P, Sterner R, Small GE, Minor EC.

J Geophys Res Biogeosci. 2018;123(5):1719-1731. doi: 10.1029/2017JG004216.

11.
12.

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts.

Sterner RM, Sakemura R, Cox MJ, Yang N, Khadka RH, Forsman CL, Hansen MJ, Jin F, Ayasoufi K, Hefazi M, Schick KJ, Walters DK, Ahmed O, Chappell D, Sahmoud T, Durrant C, Nevala WK, Patnaik MM, Pease LR, Hedin KE, Kay NE, Johnson AJ, Kenderian SS.

Blood. 2019 Feb 14;133(7):697-709. doi: 10.1182/blood-2018-10-881722. Epub 2018 Nov 21.

PMID:
30463995
13.

Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole.

Fleming JR, Schupfner M, Busch F, Baslé A, Ehrmann A, Sterner R, Mayans O.

J Mol Biol. 2018 Dec 7;430(24):5066-5079. doi: 10.1016/j.jmb.2018.10.013. Epub 2018 Oct 25.

PMID:
30367843
14.

Editorial: Progress in Ecological Stoichiometry.

Van de Waal DB, Elser JJ, Martiny AC, Sterner RW, Cotner JB.

Front Microbiol. 2018 Sep 5;9:1957. doi: 10.3389/fmicb.2018.01957. eCollection 2018. No abstract available.

15.

Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis.

Sterner RM, Kremer KN, Dudakovic A, Westendorf JJ, van Wijnen AJ, Hedin KE.

J Immunol. 2018 Aug 1;201(3):1086-1096. doi: 10.4049/jimmunol.1800174. Epub 2018 Jun 18.

16.

Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.

Kneuttinger AC, Winter M, Simeth NA, Heyn K, Merkl R, König B, Sterner R.

Chembiochem. 2018 May 29. doi: 10.1002/cbic.201800219. [Epub ahead of print]

PMID:
29808949
17.

Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures.

Linde M, Heyn K, Merkl R, Sterner R, Babinger P.

Biochemistry. 2018 Apr 24;57(16):2335-2348. doi: 10.1021/acs.biochem.7b01284. Epub 2018 Apr 11.

PMID:
29600842
18.

Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase.

Schlee S, Klein T, Schumacher M, Nazet J, Merkl R, Steinhoff HJ, Sterner R.

Biochemistry. 2018 Jun 12;57(23):3265-3277. doi: 10.1021/acs.biochem.8b00167. Epub 2018 Mar 8.

PMID:
29498826
19.

Standardized cloning vectors for protein production and generation of large gene libraries in Escherichia coli.

Rohweder B, Semmelmann F, Endres C, Sterner R.

Biotechniques. 2018 Jan 1;64(1):24-26. doi: 10.2144/000114628.

20.

Cellular therapies for chronic ischemic heart failure.

Sterner RM, Sterner RC, Brenes-Salazar JA, Yu Ballard AC.

Hellenic J Cardiol. 2018 Mar - Apr;59(2):78-90. doi: 10.1016/j.hjc.2018.01.010. Epub 2018 Jan 31. Review.

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