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Items: 25


Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system.

Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS.

Nature. 2020 Jan;577(7789):271-274. doi: 10.1038/s41586-019-1849-0. Epub 2019 Dec 18.


Harnessing type I CRISPR-Cas systems for genome engineering in human cells.

Cameron P, Coons MM, Klompe SE, Lied AM, Smith SC, Vidal B, Donohoue PD, Rotstein T, Kohrs BW, Nyer DB, Kennedy R, Banh LM, Williams C, Toh MS, Irby MJ, Edwards LS, Lin CH, Owen ALG, Künne T, van der Oost J, Brouns SJJ, Slorach EM, Fuller CK, Gradia S, Kanner SB, May AP, Sternberg SH.

Nat Biotechnol. 2019 Dec;37(12):1471-1477. doi: 10.1038/s41587-019-0310-0. Epub 2019 Nov 18.


Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.

Klompe SE, Vo PLH, Halpin-Healy TS, Sternberg SH.

Nature. 2019 Jul;571(7764):219-225. doi: 10.1038/s41586-019-1323-z. Epub 2019 Jun 12.


Harnessing "A Billion Years of Experimentation": The Ongoing Exploration and Exploitation of CRISPR-Cas Immune Systems.

Klompe SE, Sternberg SH.

CRISPR J. 2018 Apr;1(2):141-158. doi: 10.1089/crispr.2018.0012. Review.


Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.

Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA.

Nature. 2017 Oct 19;550(7676):407-410. doi: 10.1038/nature24268. Epub 2017 Sep 20.


A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9.

Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A.

Sci Adv. 2017 Aug 4;3(8):eaao0027. doi: 10.1126/sciadv.aao0027. eCollection 2017 Aug.


Conformational regulation of CRISPR-associated nucleases.

Jackson RN, van Erp PB, Sternberg SH, Wiedenheft B.

Curr Opin Microbiol. 2017 Jun;37:110-119. doi: 10.1016/j.mib.2017.05.010. Epub 2017 Jun 21. Review.


High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.

Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna JA, Greenleaf WJ.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5461-5466. doi: 10.1073/pnas.1700557114. Epub 2017 May 11.


Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.

Singh D, Sternberg SH, Fei J, Doudna JA, Ha T.

Nat Commun. 2016 Sep 14;7:12778. doi: 10.1038/ncomms12778.


Adaptation in CRISPR-Cas Systems.

Sternberg SH, Richter H, Charpentier E, Qimron U.

Mol Cell. 2016 Mar 17;61(6):797-808. doi: 10.1016/j.molcel.2016.01.030. Epub 2016 Mar 3. Review.


Conformational control of DNA target cleavage by CRISPR-Cas9.

Sternberg SH, LaFrance B, Kaplan M, Doudna JA.

Nature. 2015 Nov 5;527(7576):110-3. doi: 10.1038/nature15544. Epub 2015 Oct 28.


Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.

Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC.

Cell. 2015 Nov 5;163(4):854-65. doi: 10.1016/j.cell.2015.10.003.


Expanding the Biologist's Toolkit with CRISPR-Cas9.

Sternberg SH, Doudna JA.

Mol Cell. 2015 May 21;58(4):568-74. doi: 10.1016/j.molcel.2015.02.032. Review.


Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.


Rational design of a split-Cas9 enzyme complex.

Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2984-9. doi: 10.1073/pnas.1501698112. Epub 2015 Feb 23.


Programmable RNA recognition and cleavage by CRISPR/Cas9.

O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA.

Nature. 2014 Dec 11;516(7530):263-6. doi: 10.1038/nature13769. Epub 2014 Sep 28.


CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.

Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6618-23. doi: 10.1073/pnas.1405079111. Epub 2014 Apr 18.


Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.

Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA.

Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6.


DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA.

Nature. 2014 Mar 6;507(7490):62-7. doi: 10.1038/nature13011. Epub 2014 Jan 29.


Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA.

Haurwitz RE, Sternberg SH, Doudna JA.

EMBO J. 2012 Jun 13;31(12):2824-32. doi: 10.1038/emboj.2012.107. Epub 2012 Apr 20.


Mechanism of substrate selection by a highly specific CRISPR endoribonuclease.

Sternberg SH, Haurwitz RE, Doudna JA.

RNA. 2012 Apr;18(4):661-72. doi: 10.1261/rna.030882.111. Epub 2012 Feb 16.


RNA-guided genetic silencing systems in bacteria and archaea.

Wiedenheft B, Sternberg SH, Doudna JA.

Nature. 2012 Feb 15;482(7385):331-8. doi: 10.1038/nature10886. Review.


Substrate-specific kinetics of Dicer-catalyzed RNA processing.

Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA.

J Mol Biol. 2010 Dec 3;404(3):392-402. doi: 10.1016/j.jmb.2010.09.030. Epub 2010 Oct 13.


A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis.

Fei J, Wang J, Sternberg SH, MacDougall DD, Elvekrog MM, Pulukkunat DK, Englander MT, Gonzalez RL Jr.

Methods Enzymol. 2010;472:221-59. doi: 10.1016/S0076-6879(10)72008-5.


Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling.

Sternberg SH, Fei J, Prywes N, McGrath KA, Gonzalez RL Jr.

Nat Struct Mol Biol. 2009 Aug;16(8):861-8. doi: 10.1038/nsmb.1622. Epub 2009 Jul 13.

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