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Items: 24


Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis.

Gotlib J, Kluin-Nelemans HC, George TI, Akin C, Sotlar K, Hermine O, Awan FT, Hexner E, Mauro MJ, Sternberg DW, Villeneuve M, Huntsman Labed A, Stanek EJ, Hartmann K, Horny HP, Valent P, Reiter A.

N Engl J Med. 2016 Jun 30;374(26):2530-41. doi: 10.1056/NEJMoa1513098.


Phase Ib study of Buparlisib plus Trastuzumab in patients with HER2-positive advanced or metastatic breast cancer that has progressed on Trastuzumab-based therapy.

Saura C, Bendell J, Jerusalem G, Su S, Ru Q, De Buck S, Mills D, Ruquet S, Bosch A, Urruticoechea A, Beck JT, Di Tomaso E, Sternberg DW, Massacesi C, Hirawat S, Dirix L, Baselga J.

Clin Cancer Res. 2014 Apr 1;20(7):1935-45. doi: 10.1158/1078-0432.CCR-13-1070. Epub 2014 Jan 27.


A randomized, phase II, biomarker-selected study comparing erlotinib to erlotinib intercalated with chemotherapy in first-line therapy for advanced non-small-cell lung cancer.

Hirsch FR, Kabbinavar F, Eisen T, Martins R, Schnell FM, Dziadziuszko R, Richardson K, Richardson F, Wacker B, Sternberg DW, Rusk J, Franklin WA, Varella-Garcia M, Bunn PA Jr, Camidge DR.

J Clin Oncol. 2011 Sep 10;29(26):3567-73. doi: 10.1200/JCO.2010.34.4929. Epub 2011 Aug 8. Erratum in: J Clin Oncol. 2011 Oct 10;29(29):3948. Camidge, Ross [corrected to Camidge, D Ross].


The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.

Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A, Dirks WG, Sexl V, Bergler H, Kadin ME, Sternberg DW, Kenner L, Hoefler G.

Blood. 2007 Nov 1;110(9):3374-83. Epub 2007 Aug 9.


Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context.

Theodoraki MA, Kunjappu M, Sternberg DW, Caplan AJ.

Exp Cell Res. 2007 Nov 1;313(18):3851-8. Epub 2007 Jul 6.


Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG.

J Exp Med. 2006 Feb 20;203(2):371-81. Epub 2006 Jan 30.


The molecular pathology of acute myeloid leukemia.

Licht JD, Sternberg DW.

Hematology Am Soc Hematol Educ Program. 2005:137-42. Review.


Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

Unwin RD, Pierce A, Watson RB, Sternberg DW, Whetton AD.

Mol Cell Proteomics. 2005 Jul;4(7):924-35. Epub 2005 Apr 22.


Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton AD.

J Biol Chem. 2005 Feb 25;280(8):6316-26. Epub 2004 Nov 29.


KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32).

Levine RL, Wadleigh M, Sternberg DW, Wlodarska I, Galinsky I, Stone RM, DeAngelo DJ, Gilliland DG, Cools J.

Leukemia. 2005 Jan;19(1):27-30.


Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.

Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3130-5. Epub 2004 Feb 19.


NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a.

Gu TL, Tothova Z, Scheijen B, Griffin JD, Gilliland DG, Sternberg DW.

Blood. 2004 Jun 15;103(12):4622-9. Epub 2004 Feb 12.


The role of signal transducer and activator of transcription factors in leukemogenesis.

Sternberg DW, Gilliland DG.

J Clin Oncol. 2004 Jan 15;22(2):361-71. Review.


The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways.

Sternberg DW, Tomasson MH, Carroll M, Curley DP, Barker G, Caprio M, Wilbanks A, Kazlauskas A, Gilliland DG.

Blood. 2001 Dec 1;98(12):3390-7.


H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22).

Schwaller J, Anastasiadou E, Cain D, Kutok J, Wojiski S, Williams IR, LaStarza R, Crescenzi B, Sternberg DW, Andreasson P, Schiavo R, Siena S, Mecucci C, Gilliland DG.

Blood. 2001 Jun 15;97(12):3910-8.


Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen.

Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN.

Cancer. 2000 May 1;88(9):2037-41.


Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.

Tomasson MH, Sternberg DW, Williams IR, Carroll M, Cain D, Aster JC, Ilaria RL Jr, Van Etten RA, Gilliland DG.

J Clin Invest. 2000 Feb;105(4):423-32.


Activation of a histone H1 kinase by tyrosine phosphorylation in v-src-transformed fibroblasts.

Sternberg DW, Scholz G, Fukui Y, Hanafusa H.

EMBO J. 1993 Jan;12(1):323-30.


K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

Berg MM, Sternberg DW, Parada LF, Chao MV.

J Biol Chem. 1992 Jan 5;267(1):13-6.


The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.

Berg MM, Sternberg DW, Hempstead BL, Chao MV.

Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7106-10.


Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

Miyasaka T, Sternberg DW, Miyasaka J, Sherline P, Saltiel AR.

Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2653-7.


S-methyl glutathione synthesis is catalyzed by the cheR methyltransferase in Escherichia coli.

Terwilliger TC, Bollag GE, Sternberg DW Jr, Koshland DE Jr.

J Bacteriol. 1986 Mar;165(3):958-63.

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