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Author Correction: In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.

Jiang W, Birtley JR, Hung SC, Wang W, Chiou SH, Macaubas C, Kornum B, Tian L, Huang H, Adler L, Weaver G, Lu L, Ilstad-Minnihan A, Somasundaram S, Ayyangar S, Davis MM, Stern LJ, Mellins ED.

Nat Commun. 2020 Jan 8;11(1):242. doi: 10.1038/s41467-019-13776-0.


Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects.

Joseph CR, Benhatzel CM, Stern LJ, Hopper OM, Lockwood MD.

MAGMA. 2020 Jan 3. doi: 10.1007/s10334-019-00818-3. [Epub ahead of print]


Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.

Maben Z, Arya R, Rane D, An WF, Metkar S, Hickey M, Bender S, Ali A, Nguyen TT, Evnouchidou I, Schilling R, Stratikos E, Golden J, Stern LJ.

J Med Chem. 2020 Jan 9;63(1):103-121. doi: 10.1021/acs.jmedchem.9b00293. Epub 2019 Dec 30.


CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection.

Kamga L, Gil A, Song I, Brody R, Ghersi D, Aslan N, Stern LJ, Selin LK, Luzuriaga K.

PLoS Pathog. 2019 Nov 25;15(11):e1008122. doi: 10.1371/journal.ppat.1008122. eCollection 2019 Nov.


In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.

Jiang W, Birtley JR, Hung SC, Wang W, Chiou SH, Macaubas C, Kornum B, Tian L, Huang H, Adler L, Weaver G, Lu L, Ilstad-Minnihan A, Somasundaram S, Ayyangar S, Davis MM, Stern LJ, Mellins ED.

Nat Commun. 2019 Nov 20;10(1):5247. doi: 10.1038/s41467-019-13234-x. Erratum in: Nat Commun. 2020 Jan 8;11(1):242.


Recognition of Listeria Infection by Germline Elements of the Vγ1.1 Vδ6.3 TCR.

Negroni MP, Cho OH, Stern LJ.

Immunohorizons. 2019 Jul 18;3(7):341-351. doi: 10.4049/immunohorizons.1800040.


A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness.

Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L.

Brain Behav Immun. 2019 Oct;81:545-559. doi: 10.1016/j.bbi.2019.07.015. Epub 2019 Jul 17.


Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.

Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver GC, Von Arx C, Mura M, Marinho AT, Lu H, Morecroft EVN, Karali E, Chayen NE, Tate EW, Jurewicz M, Stern LJ, Recchi C, Gabra H.

Nat Commun. 2019 Jul 17;10(1):3134. doi: 10.1038/s41467-019-10966-8.


Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).

Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E.

Cancer Immunol Immunother. 2019 Aug;68(8):1245-1261. doi: 10.1007/s00262-019-02358-0. Epub 2019 Jun 20.


A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development.

Stadinski BD, Blevins SJ, Spidale NA, Duke BR, Huseby PG, Stern LJ, Huseby ES.

Nat Immunol. 2019 Aug;20(8):1046-1058. doi: 10.1038/s41590-019-0414-1. Epub 2019 Jun 17.


MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to β2-microglobulin.

Jurewicz MM, Willis RA, Ramachandiran V, Altman JD, Stern LJ.

Anal Biochem. 2019 Nov 1;584:113328. doi: 10.1016/j.ab.2019.05.017. Epub 2019 Jun 13.


Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses.

Becerra-Artiles A, Cruz J, Leszyk JD, Sidney J, Sette A, Shaffer SA, Stern LJ.

Eur J Immunol. 2019 Aug;49(8):1167-1185. doi: 10.1002/eji.201948126. Epub 2019 May 2.


HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.

Nanaware PP, Jurewicz MM, Leszyk JD, Shaffer SA, Stern LJ.

Mol Cell Proteomics. 2019 Mar;18(3):490-503. doi: 10.1074/mcp.RA118.000956. Epub 2018 Dec 20.


Class II MHC antigen processing in immune tolerance and inflammation.

Jurewicz MM, Stern LJ.

Immunogenetics. 2019 Mar;71(3):171-187. doi: 10.1007/s00251-018-1095-x. Epub 2018 Nov 12. Review.


Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711-718.

Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC.

J Immunol. 2018 Oct 1;201(7):1819-1826. No abstract available.


Quantitative Profiling of the Lymph Node Clearance Capacity.

Clement CC, Wang W, Dzieciatkowska M, Cortese M, Hansen KC, Becerra A, Thangaswamy S, Nizamutdinova I, Moon JY, Stern LJ, Gashev AA, Zawieja D, Santambrogio L.

Sci Rep. 2018 Jul 26;8(1):11253. doi: 10.1038/s41598-018-29614-0.


The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release.

Negroni MP, Stern LJ.

PLoS One. 2018 Jul 2;13(7):e0199704. doi: 10.1371/journal.pone.0199704. eCollection 2018.


Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

Mpakali A, Maben Z, Stern LJ, Stratikos E.

Mol Immunol. 2019 Sep;113:50-57. doi: 10.1016/j.molimm.2018.03.026. Epub 2018 Apr 17. Review.


Evaluation of a method to measure HHV-6B infection in vitro based on cell size.

Becerra-Artiles A, Santoro T, Stern LJ.

Virol J. 2018 Jan 5;15(1):4. doi: 10.1186/s12985-017-0917-z.


The cytosolic domain of T-cell receptor ζ associates with membranes in a dynamic equilibrium and deeply penetrates the bilayer.

Zimmermann K, Eells R, Heinrich F, Rintoul S, Josey B, Shekhar P, Lösche M, Stern LJ.

J Biol Chem. 2017 Oct 27;292(43):17746-17759. doi: 10.1074/jbc.M117.794370. Epub 2017 Sep 11.


Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation.

Maldonado-Contreras A, Birtley JR, Boll E, Zhao Y, Mumy KL, Toscano J, Ayehunie S, Reinecker HC, Stern LJ, McCormick BA.

Gut Microbes. 2017 Nov 2;8(6):544-560. doi: 10.1080/19490976.2017.1339006. Epub 2017 Jun 28.


Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.

Song I, Gil A, Mishra R, Ghersi D, Selin LK, Stern LJ.

Nat Struct Mol Biol. 2017 Apr;24(4):395-406. doi: 10.1038/nsmb.3383. Epub 2017 Feb 27.


Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E.

Biochemistry. 2017 Mar 14;56(10):1546-1558. doi: 10.1021/acs.biochem.6b01170. Epub 2017 Mar 2.


The melting pot of the MHC II peptidome.

Stern LJ, Santambrogio L.

Curr Opin Immunol. 2016 Jun;40:70-7. doi: 10.1016/j.coi.2016.03.004. Epub 2016 Mar 25. Review.


Autoimmune response to transthyretin in juvenile idiopathic arthritis.

Clement CC, Moncrieffe H, Lele A, Janow G, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L.

JCI Insight. 2016 Feb;1(2). pii: 85633. doi: 10.1172/jci.insight.85633. Epub 2016 Feb 25.


Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.

Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM.

J Immunol Methods. 2016 May;432:95-101. doi: 10.1016/j.jim.2016.02.016. Epub 2016 Feb 18.


The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.

Clement CC, Becerra A, Yin L, Zolla V, Huang L, Merlin S, Follenzi A, Shaffer SA, Stern LJ, Santambrogio L.

J Biol Chem. 2016 Mar 11;291(11):5576-95. doi: 10.1074/jbc.M115.655738. Epub 2016 Jan 6.


A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B.

Becerra-Artiles A, Dominguez-Amorocho O, Stern LJ, Calvo-Calle JM.

PLoS One. 2015 Nov 23;10(11):e0142871. doi: 10.1371/journal.pone.0142871. eCollection 2015.


Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.

Yin L, Maben ZJ, Becerra A, Stern LJ.

J Immunol. 2015 Jul 15;195(2):706-16. doi: 10.4049/jimmunol.1403190. Epub 2015 Jun 10.


Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC.

J Immunol. 2015 Jan 1;194(1):5-11. No abstract available.


Immune response to HHV-6 and implications for immunotherapy.

Becerra A, Gibson L, Stern LJ, Calvo-Calle JM.

Curr Opin Virol. 2014 Dec;9:154-61. doi: 10.1016/j.coviro.2014.10.001. Epub 2014 Oct 27. Review.


Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.

Yin L, Stern LJ.

Curr Protoc Immunol. 2014 Aug 1;106:5.10.1-5.10.12. doi: 10.1002/0471142735.im0510s106. Review.


Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide.

Yin L, Trenh P, Guce A, Wieczorek M, Lange S, Sticht J, Jiang W, Bylsma M, Mellins ED, Freund C, Stern LJ.

J Biol Chem. 2014 Aug 22;289(34):23449-64. doi: 10.1074/jbc.M114.585539. Epub 2014 Jul 7.


An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.

Parra-López CA, Bernal-Estévez D, Yin L, Vargas LE, Pulido-Calixto C, Salazar LM, Calvo-Calle JM, Stern LJ.

PLoS One. 2014 Jul 1;9(7):e100639. doi: 10.1371/journal.pone.0100639. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113028. Yin, Liusong [added].


Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.

Stadinski BD, Trenh P, Duke B, Huseby PG, Li G, Stern LJ, Huseby ES.

J Immunol. 2014 Jun 15;192(12):6071-82. doi: 10.4049/jimmunol.1303209. Epub 2014 May 9.


Circulating human rotavirus specific CD4 T cells identified with a class II tetramer express the intestinal homing receptors α4β7 and CCR9.

Parra M, Herrera D, Calvo-Calle JM, Stern LJ, Parra-López CA, Butcher E, Franco M, Angel J.

Virology. 2014 Mar;452-453:191-201. doi: 10.1016/j.virol.2014.01.014. Epub 2014 Feb 7.


HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.

Mellins ED, Stern LJ.

Curr Opin Immunol. 2014 Feb;26:115-22. doi: 10.1016/j.coi.2013.11.005. Epub 2013 Dec 8. Review.


HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.

Yin L, Stern LJ.

Front Immunol. 2013 Oct 17;4:336. doi: 10.3389/fimmu.2013.00336. Review.


Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.

Shen ZT, Nguyen TT, Daniels KA, Welsh RM, Stern LJ.

J Immunol. 2013 Nov 15;191(10):5139-52. doi: 10.4049/jimmunol.1300852. Epub 2013 Oct 14.


Carrying yourself: self antigen composition of the lymphatic fluid.

Santambrogio L, Stern LJ.

Lymphat Res Biol. 2013 Sep;11(3):149-54. doi: 10.1089/lrb.2013.0009. Epub 2013 Sep 11.


Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT.

PLoS Pathog. 2013;9(7):e1003487. doi: 10.1371/journal.ppat.1003487. Epub 2013 Jul 11.


CD4+ T cells provide intermolecular help to generate robust antibody responses in vaccinia virus-vaccinated humans.

Yin L, Calvo-Calle JM, Cruz J, Newman FK, Frey SE, Ennis FA, Stern LJ.

J Immunol. 2013 Jun 15;190(12):6023-33. doi: 10.4049/jimmunol.1202523. Epub 2013 May 10.


Antigenic peptide trimming by ER aminopeptidases--insights from structural studies.

Stratikos E, Stern LJ.

Mol Immunol. 2013 Oct;55(3-4):212-9. doi: 10.1016/j.molimm.2013.03.002. Epub 2013 Mar 29. Review.


HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.

Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ.

Nat Struct Mol Biol. 2013 Jan;20(1):90-8. doi: 10.1038/nsmb.2460. Epub 2012 Dec 9.


Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.

Painter CA, Stern LJ.

Immunol Rev. 2012 Nov;250(1):144-57. doi: 10.1111/imr.12003. Review.


Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides.

Farfán-Arribas DJ, Stern LJ, Rock KL.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16998-7003. doi: 10.1073/pnas.1210271109. Epub 2012 Oct 1.


HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives.

Yin L, Calvo-Calle JM, Dominguez-Amorocho O, Stern LJ.

J Immunol. 2012 Oct 15;189(8):3983-94. doi: 10.4049/jimmunol.1200626. Epub 2012 Sep 10.


Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers.

Holland CJ, Rizkallah PJ, Vollers S, Calvo-Calle JM, Madura F, Fuller A, Sewell AK, Stern LJ, Godkin A, Cole DK.

Sci Rep. 2012;2:629. doi: 10.1038/srep00629. Epub 2012 Sep 4.


Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis.

Yoon T, Macmillan H, Mortimer SE, Jiang W, Rinderknecht CH, Stern LJ, Mellins ED.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11276-81. doi: 10.1073/pnas.1113966109. Epub 2012 Jun 25.

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